• 제목/요약/키워드: dramatic development

검색결과 312건 처리시간 0.022초

GzRUM1, Encoding an Ortholog of Human Retinoblastoma Binding Protein 2, is Required for Ascospore Development in Gibberella zeae

  • Kim, Hee-Kyoung;Lee, Yin-Won;Yun, Sung-Hwan
    • The Plant Pathology Journal
    • /
    • 제27권1호
    • /
    • pp.20-25
    • /
    • 2011
  • Gibberella zeae (anamorph: Fusarium graminearum), a homothallic (self-ferile) ascomycete with ubiquitous geographic distribution, causes serious diseases in several cereal crops. Ascospores (sexual spores) produced by this fungal pathogen have been suggested as the main source of primary inoculum in disease development. Here, we report the function of a gene designated GzRUM1, which is essential for ascospore formation in G. zeae. The deduced product of GzRUM1 showed significant similarities to the human retinoblastoma (tumor suppressor) binding protein 2 and a transcriptional repressor, Rum1 in the corn smut fungus (Ustilago maydis). The transcript of GzRUM1 was detected during the both vegetative and sexual stages, but was more highly accumulated during the latter stage. In addition, no GzRUM1 transcript was detected in a G. zeae strain lacking a mating-type gene (MAT1-2), a master regulator for sexual development in G. zeae. Targeted deletion of GzRUM1 caused no dramatic changes in several traits except ascospore formation. The ${\Delta}$GzRUM1 strain produced perithecia (sexual fruit bodies) but not asci nor ascospores within them. This specific defect leading to an arrest in ascospore development suggests that GzRUM1, as Rum1 in U. maydis, functions as a transcriptional regulator during sexual reproduction in G. zeae.

고속 어뢰의 인공 초공동 특성에 대한 실험 연구 (Experimental Study on Artificial Supercavitation of the High Speed Torpedo)

  • 안병권;정소원;김지혜;정영래;김선범
    • 한국군사과학기술학회지
    • /
    • 제18권3호
    • /
    • pp.300-308
    • /
    • 2015
  • Recently supercavitating underwater torpedo moving at high speed (over 200 knots) has been interested for their practical advantage of the dramatic drag reduction. Cavitator located in front of the torpedo plays an important role to generate a natural supercavity and control the motion of the object. Supercavity can be created artificially by injection of compressed gas from the rear of the cavitator at a relatively low speed. In this paper, we investigated physical characteristics of artificial supercavities through cavitation tunnel experiments. One of the main focuses of the study was to measure pressure inside the cavity, and examined variation of the gravity effects appearing according to different amount of injected air. It was also found that a stable supercavity could be sustained at injection rates less than that required to form the stable supercavity because of hysteresis effect.

Geft is dispensable for the development of the second heart field

  • Fan, Xiongwei;Hou, Ning;Fan, Kaiji;Yuan, Jiajia;Mo, Xiaoyang;Deng, Yun;Wan, Yongqi;Teng, Yan;Yang, Xiao;Wu, Xiushan
    • BMB Reports
    • /
    • 제45권3호
    • /
    • pp.153-158
    • /
    • 2012
  • Geft is a guanine nucleotide exchange factor, which can specifically activate Rho family of small GTPase by catalyzing the exchange of bound GDP for GTP. Geft is highly expressed in the excitable tissue as heart and skeletal muscle and plays important roles in many cellular processes, such as cell proliferation, migration, and cell fate decision. However, the in vivo role of Geft remains unknown. Here, we generated a Geft conditional knockout mouse by flanking exons 5-17 of Geft with loxP sites. Cre-mediated deletion of the Geft gene in heart using Mef2c-Cre transgenic mice resulted in a dramatic decrease of Geft expression. Geft knockout mice develop normally and exhibit no discernable phenotype, suggesting Geft is dispensable for the development of the second heart field in mouse. The Geft conditional knockout mouse will be a valuable genetic tool for uncovering the in vivo roles of Geft during development and in adult homeostasis.

