• BMB Reports
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• 제52권12호
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• pp.679-688
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• 2019

The decrease of metabolism in the brain has been observed as the important lesions of Alzheimer's disease (AD) from the early stages of diagnosis. The cumulative evidence has reported that the failure of mitochondria, an organelle involved in diverse biological processes as well as energy production, maybe the cause or effect of the pathogenesis of AD. Both amyloid and tau pathologies have an impact upon mitochondria through physical interaction or indirect signaling pathways, resulting in the disruption of mitochondrial function and dynamics which can trigger AD. In addition, mitochondria are involved in different biological processes depending on the specific functions of each cell type in the brain. Thus, it is necessary to understand mitochondrial dysfunction as part of the pathological phenotypes of AD according to each cell type. In this review, we summarize that 1) the effects of AD pathology inducing mitochondrial dysfunction and 2) the contribution of mitochondrial dysfunction in each cell type to AD pathogenesis.

• 대한족부족관절학회지
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• 제18권3호
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• pp.87-92
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• 2014

Acquired adult flatfoot is a deformity characterized by a decreased medial longitudinal arch and a hindfoot valgus with or without forefoot abduction. The etiologies of this deformity include posterior tibial tendon dysfunction, rheumatoid arthritis, trauma, Charcot's joint, neurologic deficit, and damage to the medial spring ligament complex or plantar fascia. Among these, posterior tibial tendon dysfunction is the most well-known cause. Although posterior tibial tendon dysfunction has been regarded as a synonym of acquired adult acquired flatfoot, failure of the ligaments supporting the arch can also result in progressive deformity even without a posterior tibial tendon problem. The authors describe the pathophysiology, diagnosis, and nonoperative treatment of acquired adult flatfoot, focusing on posterior tibial tendon dysfunction.

• 대한물리치료과학회지
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• 제4권1호
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• pp.351-359
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• 1997

The joint dysfunction is the major cause of pain in trunk and extremities according to J. McM. Mennell who mentioned that there were no pathological changes that was found in the painful joint. The referred pain due to joint dysfunction has to be differentiated from other painful conditions, particularly of the neuromusculoskeletal system. Most of the pain in the lower extremities is due to the sacroiliac joint dysfunction according to Setsuo Hakata who had developed arthrokinematic approach(AKA) for sacroiliac joint in 1989. AKA for sacroiliac dysfunction is made up of distraction & gliding technics that are no violent to recover the disturbed intra-articular movement and result in immediate relief of pain.

• Biomolecules & Therapeutics
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• 제30권5호
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• pp.399-408
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• 2022

Diabetic cardiomyopathy (DCM) is described as abnormalities of myocardial structure and function in diabetic patients without other well-established cardiovascular factors. Although multiple pathological mechanisms involving in this unique myocardial disorder, mitochondrial dysfunction may play an important role in its development of DCM. Recently, considerable progresses have suggested that mitochondrial biogenesis is a tightly controlled process initiating mitochondrial generation and maintaining mitochondrial function, appears to be associated with DCM. Nonetheless, an outlook on the mechanisms and clinical relevance of dysfunction in mitochondrial biogenesis among patients with DCM is not completely understood. In this review, hence, we will summarize the role of mitochondrial biogenesis dysfunction in the development of DCM, especially the molecular underlying mechanism concerning the signaling pathways beyond the stimulation and inhibition of mitochondrial biogenesis. Additionally, the evaluations and potential therapeutic strategies regarding mitochondrial biogenesis dysfunction in DCM is also presented.

• Journal of Oral Medicine and Pain
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• 제10권1호
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• pp.63-71
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• 1985

A kinematical study of bite force during voluntary isometric contraction was investigated in 20 Korean men with TMJ dysfunction and 30 Korean men as normal subject, ranging from 20 to 27 years old. The author observed maximum bite force, slope of bite force graph, curve index and duration of maximum bite force with the use of the foil strain gauge (MPM-3000) and RS Dymograph (Beckman). The obtained results were as follows : 1. Maximum bite forces were 29kg and 29kg for left and right side of normal subject (p>0.05) and 19kg and 29kg for affected and non-affected side of TMJ dysfunction patient. 2. The slopes of bite force graph were $68^{\circ}$ and $68^{\circ}$ for left and right side of normal subject (p>0.05) and $59^{\circ}$ and $71^{\circ}$ for affected and non-affected side of TMJ dysfunction patient. (p<0.01) 3. The curve indices were 0.93 and 0.90 for left and right side of normal subject and 1.10 and 0.90 for affected and non-affected side of TMJ dysfunction patient. (p>0.05) 4. The durations of maximum bite force were 424 msec and 413 msec for left and right side of normal subject and 337 msec and 334 msec for affected and non-affected side of TMJ dysfunction patient. (p>0.05)

• Journal of Oral Medicine and Pain
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• 제13권1호
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• pp.71-84
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• 1988

