• Nuclear Engineering and Technology
• /
• 제50권3호
• /
• pp.519-525
• /
• 2018

Obtaining knowledge of the absorbed dose up-taken by a certain material when it is exposed to a specific ionizing radiation field is a very important task. Even though there are a plenitude of methods for determining the absorbed dose, each one has its own strong points and also drawbacks. In this article, an innovative idea for the development of a new gamma-ray dosimetry system is proposed. The method described in this article is based on optical colorimetry techniques. A color standard is fixed to the back of a BK-7 glass plate and then placed in a point in space where the absorbed dose needs to be determined. Gamma-ray-induced defects (color centers) in the glass plate start occurring, leading to a degree of saturation of the standard color, which is proportional, on a certain interval, to the absorbed dose. After the exposure, a high-quality digital image of the sample is taken, which is then processed (MATLAB), and its equivalent $I_{RGB}$ intensity value is determined. After a prior corroboration between various well-known absorbed dose values and their corresponding $I_{RGB}$ values, a calibration function is obtained. By using this calibration function, an "unknown" up-taken dose value can be determined.

• 대한한의학회지
• /
• 제31권3호
• /
• pp.1-7
• /
• 2010

Objectives: To introduce to TKM scientific dose conversion methods of human to animal or animal to human for new drug investigations. Methods: We searched guidelines of the FDA and KFDA, and compared them with references for drug-dose conversion from various databases such as PubMed and Google. Then, we analyzed the potential issues and problems related to dose conversion in safety documentation of new herbal drugs based on our experiences during Investigational New Drug (IND) applications of TKM. Results: Dose conversion from human to animal or animal to human must be appropriately translated during new drug development. From time to time, investigators have some difficulty in determining the appropriate dose, because of misunderstandings of dose conversion, especially when they estimate starting dose in clinical or animal studies to investigate efficacy, toxicology and mechanisms. Therefore, education of appropriate dose calculation is crucial for investigators. The animal dose should not be extrapolated to humans by a simple conversion method based only on body weight, because many studies suggest the normalization method is based mainly on body surface area (BSA). In general, the body surface area seems to have good correlation among species with several parameters including oxygen utilization, caloric expenditure, basal metabolism, blood volume and circulating plasma protein. Likewise, a safety factor should be taken into consideration when deciding high dose in animal toxicology study. Conclusion: Herein, we explain the significance of dose conversion based on body surface area and starting dose estimation for clinical trials with safety factor.

• Radiation Oncology Journal
• /
• 제32권2호
• /
• pp.57-62
• /
• 2014

Purpose: To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University. Materials and Methods: Retrospective study was designed for the patients with locally advanced cervical cancer, treated by radical radiotherapy from 2004 to 2009 and were evaluated by rectosigmoidoscopy. The cumulative doses of WPRT and ICBT to the maximally rectal point were calculated to the EQD2 and evaluated the association of toxicities. Results: Thirty-nine patients were evaluated for late rectal toxicity. The mean cumulative dose in term of EQD2 to rectum was 64.2 Gy. Grade 1 toxicities were the most common findings. According to endoscopic exam, the most common toxicities were congested mucosa (36 patients) and telangiectasia (32 patients). In evaluation between rectal dose in EQD2 and toxicities, no association of cumulative rectal dose to rectal toxicity, except the association of cumulative rectal dose in EQD2 >65 Gy to late effects of normal tissue (LENT-SOMA) scale ${\geq}$ grade 2 (p = 0.022; odds ratio, 5.312; 95% confidence interval, 1.269-22.244). Conclusion: The cumulative rectal dose in EQD2 >65 Gy have association with ${\geq}$ grade 2 LENT-SOMA scale.

• 대한치과보철학회지
• /
• 제50권3호
• /
• pp.184-190
• /
• 2012

연구 목적: 이 연구는 상악 전치부와 하악 구치부 치근단 방사선촬영시 이동형 구내방사선촬영기와 벽걸이 구내방사선촬영기로 촬영한 경우에서 환자의 방사선량을 알아보고자 하였다. 연구 재료 및 방법: 방사선량 측정은 선량 측정용 두경부 마네킨의 23부위에 열형광선량계 소자를 위치시키고 해당 치근단 방사선촬영을 하였다. 열형광선량계 판독기로 흡수선량을 구하였고 방사선 조사된 조직의 비율을 곱하여 방사선 가중선량을 구하였다. 국제방사선방호위원회에서 2007년에 공지한 조직 가중계수를 이용하여 각 방사선촬영의 유효선량을 구하였다. 결과: 환자의 흡수선량은 이동형 구내방사선촬영기로 촬영한 상악 전치부와 이동형 및 벽걸이 구내방사선촬영기로 촬영한 하악 구치부 치근단방사선촬영의 경우 하악체에서 가장 높았다. 유효선량은 상악 전치부 치근단 방사선촬영에서는 이동형 촬영기로 촬영한 경우 $4{\mu}Sv$, 벽걸이 촬영기로 촬영한 경우 $2{\mu}Sv$였고 우측 하악 구치부 치근단 방사선촬영에서는 각각 $6{\mu}Sv$, $2{\mu}Sv$였다. 결론: 벽걸이 구내방사선촬영기보다 이동형 구내방사선촬영기로 촬영한 치근단 방사선촬영에서의 유효선량이 더 많기 때문에 술자는 구내방사선촬영기에 따른 방사선 노출 정도를 충분히 인지하고 이를 사용하여야 한다.

