• Development and Reproduction
• /
• v.27 no.4
• /
• pp.167-174
• /
• 2023

Development of hepatocellular carcinoma (HCC) is driven by a multistep and long-term process. Because current therapeutic strategies are limited for HCC patients, there are increasing demands for understanding of immunotherapy, which has made technological and conceptual innovations in the treatment of cancer. Here, I discuss HCC immunotherapy in the view of interaction between liver resident cells and immune cells.

• Journal of the Korean association of regional geographers
• /
• v.11 no.5
• /
• pp.405-425
• /
• 2005

Transition from mass tourism to post tourism is closely related with developing various types of cultural tourism. This study attempts to construct a conceptual framework of the development of cultural tourism through identifying the existing development stages of cultural tourism sites from birth to full development. This study clarifies that there exists an organic system among tourism, cultural activities and the production of cultural artifacts. It also found that development of cultural tourism sites goes through the following three stages: positioning and building place image, hard branding, and constructing local system. This study analyzes several key elements for respective of stages, which proved helpful in understanding the development mechanism of cultural tourism sites. It also tries to analyze tourism from an integrated, geographical perspective. The analysis gives us an understanding to the relations between tourism and various aspects of regional society and economy, thus contributing to the development of a system that will lead to active interchanges among those factors. Most of the theoretical background of this study: place identity, place image, activity space, local system and network are based on the concepts and ideas of human geography.

• International Journal of Computer Science & Network Security
• /
• v.21 no.11
• /
• pp.111-118
• /
• 2021

The authors of the study highlight the conceptual foundations of the investment mechanism of innovation of enterprises in the context of strategic development. Such indicators of investment attraction for the enterprise as investment attractiveness, investment activity of the enterprise, critical mass of investments, minimum sufficiency of investments and others are singled out. It is proved that the balance of investment resources is facilitated by the action of the investment mechanism of innovation activity at the enterprise in the context of achievements of strategic development tasks. Investment processes and their intensification have an impact on the expansion of production capacity of economic entities in strategic development and on improving the efficiency of existing capacities. The investment mechanism of innovative activity at the enterprise in the context of achievement of tasks of strategic development contains system of complex actions which provides: definition of the clear purpose and tasks for the mechanism and achievement of the purposes of the enterprise; assessment of the investment potential of the enterprise; definition of tasks of innovative development of enterprises and investment resources necessary for this purpose, etc. The tasks of the investment mechanism of innovative activity at the enterprise in the context of achievements of tasks of strategic development and its economic, organizational and information components are singled out, as well as levers of influence and regulators of the investment mechanism of innovation in the enterprise.

• Science of Emotion and Sensibility
• /
• v.13 no.3
• /
• pp.573-580
• /
• 2010

The earlier KANSEI evaluation had to choose not to overlap the opposite meaning of the words, had to choose that some figures are shown step by step and had to choose be prepared things in advance. However, The Study shows a method which visualizes the imprecise evaluations of human without choosing evaluation items which are not prepared figures. The program is used the way which is entered by hand-drawing that the subjects use the way to enter their subjective feelings about the evaluations presented by using the mouse or the graphics tablet. It is possible to express imprecise things about evaluations and the method of drawing is free. The program provides that we can express our thinking by drawing and there are a few limits and the prescribed standard. The area ratio of each circle is expressed as a pie chart and the area of circle what is drawn which is counted automatically at the same time. These things are possible not only to modify a transparency, a thickness of a line, a color and the area of circle what is drawn, but also to adjust the area of circle. The conceptual model is visualized that expresses something by hand-drawing such as a circle. The conceptual model has wide range of applications such as a personnel evaluation, a suffering evaluation and product evaluation. The program currently has been testing the effective of the program's possibilities which is used with the personnel appraisal tool of the nurses themselves who work in nurse support department where the St. Marianna University School of Medicine Hospital is. And also the program is proceeding with development to visualize the conceptual model by dynamic interfaces effectively and the program is applied such as KJ method and a program is used to express the kind of the patient's pain and its level.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.33 no.2
• /
• pp.781-790
• /
• 2013

This research focuses on development of the conceptual cost estimation models for I.L.M box girder bridge. The current conceptual cost estimation for public construction projects is dependent on governmental average unit price references which has been regarded as inaccurate and unreliable by many experts. Therefore, there have been strong demands for developing a better way of conceptual cost estimating methods. This research has proposed three different conceptual cost estimating method for a P.S.C. girder bridge built with the I.L.M method. Model (I) attempts to seek the proper breakdown of standard works that are accountable for more than 95 percentage in total cost and calculates the amount of standard work's materials from the standard section and volume of I.L.M box girder bridge. Model (II) utilizes a correlation analysis (coefficient over 0.6 or more) between breakdown of standard works and input data that would be considered available information in preliminary design phase. Model(III) obtains conceptual estimating through multiple-regression analysis between the breakdown of standard works and all of input data related to them. In order to validate the clustering of coverage in the preliminary design phase, the variation of I.L.M cost coverage from multiple-regression analysis[model(III)] has been investigated which result in between -3.76% and 11.79%, comparing with AACE(Association for the Advancement of Cost Engineering) which informs its variation between -5% and +15% in the design phase. The model proposed from this research are envisioned to be improved to a great distinct if reliable cost date for P.S.C. girder bridges can be continually collected with reasonable accuracies.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2001.05a
• /
• pp.71-76
• /
• 2001

