• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.202-205
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• 2005

Cell phenotypes are determined by the concerted activity of thousands of genes and their products. This activity is coordinated by a complex network that regulates the expression of genes. Understanding this organization is crucial to elucidate cellular activities, and many researches have tried to construct gene regulatory networks from mRNA expression data which are nowadays the most available and have a lot of information for cellular processes. Several computational tools, such as Boolean network, Qualitative network, Bayesian network, and so on, have been applied to infer these networks. Among them, Bayesian networks that we chose as the inference tool have been often used in this field recently due to their well-established theoretical foundation and statistical robustness. However, the relative insufficiency of experiments with respect to the number of genes leads to many false positive inferences. To alleviate this problem, we had developed the algorithm of MONET(MOdularized NETwork learning), which is a new method for inferring modularized gene networks by utilizing two complementary sources of information: biological annotations and gene expression. Afterward, we have packaged and improved MONET by combining dispersed functional blocks, extending species which can be inputted in this system, reducing the time complexities by improving algorithms, and simplifying input/output formats and parameters so that it can be utilized in actual fields. In this paper, we present the architecture of MONET system that we have improved.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2000년도 창립총회 및 춘계학술발표회
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• pp.108-111
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• 2000

FeS/FeS$_2$ minerals have been known to be potentially useful reductant to the removal of common organic contaminants in groundwater and soil. This research is aimed at improving our understanding of factors affecting the pathways and rates of reductive transformation of Hexachloroethane by catalytical iron minerals in natural system. Hexachloroethane is reduced by FeS/FeS$_2$ minerals under anaerobic condition to tetrachloroethylene and trichloroethylene with pentachloroethyl radical as the intermediate products. The kinetics of reductive transformations of the Hexachloroethane have been investigated in aqueous solution containing FeS, FeS$_2$. The proposed reduction mechanism for the adsorbed nitrobenzene involves the electron donor-acceptor complex as a precursor to electron transfer. The adsorbed Hexachloroethane undergo a series of electron transfer, proton transfer and dehydration to achieve complete reduction. It can be concluded that the reductive transformation reaction takes place at surface of iron-bearing minerals and is dependent on surface area and pH. Nitrobenzene reduction kinetics is affected by reductant type, surface area, pH, the surface site density, and the surface charge. FeS/FeS$_2$-mediated reductive dechlorination may be an important transformation pathway in natural systems.

• Journal of Multimedia Information System
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• 제2권3호
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• pp.255-262
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• 2015

The modern manufacturing systems and technologies produce products that are more accurate day by day. This can be reached mainly by improvement the manufacturing process with at the same time restricting more and more the quality specifications and reducing the uncertainty in part. The main objective an industry becomes to lower the part's variability, since the less variability - the better is product. One of the part of this task is measuring the object's uncertainty. The main purpose of this study is to understand the application of bootstrap method for uncertainty evaluation. Bootstrap method is a collection of sample re-use techniques designed to estimate standard errors and confidence intervals. In the case study a surface of an automobile engine block - (Top view side) is measured by Coordinate Measuring Machine (CMM) and analyzed for uncertainty using Geometric Least Squares in complex with bootstrap method. The designed experiment is composed by three similar measurements (the same features in unique reference system), but with different points (5, 10, 20) concentration at each level. Then each cloud of points was independently analyzed by means of non-linear Least Squares, after estimated results have been reported. A MatLAB software tool used to generate new samples using bootstrap function. The results of the designed experiment are summarized and show that the bootstrap method provides the possibility to evaluate the uncertainty without repeating the Coordinate Measuring Machine (CMM) measurements many times, i.e. potentially can reduce the measuring time.