• 대한방사선치료학회지
• /
• 제1권1호
• /
• pp.47-51
• /
• 1985

Authors describe some useful data when constructing tissue-equivalent compensators which would compensate tissue deficit in the treatment field of high energy electromagnetic radiation Tissue equivalent compensator is made of lucite. The ratio of compensator thickness to the thickness of tissue deficit depends on radiation energy, field size and the distance from the compensator to patient skin. When the compensator is separated from skin surface, the thickness ratio is always smaller than 1.0. This means that the larger the separation, the contribution to the total dose by means of scattered radiation from a tissue equivalent compensator is smaller. Authors propose that the thickness of lucite as tissue equivalent compensator is 0.57 times tissue deficit and the separation between compensator and skin is at least 15m for Co-60 gamma ray and 25cm for 10MV X-ray.

• 대한기계학회논문집B
• /
• 제29권7호
• /
• pp.814-819
• /
• 2005

The phase change heat transfer has been applied to the processes of machines as well as of manufacturing. The cycle in a heat exchanger includes the phase change phenomena of coolant for air conditioning, the solidification in casting process makes use of the characteristics of phase change of metal, and the welding also proceeds with melting and solidification. To predict the phase change processes, the experimental and numerical approaches are available. In the case of numerical analysis, the Enthalpy method is most widely applied to the phase change problem, comparing to the other numerical methods, i.e. the Equivalent Specific Heat method and the Temperature Recovery method. It's because that the Enthalpy method is accurate and straightforward. The Enthalpy method does not include any correction step while the correction of final temperature field is inevitable in the Equivalent Specific Heat method and the Temperature Recovery method. When the temperature field is to be used in the calculation, however, there must be converting process from enthalpy to temperature in the calculation scheme of Enthalpy method. In this study, an improved method for the Equivalent Specific Heat method is introduced whose method dose not include the correction steps and takes temperature as an independent variable so that the converting between enthalpy and temperature does not need any more. The improved method is applied to the solidification process of pure metal to see the differences of conventional and improved methods.

• Journal of the Korean Physical Society
• /
• 제73권9호
• /
• pp.1377-1384
• /
• 2018

Accurate measurement of the absorbed dose and the effective dose is required in dental panoramic radiography involving relatively low energy with a rotational X-ray tube system using long exposures. To determine the effectiveness of measuring the irradiation by using passive dosimetry, we compared the entrance skin doses by using a radiophotoluminescent glass dosimeter (RPL) and an optically stimulated luminescence detector (OSL) in a phantom model consisting of nine and 31 transverse sections. The parameters of the panoramic device were set to 80 kV, 4 mA, and 12 s in the standard program mode. The X-ray spectrum was applied in the same manner as the panoramic dose by using the SpekCalc Software. The results indicated a mass attenuation coefficient of $0.008226cm^2/g$, and an effective energy of 34 keV. The equivalent dose between the RPL and the OSL was calculated based on a product of the absorbed doses. The density of the aluminum attenuators was $2.699g/cm^3$. During the panoramic examination, tissue absorption doses with regard to the RPL were a surface dose of $75.33{\mu}Gy$ and a depth dose of $71.77{\mu}Gy$, those with regard to the OSL were surface dose of $9.2{\mu}Gy$ a depth dose of $70.39{\mu}Gy$ and a mean dose of $74.79{\mu}Gy$. The effective dose based on the International Commission on Radiological Protection Publication 103 tissue weighting factor for the RPL were $0.742{\mu}Sv$, $8.9{\mu}Sv$, $2.96{\mu}Sv$ and those for the OSL were $0.754{\mu}Sv$, $9.05{\mu}Sv$, and $3.018{\mu}Sv$ in the parotid and sublingual glands, orbit, and thyroid gland, respectively. The RPL was more effective than the OSL for measuring the absorbed radiation dose in low-energy systems with a rotational X-ray tube.

