• Interdisciplinary Bio Central
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• v.4 no.1
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• pp.2.1-2.7
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• 2012

Introduction: Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from ${\varepsilon}$-N-acetyl lysine amino acids of histone proteins. Their action is opposite to that of histone acetyltransferase that adds acetyl groups to these lysines. Only few HDAC inhibitors are approved and used as anti-cancer therapeutics. Thus, discovery of new and potential HDAC inhibitors are necessary in the effective treatment of cancer. Materials and Methods: This study proposed a method using support vector machine (SVM) to classify HDAC8 inhibitors and non-inhibitors in early-phase virtual compound filtering and screening. The 100 experimentally known HDAC8 inhibitors including 52 inhibitors and 48 non-inhibitors were used in this study. A set of molecular descriptors was calculated for all compounds in the dataset using ADRIANA. Code of Molecular Networks. Different kernel functions available from SVM Tools of free support vector machine software and training and test sets of varying size were used in model generation and validation. Results and Conclusion: The best model obtained using kernel functions has shown 75% of accuracy on test set prediction. The other models have also displayed good prediction over the test set compounds. The results of this study can be used as simple and effective filters in the drug discovery process.

• The Research Journal of the Costume Culture
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• v.5 no.3
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• pp.1-25
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• 1997

The consumers, who are characterized by gathering a wide scope of information and by putting into action immediately, have come to the new group searching for emotion and have played a leading role of market. The characgeristics of consumers are the fact that they have followed the street fashion with no-concept, independent of the trends which the brand has provide for consumers. Therefore it leads to a big gap between the fashion information for enterprises and market formation for consumer class. The principal purpose of this paper is to get closer the distance between the information which is used in merchandise plan and real market for consumers, and to suggest the new direction of information management system in order to enhance the hit rate of merchandise plan. The results are as follows : (1) It is shown the enterprises should divide the information data between fashion information and market information, and understand the mutual relationship of them, and regard the statistical data related on the change of sensitivity and desire in market specialized in attributes of street fashion as the emotional expression\`s view, and manage them by the feedback style. (2) It is shown that enterprises should fully understand the fashion factors in the line of fashion stream with the independence of theme in order to plan the merchandise effectively for market which are specialized in the duality that it has both conservation and innovation at the same time, and detect their change. (3) It is shown that in order to predict exactly, enterprises should reflect the statistical data and the emotional factors in planning the merchandise, bring up the systematic organization, expert system. (4) It is also shown that enterprises should make an effort to pursuit the discriminated brand through the feedback management in which the consumer\`s lasting desires are reflected.

• Journal of The Korean Association For Science Education
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• v.31 no.5
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• pp.815-826
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• 2011

The purpose of this study was to analyze professionals' opinion about science education using history of science. For this purpose, we surveyed professionals in the field of science education and history of science (HOS), 30 professionals in the first survey and 84 professionals in the second survey. The results are as follows: First, they focused the nature of science in the science education using HOS. Second, they suggested the need for development of teaching and learning materials for using HOS in class. Third, they proposed action-based science teacher training for using HOS. Fourth, there appeared differences of professionals' opinion in some areas. Lastly, they did not make a high agreement in the need of history of eastern science including history of Korean science. It is necessary to develop teaching and learning materials in the history of eastern science.

• Journal of Educational Research in Mathematics
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• v.26 no.4
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• pp.731-754
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• 2016

The purpose of the study is to identify the point of knowing. The point of knowing is the time, which indicates that 'knowing' occurs in the recognition process. To understand recognition process, the researchers analyzed the questions in units of lessons presented in elementary mathematics textbooks. The researchers analyzed the validity of the point of knowing and found out the basis of the point of knowing. The results are as follows. First, the point of knowing is time to expect to change from a leaner's 'not-knowing' to 'knowing'. Second, the point of knowing can be identified with the questions on textbooks to ask students to do practical action. Third, the point of knowing is closely related to instructional objective in a class. Fourth, in relation to subsidiary awareness and focal awareness, the point of knowing corresponds to focal awareness. Fifth, the point of knowing is equivalent to the inflection point at which personalization/contextualization is changed into depersonalization/decontextualization.

