• Genomics & Informatics
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• v.15 no.2
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• pp.65-68
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• 2017

Ankylosing spondylitis (AS) is a chronic autoinflammatory disease that affects the spine and sacroiliac joints. Regarding its etiology, although HLA-B27 is known to be the strongest genetic factor of AS, much evidence suggests the potential contribution of non-MHC genes to the susceptibility to AS. Most of these non-MHC genes have been discovered in non-Asian populations; however, just some of them have been validated in Koreans. In this study, we aimed to identify additional AS-associated single-nucleotide polymorphism (SNP) candidates by replicating the candidate SNPs in Korean AS patients and healthy controls. For this, we selected three SNPs (rs11249215 in RUNX3, rs6556416 in IL12B, and rs8070463 in TBKBP1), which were previously reported as risk factors of AS but have not been studied in Koreans, and performed genotyping assays using a total of 1138 Korean samples (572 AS patients and 566 healthy controls). Of the three SNP candidates, one SNP in RUNX3 (rs11249215) was significantly associated with the risk of AS (odds ratio, 1.31; 95% confidence interval, 1.02 to 1.68, p = 0.03). These results will be helpful in elucidating the pathogenesis of AS and may be useful for developing AS risk prediction models in Koreans.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2006.06a
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• pp.5-7
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• 2006

In this paper, we analyzed the elements of measurement uncertainty on electrical performance test which are the most important things in photovoltaic module performance test. Repeating the performance test by 6 men, the measurement uncertainty could be calculated. In this experiment, Solar Simulator (A-Class pulse type) used for domestic certificate test of PV module is Pasan IIIb (Balval, Switzerland). The possible elements of the measurement uncertain that could effect electrical performance test of PV module are reference cell, spectrum correction, error from measurement repetition, test condition, stability and uniformity of artificial solar simulator. To find the measurement uncertainty, 6 men repeated the test by 10 times. And the results were that numerical average value was 124.44W and measurement uncertainty was $124.44W{\pm}0.75W$ with 95% confidence level for 125W PV module.

• Journal of the Korean Vacuum Society
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• v.14 no.4
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• pp.186-194
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• 2005

A Spinning Rotor Gauge was calibrated between $4.04\times10^{-3}$ Pa and $1.11\times10^{-2}$ Pa at the high vacuum standard by static expansion method. The results were analysed according to the document of 'Guide to the Expression of Uncertainty in Measurement' of ISO. The expanded uncertainty was $3.0035\times10^{-3}$ Pa at $7.5448\times10^{-3}$ Pa. $95\%$ confidence level, and coverage factor of k = 1.

• Women's Health Nursing
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• v.20 no.1
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• pp.1-13
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• 2014

Purpose: This study was to understand the meaning of women's experience of spontaneous delivery with midwives at midwifery clinics or home. Methods: van Kaam's Psychophenomenological method composed of a four-stage, 12-step format was used. In-depth interviews were carried out from January to July, 2011, with twelve women. Results: Through the data analysis, 403 significant statements, 172 elements, 48 subcategories, and 19 categories were extracted, and from the 19 categories, 8 themes were drawn. The eight themes were: "Conflict on whether a hospital or a midwifery clinic", "Choosing natural delivery with the assurance of her ability to delivery spontaneously and having trust in the midwives." "Being encouraged by a midwife and family members with one accord", "Experience of the spontaneous delivery process on body", "Comfortable delivery in spite of painful process", "Deeply impressed by the overwhelming joy of birth", "Satisfaction with spontaneous delivery", and "Deeper love among family members". Conclusion: Through this study, women's delivery experiences with midwives was of spontaneous delivery. Women's birth of self-confidence and trust between the midwives and the women to predict a spontaneous delivery is a powerful factor. Also, family support and midwives delicate care was identified as factors in spontaneous delivery.

• Proceedings of the SAREK Conference
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• 2006.06a
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• pp.560-565
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• 2006

Sprinkler system is the most effective fire suppression with high confidence among active fire extinguishing systems. According to the installation of the related system on buildings, more separation area of fire protection can be considered to the fire protection design, and also lower differential pressure (12.5 Pascal) is permitted on lobby of fire escape stairs and emergency elevator (25 Pascal shall be considered for none sprinkler system) with economic factor. More details will be handled on the related studies.

• Hwankyungkyoyuk
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• v.11 no.1
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• pp.237-250
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• 1998

'Self-esteem' is defined as 'the lived status of one's individual competence and personal worthiness in dealing with the challenges of Life over Time'. High self-esteem is associated with self-confidence, effectively coping, well-being, and responsibility and it is essential for the responsible choice and determination of environments. The purposes of this study were to develop a strategy to enhance the self-esteem and to verify the effects. A new strategy, 'Cognitive Restructuring Strategy' was based on the characteristics of self-esteem and the key idea of this was to eliminate negative thoughts and to reinforce affirmative thoughts. We developed the statement to embody this strategy and applied to the experimental group. According to the results, self-esteem for the control group(155) did not changed but that for the experimental group(158) was significantly enhanced. Continuously, environmental learning instructions of 3 units were carried out on two groups. By applying the t-test, achievement-test scores for the experimental group per unit were significantly higher than those of the control group as regards the four respective goals of EE. Therefore this strategy and statement are helpful in enhancing self-esteem and it was found that 'self-esteem' is a influential factor to form environmental responsible behaviors(ERB).

