Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Effect of pore number of titanium mesh on Bone Formation in the procedure of GBR

골유도재생술시 그물형 티타늄막의 천공수가 골형성에 미치는 영향

  • Lee, Keun-Hyuk (Department of Periodontology, College of Dentistry, Kyung Hee University) ;
  • Kwon, Young-Hyuk (Department of Periodontology, College of Dentistry, Kyung Hee University) ;
  • Park, Joon-Bong (Department of Periodontology, College of Dentistry, Kyung Hee University) ;
  • Herr, Yeek (Department of Periodontology, College of Dentistry, Kyung Hee University)
  • 이근혁 (경희대학교 치과대학 치주과학교실) ;
  • 권영혁 (경희대학교 치과대학 치주과학교실) ;
  • 박준봉 (경희대학교 치과대학 치주과학교실) ;
  • 허익 (경희대학교 치과대학 치주과학교실)
  • Published : 2004.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed to evaluate bone formation in the calvaria of rabbit by the concept of guided bone regeneration with titanium mesh membrane. Two different titanium meshes with varying number (353, 565) of pore were utilized in the study. Two surgical sites(T353, T565) were evaluated about whether or not the number of pore may have effect on the bone formation. The animal was sacrificed at 10days, 3 weeks, 6weeks, and 8 weeks after the surgery. Non-decalcified specimens were processed for histologic analysis. 1. Titanium mesh was biocompatible and capable of maintaining the spacemaking. 2. At 3 weeks, 6 weeks, and 8 weeks after GBR procedure, bone formation was more in the T353 site than in the T565 site. 3. Soft tissue layer above the regenerated bone was better developed in the T565 site. 4. There was no difference between two membranes in bone maturity with time. Within the above results, titanium mesh with lesser pore in number might be recommended for the early bone formation.

