• Journal of the Korean Data and Information Science Society
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• 제8권2호
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• pp.195-209
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• 1997

일반화 선형모형의 범위를 크게 확장한 준-우도 모형에서 반응변수의 분산성분인 산포모수가 상수가아니라 어떤 공변량들의 값에 의존하여 변하는 경우, 평균과 산포의 동시 모형화가 요구된다. 본 논문에서는 준-우도 모형에서 평균과 산포의 동시 모형화를 통해 실제 자료를 쉽게 분석하도록 해주는 통계 패키지 GENSTAT(release 5.3.2, 1996)을 활용하여, Carrol과 Ruppert(1987,pp.46-47)에 의해 소개된 에스테르 분해효소 (esterase assay)의 자료에 대해 그래픽 방법을 이용한 모형검토를 통해서 기존의 평균모형 보다는 평균과 산포의 동시 모형화를 고려해야 하는 필요성을 언급한 뒤, 그 자료에 대한 적절한 평균과 산포의 동시 모형을 찾는 방법을 연구한다.

• KSBB Journal
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• 제23권5호
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• pp.408-412
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• 2008

본 연구에서는 당뇨병치료제인 로시글리타존약물를 생분해성 PLGA 나노입자에 봉입시킴으로서 위장흡수율과 물에 대한 용해도를 증가시키기 위한 나노제제 개발에 기반을 두고 있다. 특히 제조조건에 따라 형태 및 크기가 조절가능한 나노입자를 제조하고자 하였고, 실험결과 Emulsion-evaporation방법을 사용하여 100-150 nm 크기의 고른 입자분포를 가진 나노입자를 제조하였다. 다양한 농도의 약물 존재하에서 나노입자를 제조함으로서 1%까지의 약물이 80% 이상의 봉입율로 제조될 수 있음을 확인하였다. 또한 나노입자의 크기는 PVA양을 조절하면서 크기분포를 제어하였다. 36시간 동안의 용출실험 결과 초기 약간의 Burst effect가 있었으나 36시간동안 일정하게 약물이 용출되어 나옴을 확인하였다. 앞으로의 연구를 통해, 고효율의 경구제제용 당뇨병치료제 운반체 개발에 중점을 둘 예정이다.

• 접착 및 계면
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• 제4권2호
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• pp.1-9
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• 2003

Epoxy-amine liquid prepolymers are extensively applied onto metallic substrates and cured to obtain painted materials or bonded joint structures. Overall performances of such systems depend on the created interphase between the organic layer and the substrate. When epoxy-amine liquid mixtures are applied onto more or less hydrated metallic oxide layer, concomitant amine chemical sorption and hydroxide dissolution appear lending to the chelate formation. As soon as the chelate concentration is higher than the solubility product, these species crystallize as sharp needles. Moreover, intrinsic and thermal residual stresses are developed within painted or bonded systems. When residual stresses are higher than the organic layer/substrate adhesion, buckling, blistering, debonding may occur leading to a catastrophic drop of system performances. Practical adhesion can be evaluated with either ultimate parameters (Fmax or Dmax) or the critical strain energy release rate, using the three point flexure test (ISO 14679-1997). We observe that, for the same system, the ultimate load decreases while residual stresses increase when the liquid/solid time increases. Ultimate loads and residual stresses depend on the metallic surface treatment. For these systems, the critical strain energy release rate which takes into account the residual stress profile and the Young's modulus gradient remains quite constant whatever the metallic surface treatment was. These variations will be discussed and correlate to the formation mechanisms of the interphase.

• 전기화학회지
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• 제11권4호
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• pp.227-241
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• 2008

This article involves a unified treatment of equilibrium thermodynamics of the chemical reaction coupled with other interfacial (phase boundary) reactions. The modified (restrictive) chemical potential ${\mu}_k^+$, such as electrochemical potential, hydrostatic-chemical (mechanochemical) potential (exceptionally in the presence of the pressure difference) and surface-chemical potential, was first introduced under the isothermal and isobaric conditions. This article then enlightened the equilibrium conditions in case where the release of chemical energy is counterbalanced by the supply of electrical energy, by the supply of hydrostatic work (exceptionally in the presence of ${\Delta}p$), and finally by the release of surface energy, respectively, at constant temperature T and pressure p in terms of the modified chemical potential ${\mu}_k^+$. Finally, this paper focussed on the difference between chemical and electrochemical equilibria based upon the fundamentals of the isothermal and isobaric equilibrium conditions described above.

