• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-1
• /
• pp.96-96
• /
• 2003

Telomerase activity is expressed in most types of cancer cells but not in normal somatic cells, suggesting that telomerase may be an important target for cancer chemotherapy. Inhibition of telomerase results in telomere erosion leading to the subsequent growth-arrest of cancer cells followed by senescence or cell death. In this study, we screened a chemical library for inhibition of human telomerase, identifying two groups of inhibitors. (omitted)

• 한국환경생태학회지
• /
• 제14권1호
• /
• pp.38-45
• /
• 2000

강원도 고성군 죽왕면과 토성면 일대의 소나무군락을 대상으로 1996년 4월에 발생한 산화에 따른 산림환경변화가 토양의 이화학성에 미치는 영향을 구명하기 위하여 비산화지역(NF) 산화후 비벌채지역(FNC), 산화후 벌채지역(FC) 및 산화후 조림지역(FCP)으로 분류하여 토양의 특성을 분석하였다. 전조사지역의 토성은 사질식양토이었고, 토양의 입경조성을 비교하면 비산화지역은 표토의 모래함량이 심토보다 낮았고, 점토함량은 높았지만 산화지역은 모두 표토의 모래함량이 점토에 비해 높았다. 토양공극 분포 중 전공극량은 지역별로 큰 차이가 없었으나, 조공극량과 투수성은 비산화지역 ＞ 산화후 비벌채지역 ＞ 산화후 조림지역 ＞ 산화후 벌채지역 순이었고, 세공극량과 가비중은 반대의 경향을 나타내었다. 이는 산화에 따른 산림환경변화로 지피식생이 제거되어 토양침식이 가속화되면서 토양 내 수분함유능력의 지표인 토양공극과 투수성에 큰 영향을 주면서 토양물리성을 악화시키고 있는 것으로 판단된다. 토양 pH는 비산화지역과 산화후 비벌채지역이 산화후 벌채지역과 조림지역보다 표토 및 심토 모두 높게 나타났다. 유기물함량 및 전질소함량 변화는 표토와 심토 모두 비산화지역＞ 산화후 비벌채지역＞ 산화후 조림지역＞ 산화후 벌채지역 순이었다. 양이온치환용량 및 치환성 양이온($K^{+}$ , $Na^{+}$ /, $Ca^{2+}$, $Mg^{2+}$)함량 변화는 모두 표토가 심토보다 높았으며, 지역별로는 비산화지역＞ 산화후 비벌채지역＞ 산화후 조림지역＞ 산화후 벌채지역 순으로, 이는 산화후 표토층의 침식으로 지력이 악화된 결과로 사료된다.

• 한국환경과학회지
• /
• 제15권2호
• /
• pp.177-183
• /
• 2006

The hydrolytic kinetics of biodegradable poly(l-lactide) (PLLA) have been studied by using two model systems, solution-grown single crystal (SC) and Langmuir monolayer techniques, for elucidating the mechanism for both alkaline and enzymatic degradations. The present study investigated the parameters such as degradation medium and time. The Langmuir mono layers of PLLA showed faster rates of hydrolysis when they were exposed to a basic subphase rather than they did when exposed to neutral subphase. Both degradation mediums had moderate concentrations to show a maximized activity, depending on their sizes. An alkaline degradation of SCs of PLLA showed the decrease of molecular weight of the remained crystals due to the erosion of chain-folding surface. However, the enzymatic degradation of SCs of PLLA occurred in the crystal edges thus the molecular weight of remained crystals was not changed. This behavior might be attributed to the size of enzymes which is much larger than that of alkaline ions; that is, the enzymes need larger contact area with monolayers to be activated.

• 한국토양환경학회지
• /
• 제4권1호
• /
• pp.119-126
• /
• 1999

This study was carried out to estimate the effect of forest fire on physical and chemical properties of soil The forest fire was in April 1995 at Kongju of Chungnam. Soil samples were collected at 0~5cm, 5~10cm, and 10~20cm soil depths in September 1998 from the burned and unburned sites. Soil organic matter concentrations at 0~5cm and 5~10cm soil depths were significantly greater in unburned site than in burned site. Soil concentrations were greater in unburned site than in burned site at all soil depths. Cation exchange capacity was significantly higher in unburned site than in burned site at 0~5cm soil depth. There were no differences in available soil P, exchangeable soil K, Ca, and Mg, and pH of soil between burned and unburned sites. Soil water content at 0~5cm soil depth was significantly greater in unburned site than in burned site. Bulk density at 0~5cm soil depth was significantly higher in burned site than in unburned site. Forest fire had an adverse effect on physical and chemical properties of soil in this study, Burning of vegetation and forest 리oor organic matter in burned site may reduce organic matter supply to soil and increase soil erosion. Consequently, forest fire may have adverse influence on long-term site productivity.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2003년도 하계학술대회 논문집 Vol.4 No.1
• /
• pp.370-373
• /
• 2003

