• 암석학회지
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• 제17권2호
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• pp.51-56
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• 2008

옥천변성대 암석의 생성시기는 화석의 발견과 동위원소 연대측정으로 대부분 고생대 및 신원생대인 것으로 밝혀지고 있다. 한편 동위원소 연대자료가 축적됨과 더불어 옥천변성대의 변성시기가 페름기 초기인가 혹은 페름기 말기-트라이아스기 초기인가 하는 문제가 대두되었다. 이 문제는 달리 표현하면 위의 두 시기에 해당하는 2번의 중요한 변성작용이 있었는가 혹은 후자 시기에 해당하는 한번의 변성작용인가 하는 것이다. 변성시기를 직접 지시할 수 있는 자료를 비교할 때 페름기 초기의 변성시기에 대한 자료(석류석 내 U-Pb 갈렴석 연대)는 전체적으로 오차가 클 뿐만 아니라 페름기 말기-트라이아스기 초기를 지시하는 자료(CHIME 갈렴석 연대 및 변성 저콘의 U-Pb 연대)와 어느 정도 중첩된다. 따라서 독립적인 두 종류의 자료에 의해 지지되는 후자가 보다 신빙성이 있는 것으로 생각되며, 이 시기는 임진강대와 경기육괴에서 대륙충돌과 관련되어 나타나는 중요한 변성시기와 유사하기 때문께 대륙충돌의 영향이 한반도 넓은 지역에 퍼져 있음을 시사한다.

• 한국환경성돌연변이발암원학회지
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• 제23권1호
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• pp.1-6
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• 2003

The purpose of this study was to evaluate whether the MTHFR variants, folate and vitamin $B_{12}$ deficiencies increase the risk of hyperhomocysteinaemia and adverse pregnancy outcome such as short gestational age or reduced birth weight. Healthy pregnant women (n=136; 24-28 gestational weeks; 20-40 years old), who visited Ewha Womans University Hospital for prenatal care, participated in this study. At the time of delivery, trained nurses recorded the pregnancy outcome from medical chart. We determined maternal MTHFR polymorphisms (C to T subsitution at nucleotide 677) and measured serum homocyteine, vitamin $B_{12}$, and folate concentrations. We compared serum homocysteine level by MTHFR genotype, serum folate and serum vitamin B12 levels using ANOVA. To evaluate the association between serum homocysteine level and pregnancy outcome, we compared the gestational age and birth weight by serum homocysteine levels using multiple regression analysis, adjusting for other potential predictors. Mean level of serum homocysteine was highest among pregnant women of the MTHFR variants with low levels of serum folate and vitamin $B_{12}$. Regarding association with birth outcome, we found the relationship between homocysteine levels and increased gestational age (p=0.03) and reduced birth outcome (p>0.05). Our data demonstrates that serum level of folate and vitamin $B_{12}$ among pregnant women affects significantly serum homocysteine levels, and the genetic polymorphism of MTHFR modulates the relationship between them. However, we did not have conclusive evidence of association between high homocysteine level and adverse pregnancy outcome such as preterm or low birth weight.

• Nutrition Research and Practice
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• 제8권5호
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• pp.526-532
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• 2014

BACKGROUND/OBJECTIVES: Acanthopanax sessiliflorus is a native Korean plant and used as a traditional medicine or an ingredient in many Korean foods. The free radical theory of aging suggests that cellular oxidative stress caused by free radicals is the main cause of aging. Free radicals can be removed by cellular anti-oxidants. MATERIALS/METHODS: Here, we examined the anti-oxidant activity of Acanthopanax sessiliflorus extract both in vitro and in vivo. Survival of nematode C. elegans under stress conditions was also compared between control and Acanthopanax sessiliflorus extract-treated groups. Then, anti-aging effect of Acanthopanax sessiliflorus extract was monitored in C. elegans. RESULTS: Stem extract significantly reduced oxidative DNA damage in lymphocyte, which was not observed by leaves or root extract. Survival of C. elegans under oxidative-stress conditions was significantly enhanced by Acanthopanax sessiliflorus stem extract. In addition, Acanthopanax sessiliflorus stem increased resistance to other environmental stresses, including heat shock and ultraviolet irradiation. Treatment with Acanthopanax sessiliflorus stem extract significantly extended both mean and maximum lifespan in C. elegans. However, fertility was not affected by Acanthopanax sessiliflorus stem. CONCLUSION: Different parts of Acanthopanax sessiliflorus have different bioactivities and stem extract have strong anti-oxidant activity in both rat lymphocytes and C. elegans, and conferred a longevity phenotype without reduced reproduction in C. elegans, which provides conclusive evidence to support the free radical theory of aging.