• 대한기계학회논문집B
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• 제22권12호
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• pp.1657-1668
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• 1998

In the analysis of a mushy solidification system with natural convection using a fixed grid method, the enthalpy method has been used to account for the release of latent heat. The variable viscosity, Darcy source, and hybrid methods have been employed for the velocity suppression in a mushy region. The choice of the values of solid viscosity and permeability constant in conjunction with the Darcy source term plays an important role in forming the location and shape of the phase boundaries. In this work the effects of these major parameters related to steady-state behavior in the system of mushy solidification are investigated through a simple test problem. The effective specific heat based on the spatial gradients of the enthalpy and temperature is adopted for the treatment of the release of latent heat. The effects of the Prandtl and Rayleigh numbers on the shape of mushy region are examined using the hybrid method.

• 한국응급구조학회지
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• 제24권2호
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• pp.39-50
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• 2020

Purpose: This study aimed to compare the effect of chest compression and the resulting ventilation volume in walking cardiopulmonary resuscitation (CPR), straddling CPR, and mechanical CPR while moving manikins to main stretchers. Methods: We compared the chest compressions in terms of compression depth, number of incomplete releases, complete release depth, compression rate, duration between peak time of previous compression and peak time of current compression, and respiration. We analyzed the compression comparatively with the ventilation volume in three different types of CPR. Results: The chest compression depth was significantly improved during straddling CPR as compared to walking CPR, during which women were unable to achieve sufficient chest compression depth. A constant chest compression depth was maintained during mechanical CPR. Conclusion: High-quality chest compressions were difficult to achieve in moving spaces. Further, walking CPR may be helpful in men, but straddling or applying automatic chest compressions in women would result in more effective CPR. Our findings demonstrate the limitations and trends in administering CPR in men and women, which may be useful in devising better education and training methods in the future.

• Archives of Pharmacal Research
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• 제19권1호
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• pp.30-35
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• 1996

Poly(l-lactic acid)(PLLA) microspheres loaded with ampicillin sodium (AMP-Na_, .betha.-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) wre carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experimet. The release of ampicillin sodium was constant at a rate of 1.68 $mug/ml/day$ per 1 mg of microspheres for 18 days initial burst effect.

• 대한기계학회논문집A
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• 제25권6호
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• pp.949-958
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• 2001

A semi-infinite interfacial crack propagated with constant velocity in two bonded anisotropic strips under out-of-plane clamped displacements is analyzed. Using Fourier integral transform the problem is formulated and the Wiener-Hopf equation is derived. By solving this equation the asymptotic stress and displacement fields near the crack tip are obtained, where the results get more general expressions applicable not only to isotropic/orthotropic materials but also to the extent of the anisotropic material having one plane of elastic symmetry for the interfacial crack. The dynamic stress intensity factor is obtained as a closed form, which is decreased as the velocity of crack propagation increases. The critical velocity where the stress intensity factor comes to zero is obtained, which agrees with the lower value between the critical values of parallel crack merged in the material 1 and 2 adjacent to the interface. Using the near tip fields of stresses and displacements, the dynamic energy release rate is also obtained as a form of the stress intensiy factor.

• 대한기계학회논문집
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• 제9권5호
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• pp.548-554
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• 1985

본 논문에서는 디이젤기관의 연소소음의 저감을 최종목표로 하여 Wiebe의 연 소함수에 의해 근사시킨 열발생속도의 변화가 디이젤기관의 연소소음 및 도시열효율에 미치는 영향에 관하여 수치실험을 통하여 해석검토하였다.

• 한국수소및신에너지학회논문집
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• 제23권3호
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• pp.227-235
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• 2012

Finding an alternative fuel and reducing environmental pollution are the main goals for future internal combustion engines. The purpose of this study is to obtain low-emission and high-efficiency by hydrogen enriched LPG fuel in constant volume chamber. An experimental study was carried out to obtain fundamental data for the combustion and emission characteristics of pre-mixed hydrogen and LPG in a constant volume chamber (CVC) with various fractions of hydrogen-LPG blends. To maintain equal heating value of fuel blend, the amount of LPG was decreased as hydrogen was gradually added. Exhaust emissions were measured using a HORIBA exhaust gas analyzer for various fractions of hydrogen-LPG blends. The results showed that the rapid combustion duration was shortened, and the rate of heat release elevated as the hydrogen fraction in the fuel blend was increased. Moreover, the maximum rate of pressure rise also increased. These phenomena were attributed to the burning velocity which increased exponentially with the increased hydrogen fraction in the $H_2$-LPG fuel blend. Exhaust HC and $CO_2$ concentrations decreased, while NOX emission increased with an increase in the hydrogen fraction in the fuel blend. Our results could facilitate the application of hydrogen and LPG as a fuel in the current fossil hydrocarbon-based economy and the strict emission regulations in internal combustion engines.