• Journal of Pharmacopuncture
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• v.2 no.1 s.2
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• pp.73-91
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• 1999

This study was carried out to invastigate the researches of Snake Venom and snakes which used in treatment 1. The fist literature that used the snake for treatment is Shin Nong Ben Cao Jing 2. Composition of Snake Venom is consist of Enzymatic proteins ; Phospholipase A(A1-2), Protease, L-amino acid oxidase etc, and Non-enzymatic proteins ; Crotamine(Cytolysin), Proteolytic factor(Hematoxin), Crotoxin(Neurotoxin) etc. 3. Main toxins in Snake Venom are Hematoxin, Cytolysin, Neurotoxin and Cardiotoxin. Lethal dose 50 value of Agkistrodon brevicaudus is $45.87{\mu}g$/18g, Agkistrodon saxatilis is $10.28{\mu}g$/18g, Agkistrodon ussuriensis is $8.68{\mu}g$/18g, therefore Agkistrodon ussuriensis has strongist Snake Venom of all in Korea. 4. Pharmacological actions of Snake Venom are anticoagulation, thrombolytic function, hypotensor etc. 5. Systemic syndromes and signs after snakebite are Dizziness(25.7%), Vomitting(23.1%), Fever(22%), Visual disturbance(18%), Headache(17.7%) and Dyspnea(17.6%), etc. 6. Local syndrome and sign after snakebite is Discoloration(54.2%), Bleeding(20.2%), Bullae(10.7%), Skinulcer(10.8%), etc. 7. Pathological syndromes after snakebite are WBC increase, Urine protein, Urine sugar, Haematuria and elevation of S-GDT, S-GPT etc. These syndromes are leaded by Hematoxin and Cytolysin. 8. Complication signs after snakebite are Cellulitis, Gastritis, Lympoma, Abscess etc. 9. Common function of Viperidae(Agkistrodon acutus or Zaocys dhumnades etc) is expelling the wind(祛風), removing obstruction in the channels(通絡), antipastic function(止痙). And it is used in order to cure hemiparesis, hemiplegia, facial palsy and CVA disease, etc. 10. Using way of snake for medical treatment is various like Herbal alchol therapy, pill, powder and injection etc. The Study on the Snake Venom should be carried out continuously for using of medical treatment.

• Toxicological Research
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• v.34 no.1
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• pp.7-12
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• 2018

Laboratory animal models have been developed to investigate preventive or therapeutic effect of medicinal products, or occurrence or progression mechanism of atopic dermatitis (AD), a pruritic and persistent inflammatory skin disease. The murine model with immunologic phenomena resembling human AD was introduced, which demonstrated skewedness toward predominance of type-2 helper T cell reactivity and pathophysiological changes similar as human AD following 2,4-dinitrochlorobenzene (DNCB) sensitization and challenge. Molecular mechanism on the DNCB-mediated AD was further evaluated. Skin tissues were collected from mice treated with DNCB, and each tissue was equally divided into two sections; one for protein and the other for mRNA analysis. Expression of filaggrin, an important protein for keratinocyte integrity, was evaluated through SDS-PAGE. Level of mRNA expression for cytokines was determined through semi-quantitative reverse transcriptase polymerase chain reaction. Expression of filaggrin protein was significantly enhanced in the mice treated with DNCB compared with the vehicle (acetone : olive oil = 4 : 1 mixture) treatment group or the normal group without any treatment. Level of tumor necrosis factor-alpha and interleukin-18 mRNA expression, cytokines involved in activity of type-1 helper T ($T_H1$) cell, was significantly downregulated in the AD group compared with other control groups. These results suggest that suppression of $T_H1$ cell-mediated immune response could be reflected into the skin tissue of mice treated with DNCB for AD induction, and disturbance of keratinocyte integrity might evoke a compensatory mechanism.

• 보존과학연구
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• s.26
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• pp.141-164
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• 2005

Most of the stone cultural properties is exposed to the weathering factor(rain, windetc.), so the shelter is constructed for reduction of its direct effect. But the shelter is indicated some problems that inharmoniousness of the surroundings, in section disturbance for insufficiency of light, the loss about the value of cultural properties and so on. So we have investigated on environmental condition (temperature, relative humidity, wind etc.) at the Standing Stone Buddhist Triad in Bae-ri, Gyeongju and Rock-carved Triad Buddha in Seosan because check the effect of the shelter. As the result, the Standing Stone Buddhist Triad in Bae-ri, Gyeongju is located a pine wood and a lot of bamboo grow naturally in nearing. Environmental difference on inside and outside of the shelter is not found because opened on all sides. But there is so dim for the direction of the sunlight that can't see the Standing Stone Buddhist. The base rock of Rock-carved Triad Buddha in Seosan well develop with crack and break, and the vegetation(trees, moss, lichen etc.) grow naturally in surroundings. Environmental difference on inside and outside of the shelter is found because closed on all sides and opened the front gate only inspection time. Inside of the shelter was too calm(air-velocity not detected) and humid(over 75%RH). Also the surface is occurred the dew(at 2-4 pm) and the efflorescence for effect of the water(rain, dew etc.). Besides the head of the central Buddhist is so dangerous for crack.

