• Korean Journal of Radiology
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• v.23 no.11
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• pp.1067-1077
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• 2022

Objective: To determine whether Sonazoid-enhanced ultrasound (SZUS) was noninferior to SonoVue-enhanced ultrasound (SVUS) in diagnosing hepatocellular carcinoma (HCC) using the same diagnostic criteria. Materials and Methods: This prospective, single-center, noninferiority study (NCT04847726) enrolled 105 at-risk participants (71 male; mean age ± standard deviation, 63 ± 11 years; range, 26-86 years) with treatment-naïve solid hepatic nodules (≥ 1 cm). All participants underwent same-day SZUS (experimental method) and SVUS (control method) for one representative nodule per participant. Images were interpreted by three readers (the operator and two independent readers). All malignancies were diagnosed histopathologically, while the benignity of other lesions was confirmed by follow-up stability or pathology. The primary endpoint was per-lesion diagnostic accuracy for HCC pooled across three readers using the conventional contrast-enhanced ultrasound diagnostic criteria, including arterial phase hyperenhancement followed by mild (assessed within 2 minutes after contrast injection) and late (≥ 60 seconds with a delay of 5 minutes) washout. The noninferiority delta was -10%p. Furthermore, different time delays were compared as washout criteria in SZUS, including delays of 2, 5, and > 10 minutes. Results: A total of 105 lesions (HCCs [n = 61], non-HCC malignancies [n = 19], and benign [n = 25]) were evaluated. Using the 5-minutes washout criterion, per-lesion accuracy of SZUS pooled across the three readers (72.4%; 95% confidence interval [CI], 64.1%-79.3%) was noninferior to that of SVUS (71.4%; 95% CI, 63.1%-78.6%), meeting the statistical criterion for non-inferiority (difference of 0.95%p; 95% CI, -3.8%p-5.7%p). The arterial phase hyperenhancement combined with the 5-minutes washout criterion showed the same sensitivity as that of the > 10-minutes criterion (59.0% vs. 59.0%, p = 0.989), and the specificities were not significantly different (90.9% vs. 86.4%, p = 0.072). Conclusion: SZUS was noninferior to SVUS for diagnosing HCC in at-risk patients using the same diagnostic criteria. No significant improvement in HCC diagnosis was observed by extending the washout time delay from 5 to 10 minutes.

• Korea-Australia Rheology Journal
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• v.12 no.2
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• pp.119-124
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• 2000

Employing the Phan-Thien tanner (PTT) fluids model, dynamic behavior of the non-isothermal melt spinning has been investigated. Subjects such as draw resonance instability, the effects of spinline cooling and of the fluid viscoelasticity on the spinning dynamics have been studied using the governing equations of the system. In particular, the draw resonance criterion based on the traveling times of various kinematic waves in the spinline has been confirmed, the reason why the spinline cooling is stabilizing is analyzed, and the effect of fluid viscoelasticity on the spinline stability is summarized. It is believed that the same method as in this study can be applied with equal ease to other extension deformation processes like film casting and film blowing.

• Journal of Korean Institute of Industrial Engineers
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• v.19 no.2
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• pp.15-21
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• 1993

This paper considers the optimal design of accelerated life test in which the stress is linearly increased. It discusses the special case when the life distribution under constant stress follows an exponential distribution and the accelerated equation satisfies the inverse power law. It is assumed that cumulative damage is linear, that is, the remaining life of test units depends only on the current cumulative fraction failed and current stress(cumulative exposure model). The optimization criterion is the asymptotic variance of the maximum likelihood estimator of the log mean life at a design stress. The optimal increasing rate is obtained to minimize the asymptotic variance. Table of sensitivity analysis is given for the prior estimators of model parameters.