• Journal of the Korean Institute of Educational Facilities
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• v.8 no.3
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• pp.25-35
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• 2001

This study investigated technology education, laboratory management and facilities in middle schools with the goal of finding problems. Ninety-six randomly selected schools and questionnaire was done to the teachers of 84 schools which have laboratory. Five of these schools received on-site inspections. The results of study are as follows : 1) 12.5% of schools have no laboratory. The average laboratory has less than 50% of the necessary equipment for total operations. laboratories are used an average of once or twice per two time frame. 2) 80%of the laboratories are located at the end of a row of regular class rooms. The most common laboratory style is classroom plus hallway($90m^2$) style. 77% of laboratories have a single entrance. 3) 69% of teachers reported the worktable arrangement to be inconvenience. 68% of the schools have 9 worktables per laboratory. 38% say the worktables are not wide enough and 36% said they were appropriate. Table dimensions range from $95{\sim}110cm$ in width and from $210{\sim}225cm$ in length. 65% of the teachers say table height is low with a range from $76{\sim}82cm$. 86% of the teachers say that the height of chair is low and the range of its measurement is from $37{\sim}47cm$. 84% of the teachers points out that laboratory is poorly lighted.

• Journal of KIISE
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• v.41 no.12
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• pp.1035-1049
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• 2014

This paper presents a new method to detect attack patterns in security-critical systems, based on a new notion of Behavior Ontology. Generally security-critical systems are large and complex, and they are subject to be attacked in every possible way. Therefore it is very complicated to detect various attacks through a semantic structure designed to detect such attacks. This paper handles the complication with Behavior Ontology, where patterns of attacks in the systems are defined as a sequences of actions on the class ontology of the systems. We define the patterns of attacks as sequences of actions, and the attack patterns can then be abstracted in a hierarchical order, forming a lattice, based on the inclusion relations. Once the behavior ontology for the attack patterns is defined, the attacks in the target systems can be detected both semantically and hierarchically in the ontology structure. When compared to other attack models, the behavior ontology analysis proposed in this paper is found to be very effective and efficient in terms of time and space.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.26 no.2
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• pp.541-550
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• 2016

Considering the results of the 3.20 Cyber Attack, leaks of personal information by card companies, and so on, convenience and efficiency cannot be guaranteed without security as a prerequisite. In addition, it is more likely that customers' interests seem to be interfered with in financial institutions than in any other industry. Therefore, when a security accident occurs, users may suffer mental damage and monetary loss, leading to class action, customer defection, loss of reputation, and falloff in international credibility, which all may have a significant effect on the business continuity of corporations. This study integrates the representative information security certification systems in order to improve the efficiency of information security management and demonstrate the necessity of information security management system certification for the financial sector. If the certification is needed, we would like to recommend the desirable development direction.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.7
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• pp.81-86
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• 2005

Proposed induction-heated system is innovative system which applied special high-frequency power circuit technique for thermal converse technique and IH(Induction-Heating) magnetic induction heating generated from induction-heated metallic package that is for distillation unit. In this occurs not burning, so that the working environment can be improved. This electromagnetic induction heating technique is used high frequency inverter. By using high frequency inverter high frequency alternative current (HFAC) in the range of [kHz] can be made with conventional alternative current In this contribution IGBT module is used for high frequency inverter. In this paper are discussed action analysis and characteristics analysis of 1.5[kW]-Class half-bridge resonant inverter system and resonant metallic packaged. In addition, by using this system,t how two step heating superheated steam generator is developed and application of system are also discussed.

• The Journal of the Korea Contents Association
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• v.9 no.1
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• pp.446-454
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• 2009

In this paper, we propose u-learning hub site systems which are designed and implemented based on learning activities oriented components. The proposed systems are composed of component which can process the functionalities for coming into action of learning activities through various devices. Specially, each component is broken into class units by which learning activities of users can be performed on various devices. When users try to connect u-learning system in hub site, the system explores devices of users and connection program and then selects components that are fit to the activities and combines them in realtime. Through the methodology of u-learning hub site, the system proposed in this paper provides u-learning environment so that users can use the learning activity services taking no influence on time, place, devices and programs under the consistent system. That is different to traditional e-learning system which cannot support various devices of users directly.

• The Journal of the Korea Contents Association
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• v.16 no.6
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• pp.183-192
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• 2016

The purpose of this paper is firstly to research the Capstone Design Learning Model which helps the students to acquire practical industrial skills and knowledge in real business fields, and secondly to analyze the qualitative effectiveness of this model in respect of knowledge, skill and attitude which NCS(National Competence Standards) suggest in industrial design field. In order to study, the second-year students taking the class 'Communication and Design Project(CDP)' of Industrial Design Major of DIT, took part in the Capstone Design Project and proceeded a project 'Character design of the entertainer Robert Holley' in cooperation with a relevant company and the professor in charge of this project. Through this research, it appeared that Capstone design related to visual design tasks improved the technical skills and competence of the students majoring in design. In other words, through analyzing questionnaire survey based on NCS, evaluation from relevant company, and awarding a prize of the design contest, we conclude that this instruction design and action plans have significant meanings to promote the students on-the-job competence.