• IMMUNE NETWORK
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• v.3 no.3
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• pp.201-210
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• 2003

Objective: The role of prostaglandin $E_2$ (PGE2) in the etiopathogenesis of immune and inflammatory diseases has become the subject of recent debate. To determine the role of PGE2 in rheumatoid arthritis (RA), we tested the effect of exogenous PGE2 on the production of cyclooxygenase-2 (COX-2) by rheumatoid synoviocytes. Methods: Fibroblast-like synoviocytes (FLS) were prepared from the synovial tissues of RA patients, and cultured in the presence of PGE2. The COX-2 mRNA and protein expression levels were determined by RT-PCR and Western blot analysis, respectively. The PGE2 receptor subtypes in the FLS were analyzed by RT-PCR. Electrophoretic mobility shift assay (EMSA) was used to measure the NF-${\kappa}B$ binding activity for COX-2 transcription. The in vivoeffect of PGE2 on the development of arthritis was also tested in collagen induced arthritis (CIA) animals. Results: PGE2 ($10^{-11}$ to $10^{-5}M$) dose-dependently inhibited the expression of COX-2 mRNA and the COX-2 protein stimulated with IL-$1{\beta}$, but not COX-1 mRNA. NS-398, a selective COX-2 inhibitor, displayed an additive effect on PGE2-induced COX-2 downregulation. The FLS predominantly expressed the PGE2 receptor (EP) 2 and EP4, which mediated the COX-2 suppression by PGE2. Treatment with anti-IL-10 monoclonal antibodies partially reversed the PGE2-induced suppression of COX-2 mRNA, suggesting that IL-10 may be involved in modulating COX-2 by PGE2. Experiments using an inducer and an inhibitor of cyclic AMP (cAMP) suggest that cAMP is the major intracellular signal that mediates the regulatory effect of PGE2 on COX-2 expression. EMSA revealed that PGE2 inhibited the binding of NF-${\kappa}B$ in the COX-2 promoter via a cAMP dependent pathway. In addition, a subcutaneous injection of PGE2 twice daily for 2 weeks significantly reduced the incidence and severity of CIA as well as the production of IgG antibodies to type II collagen. Conclusion: Our data suggest that overproduced PGE2 in the RA joints may function as an autocrine regulator of its own synthesis by inhibiting COX-2 production and may, in part, play an anti-inflammatory role in the arthritic joints.

• Korean journal of applied entomology
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• v.13 no.2 s.19
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• pp.93-97
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• 1974

This paper describes experiments made to develop a technique for marking insects and get the informations for ecological studies as a means of tagging flies with radioactive phosphorus, and also to learn the effect on the subsequent generation of flies. Tests were conducted with house flies, Musca domestica L. emerged front the larvae that had reared in a media containing various concentrations of P-32. Radioactivity of the flies was measured with end-window type $(2mg/cm^2)$ Geiger-Muller counter and proportional counter made by Aloka. In following the daily increases in counting rates by 6-day-old larvae it was apparent the larvae in the starting media containing the higher concentrations of P-32 were showing high counting rates. It was found that about 13.2 per cent of the radioactive material remained in the empty puparia after the flies emerged. Radioactivity of the emerged flies decreased gradually and the biological halflife of phosphorus-32 was approximately 6.14 days with considerable variation. A significant amount of P-32 were detected in the abdominal and thoracic sections as compared with other parts of adult. The activity of phosphorus·32 in eggs and larvae produced by adults reared in medium containing 0.2 microcurie or more of P-32 per gram were readily detected with Geiger-Mi·lier counter. On the other hand, the radioactivity of eggs and larvae produced by the treated males crossed with untreated normal females could be only detected in the medium containing more of 2.0 microcurie with G.M. counter. There was no apparent damage to the flies at dosages as high as 0.5 microcurie per gram of medium. For field studies a concentration of 0.5 microcurie of P-32 per gram of artificial medium appears to give adequate labeling for positive identification of flies and their egg masses.