• International Journal of Reliability and Applications
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• v.17 no.1
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• pp.85-105
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• 2016

In this paper accelerated life testing is incorporated in quality control technique of acceptance sampling plan to induce early failures in high reliability products.Stress under accelerated condition can be applied in constant-stress, step-stress and progressive-stress or combination of such loadings. A ramp-stress results when stress is increased linearly (from zero) with time. In this paper optimum failure-censored ramp-stress accelerated life test sampling plan for log-logistic distribution has been formulated with cost considerations. The log-logistic distribution has been found appropriate for insulating materials. The optimal plans consist in finding optimum sample size, sample proportion allocated to each stress, and stress rate factor such that producer's and consumer's interests are safeguarded. Variance optimality criterion is used when expected cost per lot is not taken into consideration, and bilevel programming approach is used in cost optimization problems. The methods developed have been illustrated using some numerical examples, and sensitivity analyses carried out in the context of ramp-stress ALTSP based on variable SSP for proportion nonconforming.

• Structural Engineering and Mechanics
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• v.6 no.6
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• pp.711-725
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• 1998

Mixed finite element formulations for incompressible materials show pressure oscillations or pressure modes in four-node quadrilateral elements. The criterion for the stability in the pressure solution is the so-called Babu$\check{s}$ka-Brezzi stability condition, and the four-node elements based on mixed variational principles do not appear to satisfy this condition. In this study, a pressure continuity residual based on the pressure discontinuity at element edges proposed by Hughes and Franca is used to study the stabilization of pressure solutions in bilinear displacement-constant pressure four-node quadrilateral elements. Also, a solid mechanics problem is presented by which the stability of mixed elements can be studied. It is shown that the pressure solutions, although stable, are shown to exhibit sensitivity to the stabilization parameters.

• Steel and Composite Structures
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• v.4 no.1
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• pp.9-21
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• 2004

The present study aims at the reliability analysis of steel towers against the limit state of deflection. For this purpose tip deflection of the tower has been obtained after carrying out the dynamic analysis of the tower using modal method. This tip deflection is employed for subsequent reliability analysis. A limit state function based on serviceability criterion of deflection is derived in terms of random variables. A complete procedure of reliability computation is then presented. To study the influence of various random variables on tower reliability, sensitivity analysis has been carried out. Design points, important for probabilistic design of towers, are also located on the failure surface. Some parametric studies have also been included to obtain the results of academic and field interest.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.1028-1034
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• 2003

We consider the sensitivity of average inventory cost rate when true values of the parameters In the EOQ model are unknown over known ranges. In particular, In the case that the valid range on the true economic lot size are known. we provide a formula for estimating the lot size under minimax criterion. Moreover, to estimate the valid range, we apply the propagation of errors technique. Then, we present a scheme to find a (valid) lot size. based on the estimated range of the true lot size from the propagation or errors technique.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.6
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• pp.914-922
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• 2003

In this paper, the strain localization of voided ductile material has been analyzed by nonlocal plasticity formulation in which the yield strength not only depends on an equivalent plastic strain measure (hardening parameter), but also on the Laplacian thereof. The gradient terms in yield criterion show an important role on modeling strain-softening phenomena of material. The influence of the mesh size on the elastic -plastic deformation behavior and the effect of the characteristic length parameter for localization prediction are also investigated. The proposed nonlocal plasticity shows that the load -strain curves converge to one curve. Results using nonlocal plasticity also exhibit the dependence of mesh size is much less sensitivity than that for a corresponding local plasticity formulation.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.356-359
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• 1995

This paper uses a new method to improve the performance criterion of an active suspension car. The used control strategy is based on robust H$_{\infty}$ control theory taking into consideration the chasis flexibility. It will be shown that the modeling errors can be lumped into an unstructured uncertainty and the robust controller designed in the presence of these perturbations could maintain the stability and performance even for the controlled true system..

• International journal of advanced smart convergence
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• v.1 no.1
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• pp.6-13
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• 2012

An improved algorithm for image quality assessment is presented. First a simple model of human visual system, consisting of a nonlinear function and a 2-D filter, processes the input images. This filter has one user-defined parameter, whose value depends on the reference image. This way the algorithm can adapt to different scenarios. In the next step the average value of locally computed correlation coefficients between the two processed images is found. This criterion is closely related to the way in which human observer assesses image quality. Finally, image quality measure is computed as the average value of locally computed correlation coefficients, adjusted by the average correlation coefficient between the reference and error images. By this approach the proposed measure differentiates between the random and signal dependant distortions, which have different effects on human observer. Performance of the proposed quality measure is illustrated by examples involving images with different types of degradation.