• 대한기계학회논문집B
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• 제39권2호
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• pp.161-168
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• 2015

정상초음파장의 구동 주파수가 메탄-공기 예혼합화염의 전파특성에 미치는 영향을 규명하고자 하는 실험결과를 제시한다. 고속카메라를 이용하여 화염의 전파영상을 획득하였으며, 영상 후처리를 통해 화염선단의 구조와 속도변이를 포함하는 화염의 거시적 거동을 상세히 관찰하였다. 정상초음파가 연소반응을 촉진시켜 화염 전파속도의 증대와 화염선단 구조의 변이를 유발한다는 사실에 더하여, 초음파구동 주파수와 당량비에 대한 화염거동의 종속성을 확인하였다.

• Biomolecules & Therapeutics
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• 제15권1호
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• pp.34-39
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• 2007

Alzheimer's disease (AD) is an abnormal accumulation of the ${\beta}$-amyloid protein $(A{\beta})$ in specific brain region. It has been speculated that disturbance in cholesterol homeostasis may contribute to the etiology of AD by increasing $A{\beta}$ generation. However, conclusive evidence and possible mechanism has not been reported. In the present study, we demonstrated that rabbits treated with 0.5% cholesterol for 16 weeks increased serum total cholesterol, triacylglycerol, and low-density lipoprotein levels. $A{\beta}$ levels is higher in the hippocampus of brain in cholesterol dieted rabbits than that of normal diet rabbis. Expression and activities of ${\beta}-$ and ${\gamma}-$ secretases, the enzymes that cleave ${\beta}$-amyloid precursor protein to generate $A{\beta}$, were also increased in hippocampus of high cholesterol dieted rabbit than those of normal dieted rabbits. Our results suggest that high cholesterol diet may be associated with increased $A{\beta}$ accumulation in the brain of rabbits, and suggest that high cholesterol diet may be causal factor in the development or progression of AD.

• 한방재활의학과학회지
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• 제27권4호
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• pp.85-96
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• 2017

Objectives To summarize and evaluate the efficacy of traditional Chinese herbal medicine (TCHM) treatment for antibiotic associated diarrhea (AAD). Methods Eight electronic databases were searched from their inception to August 2017. Randomized controlled trials (RCTs) assessing the efficacy of TCHM treatment for AAD were included. The risk of bias was assessed using the Cochrane risk of bias assessment tool. Data analysis was performed using RevMan software version 5.3. Results Seventeen RCTs involving 1138 patients with AAD were included for qualitative synthesis. TCHM treatment improved total effective rate (TER). However, the results that TER in experimental group was significantly higher than in control group were different between the included studies. TCHM enema treatment improved TER, but not significantly higher than control group. The most frequently used herbal formulas were Gamiwekwanjeon, Gamiinsampaedoksan, and Samryungbaekchulsan. The most frequently used TCHMs were Atractylodes macrocephala (Bai Zhu), Dioscorea batatas (Shan Yao). Within the studies documenting the adverse events, no serious adverse events associated with TCHM treatment were observed. Conclusions Evidence of TCHM treatment efficacy for AAD is encouraging, but not conclusive, because of the low methodological qualities, diversity of TCHM treatment prescriptions. Further well-designed RCTs with rigorous randomization and blinding method are needed to confirm these results.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5673-5679
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• 2014

Background: Previous published data on the association between CYP1A2 rs762551, rs2069514, rs2069526, and rs2470890 polymorphisms and lung cancer risk have not allowed a definite conclusion. The present meta-analysis of the literature was performed to derive a more precise estimation of the relationship. Materials and Methods: 8 publications covering 23 studies were selected for this meta-analysis, including 1,665 cases and 2,383 controls for CYP1A2 rs762551 (from 8 studies), 1,456 cases and 1,792 controls for CYP1A2 rs2069514 (from 7 studies), 657 cases and 984 controls for CYP1A2 rs2069526 (from 5 studies) and 691 cases and 968 controls for CYP1A2 rs2470890 (from 3 studies). Results: When all the eligible studies were pooled into the meta-analysis for the CYP1A2 rs762551 polymorphism, significantly increased lung cancer risk was observed in the dominant model (OR=1.21, 95 % CI=1.00-1.46). In the subgroup analysis by ethnicity, significantly increased risk of lung cancer was observed in Caucasians (dominant model: OR=1.29, 95%CI=1.11-1.51; recessive model: OR=1.33, 95%CI=1.01-1.75; additive model: OR=1.49, 95%CI=1.12-1.98). There was no evidence of significant association between lung cancer risk and CYP1A2 rs2069514, s2470890, and rs2069526 polymorphisms. Conclusions: In summary, this meta-analysis indicates that the CYP1A2 rs762551 polymorphism is linked to an increased lung cancer risk in Caucasians. Moreover, our work also points out the importance of new studies for rs2069514 associations in lung cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the rs2069514 polymorphism in lung cancer development.