As the integrated circuit device shrinks to the smaller dimension, the chemical mechanical polishing (CMP) process was required for the global planarization of inter-metal dielectric(IMD) layer with free-defect. However, as the IMD layer gets thinner, micro-scratches are becoming as major defects. Chemical-Mechanical Planarization(CMP) of conductors is a key process in Damascene patterning of advanced interconnect structure. The effect of alternative commerical slurries pads, and post-CMP cleaning alternatives are discuess, with removal rate, scratch dentisty, surface roughness, dishing, erosion and particulate density used as performance metrics. Electroplated copper depostion is a mature process from a historical point of view, but a very young process from a CMP persperspective. While copper electrodepostion has been used and stuidied for dacades, its application to Cu damascene wafer processing is only now ganing complete accptance in the semiconductor industry. The polishing mechanism of Cu CMP process has been reported as the repeated process of passive layer formation by oxidizer and abrasion action by slurry abrasives. however it is important to understand the effect of oxidizer on copper pasivation layer in order to obtain higher removal rate and non-uniformity during Cu-CMP process. In this paper, we investigated the effects of oxidizer on Cu-CMP process regarding the additional volume of oxidizer.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.1
• /
• pp.20-23
• /
• 2004

As the integrated circuit device shrinks to the smaller dimension, the chemical mechanical polishing(CMP) process was required for the global planarization of inter-metal dielectric(IMD) layer with free-defect. However, as the IMD layer gets thinner, micro-scratches are becoming as major defects. Chemical-Mechanical polishing(CMP) of conductors is a key process in Damascene patterning of advanced interconnect structure. The effect of alternative commercial slurries pads, and post-CMP cleaning alternatives are discuss, with removal rate, scratch dentisty, surface roughness, dishing, erosion and particulate density used as performance metrics. Electroplated copper deposition is a mature process from a historical point of view, but a very young process from a CMP perspective. While copper electro deposition has been used and studied for decades, its application to Cu damascene wafer processing is only now gaining complete acceptance in the semiconductor industry. The polishing mechanism of Cu-CMP process has been reported as the repeated process of passive layer formation by oxidizer and abrasion action by slurry abrasives. however it is important to understand the effect of oxidizer on copper passivation layer in order to obtain higher removal rate and non-uniformity during Cu-CMP process. In this paper, we investigated the effects of oxidizer on Cu-CMP process regarding the additional volume of oxidizer.

• 한국지구과학회지
• /
• 제35권1호
• /
• pp.1-18
• /
• 2014

이 연구의 목적은 2008년 5월 29일 우리나라에 영향을 미치는 황사를 예측하기 위해 WRF-Chem 모델 내 에어로졸 스킴과 광물성 먼지 옵션에 따른 미세먼지 농도 변화와 그에 따른 기상장의 민감도를 분석하는 것이다. 미세먼지의 인위적 배출량에 대해서는 $0.5^{\circ}{\pm}0.5^{\circ}$ RETRO 전구 배출량을, 광해리의 경우 Fast-J 광해리 스킴을, 그리고 황사 발생량을 추정하기 위해 RADM2 화학메커니즘 및 MADE/SORGAM 에어로졸 시나리오, MOSAIC 8 섹션 에어로졸 시나리오, 그리고 GOCART 먼지 침식 시나리오를 각각 적용하였다. 그 결과 RADM2 화학메커니즘 및 MADE/SORGAM 에어로졸 시나리오가 다른 시나리오들보다 우리나라 황사 먼지 농도와 배경 PM 농도를 더 높게 모사하였다. 그리고 이 시나리오와 서울의 각 대기질 측정망의 평균 PM10 농도와의 비교 결과, 상관계수는 0.67, 평균제곱근오차는 $44{\mu}gm^{-3}$으로 나타났다. 또한 WRF-Chem 모델에서 상기 3가지 시나리오와 이들 시나리오가 없는 순수 기상에서의 온도, 풍속, 경계층 높이, 장파복사의 기상 민감도를 분석한 결과, 1,800-3,000 m 경계층 높이와 $2-16ms^{-1}$ 풍속 U 성분의 공간적 분포가 황사 먼지 발생의 공간적 분포와 유사하게 나타났다. 그리고 GOCART 먼지 침식 시나리오와 RADM2 화학메커니즘 및 MADE/SORGAM 에어로졸 시나리오는 황사 먼지 또는 에어로졸과 기상이 온라인으로 상호작용함으로써 지구장파복사가 더 낮게 모사되었다.

