• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.42-47
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• 2010

The pulse diagnosis is an important method in Oriental Medicine. Recently, there have been continuous attempts to replace the finger palpation by Oriental medical doctors (OMDs) by more objective tools based on machines, e.g., pulse analyzers. To improve the performance of the pulse analyzers, both the machine-appropriate interpretations for the pulse images appeared in the literature and the improvement in the repeatability and reproducibility of the measurement sensors are to be developed. As an attempt towards the transformation of the pulse images in terms of machine-appropriate language, in this work, we suggest an upgraded algorithm for the solid/deficient pulses, which are the two representative pulse images informing us how strong the pulse pressure is. It has been argued that one could determine the solid/deficient pulses by the maximum pulse pressure from pulse analyzers. However, by a clinical test, we found that the maximum pulse pressure alone is not sufficient to determine the solid/deficient pulses. In addition to the maximum pulse pressure, the mean pulse pressure averaged over for five different hold-down pressures(3-D MAC) is needed to improve the agreement with the OMD's decision for the solid/deficient pulse. We found that, among the data diagnosed with having either the solid pulse or deficient pulse by OMDs, the novel algorithm showed 86.0% diagnosis rate and 81.6% concordance rate.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.2
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• pp.25-32
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• 2018

Objectives : This study was conducted to investigate the frequent diseases among the people who had been treated by collaborative treatment of Korean medicine and Western medicine, and to compare their medical use behaviors before and after the collaborative first-stage pilot project between Korean medicine and Western medicine. Methods : 4,467 patients were identified as the patients who are participated in the collaborative first-stage pilot project between Korean medicine and Western medicine during the period between July 15, 2016 and March 31 2017. We used 28,480 records of Korean national health insurance claim data from January 1 2016 to March 31 2017 to analyzed present condition of cooperative medical usage. Also we conducted a paired t test to compare the percentage of collaborative treatment days before and after the pilot project period. Results : We found that the most frequent diseases treated in the pilot project were the diseases of musculoskeletal and nervous system and then 10 major diseases such as H, K, J, C (D), N, L, E, A, H and F disease codes in order. Also it was confirmed that 14 major and 53 medium diseases are included from more than 90% of total patients. As a result of high frequency of medical treatment in Western medicine or Korean medicine is "administration of Korean medicine", which is same as before and within the pilot project. The ratio of utilizing both Western and Korean medical care for the same disease on the same day by both general patients and patients in KCD-7 disease code group C, G, I, M and S had been increased significantly. Conclusions : The pilot project might change the behavior of utilizing the medical care service by increasing the ratio of collaborative treatment of Western medicine and Korean medicine for the same disease on the same day.

• Toxicological Research
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• v.19 no.4
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• pp.267-275
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• 2003

The purpose of our study was to evaluate the toxicity of the thimerosal in embryos and neonates. Thimerosal (also known as mercurothiolate) is a mercury-containing compound used in trace amounts to prevent bacteria and other organisms from contaminating vaccines, especially in opened multi-dose vials. The toxicity of mercury is well known and those most at risk occurrs in unborn babies and newborn babies. Test methods included in vitro whole embryo culture (WEC) system and in vivo test of neonatal toxicity in Wistar rats. Ethylmercury and methylmercury were used as positive controls for the evaluating of toxic effects of mercury. In WEC assay, treated concentrations of thimerosal, ethylmercury and methylmercury were up to 0.01, 0.025, 0.05, 0.1, 0.25, 0.5, 1, 2.5 and 5 $\mu\textrm{g}$/$\textrm{m}{\ell}$, respectively. All compounds didn't show any morphological abnormalities, but showed retardation of growth and development in dose dependent manner (> 0.5 $\mu\textrm{g}$/$\textrm{m}{\ell}$). These data indicated that thimerosal showed developmental toxicity in vitro. In vivo neonatal toxicity, Wistar rats were administered subcutaneously with thimerosal, ethyl mercury, or methylmercury (5, 25, 50, 250, and 500 $\mu\textrm{g}$/kg) during from postnatal day (PND) 4 to 25. Significant effects of these compounds on relative organ weights and organ morphology were not observed in this experiment. However, accumulation of mercury was detected in the kidney and testis when treated with thimerosal, ethylmercury, or methylmercury. These results suggest that thimerosal may be a harmful compound to embryo and neonate, but used concentration of thimerosal in these experiments is much higher than that of clinical application. Further investigation is needed on the safety of vaccine components, i.e. a thimerosal using in vitro and in vivo tests in the future.

