• Radiation Oncology Journal
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• v.33 no.2
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• pp.149-154
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• 2015

Purpose: We performed exome sequencing in a breast cancer family without BRCA mutations. Materials and Methods: A family that three sisters have a history of breast cancer was selected for analysis. There were no family members with breast cancer in the previous generation. Genetic testing for BRCA mutation was negative, even by the multiplex ligation-dependent probe amplification method. Two sisters with breast cancer were selected as affected members, while the mother of the sisters was a non-affected member. Whole exome sequencing was performed on the HiSeq 2000 platform with paired-end reads of 101 bp in the three members. Results: We identified 19,436, 19,468, and 19,345 single-nucleotide polymorphisms (SNPs) in the coding regions. Among them, 8,759, 8,789, and 8,772 were non-synonymous SNPs, respectively. After filtering out 12,843 synonymous variations and 12,105 known variations with indels found in the dbSNP135 or 1000 Genomes Project database, we selected 73 variations in the samples from the affected sisters that did not occur in the sample from the unaffected mother. Using the Sorting Intolerant From Tolerant (SIFT), PolyPhen-2, and MutationTaster algorithms to predict amino acid substitutions, the XCR1, DLL1, TH, ACCS, SPPL3, CCNF, and SRL genes were risky among all three algorithms, while definite candidate genes could not be conclusively determined. Conclusion: Using exome sequencing, we found 7 variants for a breast cancer family without BRCA mutations. Genetic evidence of disease association should be confirmed by future studies.

• BMB Reports
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• v.44 no.4
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• pp.238-243
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• 2011

We generated 16,993 expressed sequence tags (ESTs) from two libraries containing full-length cDNAs from the brain and liver of the Korean Jindo dog. An additional 365,909 ESTs from other dog breeds were identified from the NCBI dbEST database, and all ESTs were clustered into 28,514 consensus sequences using StackPack. We selected the 7,305 consensus sequences that could be assembled from at least five ESTs and estimated that 12,533 high-quality single nucleotide polymorphisms (SNPs) were present in 97,835 putative SNPs from the 7,305 consensus sequences. We identified 58 Jindo dog-specific SNPs in comparison to other breeds and predicted seven synonymous SNPs and ten non-synonymous SNPs. Using PolyPhen, a program that predicts changes in protein structure and potential effects on protein function caused by amino acid substitutions, three of the non-synonymous SNPs were predicted to result in changes in protein function for proteins expressed by three different genes (TUSC3, ITIH2, and NAT2).

• 한국HCI학회:학술대회논문집
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• 2009.02a
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• pp.186-192
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• 2009

In this paper, we represent the recognition method for human frontal upper body pose. In HCI(Human Computer Interaction) and HRI(Human Robot Interaction) when a interaction is established the human has usually frontal direction to the robot or computer and use hand gestures then we decide to focus on human frontal upper-body pose, The two main difficulties are firstly human pose is consist of many parts which cause high DOF(Degree Of Freedom) then the modeling of human pose is difficult. Secondly the matching between image features and modeling information is difficult. Then using Pictorial Model we model the human main poses which are mainly took the space of frontal upper-body poses and we recognize the main poses by making main pose database. using determined main pose we used the model parameters for particle filter which predicts the posterior distribution for pose parameters and can determine more specific pose by updating model parameters from the particle having the maximum likelihood. Therefore based on recognizing main poses and tracking the specific pose we recognize the human frontal upper body poses.

• Journal of Internet Computing and Services
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• v.6 no.3
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• pp.71-84
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• 2005

Recently, the expert call center solution has become the center of interest, since finance and tele-marketing system, which is focused on a communication industry, have been increasing, Specially, the call center market is growing up with a supporting Caller-ID for a cellular phone in Korea, In the present, although large size companies are developing expensive solutions and instruments to service only for the big companies, there little solutions for SOHO markets, Therefore, in this paper we have shown a design and an implementation of a CTI system which is capable of in/outbound call processing by using CTI, and providing stable services by linking the customer's DB. And these functionalities have become possible by integrating functions of PBX and the computer control of the PBX. First, we have constructed call flows and analyzed packets for the standard communication through the PBX in call. Then, we have designed and implemented a middleware which linked a call between a client and a customer. Finally, we have constructed a database module for applying the CRM technology to the management of customer's contents.