• The Korean Journal of Pain
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• 제22권1호
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• pp.1-15
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• 2009

Neuropathic pain is often refractory to intervention because of the complex etiology and an incomplete understanding of the mechanisms behind this type of pain. Glial cells, specifically microglia and astrocytes, are powerful modulators of pain and new targets of drug development for neuropathic pain. Glial activation could be the driving force behind chronic pain, maintaining the noxious signal transmission even after the original injury has healed. Glia express chemokine, purinergic, toll-like, glutaminergic and other receptors that enable them to respond to neural signals, and they can modulate neuronal synaptic function and neuronal excitability. Nerve injury upregulates multiple receptors in spinal microglia and astrocytes. Microglia influence neuronal communication by producing inflammatory products at the synapse, as do astrocytes because they completely encapsulate synapses and are in close contact with neuronal somas through gap junctions. Glia are the main source of inflammatory mediators in the central nervous system. New therapeutic strategies for neuropathic pain are emerging such as targeting the glial cells, novel pharmacologic approaches and gene therapy. Drugs targeting microglia and astrocytes, cytokine production, and neural structures including dorsal root ganglion are now under study, as is gene therapy. Isoform-specific inhibition will minimize the side effects produced by blocking all glia with a general inhibitor. Enhancing the anti-inflammatory cytokines could prove more beneficial than administering proinflammatory cytokine antagonists that block glial activation systemically. Research on therapeutic gene transfer to the central nervous system is underway, although obstacles prevent immediate clinical application.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2002년도 춘계학술대회 논문집
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• pp.429-434
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• 2002

For companies assembling end products from sub assemblies or components, MRP (Material Requirement Planning) logic is frequently used to synchronize and pace the production activities for the required parts. However, in MRP, the planning of operational-level activities is left to short term scheduling. So, we need a good scheduling algorithm to generate feasible schedules taking into account shop floor characteristics and multi-level job structures used in MRP. In this paper, we present a GA (Genetic Algorithm) solution for this complex scheduling problem based on a new gene to reflect the machine assignment, operation sequences and the levels of the operations relative to final operation. The relative operation level is the control parameter that paces the completion timing of the components belonging to the same branch in the multi-level job hierarchy. In order to revise the fixed relative level which solutions are confined to, we apply large step transition in the first step and GA in the second step. We compare the genetic algorithm and 2-phase optimization with several dispatching rules in terms of tardiness for about forty modified standard job-shop problem instances.

• Nuclear Engineering and Technology
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• 제50권6호
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• pp.915-922
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• 2018

Metallic fuel has been considered for sodium-cooled fast reactors because it can maximize the uranium resources. It generates rare earth elements as fission products, where it is reported by aggravating the fuel-cladding chemical interaction at the operating temperature. Rare earth elements form a multicomponent alloy (Ce-Nd-Pr-La-Sm-etc.) during reactor operation, where it shows a higher reaction thickness than a single element. Experiments have been carried out by simplifying multicomponent alloys for mono or binary systems because complex alloys have difficulty in the analysis. In previous experiments, xCe-yNd was fabricated with two elements, Ce and Nd, which have a major effect on the fuel-cladding chemical interaction, and the thickness of the reaction layer reached maximum when the rare earth elements ratio was 1:1. The objective of this study is to evaluate the effect and relationship of rare earth elements on such synergistic behavior. Single and binary rare earth model alloys were prepared by selecting five rare earth elements (Ce, Nd, Pr, La, and Sm). In the single system, Nd and Pr behaviors were close to diffusion, and Ce showed a eutectic reaction. In the binary system, Ce and Sm further increased the reaction layer, and La showed a non-synergy effect.

• International Journal of Computer Science & Network Security
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• 제21권7호
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• pp.87-92
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• 2021

Analysis of current state of construction industry functioning in Ukraine allows us to identify a number of problems having negative impact on sustainable development of construction industry, especially in terms of its organization. Therefore, it is absolutely essential to study existing methods of organization system supplying construction sites with necessary material resources. Companies can develop their own logistics departments, which independently solve logistics issues related to transportation organization and management, accounting and inventory management, acquisition and warehousing, intercommunication (ability to obtain both final and intermediate information during transporting materials). Using a complex of methods is substantiated: the hierarchy analysis method (Saati's method), the network method, the defect elimination algorithm DEA, the transportation problem that finds optimal problem solutions for construction sector with the purpose of rational supplying uninterrupted construction with building resources in the designed model "provider-transportation-costs".