• 한국재료학회지
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• 제23권6호
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• pp.329-333
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• 2013

The structural phase transformations of $0.7Pb(Mg_{1/3}Nb_{2/3})O_3-0.3PbTiO_3$ (PMN-0.3PT) were studied using high resolution x-ray diffraction (HRXRD) as a function of temperature and electric field. A phase transformational sequence of cubic (C)${\rightarrow}$tetragonal (T)${\rightarrow}$rhombohedral (R) phase was observed in zero-field-cooled conditions; and a $C{\rightarrow}T{\rightarrow}$monoclinic $(M_C){\rightarrow}$ monoclinic ($M_A$) phase was observed in the field-cooled conditions. The transformation of T to $M_A$ phase was realized through an intermediate $M_C$ phase. The results also represent conclusive and direct evidence of a $M_C$ to $M_A$ phase transformation in field-cooled conditions. Beginning from the zero-field-cooled condition, a $R{\rightarrow}M_A{\rightarrow}M_C{\rightarrow}T$ phase transformational sequence was found with an increasing electric field at a fixed temperature. Upon removal of the field, the $M_A$ phase was stable at room temperature. With increasing the field, the transformation temperature from T to $M_C$ and from $M_C$ to $M_A$ phase decreased, and the phase stability ranges of both T and $M_C$ phases increased. Upon removal of the field, the phase transformation from R to $M_A$ phase was irreversible, but from $M_A$ to $M_C$ was reversible, which means that $M_A$ is the dominant phase under the electric field. In the M phase region, the results confirmed that lattice parameters and tilt angles were weakly temperature dependent over the range of investigated temperatures.

• 동의생리병리학회지
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• 제29권6호
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• pp.523-529
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• 2015

The purpose of this case-series study is to report the effect of Seungmahwangryeontang-gami and facial venesection on Hot flush patients. For this report, two of patients had taken Seungmahwangryeontang-gami for 45 days and the other patient had taken eungmahwangryeontang-gami for 60 days. Also, one of the patients had taken twice facial venesection, and the other two patients had done it three times during the treatment. During this period, we tried to find out that there were objective change and subjective change in reduction of hot flush. We were going to ascertain the subjective change through the change of VAS score. In case of objective change, we used the change of the color which were taken by the Derma Vision. The result of the treatment, each patients' VAS score reduced from 73 to 41, 67 to 44, and 71 to 51. Based on the Derma vision's facial color change, the score of Red and Dark Red, which mean Hot flush, were reduced. On the other hand, that of Blue and Dark Blue were increased. According to the results, we had obtained positive clinic effects from Seungmahwangryeontang-gami and facial venesection on Hot flush patients respectively. Although this report is based on few patients' treatments on hot flush with Seungmahwangryeontang-gami and facial venesection, we can use this result in a good way. However, the limitation of this report is that we can't generalize the following result because of the lack of the cases and we can't present a conclusive evidence which can prove the validity of the Hot flush from the case-series study.

• Journal of Astronomy and Space Sciences
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• 제34권4호
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• pp.257-270
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• 2017

Solar activity is known to be linked to changes in the Earth's weather and climate. Nonetheless, for other types of extreme weather, such as tropical cyclones (TCs), the available evidence is less conclusive. In this study the modulation of TC genesis over the western North Pacific by the solar activity is investigated, in comparison with a large-scale environmental parameter, i.e., El-$Ni{\tilde{n}}o$-Southern Oscillation (ENSO). For this purpose, we have obtained the best track data for TCs in the western North Pacific from 1977 to 2016, spanning from the solar cycle 21 to the solar cycle 24. We have confirmed that in the El-$Ni{\tilde{n}}o$ periods TCs tend to form in the southeast, reach its maximum strength in the southeast, and end its life as TSs in the northeast, compared with the La-$Ni{\tilde{n}}o$ periods. TCs occurring in the El-$Ni{\tilde{n}}o$ periods are found to last longer compared with the La-$Ni{\tilde{n}}o$ periods. Furthermore, TCs occurring in the El-$Ni{\tilde{n}}o$ periods have a lower central pressure at their maximum strength than those occurring in the La-$Ni{\tilde{n}}o$ periods. We have found that TCs occurring in the solar maximum periods resemble those in the El-$Ni{\tilde{n}}o$ periods in their properties. We have also found that TCs occurring in the solar descending periods somehow resemble those in the El-$Ni{\tilde{n}}o$ periods in their properties. To make sure that it is not due to the ENSO effect, we have excluded TCs both in the El-$Ni{\tilde{n}}o$ periods and in the La-$Ni{\tilde{n}}o$ periods from the data set and repeated the analysis. In addition to this test, we have also reiterated our analysis twice with TCs whose maximum sustained winds speed exceeds 17 m/s, instead of 33 m/s, as well as TCs designated as a typhoon, which ends up with the same conclusions.