Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Effect of Enamel Matrix Derivative on Guided Bone Regeneration with Intramarrow Penetration

골수내천공을 동반한 골유도재생술시 법랑기질유도체의 효과

  • Lee, Young-Jong (Department of Periodontology, Kyung Hee University) ;
  • Park, Joon-Bong (Department of Periodontology, Kyung Hee University) ;
  • Kwon, Young-Hyuk (Department of Periodontology, Kyung Hee University) ;
  • Herr, Yeek (Department of Periodontology, Kyung Hee University) ;
  • Cho, Kyoo-Sung (Department of Periodontology, College of Dentistry, Yonsei University)
  • 이영종 (경희대학교 치과대학 치주과학교실) ;
  • 박준봉 (경희대학교 치과대학 치주과학교실) ;
  • 권영혁 (경희대학교 치과대학 치주과학교실) ;
  • 허익 (경희대학교 치과대학 치주과학교실) ;
  • 조규성 (연세대학교 치과대학 치주과학교실)
  • Published : 2004.06.30
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Abstract

The purpose of this study was to investigate effect of enamel matrix derivative on guided bone regeneration with intramarrow penetration in rabbits. Eight adult male rabbits (mean BW 2Kg) were used in this study. Intramarrow penetration defects were surgically created with round carbide bur(HP long #6) on calvaria of rabbits. Defects were assigned to the control group grafted with mixture of the same quantity of demineralized freeze-dried bone allograft and deproteinized bovine bone mineral. Then, guided bone regeneration was carried out using resorbable membrane and suture. Enamel matrix derivative applied to defects was assigned to the test group. And treated as same manners as the control group. At 1, 2, 3 and 8 weeks after the surgery, animals were sacrificed, specimens were obtained and stained with Hematoxylin-Eosin for light microscopic evaluation. The results of this study were as follows : 1. At 1, 2 and 3 weeks, no differences were observed between the control group and the test group in the aspect of bone formation around bone graft. 2. Proliferation of blood capillary was faster in the test group than in the control group. 3. Bone regeneration in intramarrow penetration was faster in the test group than in the control group. 4. At 8 weeks, new osteoid tissue formation around bone graft was more prominent in the test group than in the control group. From the above results, enamel matrix derivative might be considered as the osteopromotion material and effective in the guided bone regeneration with intramarrow penetration.

Keywords

References

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