• Journal of Ecology and Environment
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• v.44 no.3
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• pp.162-177
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• 2020

Background: Ecologists have achieved much progress in the study of mechanisms that maintain species coexistence and diversity. In this paper, we reviewed a wide range of past research related to these topics, focusing on five theoretical bodies: (1) coexistence by niche differentiation, (2) coexistence without niche differentiation, (3) coexistence along environmental stress gradients, (4) coexistence under non-equilibrium versus equilibrium conditions, and (5) modern perspectives. Results: From the review, we identified that there are few models that can be generally and confidently applicable to different ecological systems. This problem arises mainly because most theories have not been substantiated by enough empirical research based on field data to test various coexistence hypotheses at different spatial scales. We also found that little is still known about the mechanisms of species coexistence under harsh environmental conditions. This is because most previous models treat disturbance as a key factor shaping community structure, but they do not explicitly deal with stressful systems with non-lethal conditions. We evaluated the mainstream ideas of niche differentiation and stochasticity for the coexistence of plant species across salt marsh creeks in southwestern Denmark. The results showed that diversity indices, such as Shannon-Wiener diversity, richness, and evenness, decreased with increasing surface elevation and increased with increasing niche overlap and niche breadth. The two niche parameters linearly decreased with increasing elevation. These findings imply a substantial influence of an equalizing mechanism that reduces differences in relative fitness among species in the highly stressful environments of the marsh. We propose that species evenness increases under very harsh conditions if the associated stress is not lethal. Finally, we present a conceptual model of patterns related to the level of environmental stress and niche characteristics along a microhabitat gradient (i.e., surface elevation). Conclusions: The ecology of stressful systems with non-lethal conditions will be increasingly important as ongoing global-scale climate change extends the period of chronic stresses that are not necessarily fatal to inhabiting plants. We recommend that more ecologists continue this line of research.

• Biomolecules & Therapeutics
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• v.15 no.1
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• pp.34-39
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• 2007

Alzheimer's disease (AD) is an abnormal accumulation of the ${\beta}$-amyloid protein $(A{\beta})$ in specific brain region. It has been speculated that disturbance in cholesterol homeostasis may contribute to the etiology of AD by increasing $A{\beta}$ generation. However, conclusive evidence and possible mechanism has not been reported. In the present study, we demonstrated that rabbits treated with 0.5% cholesterol for 16 weeks increased serum total cholesterol, triacylglycerol, and low-density lipoprotein levels. $A{\beta}$ levels is higher in the hippocampus of brain in cholesterol dieted rabbits than that of normal diet rabbis. Expression and activities of ${\beta}-$ and ${\gamma}-$ secretases, the enzymes that cleave ${\beta}$-amyloid precursor protein to generate $A{\beta}$, were also increased in hippocampus of high cholesterol dieted rabbit than those of normal dieted rabbits. Our results suggest that high cholesterol diet may be associated with increased $A{\beta}$ accumulation in the brain of rabbits, and suggest that high cholesterol diet may be causal factor in the development or progression of AD.

• Korean Journal of Cognitive Science
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• v.12 no.4
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• pp.1-9
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• 2001

Mobile Internet can be used anytime and anyplace thanks to the portability of mobile phones and wireless connectivity to the Internet. Therefore Mobile Internet users can be in various contexts compared with Wire Internet users in stationary contexts. In this research out of various context attributes, we selected physical context attributes of hands feet and eyes and studied how these affect the performance of Internet use and user\\` satisfaction. For this research we made control1ed experiments in performing the given task in each attribute and measured the task accuracy and the subjective satisfaction. The experiments indicated that each attribute doesn\\`t affect the accuracy and satisfaction when it is given individually but when two of more context attributes are given simultaneously in context of disturbance of eyes and motion of legs the accuracy and satisfaction declines. This suggests that the subjects need more attention for the physical context of two or more factors than one factor because of the attention capacity limit. As the result, the attention capacity for the task shrinks.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.05a
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• pp.464-465
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• 2018

Bass and Bluegill, which are representative ecosystem disturbance species, are reported to be the most important factor in the reduction of domestic native fish populations in Korea. Therefore, it is necessary to develop system and field application technology for the extermination of these foreign species. Recently, the CNN(Convolutional Neural Network), one of the deep learning systems for the recognition, classification, and learning, has shown excellent performance. However, CNN data used for object recognition and classification were mainly applied to recognition and classification of other objects with distinct characteristics. This study proposes a system that applies CNN to the classification of fish species with similar characteristics.