• Clinical and Experimental Reproductive Medicine
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• v.20 no.1
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• pp.37-43
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• 1993

In 27 patients with the past history of poor response to the gonadotropin superovulation induction due to poor follicular growth or permature surge of endogenous luteinizing hormone, the effectiveness of pituitary supperssion with the gonadotropin releasing hormone agonist(GnRH-a) in in vitro fertilization(IVF) program was evaluated in 43 cycles using a combination regimen of D-Trp-6 LHRH(Decapeptyl, Ferring)and FSH/hMG from June, 1989 to August, 1990 at Korea University Hospital IVF Clinic. At midluteal phase of menstrual cycle, Decapeptyl-CR was administered by long-term protocol to minimize initial agonistic effect of endogenous gonadotropins. After the confirmation of pituitary suppression, about 2-3 weeks after GNRH-a administration, ovarian follicle growth was stimulated with FSH/hMG and followed by transvaginal ultrasonic measurement of follicle size and by monitoring of serm E2 and LH if necessary. When compared with the control group stimulated with gonadotropin regimen only, the cancellation rate and occurrence rate of premature LH surge during gonadotropin treatment were significantly lower in study group(11.6% and 2.4%, respectively). There is no significant differences in the mean number of aspirated oocytes, fertilization/cleavage rate, embryo transfer(ET) rate, and mean number of embryos transferred between the two groups. The pregnancy rate per treatment cycle, 16.3%, and per ET cycle, 23.3%, were significantly higher in the study group compared with those of control group. These data suggest that GnRH-a therapy is effective for previous poor responder In gonadotropin superovulation induction for IVF.

• Clinical and Experimental Reproductive Medicine
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• v.23 no.3
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• pp.277-282
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• 1996

Serum inhibin concentrations, determimed by radioimmunoassay, were measured in women undergoing pituitary suppression with Decapeptyl and subsequently ovarian stimulation with Highly Purified-Metrodin(HP-FSH) to appraise follicular development. Early follicular basal serum inhibin level correlated with the number of oocytes retrieved(r=0.89, n=8, p<0.05). The number of oocytes retrieved showed a significant correlation with serum inhibin level on the day of hCG administration(r=0.73, n=8, p<0.05). The number of mature oocytes showed a significant correlation with serum inhibin level on the day of hCG administration(r=0.73, n=8, p<0.05). These data suggest that: (1) In the early follicular phase, basal serum inhibin may be a valid index to predict ensuing follicular growth : (2) In the preovulatory phase, maximum serum inhibin may be one of the indexes of follicular development during hyperstimulation cycles.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.3
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• pp.33-49
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• 2018

Objectives: The purpose of this study was to investigate the correlation between Pattern identification instrument and biomarkers in polycystic ovary syndrome patients. Methods: Pattern identification instrument questionnaire, Sasang constitutional test, body composition test, pulse analyzing test, laboratory test were performed and the results were analyzed. Correlation analysis was performed between pattern identification and laboratory test results. Results: Testosterone, SHBG, $17{\alpha}$-OH-progesterone, AMH were highest in the Kidney-Yang Deficiency (腎陽虛) group. LH, FSH, LH/FSH ratio were the highest in the Endogenous Heat due to Yin Deficiency (陰虛內熱) group. DHEA-S was the highest in the Dampness-Heat in Liver Meridian (肝經濕熱) group. E2, Prolactin, Cholesterol, Triglyceride, HDL-Cholesterol, LDL-Cholesterol, Glucose (FBS), Insulin, HOMA-IR ratio, HbA1c were the highest in the Phlegm-Dampness (痰濕) group. Conclusions: In this study, we obtained basic data analyzing the correlation between pattern identification instrument and biomarkers in polycystic ovary syndrome patients. If further studies are performed, we expect to be able to obtain clues to study the mechanism of polycystic ovary syndrome.

• Journal of the East Asian Society of Dietary Life
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• v.24 no.6
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• pp.723-738
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• 2014

This study examined nutrient intake of long-lived men and women living in Jeollanam-do (Gangjin, Goksung, Gurye, Damyang, Boseong, Suncheon, Jangheung) which is known as representative Korean longevity area. Using the 24 hr recall method, dietary nutrient intake data were collected from 134 subjects (67 for 80~89 years old, 67 for more than 90 years old) in spring and fall 2012. Nutrient for each subject were calculated using CAN-pro. Subjects' daily mean intake levels of macronutrients, vitamins and minerals were higher in fall than in spring. Compared to KDRIs, subjects less than recommend (RNI/AI). East consumed nutrients compared to KDRIs were folate, potassium, calcium, vitamin $B_1$, vitamin $B_2$ and vitamin E. Subjects 232.8~363.1% of recommended intake level for natrium. The nutrient adequacy ratio (NAR) was 0.87 for subjects in their 80s and 0.79 for than 90 years old. The average NAR of all subjects was 0.83. The index of nutritional quality (INQ) exceeded 1 for most nutrients except for Ca (0.87), K (0.77), vitamin $B_1$ (0.84), vitamin $B_2$ (0.70) and folate (0.68). The average INQ was 1.31. This study concluded that even though long-lived men and women living in Jeollanam-do consumed less than RNIs, nutrition consumption quality was relatively fine based on NAR and INQ results.