• Journal of Radiation Protection and Research
• /
• 제19권3호
• /
• pp.199-208
• /
• 1994

한국 환경을 고려하여 개발된 동적 섭식경로 모델을 이용하여 한국인이 섭취하는 음식물에 대한 유도개입준위를 산정하였다. 섭식경로에 있어 중요한 피폭효과를 가지는 I-131은 유아의 갑상선에 대한 예탁선량당량에 대해, Cs-137과 Sr-90은 전신에 대한 예탁선량당량에 근거한 선량개입준위로부터 연령군별로 13개 음식물에 대해 유도개입준위를 산정하였다. 성인은 Cs-137과 Sr-90의 음식물에 대한 유도개입준위 산정에 있어 가장 중요한 연령 군으로 평가되었다. 성인의 경우 쌀에서 Cs-137과 Sr-90의 유도개입준위는 여름철 침적의 경우 각각 2390, 47 Bq/kg, 겨울철 침적의 경우 각각 198, 79 Bq/kg으로 침적시점과 핵종에 따라 매우 다른 값의 변화를 보여주었다.

• 한국의학물리학회지:의학물리
• /
• 제4권2호
• /
• pp.9-17
• /
• 1993

본 논문의 목적의 NEC LINAC 6 MVX 선의 소조사면에 대한 선량분포를 복잡한 물팬톰 및 ion chamber대신 film 및 고체 물팬톰을 이용하여 간단히 측정하고 분석하는 시스템을 개발하는 데 있다. 단일 선속측정을 위하여 필름과 고체 물팬톰이 이용되었으며, 측정된 데이타는 percent depth dose (PDD), off-axis ratio (OAR) 등을 포함하며, 한변이 1, 2, 3cm의 정사각형 소조사면에 대하여 측정이 이루어 졌다. 또한 Output factor측정은 ion chamber로 측정되었으며, 필름에 의하여 측정된 PDD, OAR 등은 ion chamber측정기로 측정된 값과 비교 검토되었다. 필름으로 부터 측정된 PDD값으로 부터 환산식을 이용하여 tissue maximum ratio (TMR) 값을 얻었으며, 본 실험에서 얻어진 TMR, OAR 값들은 같은 에너지를 나타내는 Philips LINAC의 선량 데이타와 유사한 결과를 보여주었다. 고체 물팬톰 및 필름을 이용한 소조사면 측정은 간편하고도 유용한 방법이었으며, 특히, 자체 개발된 필름팬톰은 뇌정위적 방사선 수술을 위한 OAR 선량을 측정하는 데 유용하였다.

• Nuclear Engineering and Technology
• /
• 제49권8호
• /
• pp.1752-1757
• /
• 2017

The aim of this study is to evaluate the radioactivity levels and radiological impacts of representative black sand samples collected from different locations in the Rashid area, Egypt. These samples were prepared and then analyzed using the high-resolution gamma ray spectroscopy technique with a high-purity germanium detector. The activity concentration ($A_c$), minimum detectable activity, absorbed gamma dose rate, external hazard index ($H_{ex}$), annual effective dose rate equivalent, radium equivalent, as well as external and internal hazard index ($H_{ex}$ and $H_{in}$, respectively) were estimated based on the measured radionuclide concentration of the $^{238}U$($^{226}Ra$) and $^{232}Th$ decay chains and $^{40}K$. The activity concentrations of the $^{238}U$, $^{232}Th$ decay series and $^{40}K$ of these samples varied from $45.11{\pm}3.1Bq/kg$ to $252.38{\pm}34.3Bq/kg$, from $64.65{\pm}6.1Bq/kg$ to $579.84{\pm}53.1Bq/kg$, and from $403.36{\pm}20.8Bq/kg$ to $527.47{\pm}23.1Bq/kg$, respectively. The activity concentration of $^{232}Th$ in Sample 1 has the highest value compared to the other samples; this value is also higher than the worldwide mean range as reported by UNSCEAR 2000. The total absorbed gamma dose rate and the annual effective dose for these samples were found to vary from 81.19 nGy/h to 497.81 nGy/h and from $99.86{\mu}Sv/y$ to $612.31{\mu}Sv/y$, which are higher than the world average values of 59 nGy/h and $70{\mu}Sv/y$, respectively. The $H_{ex}$ values were also calculated to be 3.02, 0.47, 0.63, 0.87, 0.87, 0.51 and 0.91. It was found that the calculated value of $H_{ex}$ for Sample 1 is significantly higher than the international acceptable limit of <1. The results are tabulated, depicted, and discussed within national and international frameworks, levels, and approaches.