• 대한화장품학회지
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• 제33권2호
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• pp.93-97
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• 2007

일반적으로 음이온 계면활성제는 효소의 disulfide bond를 분해시켜 효소의 활성이 없어진다. 따라서 특정한 캡슐에 효소를 포집하여 안정도를 증대시킨다. 본 연구에서는 polyethylene glycol (PEG), polypropylene glycol (PPG), 그리고 PEG-PPG-PEG block copolymer 등의 폴리올을 이용하여 papain 효소의 안정도를 증대시켰다. Energy dispersive spectroscopy (EDS)와 confocal laser scanning microscope (CLSM) 분석을 통하여 폴리올은 고분자층과 효소의 중간에 위치하며, 이들은 완충액으로 작용하여 효소의 안정도를 증대시키는 것으로 확인하였다. 또한, 이온 복합체를 이용하여 다층 캡슐을 제조하여 wash-off 형태의 세정제에 응용하였다. 세정제 내에서 계면활성제와 물은 효소캡슐의 표면에 분산되었으며, 캡슐의 중앙부분으로 서서히 침투되었다. 반면에 본 연구에서 사용된 sodium lauroyl sarcosinate와 polyguaternium-6는 물이 효소부분으로 침투하지 않는 것을 in vivo 시험을 통하여 확인하였다.

• 한국의상디자인학회지
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• 제12권3호
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• pp.43-55
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• 2010

The major advantages to use CAD System are that it reduce time and effort to manufacture products, and also can demonstrate the condition of the final product prior to the actual manufacturing process of the selected design using the simulation programs in CAD system. Specially in weave design, for use as Computer-Aided Weaving system, the complicated Dobby weave can figured out easily through calculating the complex weave plans of multi shafts. As to one of dobby weave structures, Supplementary warp is the warp threads which are in addition to the regular warps of the woven fabrics, and used for decorating the band or expressing some patterns. The purpose of this study is to research the weave design of Supplementary warp using Computer-Aided Weaving system, which is dobby weave design program of Weave Point. For performing this design study, it was researched the classified woven fabrics depending upon weaving processing, Computer-Aided Weaving system, and the characteristic of Supplementary warp fabrics. On the basis of the theoretical research, Supplementary warp was worked for the 24-shafts AVL computer dobby loom that applied to the various patterned images. The design work was done by Weave Point program of dobby weave, and simulated to fabrics before woven into the computer dobby loom. To see the visual images of fashion items, these simulated bobby fabrics were processed by three-dimension modeling through YoungWoo CNI CAD system. All the patterns of the Supplementary warp in this study could be applied for decorating the fashion clothing and accessories.

• 한국산학기술학회논문지
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• 제22권1호
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• pp.786-791
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• 2021

본 논문에서는 기존 실내 위치인식 시스템들이 가지는 신호 간섭과 측위 오차 등 제한점들을 최소화하고자, 전파 가시성이 뛰어나고 정밀 측위가 가능한 스마트 LED 기반 측위 시스템을 구성하여 실내 위치인식 정밀도를 개선하고자 한다. 이를 위해 스마트 LED의 SMPS 보드에 IEEE 802.4 Zigbee 모듈을 탑재하고 이동체 태그로부터 RSSI와 LQI 신호를 수신하여 게이트웨이를 통해 측위 서버로 전달하는 시스템을 구성하였다. 실험을 위해 게이트웨이, 스마트 LED 모듈 등 필요한 하드웨어는 별도로 설계하였으며, 외부 현장 사무실에서 시스템 구성 후 실험을 진행하였다. 스마트 LED에서 수신되는 이동체의 신호와 함께, 방향 센서로부터 획득한 이동체의 벡터 값을 전달하여 측위 서버에서 복합연산을 수행한 결과, 측위 오차가 70cm 이내로 이루어짐을 확인하였다. 이 결과는 기존 근거리 무선통신 기반 시스템보다 측위오차가 대폭 개선된 결과로서, 상용화 제품을 구현할 수 있는 수준을 보여준 것이라 할 수 있다. 또한, 본 실험 결과를 기반으로, 향후 신호 간섭이 상존하는 다양한 환경에서 시스템 성능을 튜닝할 경우, 신규 LED 설치 건물에서 위치 측위용으로 다양한 응용으로 사용이 가능할 것이다.