• Archives of Pharmacal Research
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• v.26 no.1
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• pp.83-88
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• 2003

KR-984055 is a new oral cephalosporin antibiotic with activity against both gram-positive and gram-negative bacteria. Lipophilic ester-type prodrugs of KR-984055, i.e., KR-999001 and KR-999002, have been synthesized in an attempt to increase the oral bioavailability of this broad-spectrum antibiotic agent. In this study we determined the oral bioavailability of KR-984055 and its prodrugs in the rat, and evaluated the pharmacokinetic model that best describes the plasma concentration behavior following single intravenous (IV) and oral single dose. In addition, concentrations in plasma as well as biliary and urinary recovery of KR-984055 were determined. Also, protein binding of KR-984055 in plasma was examined in vitro. The degree of protein binding of KR-984055 was in the range of 92.09~94.77%. KR-984055 exhibited poor oral bioavailability (7.02$\pm$1.58%). The observed oral bioavailabilities of KR-984055 from KR-999001 and KR-999002 were 38.77$\pm$2.81 % and 39.81$\pm$5.25%, respectively. These data were calculated from the levels of free KR-984055 in plasma. Oral KR-999001 and KR-999002 were not recovered from plasma, suggesting that it was readily cleaved to free KR-984055. KR-999001 and KR-999002 appear to be an efficient oral prod rug of KR-984055 that deserved further clinical evaluation in human.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.12 no.3
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• pp.404-412
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• 2005

Purpose: This study was done to examine the correlations between personality type and job satisfaction of nurses. Methods: Subjects included three hundred twelve nurses ages from 21 to 55. The Myers-Briggs Type Indicator(MBTI) was administered to determine the personality types of the nurses(n=312). A job satisfaction survey including a demographic and career questionnaire was also used. Data were analyzed using ANOVA. Results: The mean score fur job satisfaction was 113.68 out of 205. The result showed that there was no statistically significant correlation between job satisfaction and information gathering functions, S: Sensing, N: Intuition (t=.667, p=.499), T; Thinking, F; Feeling (t=.822, p=.412). The results, however, indicated that style for gaining energy(I: Introversion, E: Extroversion)(t=2.008, p=.046) and life dealing style(J : Judgement, P : Perception)(t=2.290, p=.023) were significantly correlated with job satisfaction. The extrovert focuses on the outside and get energy through interacting with people and doing things. Judgement type is described as organized, decisive, and orderly. Conclusion: Nurses in the extrovert and judgement types were more satisfied with their Jobs than those in the introvert and perceptive type. Other results support that educational level, marital status, job characteristics, clinical experiences, motivation for nursing, and night duty were correlated with job satisfaction.

• Speech Sciences
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• v.8 no.4
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• pp.139-156
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• 2001

Speech intelligibility in patients with complete dentures is an important clinical problem depending on the material used. The objective of this study was to investigate the speech of two edentulous subjects fitted with a complete maxillary prosthesis made of two different palatal materials: chrome-cobalt alloy and acrylic resin. Three patients with complete dentures in the experiment group and ten people in the controls groups participated in the experiment. CSL, Visi-Pitch were used to measure speech characteristics. The test words consisted of a simple vowel /e/, meaningless three syllabic words containing fricative, affricated and stops sounds, and sustained fricative sounds /s/ and /$\int$/. The analysis speech parameters were vowel and lateral formants, VOT, sound durations, sound pressure level and fricative frequency. Data analysis was conducted by a series of paired T-test. The findings like the following: (1) Vowel formant one of patients with complete denture is higher than that of the control group (p<0.05), while lateral formant three of patients with complete denture is lower than that of the control group (p<0.0l). (2) Patients with complete denture produced lower speech intelligibility with low fricative frequency (/$\int$/) than control group (p<0.0). The speech intelligibility of patients with metal prosthesis was higher than that of those with resin prosthesis (p<0.05). (3) Fricative, lateral and stop sound durations of patients with complete denture were longer than those of the control group (p<0.01 and p<0.05), respectively. Total sound durations of patients with metal prosthesis were similar to that of the control group (p<0.05), while those with resin prosthesis had a shorter duration (p<0.01). This implied that those with metal prosthesis had higher speech intelligibility than those with resin prosthesis. (4) Patients with complete denture had higher sound pressure levels /t/ and /c/ than the control group (p<0.01). However, sound pressure levels for /c/ of patients with metal prosthesis or resin prosthesis was similar to the control group (p<0.05). (5) Patients with complete denture had higher fundamental frequency than the control group (p<0.01).