• 수산경영론집
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• 제28권1호
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• pp.85-117
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• 1997

This paper is focused on management control system. From a management control perspective, strategies should be viewed as useful, but not absolutely necessary, guides to the proper design of an MCS. When strategies are formulated more clearly, more control alternatives become feasible and it becomes easier to implement each form of management control effectively. The common and important category of controls are action controls, personnel and cultural controls, and results controls. Action controls involves ensuring that employees perform(or do not perform) certain actions that are known to be beneficial(or harmful) to the organization. Personnel and cultural controls take steps to ensure that employees will control each others' behaviors. Results controls involve rewarding individuals(and sometimes groups of individuals) for generating good outcomes or punishing them for poor outcomes. The results controls of ROI-type measure cause to make managers excessively short- term oriented, or myopic. When managers' orientations to the short - term become excessive -when the management are more concerned with short-term profit than entity value-the managers are said to be myopic. We car, solve myopic problem by introducing AR(abnormal return), near-perfect indicators of value creation. The results - control ideal would be to hold all employees accountable for the wealth they individually create(or destroy) for the owners of the entities in which they work. This ideal is approachable for top management of publicly traded corporations because for these organizations, the wealth created(returns to shareholders) can be measured directly for any period(such as a year, a quarter, or a month) as the measurement period pin(or minus) the change in the market value of the stock.

• 복식
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• 제45권
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• pp.179-199
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• 1999

Indeterminancy is one of the thought systems which explains all things with not 'either-or' but 'both-and' the conditions and qualities of human identities and inner state. A view of the world of Dionisos of Nietzsche's and the character of Manneristic trend which has resolved the sense of alienation of men by paradoxic expression has succeeded to romanticism surrealism and postmodernism. 1. Cross-dressing has increased under contemporary conditions. There also have been various cross-dressing phenomena in the past but it appears strongly now that it would destroy the cultural stereotypes and give rise to the cultural insecurities in contemporary conditions. 2. The indeterminancy of status that is wealth versus poverty impacts on variations of contemporary dress. This has been represented by neglecting traditional code which is related to wealth in costume by conversion of the symbols of wealth and poverty as disguise with moderation simplicity and additionally poverty image instead of ostentation. 3. In the cultural aspect that is mother culture/ subculture the author has investigated black street fashion which has newly become visible. The black street fashion is wide spread in black popular music such as jazz Rhythm & Blues Reggae and Rap which is subculture against white. The external values of indeterminancy in fashion are n대-manneristic tendencies as deformation eclectic friction and irrational structure and graffiti method. The inner values by indeterminant expression in fashion are irony and paradox grotesque satire and amusement.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.905-910
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• 2016

Breast cancer is one of the major threats to female health, and its incidence is rapidly increasing in many countries. Currently, breast cancer is treated with surgery, followed by chemotherapy or radiation therapy, or both. However, a substantial proportion of breast cancer patients might have a risk for local relapse that leads to recurrence of their disease and/or metastatic breast cancer. Therefore searching for new and potential strategies for breast cancer treatment remains necessary. Immunotherapy is an attractive and promising approach that can exploit the ability of the immune system to identify and destroy tumors and thus prevent recurrence and metastatic lesions. The most promising and attractive approach of immunotherapeutic research in cancer is the blockade of immune checkpoints. In this review, we discuss the potential of certain inhibitors of immune checkpoints, such as antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death 1 (PD-1) and lymphocyte activation gene-3 (LAG-3), in breast cancer therapeutics. Immune checkpoint inhibitors may represent future standards of care for breast cancer as monotherapy or combined with standard therapies.

• 약학회지
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• 제49권5호
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• pp.422-427
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• 2005

Our previous data showed the protein isolated from Coptidis Rhizoma (CRP) had antifungal activity. In present study, we examined mode of action of the CRP and its activity against subcutaneous candidiasis due to C. albicans yeast cells. Results showed that the CRP blocked hyphal production from yeast form of C. albicans. The CRP also activated RAW 264.7 monocyte/macrophage cell line, which resulted in nitiric oxide (NO) production from the cells. This activation seemed to increase macrophage phagocytosis to destroy the invaders. Like other antimicrobial peptides, CRP was influenced by ionic strength, thus resulting in a decrease of antifungal activity. In murine model of a subcutaneous candidiasis, the sizes of infected areas of the nude mice given the CRP after subcutaneous injection of C. albicans yeast cells to the dorsal skin were $90\%$ less than those of the nude mice groups that received DPBS instead of the CRP. All data indicate that the CRP, which appeared to act like an antimicrobial peptide and to inhibit the morphological transition from blastoconidia, was effec­tive against the subcutaneous disease.

• 한국시뮬레이션학회논문지
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• 제17권3호
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• pp.45-51
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• 2008

개전 초,적군은 다양한 화력지원수단을 이용하여 아군의 핵심시설 파괴를 기도할 것이다. 이러한 화력지원수단 중 포병은 가장 큰 비중을 차지하고 있다. 갱도포병은 생존성 측면에서 아군에 비해 월등한 우세를 점하고 있어 아군에게 큰 위협요소로 판단된다. 갱도포병을 타격하는 연구는 지금까지 군 내부의 연구를 통해서 발전해 왔다. 그러나 이러한 연구의 대부분이 정성적인 분석방법으로 이루어져 객관적이지 못하고 다양하지 못한 방법이라는 한계를 지니고 있다. 이에 본 연구에서는 아군이 생존성의 약점을 극복하기 위하여 갱도포병이 갱도 출구를 개방하고 사격을 개시하기 전에 타격하는데 초점을 맞추고 갱도 포병을 타격하기 위한 정량적인 분석 방법으로 DEVS를 이용한 시뮬레이션 연구를 수행하고자 한다.