• Journal of Environmental Health Sciences
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• v.43 no.3
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• pp.167-175
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• 2017

Objectives: Children may be more exposed to certain environmental contaminants because they react with greater sensitivity and have different food intakes and breathing rate per unit of body weight compared to adults. The aim of this study was to determine general exposure factors such as skin surface area, period and frequency of exposure, and others among Korean children aged ${\leq}18$ years old. This study was carried out as the first of its kind in Korea. Methods: We developed 23 recommended exposure factors for Korean children aged 0 to 18 years by reclassifying raw data from the National Health and Nutrition Examination Survey and the National Statistical Information Service, as well as through investigation by experiments in the absence of related data. Results: Reflecting the activity patterns of about 9,000 children, the daily inhalation rates for long-term exposure ranged from $9.49m^3/day$ for children from birth to <2 years to $14.98m^3/day$ for children aged 16 to <18 years. The research found that Korean children spent an average of 22.21 hours indoors, 0.67 hours outdoors, and 1.12 hours in-transit every day. Young children (${\leq}2$ years old) spent approximately 34 more minutes outdoors on weekends than they did on weekdays. Conclusion: Various physiological variables in the human body reflect characteristics of children that can directly influence risk exposure. Therefore, the identification of general exposure factors based on Korean children is required for appropriate risk assessment.

• Journal of the Korean earth science society
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• v.22 no.2
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• pp.96-104
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• 2001

To approach science education for all which has been required in STS program, it is indispensable to develop variously differentiated education courses that are suitable for various students. In order to do that, we have to abstract essential items that are dealt with in common from science textbook which is regarded as the kernel of science education. Then, these items are developed by fitting for each level-STS science study models. The purpose of this study is to improve the level-based investigation competence by applying these models to various level learning. We obtained some results as the following: First, there has been a positive change for attitude to study science in part. Second, we find the materials in our life and this study is relating to science, technique and society. So we find out the fact that there is close connection between science technique and our life. And also it helps encourage to learn. Third, in the process of searching for and producing STS materials, students have a chance to study for themselves by working out self-leading research activity. Finally, students can reduce a preconception that science is difficult by encouraging attitudes to search for and make our problems in our life scientifically and the habits thinking of and understanding our daily life itself in the scientific sight.

• Journal of Korean Academy of Nursing
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• v.4 no.1
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• pp.64-80
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• 1974

The social understanding of the rehabilitation and welfare work for the handicapped children is nearly devoid in Korea. Especially the medical rehabilitation or nursing for them is left ign. ored as well as the literature preferential to this study is wanted. For the purpose of conducting the study of this thesis Sam Yook Children's Rehabilitation Center, Inc. and Crippled Children's Center, Yonsei University Medical center sampled out; covering three months from Aug. 1 to Oct. 30, 1973, the problems of children's rehabilitation, the characteristics of the children, the medical rehabilitation, nursing, education, and vocational rehabilitation were interviewed and widely grasped. This thesis aimed at developing the rehabilitation, the professional nursing and especially aimed at contributing to the improvement of welfare for the handicapped by analysing, observing the result of this study. The result is as follows: 1. Sam Yook Children's Rehabilitation Center, Inc. has, since its establishment, contributed to the advancement of the crippled children and its purpose consists in implementing services, medical rehabilitation, nursing, education and vocational training. Crippled Children's Center, Yonsei University Medical Center is, being based on Christianity, aiming at the medical treatment and education for the crippled children. 2. All of the children admitted in the children's rehabilitation centers are the crippled children. The ratio of boys io girls is three to two. Boys are more than girls. Orphan formed 55.2 per sent of them. About 60 per cent of them is receiving medical attention free of charge. But there is no orphan in Crippled Children's Center, Yonsei University Medical Center. 3. 15.7 per cent of them have received the previous medical attention before their admitting in the centers; in Sam Yook Children's Rehabilitation Center 8.6 percent, Crippled Children's Center, Yonsei University Medical Center 50 percent; there is remarkable difference between the two. 4. On the standpoint of period of being in the centers, the children who have been over three years in Sam Yook Children's Rehabilitation Center formed 48.7 per cent; in Crippled Children's Center, Yonsei University Medical Center 2.6 percent; there is also considerable difference between the two; they couldn't discharge from the centers owing to the economic conditions and being orphan. 5. Among the diagnosis of the crippled children, poliomyelitis formed highest 51.7 percent of them ; cerebral palsy formed 30 percent secondly in order. Environmental factors (67.8 percent formed about three times of congenital factors (23.7 percent). 6. The children who are capable of doing independently activity of daily living formed 87.9 percent; 73.2 percent can walk about 300 m by wearing brace and so on. The ratio of wearing brace or leg prosthesis formed 47.4 per cent: crutch 44.3 per cent. The medical rehabilitation service and education for the crippled, are comparatively well carried out. But it is desired to improve and cultivate the vocational training, vocational guidance and special nursing to the insufficiency of their implementation. In the tendency that the rehabilitation and welfare for the handicapped are today emphasized, International Handicapped Rehabilitation Association, declaring that 1970s are the decade of rehabilitation, urged to improve positively the policy of rehabilitation and welfare for the handicapped. But here in korea the handicapped, being the object of social prejudice, ignorance, disdain lives in obscurity. Therefore the government or the community should draw up countermeasure on social under-standing, financial support, and rehabilitation services for the handicapped as well as should endeavor to make them participate in social activities as the productive total- person though they are physically imperfect.

