• Nutrition Research and Practice
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• v.6 no.5
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• pp.414-420
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• 2012

Forty guinea pigs were divided into four groups and fed 0.04% cholesterol based control diet, plus 0.05% simvastatin, and statin plus 0.1% CoQ10 or 10% Ardisia Japonica Blume (AJB) leave powder for 4 weeks. Plasma total cholesterol levels decreased significantly in all groups fed the statin-containing diet compared with that in guinea pigs fed the control diet (P < 0.01). Plasma and liver triglycerides decreased significantly in the statin plus CoQ10 group compared with those in the control (both P < 0.05). Maximum platelet aggregation was significantly higher in the statin plus CoQ10 group than that in the other groups (P < 0.05). Na-K ATPase activity increased in the statin group and decreased in the statin plus CoQ10 group (P < 0.01). Na-K co-transport and Na passive transport decreased significantly in the control group compared with those in the other groups (both P < 0.05). Intracellular Na was highest in the statin group and lowest in the statin plus CoQ10 group and was correlated with Na-K ATPase activity. Thiobarbituric acid reactive substance production in platelet-rich plasma and liver tended to decrease in the statin plus CoQ10 group compared with those in the other groups. Plasma glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase increased significantly in the statin group compared with those in the control (P < 0.05). These result suggest that antioxidant rich AJB did not have positive effects on cardiovascular disease parameters. The statin plus CoQ10 seemed to decrease cholesterol more efficiently than that of statin alone.

• Water for future
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• v.27 no.2
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• pp.97-109
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• 1994

Parameters for the Synthetic Unit Hydrograph(SUH) using SCS and v methods(including modified type) are derived by regression analysis of the Representative Unit Hydrograph(RUH) of 22 basins in Korea. These derived SUHs were compared with the RUHs and those of Snyder and HYMO given by the Korea Institute of Construction Technology (KICT) for selected 4 basins. In SCS method, when correlated with the lag time of SUHs based on the whole basin rather than on the riverwise basins the peak discharge(excluding Bocheng stream) is close to that of RUH. BUt the peak time given by riverwise basins agrees closer to the RUH than by the whole basins. The modified Nakayasu type SUH(excluding Wi stream) associated with lag time based on riverwise basins gives better agreements to the RUH than that of Nakayasu method. And the modified Nakayasu type SUH gives much better agreement to the RUH than that of Nakayasu method for the case of both whole and riverwise basins.

• Korean Chemical Engineering Research
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• v.55 no.4
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• pp.520-529
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• 2017

Viscosity data were measured at 298.15 K and 308.15 K for formamide + 1-propanol, 2-propanol, 1-butanol, 2-methyl-1-propanol or 2-methyl-2-propanol mixtures. For an equimolar mixture, deviation in viscosity follows the sequence: 2-methyl-2-propanol >2-methyl-1-propanol>1-butanol>2-propanol>1-propanol. The viscosity data were further analyzed in terms of graph theory. Free energy of activation was also calculated from experimental viscosity data along with previously reported excess volume data. The deviation in viscosity and free energy of activation were fitted to Redlich-Kister polynomial equation. The viscosity data were also correlated by correlations like Grunberg-Nissan, Tamura-Kurata, HindMcLaughlin-Ubbelohde, and Katti-Chaudhari relation. Various adjustable parameters, $G_{12}$, $T_{12}$, $H_{12}$, and $W_{vis}/RT$, of various correlations were used to predict viscosity deviation of binary mixtures. Positive value of $G_{12}$ indicates strong interaction in the studied systems. Grunberg-Nissan relation has lowest deviation among the four correlations for formamide + 1-propanol or 2-propanol mixtures; and for mixtures of formamide with 1-butanol or 2-methyl-1-propanol, TamuraKurata has lowest deviation. Grunberg-Nissan gives lowest deviation for formamide + 2-methyl-2-propanol mixtures.

• The Journal of Korean Medicine
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• v.32 no.4
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• pp.83-99
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• 2011

Objective: This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury. Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3, and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue. Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.

• The Journal of Korean Medicine
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• v.32 no.2
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• pp.63-78
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• 2011

Objective: This study aimed to evaluate the protective effects of Maekmundong-tang (MMDT) on an elastase-induced COPD model. Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin, collagen, and caspase 3, and protein level of Cdc2 in lung tissue. Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.

• Journal of Pharmaceutical Investigation
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• v.22 no.1
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• pp.41-48
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• 1992

Six common tablet disintegrants (corn starch, Avicel PH102, calcium carboxymethylcellulose, Primojel, Kollidon CL and Ac-Di-Sol) were used at the concentration of 0, 2, 4 and 6% (w/w) in salicylamide tablets made with wet granulation method. Certain physical parameters of the disintegrants (moisture sorption, hydration capacity and bulk density) were determined to evaluate their relative efficiency. The disintegration time and dissolution rate of the tablets were correlated well with the ranks of initial rate of moisture sorption for each disintegrant as follows; Ac-Di-Sol, Kollidon CL, primojel, calcium CMC, corn starch and Avicel PH102. The initial rate of moisture sorption was important for the disintegration capacity as well as hydration capacity. The effect of storage at different temperatures and relative humidity upon the tablets containing various disintegrants was evaluated in terms of tablet hardness and disintegration time. Storage at high temperature reduced the hardness substantially and retarded the disintegration of the all tablets studied. Especially, the hardness of tablets containing Kollidon CL was significantly reduced. Although the tablet hardness was decreased and the disintegration time was increased under a moderate humid condition, both of them were decreased under the severely high humid condition of 80 or 90% RH, which was due to the breakrupture of tablet matrix bonds by the excessive uptake of moisture. Therefore, the stability caused by moisture sorption should be considered, when disintegrants having high moisture sorption such as Kollidon CL, Ac-Di-Sol and Primojel were employed in the tablets containing water-labile or hygroscopic drugs.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.39 no.spc1
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• pp.214-222
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• 2006