• Journal of Korean Library and Information Science Society
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• v.43 no.4
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• pp.69-88
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• 2012

This research is to find a direction of development through operating status survey of public library in Busan metropolitan city. First, Normally library users visit the library to check out books or to have a private study session. Also users normally obtained information about upcoming events done in the library through using offline search methods. Second, although the usage of the website was low, however the users demanded the increase in computer numbers in the library and online database for home access. Third, the users acknowledged the importance of the public library to their local community. Library policy indicator rated high in importance to the local community(m=3.86). However the reference desk(m=2.87), checkout desk(m=2.41), computer availability(m=2.47), as well as up-to-date artifact availability(m=2.64) did not reach the average point of 3.0. Thus, revealing that the public library's management policies were not sufficient enough to satisfy the needs of the library users.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.8
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• pp.1843-1850
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• 2004

If the location information of a great number of cars kept for business with telematics terminals is acquired and managed efficiently, this information forms the foundation for controlling cars and traffic flows. The studies on the pure spatial indices have focused on the efficient retrievals. However, the acquisition and management of the terminal location of moving objects are more important than the efficiency of the query processing in the moving object databases. Therefore, it will be need to adopt parallel processing system for the moving object databases which should maintain the object's current location as precise as possible. This paper proposes a location management system using CDMA communications of telematics terminals. More precisely, we propose a architecture of spatial indexing mobile objects using multiple processors, and also newly propose a method of splitting buckets using the properties of moving objects in order to minimize the number of database updates. We also propose a acquisition method for gathering the location information of moving objects and passing the information of the bucket extents in order to reduce the amount of passed messages between processors.

• The Journal of Korean Institute for Practical Engineering Education
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• v.3 no.2
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• pp.47-52
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• 2011

Recently, in order to increase the effectiveness of engineering education, it is a trend to get out of teacher-centered, traditional pedagogical strategy which emphasizes knowledge delivery and to utilize diverse pedagogical strategies such as project-based learning, problem-based learning, and so on. Especially utilization of project-based learning(PBL) that is very effective to improve practical ability by doing projects which students can apply their knowledge learned in class has been increasing. By the way, although students work on one or more projects in your course, only the fact shouldn't say that you properly utilizes PBL. That is, many teachers make students perform projects in their courses, but only a few teachers properly utilize PBL. This paper presents PBL procedures, evaluation criteria on project subjects, an evaluation method of team project, an evaluation table of PBL accomplishment, etc. based on many years experience in PBL as a guideline for PBL in engineering education. Also, this paper proposes some complements for better PBL by analysing strength and weakness of PBL.

• Journal of KIISE:Software and Applications
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• v.27 no.3
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• pp.248-256
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• 2000

This paper presents a personalized web agent that constructs user profile which consists of user preferences on the web and recommends his/her relevant information to the user. The personalized web agent consists of monitor agent, user profile construction agent, and user profile refinement agent. The monitor agent makes a user describe his/her preferences directly and it creates the database of preference document, finally performs several keyword extraction to increase the accuracy of the DB. The user profile construction agent transforms the extracted keywords into user profile that could be confirmed and edited by the user. and the refinement agent refines user profile by recursively learning and processing user feedback. In this paper, we describe the several keyword weighting and inductive learning techniques in detail. Finally, we describe the adaptive web retrieval and push agent that perform adaptive services to the user.

• International Journal of Highway Engineering
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• v.20 no.3
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• pp.85-92
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• 2018

PURPOSES : In this study, analyze the characteristics of IOC indicator 'threshold' which is needed when evaluating the traffic signal operation status with ESPRESSO in various grade road traffic environment of Seoul metropolitan city and derive suggested value to use in field practice. METHODS : Using the computerized database program (Postgresql), we extracted data with regional characteristics (Arterial, Collector road) and temporal characteristics (peak hour, non-peak hour). Analysis of variance and Duncan's validation were performed using statistical analysis program (SPSS) to confirm whether the extracted data contains statistical significance. RESULTS : The analysis period of the main and secondary arterial roads was confirmed to be suitable from 14 days to 60 days. For the arterial, it is suggested to use 20 km/h as the critical speed for PM peak hour and weekly non peak hour. It is suggested to use 25 km/h as the critical speed for AM peak hour and night non peak hour. As for the collector road, it is suggested to use 20 km/h as the critical speed for PM peak hour and weekly non peak hour. It is suggested to use 30 km/h as the critical speed for AM peak hour and night non peak hour. CONCLUSIONS : It is meaningful from a methodological point of view that it is possible to make a reasonable comparative analysis on the signal intersection pre-post analysis when the signal operation DB is renewed by breaking the existing traffic signal operation evaluation method.

• Journal of the Korean Society for Library and Information Science
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• v.50 no.4
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• pp.55-75
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• 2016

We analyzed the characteristics of the physicians preferred information sources and barriers through in-depth interviews. Information searches for patient treatment were subdivided into deciding patient treatment methods, understanding the latest treatment trends, and preparing presentation materials for conferences. The variables that affected the search behaviors were identified as being background knowledge on the topic, clinical experience, job title, search skills, user training, and familiarity with the library homepage. PubMed was the most preferred choice because of users' familiarity, reliability, and the vastness of information; Google was also used frequently for easy access and fast search result. The accuracy and the recentness of information were the most significant criteria. Easy interface and convenient access were also considered important due to physicians' time constraints. Searching obstacles were divided into difficulty of searching system, unfamiliar term, too vast resources, difficulty to get fulltext articles and complex advanced search features. The results of this study can be utilized as a basis for improving information service of library and curriculum development for physicians.