• Industry Promotion Research
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• v.5 no.2
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• pp.71-81
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• 2020

This study has verified the process of helping actors recognize their sexual problems linked to sexual violence cases through early sexual experience history, and exploring and insighting the stuck feelings of sexual violence actors through psychodrama, which focuses on expressing behavior and emotions. The research questions were divided into sexual violence cases and perceptions of actors, actual insights through psychodrama, and dealt with past biblical history related to actors' events and events, exploration of childhood trauma, and insights and changes in emotions through psychodrama. The results from the study are as follows. First, they showed low self-understanding levels and frequent use of defense mechanisms against sexual violence cases in an environment related to cases involving sexual offenders, and were aware of the problematic factors affecting the cases in the course of their daily lives, but did not take them seriously. Second, there were many distorted masculinity and adult sites related to participants' biblical experience history. In the early experience of sexual activity, it was often viewed as a sexual object rather than an emotional exchange with a lover, and the contents of the initial Bible experience were linked to actual sexual violence cases committed by participants. Third, childhood trauma of participants through psychodrama led to rapidly changing family circumstances and abuse by fathers. Fourth, the actual content of emotions represented by anger in the early stages of psychodrama is meaningful in that it revealed the process of sadness, pain, regret and longing for a departing mother leading to objective insight into emotions through the catharsis process.

• Journal of Periodontal and Implant Science
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• v.25 no.3
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• pp.603-613
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• 1995

The purpose of this investigation was to evaluate on the biodegradability, biocompatibility and tissue regenerative capacity of synthetic bioabsorbable membranes in beagle dogs. For animal study, 9 adult beagle dogs were used to examination, on the surgical implantation of membranes and histological analysis. In each animal, the 3rd and 4th premolars of the both sides of the mandible were selected as test teeth. Two types of bioresorbable membranes including "Guidor membrane", "S-membranes" were used to examining for biological activity, and also Gore-tex membranes was used for positive control. Surgically created defects were made in 2 premolars of both sides of the mandible at $3{\times}4mm^2$ in size and tested membranes were implanted in the defected area. A plaque control regimen was instituted with daily tooth brushing with a 0.1% chlorhexidine digluconate during experimental periods. All the experimental animals were sacrificed after 2, 4, and 8 weeks from surgery and undecalcified slides were prepared using the "sawing and grinding" technique described by Donath and Breuner". In biodegradability, all the membranes were started their biodegradation from two weeks after implantation and gradually demolished of their frame morphology from eight weeks. However, demolition of membranes in 8 weeks after implantation was highest in Guidor membranes and followed by S-membranes. Biocompatibilityof two kinds of biodegradable membranes including Guidor and S-mambrane were shown to be well tolerated to the surrounding tissue, and were minimal accumulation of inflammatory cell infiltration around the implanted membranes to compare with Gore-tex membrane. Regeneration of defected alveolar bone was initiated from two weeks of membrane implantation and new bone formation was gradually increased from that time. However, pattern of new bone formation on the defected areas of two kinds of biodegrable membranes was almost similar and quite competitive comparing with Gore-tex membrane. These results implicate that bioresorbable membranes should be highly useful tool for guided tissue regeneration of periodontal defects.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.59.5-60
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• 2017

