Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10a
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- Pages.96-96
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- 2003
Potent Inhibition of Human Telomerase by Small Chemical Compounds
- Kim, Joo-Hee (Department of Biology, and Molecular Aging Research Center, Yonsei University) ;
- Kim, Jun-Hyun (Department of Biology, and Molecular Aging Research Center, Yonsei University) ;
- Lee, Gun-Eui (Department of Biology, and Molecular Aging Research Center, Yonsei University) ;
- Chung, In-Kwon (Department of Biology, and Molecular Aging Research Center, Yonsei University)
- Published : 2003.10.01
Abstract
Telomerase activity is expressed in most types of cancer cells but not in normal somatic cells, suggesting that telomerase may be an important target for cancer chemotherapy. Inhibition of telomerase results in telomere erosion leading to the subsequent growth-arrest of cancer cells followed by senescence or cell death. In this study, we screened a chemical library for inhibition of human telomerase, identifying two groups of inhibitors. (omitted)
Keywords