Synthesis of Dihydroxylated Chalcone Derivatives with Diverse Substitution Patterns and Their Radical Scavenging Ability toward DPPH Free Radicals

  • Kim, Beom-Tae;O, Kwang-Joong;Chun, Jae-Chul;Hwang, Ki-Jun
    • Bulletin of the Korean Chemical Society
    • /
    • 제29권6호
    • /
    • pp.1125-1130
    • /
    • 2008
  • A series of dihydroxylated chalcone derivatives with diverse substitution patterns on a phenyl ring B and the para-substituents on a phenyl ring A were prepared, and their radical scavenging activities were evaluated by simple DPPH test to determine quantitative structure-activity relationship in these series of compounds. The chalcone compounds with the ortho- (i.e. 2',3'- and 3',4'-) and para- (i.e. 2,5'-) substitution patterns show an excellent antioxidant activities (80-90% of control at the concentration of 50 $\mu$M) which are comparable to those of ascorbic acid and $\alpha$ -tocopherol as positive reference materials. On the contrary, the compounds with meta- (i.e. 2',4'-, 3',5'-) substitution pattern demonstrate very dramatic decrease in activities which are around 25% of the control even at the concentration of 200 $\mu$ M (IC50 > 200 $\mu$ M). These dramatic differences could be interpreted in terms of the ease formation of fairly stable semiquinone radicals from the ortho- and parasubstituted chalcone molecules through facilitating electron delocalization. Our results indicate that the substitution patterns of two hydroxyl groups on ring B are very important structural factors for their radical scavenging activity enhancement. Meanwhile, the substituents at para-position of the phenyl ring A of chalcones have no influence on the activity.

애니메이션 캐릭터와 성격장애 상관 연구 : 사회 고립형 성격장애를 중심으로 (A study of the relation between an animation character and personality trouble: Focus to the personality trouble on social isolation)

  • 김은주;김재웅
    • 만화애니메이션 연구
    • /
    • 통권14호
    • /
    • pp.65-82
    • /
    • 2008
  • 애니메이션은 전체적인 서사구조 속에서 캐릭터의 미적특징과 행동이 융합되어 표현되며, 이와 같은 캐릭터의 창조는 그것을 탄생하게 한 사회문화적 배경과 극적 구조 속에서 심리학적 접근이 필요하다. 본 연구는 애니메이션 캐릭터 창조에 있어 보다 현실성에 바탕을 둔 캐릭터를 형상화합과 동시에 개성적이고 독창적인 캐릭터와 네러티브 개발의 필요에 의해 시작되었다. 본 논문에서는 미국 정신의학회의 DSM-IV 정신장애와 진단 및 통계편람 을 통해 애니메이션 캐릭터의 성격장애를 분석해 본 결과 캐릭터의 성격유형은 일반적인 경향보다는 과장되게 표현됨으로써 극적인 동기유발과 극에 있어서 개연성을 위한 도구로 쓰였다. 또한 애니메이션 캐릭터에 성격장애와 같은 증세를 성격에 부여받음으로 네러티브 전개에 있어 변화를 가져 왔으며, 애니메이션 캐릭터가 비록 성격장애는 아닐지라도, 성격장애와 같은 기질이 과장 혹은 증폭되어 나타나고 있음을 알 수 있다.

  • PDF

신역사주의적 극장성의 재고(再考) -17세기 중반 뉴스북과 플레이릿 연구를 중심으로 (What's happening to theatricality after the rise of New Historicism?: A Study of Newsbooks and Playlets During the English Civil Wars and Their Significance as Textual and Theatrical Forms)

  • 최재민
    • 영어영문학
    • /
    • 제58권2호
    • /
    • pp.279-304
    • /
    • 2012
  • Since the publication of Foucault's Discipline and Punish, theatricality has become one of the key concepts in New Historicism. By defining theatricality as the most definitive feature of early modern society and culture, New Historicists have promoted the idea that theatrical practices in every day life were eventually replaced by textual practices as the western society started to undergo modernization with the advent of print culture and technologies. This paper questions this linear model of English literature, the shift of literary practices from theatricality to textuality in the event of modernization, by closely looking at the ways in which newsbooks and playlets during the English civil wars appealed to their target readers. The early print-based literary commodities during the English civil war (i.e. newsbooks and playlets) were able to win the attention of their audience not by breaking away from theatrical energy and creativity but instead by embracing and taking advantage of them through the use of dramatic conventions, dialogues, and many others. The newsbooks and the playlets during the time, however, did not simply replicate the dramatic forms and experiences of the previous generation. Instead, as the case study of Craftie Cromwell exemplifies, they went further to produce a different mode of theatricality by reshaping everyday lives into serialized drama, whose resolution is always already delayed and postponed into the ever-receding future. In conclusion, the study of the newsbook and playlets during the civil wars suggests that the textuality of modern times, materialized in print forms, have been co-evolved with the development of new theatricality, whose contents and forms are susceptible to the changes of everyday reality.