• 농촌계획
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• 제17권1호
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• pp.43-58
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• 2011

This paper is performed to study for the plants ecosystems for the rural community forest of designated as natural monument. In addition, it is also proposed the plan of the rural community forest's conservation and restoration for avoiding to the destroy of indiscriminate development such as land-use, cultivation. The rural community forest is a mirror that reflect the regional culture and history, as well as environment. According to this view, undoubtedly, we need to recognise the formative background of rural community forest, the relations between the environment around and the characteristic of plants ecosystem comprehensively. For the purpose of proposing to the plan of rural village forests' conservation and restoration, therefore, this study is: 1) reviews the previous research and ancient documents, and 2) surveys the vegetation structure and the growing conditions in rural village forest directly.

• Biomolecules & Therapeutics
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• 제26권1호
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• pp.4-9
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• 2018

Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells. In cancer cells, depending on the driving oncogenic event, metabolism is re-wired for nutrient import, redox homeostasis, protein quality control, and biosynthesis to support cell growth and division. In general, resting cells rely on oxidative metabolism, while proliferating cells rewire metabolism toward glycolysis, which favors many biosynthetic pathways for proliferation. Oncogenes such as MYC, BRAF, KRAS, and PI3K have been documented to rewire metabolism in favor of proliferation. These cell intrinsic mechanisms, however, are insufficient to drive tumorigenesis because immune surveillance continuously seeks to destroy neo-antigenic tumor cells. In this regard, evasion of cancer cells from immunity involves checkpoints that blunt cytotoxic T cells, which are also attenuated by the metabolic tumor microenvironment, which is rich in immuno-modulating metabolites such as lactate, 2-hydroxyglutarate, kynurenine, and the proton (low pH). As such, a full understanding of tumor metabolism requires an appreciation of the convergence of cancer cell intrinsic metabolism and that of the tumor microenvironment including stromal and immune cells.

• Journal of the Korean Wood Science and Technology
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• 제42권5호
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• pp.555-562
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• 2014

Characteristics of carbonized fiberboard such as chemical materials absorption, electromagnetic shielding, and electrical and mechanical performance were determined in previous studies. The carbonized board therefore confirmed that having excellent abilities of these characteristics. In this study, the effect of density on physical properties and sound absorption properties of carbonized fiberboards at $800^{\circ}C$ were investigated for the potential use of carbonized fiberboards as a replacement of conventional sound absorbing material. The thickness of fiberboards after carbonization was reduced 49.9%, 40.7%, and 43.3% in low density fiberboard (LDF), medium density fiberboard (MDF), and high density fiberboard (HDF), respectively. Based on SEM images, porosity of carbonized fiberboard increased by carbonization due to removing adhesives. Moreover, carbonization did not destroy structure of wood fiber based on SEM results. Carbonization process influenced contraction of fiberboard. The sound absorption coefficient of carbonized low density fiberboard (c-LDF) was higher than those of carbonized medium density fiberboard (c-MDF) and carbonized high density fiberboard (c-HDF). This result was similar with original fiberboards, which indicated sound absorbing ability was not significantly changed by carbonization compared to that of original fiberboards. Therefore, the sound absorbing coefficient may depend on source, texture, and density of fiberboard rather than carbonization.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4997-4999
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• 2015

Advanced oral squamous cell carcinoma (SCC) is a possible risk factor for myiasis, a parasitic infestation of vital tissue of humans or other mammals by dipterous larvae (maggots). Oral myiasis is a rare entity, and is mostly associated with various medical and anatomical conditions, such as neglected mandibular fracture, lip incompetence, cerebral palsy, poor oral hygiene, suppurative lesions, and cancerous wounds. Larvae cause itching and irritation due to their crawling movements and can destroy vital tissues, inducing serious or even life-threating hemorrhage. The aim of the present article was to highlight the occurrence of oral myiasis in association with squamous cell carcinoma and also to highlight the treatment and preventive approaches for such cases. A literature search was performed using MEDLINE for articles published in English relating to the occurrence of oral myiasis in oral SCC. Our search revealed 6 reports on myiasis associated with oral SCC. The surgical debridement of infected tissue with the removal of maggots is the treatment of choice in most cases of oral myiasis.

• ALGAE
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• 제20권3호
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• pp.239-249
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• 2005

Some marine coenocytic green algae could form protoplasts from the extruded protoplasm in seawater. The dissociated cell components of the coenocytic protoplasm could be reunited into live cells and, hence, the formation of new species by mixing protoplasms from different coenocytic cells has been predicted. Our results showed that an incompatibility barrier was present during protoplast formation in coenocytic algae to exclude foreign inorganic particles or alien cell components. No inorganic particles or alien cell components were incorporated into protoplast formed spontaneously in seawater. Even when the inorganic particles or alien cell and/or cell component were incorporated into protoplast in some experimental condition, they were expelled from the protoplast or degenerated within several days. A species-specific cytotoxicity was observed during protoplast hybridization between the protoplasms of Bryopsis spp. and Microdictyon umbilicatum. The cell sap of M. umbilicatum could destroy the cell components of Bryopsis spp., but had no effect on Chaetomorpha moniligera. Species C. moniligera and Bryopsis did not affect protoplast generation of either species. The wound-induced protoplast formation in vitro might have evolved in some coenocytic algae as a dispersal method, and the incompatibility barrier to alien particles or cell and/or cell component could serve as a protective mechanism for successful propagation.