• 한국해양바이오학회지
• /
• 제14권2호
• /
• pp.133-142
• /
• 2022

The increased production and consumption of polyethylene terephthalate (PET)-based products over the past several decades has resulted in the discharge of countless tons of PET waste into the marine environment. PET microparticles resulting from the physical erosion of general PET wastes end up in the ocean and pose a threat to the marine biosphere and human health, necessitating the development of new technologies for recycling and upcycling. Notably, enzyme-mediated PET degradation is an appealing option due to its eco-friendly and energy-saving characteristics. PETase, a PET-hydrolyzing enzyme originating from Ideonella sakaiensis, is one of the most thoroughly researched biological catalysts. However, the industrial application of PETase-mediated PET recycling is limited due to the low stability and poor reusability of the enzyme. Here we developed the whole-cell catalyst (WCC) in which functional PETase is attached to the outer membrane of Escherichia coli. Immunoassays are used to identify the surface-expressed PETase, and we demonstrated that the WCC degraded PET microparticles most efficiently at 30℃ and pH 9 without agitation. Furthermore, the WCC increased the PET-degrading activity in a concentration-dependent manner, surpassing the limited activity of soluble PETase above 100 nM. Finally, we demonstrated that the WCC could be recycled up to three times.

• Journal of Forest and Environmental Science
• /
• 제36권2호
• /
• pp.133-142
• /
• 2020

Soil physical and chemical properties at three layers such as top (0-10 cm), middle (10-20 cm) and bottom (20-30 cm) layers under three different vegetation types were studied. Soil samples were collected from Acacia forest, vegetable and fallow lands of Chittagong university campus, Chittagong, Bangladesh. Results showed that sand was the dominant soil particle followed by clay and silt fractions in all soil depths under different vegetation types. Soils of fallow land showed the highest values of bulk density while forest soils had the lowest values at three depths. Acacia forest soil having lowest values of dispersion ratio (DR) is less vulnerable while fallow soil with highest DR values is more vulnerable to soil erosion. The lower pH value at all soil layers in three ecosystems represented that soils under study are acidic in nature. Contents of organic matter, total nitrogen, exchangeable cations (Ca²⁺, Mg²⁺, K⁺ and Na⁺) and cation exchange capacity (CEC) were observed higher in Acacia forest soils compared to vegetable and fallow soils. Only soils of vegetable land had higher level of available phosphorus in three layers than that of other two land covers. The study also revealed that different soil properties were observed in three different vegetation types might be due to variation in vegetation and agronomic practices.

• 한국가스학회지
• /
• 제10권1호
• /
• pp.48-55
• /
• 2006

한국적 상황에 적절한 사회적 위험기준을 제시하고, 도시가스시설에 대한 화재 및 폭발사고에 대한 포괄적이고 정량적인 예측프로그램을 만들기 위하여 최근 11년간의 가스사고 데이터베이스를 분석하였다. 동종유형의 가스사고 발생가능성을 판단할 수 있는 Poisson분석 방법을 적용한 결과(t=5년), 시공 작업 부주의-폭발-배관의 항목의 사고발생반도가 가장 작았으며, 배관연결부이완부식-누출-배관의 경우는 가장 높은 빈도를 나타내었다. 따라서 이에 대한 적절한 가스사고 대응책이 마련되어야 할 것이다 향후 가스사고에 대한 신뢰성 있는 분석을 위해서는 가스로 인한 화재 폭발사고에 대한 데이터베이스를 지속적으로 확충보완을 시켜야 되며, 이를 위한 표준 코드화 작업이 요구된다.