• Clinical and Experimental Pediatrics
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• v.64 no.10
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• pp.538-542
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• 2021

Background: The relationship between small for gestational age (SGA) and autism spectrum disorders (ASDs) remains unknown. Purpose: This meta-analysis aimed to investigate the relationship between SGA and the risk of ASD. Methods: We searched PubMed, Web of Science, and Scopus databases from inception to November 2020. The heterogeneity across studies was explored using the I² statistic. The possibility of publication bias was assessed using Begg test. The results were reported using the odds ratio (OR) and 95% confidence interval (CI) using a random-effects model. Results: The literature search yielded 824 articles with 8,752,138 participants. We assessed the association between SGA and the risk of ASD in cohort and case-control studies. Based on the random-effects model, compared with SGA, the estimated OR of the risk of ASD was 1.17 (95% CI, 1.09-1.24). Therefore, there was a significant association between SGA and the risk of ASD. Conclusion: Based on OR reports in epidemiological studies, we showed that SGA is a risk factor for and can increase the risk of ASD. The association between SGA and ASD risk has further relevance to the current public health emphasis on appropriate prepregnancy weight and pregnancy weight gain.

• Journal of Gastric Cancer
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• v.21 no.3
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• pp.236-245
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• 2021

Purpose: The numeric N stage has replaced the topographic N stage in the current tumor node metastasis (TNM) staging in gastric carcinoma. However, the usefulness of the topographic N stage in the current TNM staging system is uncertain. We aimed to investigate the prognostic value of the topographic N stage in the current TNM staging system. Materials and Methods: We reviewed the data of 3350 patients with gastric cancer who underwent curative gastrectomy. The anatomic regions of the metastatic lymph nodes (MLNs) were classified into 2 groups: perigastric and extra-perigastric. The prognostic value of the anatomic region was analyzed using a multivariate prognostic model with adjustments for the TNM stage. Results: In patients with lymph node metastasis, extra-perigastric metastasis demonstrated significantly worse survival than perigastric metastasis alone (5-year survival rate, 39.6% vs. 73.1%, respectively, P<0.001). Extra-perigastric metastasis demonstrated significantly worse survival within the same pN stage; the multivariate analysis indicated that extra-perigastric metastasis was an independent poor prognostic factor (hazard ratio=1.33; 95% confidence interval=1.01-1.75). The anatomic region of the MLNs improved the goodness-of-fit (likelihood ratio statistics, 4.57; P=0.033) of the prognostic model using the TNM stage. Conclusions: The anatomic region of MLNs has an independent prognostic value in the numeric N stage in the current TNM staging of gastric carcinoma.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.4
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• pp.2094-2112
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• 2019

Focusing on the issue that the conventional Kernel Correlation Filter (KCF) algorithm has poor performance in handling scale change and obscured objects, this paper proposes an anti-occlusion and scale adaptive tracking algorithm in the basis of KCF. The average Peak-to Correlation Energy and the peak value of correlation filtering response are used as the confidence indexes to determine whether the target is obscured. In the case of non-occlusion, we modify the searching scheme of the KCF. Instead of searching for a target with a fixed sample size, we search for the target area with multiple scales and then resize it into the sample size to compare with the learnt model. The scale factor with the maximum filter response is the best target scaling and is updated as the optimal scale for the following tracking. Once occlusion is detected, the model updating and scale updating are stopped. Experiments have been conducted on the OTB benchmark video sequences for compassion with other state-of-the-art tracking methods. The results demonstrate the proposed method can effectively improve the tracking success rate and the accuracy in the cases of scale change and occlusion, and meanwhile ensure a real-time performance.

• Molecules and Cells
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• v.42 no.2
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• pp.161-165
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• 2019

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide and has high rates of metastasis. Transforming growth factor beta-inducible protein (TGFBI) is an extracellular matrix component involved in tumour growth and metastasis. However, the exact role of TGFBI in NSCLC remains controversial. Gene silencing via DNA methylation of the promoter region is common in lung tumorigenesis and could thus be used for the development of molecular biomarkers. We analysed the methylation status of the TGFBI promoter in 138 NSCLC specimens via methylation-specific PCR and evaluated the correlation between TGFBI methylation and patient survival. TGFBI promoter methylation was detected in 25 (18.1%) of the tumours and was demonstrated to be associated with gene silencing. We observed no statistical correlation between TGFBI methylation and clinicopathological characteristics. Univariate and multivariate analyses showed that TGFBI methylation is significantly associated with poor survival outcomes in adenocarcinoma cases (adjusted hazard ratio = 2.88, 95% confidence interval = 1.19-6.99, P = 0.019), but not in squamous cell cases. Our findings suggest that methylation in the TGFBI promoter may be associated with pathogenesis of NSCLC and can be used as a predictive marker for lung adenocarcinoma prognosis. Further large-scale studies are needed to confirm these findings.