Keywords

References

  1. Aukil, I., Greco, G., Suggs, C. : Root resoption potential of granulation tissue from bone and flap connection tissue. J. Periodont. Res. 21 : 531-542,1986
  2. Aukil, I., Simson, D. M., Schaberg, T. V. : An experimental study of new attachment proce dures in beagle dogs. J. Periodont. Res. 18 : 643-654, 1983
  3. Caton, J., Nyman, S., Zander, H. : Histmetric evaluation of pericxlontal surgery II : Connective tissue attach- ment levels after four regenerative procedures. J. Clin, Peridontol. 7 : 224-231, 1980
  4. Gottlow, J., Nyman, S., Karring, T. : Newattachment formation as a result of controlled tissue regeneration. J. Clin. Pericxlontol. 11 : 494-503, 1984
  5. Gottlow. J., Nyman, S., Lindhe, F., Karring, T. & Wennstrom, J. : New attachment formation in the human per- iodontium by guided tissue regeneration. Case reports. J. Clin, Periodontol., 13 : 604-616, 1986
  6. Karring, T., Isidor, F., Nyman, S. : Healing following implantation pericxlon- tal affected roots into bone tissue. J. Clin. Pericxlontol. 7 : 96-105, 1980
  7. Karring, T., Nyman, S. : Potentials for root resorption during pericxlontal wound healing. J. Clin. Pericxlontol. 11 : 41-52,1984. https://doi.org/10.1111/j.1600-051X.1984.tb01307.x
  8. Nyman, S., Karring, T., and Lindhe, J. : The regenerative potential of the per- iodontalligament, An experimental study in the monkey. J. Clin. Periodontol.,9: 257-265, 1982
  9. Nyman, S., Karring, T., and Lindhe, J. : Healing following implantation of per- icxlontal affected roots into gingival con- nective tissue. J. Clin. Pericxlontol. 7: 394-401, 1980
  10. Nyman. S., Lindhe, J., Karring, T. : New attachment following surgical tre- atment of human peridontal disease. J. Clin. Periodontol. 9 : 290-296,1982
  11. Niederman, R., Savitt, E. D., Heeley, J. D., and Duckworth, J. E. : Regeneration of furca bone using Gore-Tex periodontal material. Int. J. Periodont. Res. Dent. 9(6) : 468-480,1989
  12. Pontoriero, R., Lindhe, J., Nyman, S., Karring, T., Rosenberg, E., and Sanavi, F. : Guided tissue regenerationin the treatmentof furcation defects in man- dibular molars. A clinical study of degree III involvements. J. Clin. Perio- dontol, 16(3) : 170-174, 1988
  13. Dahlin, C., Linde, A., Gottiow, J., Ny-man, S. : Healing of bone defects by guided tissue regeneration. Plast, Re- constr, Surg, 81 : 672-676, 1988 https://doi.org/10.1097/00006534-198805000-00004
  14. Becker, W., Dahlin, C., Becker, B. E. : The use of e-PTFE barrier membranes for bone promotion around titanium implants placed into extraction socket: A prospective multicenter study. Int. J. Oral Maxillofac. Implants, 9 : 31-40, 1994
  15. Dahlin, C., Gottlow, J., Linde, A., Ny- man, S. : Healing of maxillary & man- dibular bone defectsusing a membrane technique. Anexperimental study in monkeys. Scand. J. Plast, Reconst. Surg, 24: 13-19, 1990
  16. Dahlin, C., Andersson, L., Lindhe, A. : Bone augmentation at fenestrated im- plants byan ostteopromotive membrane technique, : A controlled clinical study. Clin, Oral. Implants Res, 2 :159-165,1991
  17. Dahlin, C., Sennerby, L., Lekholm, U., Linde, A., Nyman, S. : Generation of new bone around titanium implants using a membrane technique. An ex- perimental study in rabbits, Int. J. Oral. Maxillofac. Implants, 4 : 19-25, 1989
  18. Seibert, J., Nyman, S. : Localized ridge augmentation in dogs, A pilot study using membranes and hydroxyapatite, J. Periodontol. 61 : 157-165, 1990
  19. Becker W, Becker B, Handlesman M, Celletti R, Ochsenbein C, Hardwick R, Langer B, : Bone formation at dehisced dental implant sites treated with im- plant augmentationmaterial: A pilot study in dogs. Int. J. Periodont, Rest. Dent. 10: 93-101,1990
  20. Warrer K, Gotfredsen K, Hjorting- Hansen E, Karring T. : Guided tissue regeneration ensures osseointegration of dental implants placed into extraction sockets. Clin. Oral. Impl, Res. 2 : 166-171,1991
  21. Gotfredsen K, Nimb L, Buser D, Hjorting-Hansen E. : Evaluation of guided bone regeneration around im- plants placed into fresh extraction sockets. An experimental study in dogs. J. Oral. Maxillofac. Surg, 51 : 879-884,1993
  22. Lekholm U, Becker W, Dahlin C, Becker B, Donath K, Morrison E. : The role of early versus late removal of $GTAM^{\circledR}$ membrane on bone formation at oral implants placed into immediate extraction sockets. An experimental study in dogs. Clin. Oral. Impl, Res. 4 : 121-129, 1993
  23. Buser D, Bragger U, Lang NP, Nyman S. : Regeneration and enlargement of jaw bone using guided tissue regenera- tion, Clin, Oral. Impl, Res. 1 : 22-32, 1990
  24. Dahlin C,Andersson L, Linde A. : Bone augmentation at fenestrated im- plants by an osteopromotive membrane technique. Clin. Oral. Impl, Res. 2: 159-165, 1991
  25. Buser D, Dula K, Belser U, Hirt H.P, Berthold H. : Localized ridge augmenta- tion using guided bone regeneration. I. Surgical procedure in the maxilla. Int. J. Periodont, Rest. Dent. 13: 29-45, 1993