We present the relationship between vector magnetic field parameters and solar major flare occurrence rate. Based on this, we are developing a forecast model of major flare (M and X-class) occurrence rate within a day using hourly vector magnetic field data of Space-weather HMI Active Region Patch (SHARP) from May 2010 to April 2017. In order to reduce the projection effect, we use SHARP data whose longitudes are within ${\pm}60$ degrees. We consider six SHARP magnetic parameters (the total unsigned current helicity, the total photospheric magnetic free energy density, the total unsigned vertical current, the absolute value of the net current helicity, the sum of the net current emanating from each polarity, and the total unsigned magnetic flux) with high F-scores as useful predictors of flaring activity from Bobra and Couvidat (2015). We have considered two cases. In case 1, we have divided the data into two sets separated in chronological order. 75% of the data before a given day are used for setting up a flare model and 25% of the data after that day are used for test. In case 2, the data are divided into two sets every year in order to reduce the solar cycle (SC) phase effect. All magnetic parameters are divided into 100 groups to estimate the corresponding flare occurrence rates. The flare identification is determined by using LMSAL flare locations, giving more numbers of flares than the NGDC flare list. Major results are as follows. First, major flare occurrence rates are well correlated with six magnetic parameters. Second, the occurrence rate ranges from 0.001 to 1 for M and X-class flares. Third, the logarithmic values of flaring rates are well approximated by two linear equations with different slopes: steeper one at lower values and lower one at higher values. Fourth, the sum of the net current emanating from each polarity gives the minimum RMS error between observed flare rates and predicted ones. Fifth, the RMS error for case 2, which is taken to reduce SC phase effect, are smaller than those for case 1.

• Communications of Mathematical Education
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• v.31 no.4
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• pp.433-456
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• 2017

The purpose of this study is to suggest the directions for the development and improvement of mathematics textbooks in Korea by examining these characteristics of German textbooks. As a result, German mathematics textbooks were free for unit order and names of units. German mathematics textbooks defined a function for various real life and natural phenomena, relation after intuitively knowing the correspondence between two variables through a graph. In addition, it exercises interpreting the characteristics and information of the graph, guides the activity of graphing various functional situations, and contents to convert various expression methods such as graphs, tables, relational expressions, mathematical terms and sentences. In the German mathematics textbooks, mathematical expressions of the functional relations of the materials in various contexts of daily life, and the activities of predicting and predicting the future, were made to feel the usefulness of mathematics. It has raised functional thinking and provided problems related to other subjects, thus enhancing connectivity with other disciplines. It also included open issues and issues that required mathematical communication.

• Journal of muscle and joint health
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• v.1 no.1
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• pp.31-47
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• 1994

The purposes of this research are to examine the effects of muscle relaxation to the rheumatoid arthritis patients' physiological, psychological, and social adaptation, and to verify that the technique Is an effective tool for improving the patients' adaptation. This research utilized a qusi-experimental design that compares the pre-experiment measures and the post-experiment measures. The subjects of this study were 37 out-patients who were diagnosed for rheumatoid arthritis in P university hospital and K clinic between September 12, 1993 and November 30, 1993. The experimental group consisted of patients treated on Monday, Wednesday and Friday. The control group consisted of patients treated on Tuesday, Thursday and Saturday The pre-experimental survey utilized the following tools. The physiological adaptation was measured by a graphic rating scale for pain and activity of daily living. The psychological adaptation was measured by Zung's depression scale and Rosenberg's self-esteem scale : and the social adaptation was measured by Derogatis' psychosocial adjustment scale. The experimental group received muscle relaxation treatment for 15 minutes per day for the period of 2 weeks, the control group received no treatment and had quiet time. The post-experiment measurement was carried out similar to the pre-experiment survey, SPSS $PC^+$ is used to analyze the collected data. The reliabilities of the measurement tools were examined by Cronbach's ${\alpha}$ coefficients. The homogeneities between the experimental and control groups were tested by t-test and chi-square test, hypotheses were tested by t-test. This research found that the general characteristics between the groups were statistically homogenious. The physiological, psychological, and social adaptation between the groups in the pre-experimental survey were also statistically homogenious. The results of this research can be summarized as follows : 1. Concerning the Physiological adaptation, the experimental group showed a statistically lower pain score than the control group. Thus, muscle relaxation was effective to relieve the pain of rheumatoid arthritis patients (t=-2.95, p=.006). 2. Concerning the psychological adaptation, the experimental group showed a statistically lower depression score than the control group. Thus, muscle relaxation was effective to reduce the patient's depression(t=-4.00, p=.001). 3. Concerning social adaptation, the experimental group showed a statistically higher score for the health maintenance and disease control than the control groups. Thus, muscle relaxation was effective for the health maintenance and disease control (t=2.09, p=.004). This research showed that the muscle relaxation is a nursing intervention that can promote the physiological, psychological and social adaptation of the rheumatoid arthritis patients in terms of short-term and cognitive changes. However, more fundomental changes in behavior and long-term physiology could not be found through such a short-term relaxation treatment.