• Journal of Oral Medicine and Pain
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• v.22 no.2
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• pp.359-371
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• 1997

Stress is recognized as a major predisposing and/ or precipitating factor in long-lastig intractable chronic pain, such as temporomandibular disorders, headache, and other psychophysiological disorders. So it is necessary to detect physical and psychological changes induced by stress as soon as possible for positive treatment outcome. This study was performed to investigate the occurrence rate of stress symptoms according to anatomic region, type of symptom, and other personal and social factors. 859 subjects from general population answered the stress symptom questionnaire devised by the author and composed of 50 items. Data from the questionnaire were analyzed statistically with SPSS program and the results obtained were as follows : 1. Oral symptom which showed the highest frequency rate of 38.8% was vesicular lesion of the lip and cheek. The other symptoms with more 20% occurrence rate were ulcerative leion of lip and cheek, toothache, paresthesia of teeth, eruption of tongue, tongue coating and taste change in descending order. 2. In extraoral symptoms, ？데 disturbance was the item which showed the highest frequency rate of 62.0%, and the items for stiffness of suboccipital region and neck, headache, facial swelling, furuncle of face were answered more than 45% of the subjects whereas only 14.0% of the subjucts complained jaw pain under stress. 3. The better one who thought his or her health status was, the fewer items were answered and the difference of symptom frequency by dwelling place and by having hobby were shown in extraoral symptoms only. 4. For relief of stress symptoms, 79.2% of the subjects replied only to take a rest whereas not more than 13, 5% of the subjects visited dental clinic. Correlationship between symptom sites were very high.

• The Transactions of the Korean Institute of Power Electronics
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• v.5 no.5
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• pp.419-426
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• 2000

Generally diode rectifier has been used as Preregulator of arc- welding machine. Its defect is the generation of high current harmonics which result In utility pollution. In this parer, using the three-phase PWM converter, the input performance of arc-welding machine is improved by increasing the input power factor. When the diode rectifier in the arc-welding machine is replaced with three-phase PWM converter, PWM converter should control DC voltage of the output side. If PI controller is used for the output DC voltage regulator, the output DC voltage has high ripple voltage due to the instantaneous load variation in the arc-welding machine. In this paper, the feedforward compensator has been introduced to reduce the DC voltage ripple. It lessens the influence of load current which is the disturbance of the output DC voltage regulator. Theoretical prediction of this analysis has been verified by comparing with experimental data

• The Korean Journal of Ecology
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• v.23 no.2
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• pp.83-88
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• 2000

When interpreting change over time in forest ecosystems, distinguishing the effects of forest succession from the effects of environmental stress can be difficult. The result may be a simplistic interpretation. citing a specific successional or environmental cause of forest change when both types may be occurring. We present two case studies of changes in the forest floor in northern hardwoods. First, the belief that 50% of soil organic matter is lost in the first 20 years after logging was based on a study comparing northern hardwood stands of different ages. We resampled a series of 13 such stands after an interval of 15 years, and found that the young stands were not, in fact. losing organic matter as rapidly as predicted from the original chronosequence study. The pattern of higher organic matter content in the forest floors of older stands compared to young stands could be equally well explained by changes in logging practices over the last century as by the aging of the stand. The observed pattern of forest floor organic matter as a function of stand age was previously interpreted as a successional pattern, ignoring changes in treatment history. In the second case study, observed losses of base cations from the forest floor were attributed to cation depletion caused by acid rain and declining calcium deposition. We found that young stands were gaining base cations in the forest floor; losses of base cations were restricted to older stands. Differences in litter chemistry in stands of different ages may explain some of the pattern in cation gains and losses. In this case, the contribution of successional processes to cation loss had been overlooked in favor of environmental stress as the dominant mechanism behind the observed changes. Studies of environmental stress use repeated measures over time. but often don't consider stand age as a factor. Studies of successional change often assume that environmental factors remain constant. We were able to consider both forest succession and external factors because we repeatedly sampled stands of different ages.