  26. Linde A, Thorfen C, Dahlin C, Sandberg E. : Creation of new bone by an osteo- promotive membrane technique. J. Oral. Maxillofac. Surg, 51: 892-897, 1993
  27. Tinti C, Vincenzi G, Cochetto R. : Guided tissue regeneration in mucog- ingival surgery. J. Periodontol. 64: 1184-1191,1993
  28. Lundgren, D., Lundgren, A. K., Sen- nerby, L., Nyman, S. : Augmentation of intramembmeous bone beyond the skeletal envelope using an occlusive titanium barrier. Clin. Oral. Implants Res.,6: 67-72,1995
  29. Malchiodi, L., Scarano, A., Quaranta, M., Piattelli, A. : Rigid fixation by means of titianium mesh in edentulous ridge expansion for horizontal ridge augmentation in the maxilla. Int. J. Oral Maxillofac. Implants, 13 : 701-705, 1998
  30. von Arx, T., Kurt, B. : Implant place- ment and simultaneous peri-imlant bone grafting using a micro titaniummesh for graft stabilization. Int. J. Periodont. Rest. Dent., 18: 117-127, 1998
  31. von Arx,T., Wallkamm, B., Hardt, N. : Localized ridge augmentation using a micro titanium mesh: a report on 27 implants followed from 1 to 3 years after functional loading. Clin, Oral Impl, Res.,9: 123-130, 1998
  32. von Arx, T., Kurt, B. : Implant place- ment and simultaneous ridge augmenta-tion using autogenous bone and a micro titanium mesh: a prospective clinical study with 20 implants. Clin, Oral Impl, Res., 10 : 24-33, 1999
  33. Leghissa, G.C., Zaffe, D., Assenza, B., Botticelli, A.R. : Guided bone regener- tion using titanium grids: report of 10 cases. Clin. Oral Impl. Res., 10 : 62-68, 1999
  34. Assenza, B., Piattelli, M., Scarano, A, Iezzi, G., Petrone, G., Piattelli, A : Localized ridge augmentation using titanium micromesh. J. Oral Implantol.,27 : 287-292, 2001
  35. van Steenberghe, D., Johansson, C., Quirynen, M., Molly, L., Albrektsson, T., Naert, I. : Bone augmentationby means of a stiffocclusive titanium barrier. Clin, Oral Impl. Res., 14: 63-71, 2003
  36. Majzoub, Z., Berengo, M., Giardino, R., and Cordioli, G. : Roleof intramarrow penetration in osseous repair : A pilot study in the rabbit calvaria. J. periodontol.,70 : 1501-1510, 1999
  37. Schmid, J., Hammerle, C. H. F., Olah, A. J., and lang, N. P. : Membrane permeability is unnecessary for the guided generation of new bone. An experimental study in rabbit. Clin, Oral. Implants Res.,5 : 125-130, 1994
  38. Lundgren, A. K., Lundgre, D., Taylor, A. : Influence of barrier occlusiveness on guided bone augmentation. An ex- perimental study in the rat. Clin. Oral Impl, Res., 9: 251-260, 1998
  39. Bartee, B. K. : Evaluation of a new polytetrafluoroethylene guided tissue regeneration membrane in healingex- traction sites. Compendium, 19: 1256- 1264, 1998
  40. Kubo, K., Tsukasa, N., Iki, K., Uehara, M.m Shimotsu, A., Seto, Y., Hyon, S.-H., Ikada, Y., Kubota,T., Sueda,T. : Occlusive effects of lactic acid-glycolic acid copolymer membrane on gingival fibroblasts in vitro. J. Biomed. Mater. Res., 39: 554-559, 1998
  41. Fukuda, T., Ezawa, T., Tanaka, K, Ito, K. : Peripheral occluding effects of non-absorbable membranes on ingrowth of cultured gingival connective tissue cells. J. Periodontol., 71 : 1680-1686, 2000
  42. Schmid, J., Hammerle, C. H. F., and Fluckiger, L. : Blood filled spaces with and without filler materials in guided bone regeneration. A comparative exper- imental study in rabbit using biore- sorbable membranes. Clin. Oral. Implants. Res.,8: 75-81, 1997
  43. Melloning, J. T., Bowers,G .W., Bright, R .W., and Lawrence, J. J. : Clinical evaluation of freeze-dried allografts in periodontal osseous defects. J. per- iodontol., 47: 125-131, 1976
  44. Schenk, R. K., Hardwick, W. R., Dahlin, C. : Healing pattern of bone rege- neration in membrane-protected defects. A histologic study in the canine mandible. Int. J. Oral, Maxillofac. Implants, 9 : 13-29, 1994
  45. Jovanovic, S. A., Nevins, M. : Bone formation utilizing titanium-reinforced barrier membranes. Int. J. Periodont. Res. Dent. 15(1) : 57-69, 1995
  46. Schimid, J., Wallkamm, B., Hammerle, CHF., Gogolewski, S., and Lang, N.P. : The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment. Clin. Oral. Impants Res. 8 : 244-248, 1997
  47. Urist, M., Strates, B. S. : Bone morphogenetic protein. J, Dental Res., 50: 1392-1406, 1971
  48. Urist, M. R., Hue, Y. K., Brownell, A. G. : Purification of bovine bone mor- phogenetic protein by hydroxyapatite chromatography. Proc, Natl. Sci., USA. 81 : 371-375, 1984
  49. Mohan, S., Baylink, D. J. : Bone growth factors. Clin. Orthop., 263 : 30-48, 1991
  50. Lindholm, T. C., Lindholm, T. S., Marttinene, A., Urist, M. R. : Bovine bone morphogenetic protein( bBMP/NCP) -induced repair of skull trephine defects in pigs. Clin, Orthop., 301 : 263-270,1994
  51. Boyne, P. J., Marx, R. E., Nevins, M., Tripplett, G., Lazaro, E., Lilly, L., Ader, M., Nummikoski, P. : A feasibility study evaluating rhBMP-2/ absorbale collagen sponge for maxillary sinus floor augmentation. Int. J. Periodont. Rest. Dent., 17: 11-25, 1997
  52. Wozney, J. M. : Biology and clinical applications of rhBMP-2. Tissue Eng- ineering, Ist, ed., pp 103-123. Quin- tessence, 1999