This paper describes a research work of developing system for conceptual die design system for Fine blanking. The method of approaching to the system is based on the knowledge-based rules. Knowledge for the system is formulated from experimental results and the empirical knowledge of field experts. This system has been written in VisualLISP on the AutoCAD using a personal computer and in Microsoft Visual Basic ver.6.0. Transference of data is accomplished by DXF (Drawing Exchange Format) method. This system consists of six modules, which are cognition of a drawing, cognition of shear length, calculation of shear force, materials properties database, determination of degree of difficulty of the product, determination of approximate life of punch and die modules. Results carried out in each module will provide efficiency to the designer and the manufacturer of die for Fine blanking. But the main focus of this system is the design of die for Fine blanking in the level of general concept. In order to use powerful tool in this field, developed system will be studied continuously.

• Journal of Engineering Education Research
• /
• v.15 no.5
• /
• pp.125-130
• /
• 2012

This study proposes content and instruction of leadership education based on the results of evaluation and analysis of leadership skill of present levels of students who registered for 'leadership development and training' course which is liberal arts elective course of the 'Accreditation Board of Engineering Education in Korea' and provides best practices to develop leadership skill and to attain academic achievement 2, 4, 6, 7 of 12 academic achievement required by KEC2005. To accomplish a purpose of the study, I divide leadership skill into technical skill, human skill and conceptual skill that suggested by Katz and then measure students' leadership skill. The contents of leadership education to develop and enforce three leadership skills are as follows. First, for developing technical skill, there is a need for systematic education of basic working experience relevant to a major field of study. Second, for developing human skill, there is a need for education of leadership, motivation, conflict management, communication, group dynamics and presentation etc. Third, for developing conceptual skill, there is a need for education of founding vision, business strategy and creative idea etc.

• Journal of the Korean Society for information Management
• /
• v.21 no.2
• /
• pp.249-267
• /
• 2004

Although MARC can define the detail cataloguing data, it has complex structures and frameworks to represent bibliographic information. On account of these idiosyncratic features of MARC, XML DTD or RDF/S that supports simple hierarchy of conceptual vocabularies cannot capture MARC formalism effectively. This study implements bibliographic ontology by means of abstracting conceptual relationships between bibliographic vocabularies of MARC. The bibliographic ontology is formalized with OWL that can represent the logical relations between conceptual elements and specify cardinality and property value restrictions. The bibliographic ontology in this study will provide metadata for cataloguing data and resolve compatibility problems between cataloguing systems. And it can also contribute the development of next generation bibliographic information system using semantic Web services.

• Journal of Korean Library and Information Science Society
• /
• v.36 no.3
• /
• pp.275-289
• /
• 2005

In this paper, the conceptual model for bibliographic Information consistent and compatible with MARC is presented. The modeling requirements are derived from MARC-related models such as MARC21, MARCXML and MODES. To meet these requirements, this paper proposes the conceptual model based on MARC formalism. The model composed with aggregation relationships among bibliographic data elements can use semantic tags of XML. As the model can be realized into diverse structures, it will be effectively applied for the development of bibliographic information management systems. Since MARC defines only record format and has the limitations in semantic representation, the metadata system that can expand bibliographic data elements in MRAC into metadata level is strongly required.

• Journal of the Korean Society of Systems Engineering
• /
• v.9 no.2
• /
• pp.83-90
• /
• 2013

Integrated aircraft synthesis process for rapid analysis and design is described in this paper. Data flow between different analysis fields is described in details. All the data are divided into several groups according to importance and source of the data. Analysis of design requirements and certification regulations is carried out to determine baseline configuration of an aircraft. Overall design process can be divided into initial sizing, conceptual and preliminary design phases. Basic data for conceptual design are obtained from initial sizing, CAD and geometry analysis. Basic data are required input for weight, aerodynamics and propulsion analyses. Results of this analysis are used for stability and control, performance, mission, and load analysis. Feasibility of design is verified based on analysis results of each discipline. Design optimization that involves integrated process for aircraft analysis is performed to determine optimum configuration of an aircraft on a conceptual design stage. The process presented in this paper was verified to be used for light aircraft design.