열린 끝단과 중앙 홈을 갖는 스퀴즈 필름 댐퍼의 감쇠 특성에 대한 실험적 규명 (Experimental Identification of the Damping Characteristics of a Squeeze Film Damper with Open Ends and Central Groove)

  • 김남규;김태호;강경대
    • Tribology and Lubricants
    • /
    • 제40권1호
    • /
    • pp.28-37
    • /
    • 2024
  • This paper presents the development of a squeeze film damper (SFD) test rig and experimental identification of the effects of clearance, damper length, journal eccentricity ratio, excitation amplitude, oil supply pressure, and oil flow rate on the damping coefficients of a test SFD with open ends and a central groove. Test data are compared with predictions from a simple model developed for short SFDs with open ends and a central groove. The test results show a significant decrease in the damping coefficient with increasing clearance and a dramatic increase with damper length, which are in good agreement with the simple model predictions. According to the simple model, the damping coefficient is inversely proportional to the cube of the clearance and directly proportional to the cube of the length. An increase in the journal eccentricity ratio results in a dramatic increase in the damping coefficient by as much as 15 times that of the concentric case, particularly at low excitation frequencies. By contrast, the measured damping coefficient remains almost constant with changes in the excitation amplitude and supply pressure, which are not major factors in the damper design. In general, the test data agree well with the simple model predictions, excluding cases that show increases in the SFD length and journal eccentricity, which indicate significant dependency on the excitation frequency.

Strength Development of Alkali-Activated Fly Ash Exposed to a Carbon Dioxide-Rich Environment at an Early Age

  • Park, Sol-Moi;Jang, Jeong-Gook;Kim, Gwang-Mok;Lee, Haeng-Ki
    • 한국세라믹학회지
    • /
    • 제53권1호
    • /
    • pp.18-23
    • /
    • 2016
  • The development of a binder system with a lower carbon footprint as an alternative to Portland cement has been intensely researched. In the present study, alkali-activated fly ash exposed to carbon dioxide at an early age was characterized in compressive strength tests and by MIP, XRD and FT-IR analyses. The compressive strength of carbonated specimens experienced a dramatic increase in comparison to uncarbonated specimens. The microstructural densification of the carbonated specimens was evidenced by MIP. The XRD pattern showed peaks assigned to nahcolite, indicating that the pH was lower in the carbonated specimens. Under the carbon dioxide-rich environment, the aluminosilicate gel reached a more Si-rich state, which improved the mechanical properties of the alkali-activated fly ash.

Lmbr1 Expression in Early Embryo Development Stages in White Leghorn and Chinese Silky

  • Zhang, Ying;Xu, Weizhuo;Li, Ning
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제22권1호
    • /
    • pp.7-12
    • /
    • 2009
  • Lmbr1 is regarded as a key gene that controls the digital model formation in early developmental stages of the chicken. However, there are few reports of lmbr1 expression levels and tendencies in 4-toe and 5-toe chicken species. Therefore, the objective of this study was to compare the lmbr1 expression in White Leghorn (4-toe) and Chinese Silky (5-toe). Firstly, total RNA was extracted from 14 different embryonic development stages (HH3 to HH31) in White Leghorn and Chinese Silky. Secondly, dramatic gene expression changes of lmbr1 were monitored by RT-PCR, which indicated a general up-down-up tendency with subtle differences between these two species. Moreover, Q-PCR reactions were performed to quantitate the expression level of lmbr1 in the 14 selected developmental stages. These data demonstrated a first lmbr1 expression peak of 18.68 and 15.32, a lmbr1 expression trough of 6.61 and 1.80, and a second lmbr1 expression peak of 22.33 and 12.48 in White Leghorn and Chinese Silky, respectively. Finally, embryonic in situ hybridization analysis identified that lmbr1 expressed in the ectoderm in HH21, HH23 and HH24 developmental stages in both species.

차폐선을 이용한 미얀마 500kV 변전소 차폐보호범위 계산 (Calculation of shielding range using shield wires in Myanmar 500kV Substation)

  • 박흥석;김태영;조영선;박찬섭;주세환
    • 대한전기학회:학술대회논문집
    • /
    • 대한전기학회 2005년도 추계학술대회 논문집 전력기술부문
    • /
    • pp.189-191
    • /
    • 2005
  • In the past, dramatic economical development of Korea could be achieved by well-organized 154kV power system network. Electric power Is a key Industry for the nation and industrial development. Nowadays we operates 345kV Power system with based transmission network and also we are operating 765kV power system to supply to the capital region. Currently developing countries in Southeast Asia are requiring the electric power technology to Korea so that they can acquire the source of the development-power system network. Therefore, it Is important to design transmission line and substation with appropriate methods. In this paper, a calculation and calculating process of shielding range using shield wires in Myanmar 500kV substation are reviewed according to the Myanmar 500kV power system project performed by the overseas projects section of the Korea Electric Power Corporation.

  • PDF