Dominant species of macrobenthos were analyzed based on differentiation of three distinct methods: the density based method, the biomass based method and LeBris method, by considering the frequency of occurrence using quantitative data collected over 5 years (1993-1998) at 21 stations in Chonsu Bay. Sedimentary environments as well as species composition and diversity showed the spatial and temporal distribution patterns. The ranks of dominant species as determined by the density based method were more similar to the results by the LeBris method than to those from the biomass based method. Considering the temporal variation, LeBris method were more efficient than any other methods for the determination of dominant species in Chonsu Bay. Lumbrineris longifolia, Theora fragilis, and Moerella jedoensis were recognized by all three methods. A one-way analysis of variance indicated spatial distributions patterns among most of the dominant species. These species showed positive correlations to sedimentary parameters such as mean grain size. However, T. fragilis and Paraprinospio pinnata showed the temporal patterns in their distribution, and were also correlated to the benthic environment, organic content and dissolved oxygen. Some dominant species, e.g., T. fragilis, S. scutata, G. gurjanovae proved to be useful benthic indicators based on the environmental variations determinated by long-term benthic ecological monitoring in Chonsu Bay.

• Speech Sciences
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• v.10 no.3
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• pp.145-155
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• 2003

This study compared $F_{0}$ and the first three formants of eight Korean monophthongs produced by nine transgenders (male to female) to those of eighteen normal adults. Voice analysis was done by Praat (version 4.049). A one-way ANOVA with Tukey HSD post hoc tests were performed to determine statistical differences in $F_{0}$ and formant values obtained from transgenders, and normal male and female subjects. Results indicated that there was no significant difference in $F_{1}$ of /u/, /$\Lambda$/, and /o/, $F_{2}$ of /u/, /$\Lambda$/, and /i/ and $F_{3}$ of /u/ among the 3 groups (transgenders, normal males and normal females). However, in the comparison of transgenders vs. males, a significant difference was observed in $F_{0}$ of /o/, and $F_{2}$ of /i/, /a/, /e/, and /${\ae}$/ and $F_{3}$ of /e/. Furthermore, in the comparison of transgenders vs. females, a significant difference was also observed in $F_{0}$ of all vowels, $F_{1}$ of /i/, /$\alpha$/, /e/, /${\ae}$/, and /i/. $F_{2}$ of /i/, and /${\ae}$/, and $F_{3}$ of /i/, /$\alpha$/, /$\Lambda$/, /e/, /${\ae}$/, /i/, and /o/. Also, perceptual judgment of the transgenders' voice came out somewhat correlated strongly with their $F_{0}$ values but not much with the formant values. It was concluded that the transgenders' acoustic parameters are placed in between those of the normal males and females in. terms of fundamental and formant frequency analyses of vowels. Thus, it was assumed that those differences might stem from the transgenders' original big resonating cavities.

• Environmental Engineering Research
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• v.15 no.4
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• pp.215-223
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• 2010

This study attempted to develop and suggest a more appropriate method for the determination of event mean concentration (EMC) and pollutant removal efficiency of a stormwater best management practice (BMP) considering rainfall. The stormwater runoff and hydrologic data gathered from 22 storm events during a 28-month monitoring period on a swirl and filtration type of BMP were used to evaluate the developed methods. Based on the findings, the modified EMC method resulted in lower (average) values than the overall EMC, although the differences were not significant (P>0.05). By comparison, the developed 'Rainfall Occurrence Ratio' (ROR) method was most significantly correlated (r=0.967 to 988, P<0.009) with the other existing removal efficiency determination methods such as the 'Efficiency Ratio' (ER), 'Summation of Loads' (SOL) and 'Regression of Loads' (ROL) methods. In addition, the ROR method gave the highest efficiency values, with no significant differences with any of the pollutant parameters, unlike the other three methods. These results were obtained because the ROR method integrated both pollutant loading and rainfall, which are not considered by the other three methods. Therefore, this study proved the suitability of the modified EMC and ROR methods for application in other BMP monitoring studies.

• Journal of Animal Science and Technology
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• v.60 no.5
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• pp.13.1-13.7
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• 2018

Background: The objective of this study was to underline that litter size as a key trait of sows needs new parameters to be evaluated and to target an individual optimum. Large individual variation in litter size affects both production and piglet's survival and health negatively. Therefore, two new traits were suggested and analyzed. Two data sets on 5509 purebred German Landrace sows and 3926 Large White and crossing sows including at least two parental generations and at least five parities were subjected to variance components analysis. Results: The new traits for evaluating litter size were derived from the individual numbers of total born piglets (TBP) per parity: In most cases, sows reach their maximum litter size in their fourth parity. Therefore, data from at least five parities were included. The first observable maximum and minimum of TBP, and the individual variation expressed by the range were targeted. Maximum of TBP being an observable trait in pig breeding and management yielded clearly higher heritability estimates ($h^2{\sim}0.3$) than those estimates predominantly reported so far. Maximum TBP gets closer to the genetic capacity for litter size than other litter traits. Minimum of TBP is positively correlated with the range of TBP ($r_p=0.48$, $r_g$ > 0.6). The correlation between maximum of TBP and its individually reached frequency was negative in both data sets ($r_p=-0.28$ and - 0.22, respectively). Estimated heritability coefficients for the range of TBP comprised a span of $h^2=0.06$ to 0.10. Conclusion: An optimum both for maximum and range of total born piglets in selecting sows is a way contributing to homogenous litters in order to improving the animal-related conditions both for piglets' welfare and economic management in pig.