The author examined 206 temporomandibular disorders patients, who visited department of Oral Diagnosis and Oral Medicine in Seoul National University Hospital during the period from May 1st 1987 to April 30th 1988, clinically and radiologically and with prepared questionnaire. By clinical and radiological examination, the patients were divided into 2 groups(the patients with temporomandibular joint internal derangement and myofacial pain dysfunction syndrome or with myofacial pain dysfunction syndrome: the patient with temporomandibular joint internal derangement only). The symptom severity index and contributing factors were examined with the questionnaire, and differences in 2 groups were studied. The conclusions are followings : 1. The symptom severity index presenting the severity of symptom was higher and the scope of symptom was wider in the patients with temporomandibular joint internal derangement and myofacial pain dysfunction syndrome or with myofacial pain dysfunction compared to the patients with temporomandibular joint internal derangement only. 2. Emotions, behaviors, cognitions, and social factors were more undesirable in the patients with temporomandibular joint internal derangement and myofacial pain dysfunction syndrome or with myofacial pain dysfunction syndrome than the patients with temporomandibular joint internal derangement only.

• 한국융합학회논문지
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• 제11권8호
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• pp.331-340
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• 2020

만성통증을 동반한 류마티즘 환자에서 자율신경계 이상(autonomic nervous system dysfunction)이 동반되기도 한다. 특히 만성통증 환자에서 자율신경계 이상은 국소 통증 강도 증가 및 통증 역치 감소를 발생하여 만성 근골격계 통증에 악영향을 미친다고 확인되었다. 이런 만성 근골격계 통증 환자에 온열-척추 마사지 치료를 실시한 실험에서 통증경감과 자율신경계 회복이 되었다고 보고되고 있다. 그래서 우리는 만성 통증과 자율신경계 이상이 동반된 류마티즘 환자에 온열-척추 마사지 치료를 적용하였고 자율신경기능의 회복과 통증의 감소를 경험한 사례가 있어 보고하고자 한다.

• 대한한방내과학회지
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• 제22권4호
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• pp.627-631
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• 2001

Objective : Infrared thermal image is usually utilized for the diagnotic value of verious disease. We investigated the penile temperature of erectile dysfunction patient. Methods : We mesured the thermal difference of penile infrared thermal image in erectile dysfunction patient group and control group. Results : 1. Patient group's thermal degree is lower than Control group's in Kwanwon, Left scrotum, medial part of thigh. 2. The Kwanwon's temperature is especially showed lower than other mesured point's in erectile dysfunction patient group. Conclusion : According to the above results, it could be suggested that penile infrared image help us diagnostic value of erectile dysfunction patient.

• The Journal of Korean Physical Therapy
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• 제15권4호
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• pp.412-430
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• 2003

Functional stability is dependent on integrated local and global muscle function. Movement dysfunction can present as a local and global problem, though both frequently occur together. To good understand how movement induces pain syndrome, the optimal actions and interaction of the multiple anatomic and functional systems involved in motion must be considered. Minor alterations in the precision of movement cause microtrauma and, if allowed to continue, will cause macrotrauma and pain. These alteration of the movement result in the development of compensatory movement and movement impairment. Muscle that become tight tend to pull the body segment to which they are attached, creating postural deviation. The antagonistic muscles may become weak and allow postural deviations due to lack of balanced support. Both hypertonic and inhibited muscles will cause an alteration of the distribution of pressure over the joint(s) that they cross and, thus, may not only result from muscle dysfunction, but produce joint dysfunction as well. Alteration of the shoulder posture and movement dysfunction may sometimes result in compression of neurovascular structures in the shoulder and arm. There is a clear link between reduced proprioceptive input, altered motor unit recruitment and the neurovascular compression. This report start with understanding of the impaired alignment, movement patterns and neuromuscular compression of the shoulder girdle by movement impairment to approach method of the movement dysfunction.

• 정보교육학회논문지
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• 제11권4호
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• pp.407-416
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• 2007

본 연구는 문제중심학습을 정보 역기능 예방 학습에 적용하여 문제중심학습이 초등학교의 정보 역기능 대처 능력과 ICT 활용 능력, 학습 성취도에 어떠한 영향을 미치는지를 규명한 연구이다. 이를 위해 문제중심학습을 적용한 초등학교 정보 역기능 예방 수업을 설계하고 문제중심학습 수업의 실험집단과 전통적 수업의 비교집단으로 나누어 실제 수업에 적용한다. 문제중심학습 수업이 정보 역기능 대처 능력과 ICT 활용 능력에 함양하고 학습 성취도에 어떤 효과가 있는지 확인한다. 본 연구는 정보 역기능 예방 교육을 위한 수업 방법의 개선에 교사들에게 의미 있는 정보를 제공하고 아동들이 정보 역기능에 대한 올바른 이해와 예방 의식을 가지도록 하는데 의의가 있다.