• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.70-70
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• 2003

Estrogen receptor is a ligand-activated transcription factor. Its action depends on the receptor, its ligand, and its coactivator proteins. As a consequence, the concentration of the receptor is a major component that governs the magnitude of the estrogen response. Despite the extensive knowledge on mechanism of estrogen receptor action, regulation of estrogen receptor itself is not very well understood. Estrogen receptor is known to be downregulated under hypoxia leading to inhibition of estrogen receptor mediated transcription activation. We have studied mechanism of loss of estrogen responsiveness under hypoxia. We found that Hif-l${\alpha}$, a major transcription factor regulating hypoxic response, inhibited transcription of estrogen response element driven luciferase gene by expression of HIF-l${\alpha}$/vp16 construct designed to contain transcription activity under normoxia. This loss of estrogen responsiveness appears to be the result of ER${\alpha}$ downregulation. ER${\alpha}$was downregulated at the levels of ligand-biding and protein within l2-24h, and the response was blocked by the proteasome inhibitor MG132, protein synthesis inhibitor cyclohexamide, and tyrosine kinase inhibitor Genistein. These results demonstrate that Hif-l${\alpha}$ downregulates ER${\alpha}$ by proteasome dependent pathway.

• KSTLE International Journal
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• v.3 no.1
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• pp.1-6
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• 2002

The purpose of this paper is to investigate the effects of design parameters on the friction loss in piston skirt. An analytical model to describe the friction characteristics of piston skirt has been presented, which is based on the secondary motion of piston and mixed lubrication theory, It could be shown that the skirt friction closely depends on the side force acted on the piston pin. The side force is inf1uenced by cylinder pressure at low engine speed, but by inertia force at high engine speed. The usage of extensive skirt area and low weight piston is effective to reduce the friction loss at high speed. The low viscosity oil considerably decreases viscous friction as engine speed increases, but it increases boundary friction at low engine speed. From the parametric study, it is found that the skirt axial profile is the most important design parameter related to the reduction of skirt friction.

• Physical Therapy Korea
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• v.5 no.1
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• pp.63-78
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• 1998

The decrease of muscle power and muscle size between twenties and seventies was about 30% and 40% respectively. The loss of muscle mass by aging resulted in the decrease of muscle power. The loss of muscle mass was due to the decrease of number of Type I fiber and Type II fiber and size of each muscle fiber. The aging skeletal muscle didn't show the loss of glycolysis capacity but showed 20% decrease of the oxidative enzymes and muscle vascularization. The vigorous endurance exercise training with graded intensity played a role in the vascular proliferation, increase of activity of oxidative enzymes and improvement of $VO_2$ max. The graded resistance exercise also played a role in the muscle hypertrophy and increase of muscle power, if it performed with adequate intensity and period. The exercise adaptation of aging skeletal muscle prevented it from sarcopenia, provided the activity of daily living with great effect and provided the aging related disease, that is Type II diabetes mellitus, arteriosclerosis, hypertension, osteoporosis and obesity, with great effect.

• Journal of the Korean Institute of Telematics and Electronics T
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• v.35T no.3
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• pp.31-36
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• 1998

In this paper, Image Rejection Interdigital Filter(IRIF) for 5.8GHz wireless LAN was designed and implemented. When the input signal is -30dBm in the 4~8㎓ frequency band, the insertion loss including all kinds of loss is 6.3dB in the center frequency 5.775GHz. Therefore, it was showed practically insertion loss of about -3.3dB. Especially, image signal rejection is about -l7dB in the image frequency 6.475GHz. and skirt characteristics of the high frequency band is very excellent. Therefore, it was confirmed that the proposed IRIF is suitable for RF image signal rejection in the 5.8GHz wireless LAN system.

• Journal of Korean Public Health Nursing
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• v.25 no.2
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• pp.197-208
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• 2011

Background: This study investigated the hearing status in Korean adults according to data from the Korea National Health and Nutrition Examination Survey 2009. Methods: The data of 3,479 adults(${\geq}20$ years, 1,492 men, 1,987 women) collected by the Korean Center for Disease Control was analyzed using ${\chi}^2$-test and logistic regression. Results: Differences in hearing loss according to individual factors were evident by follows gender, region, education status, economic status, current smoking and recognition of stress. Differences in - hearing loss according to ear related factors were evident subjective hearing status, experience of tinnitus, prevalence of chronic otitis media, and tympanomembrane abnormality. Conclusion: Hearing-related disorders can cause many social problems. This study investigated a representative cross-section of Koreans to determine the hearing status. The study was limited in that the risk factors of hearing loss were not identified. It is also recommended that a program be developed that can help control the variables identified in this study along with follow-up studies to verify the model.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.3
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• pp.421-432
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• 2002

In this study the modal characteristics and responses of an asymmetric structure with added viscoelastic dampers were investigated for design parameters such as eccentricity of stiffness and added dampers, the loss factor of the damping materials used. For modal characteristics, variation of the quantities such as natural frequencies, modal damping ratios, modal participation factors, and dynamic amplification factors were observed, and displacements at flexible and stiff edges, and at center of mass were obtained. Based on the results, the problem of the optimum damper distribution to minimize the torsional effects was addressed, and the proposed method for optimum damper distribution was applied to a multi-story structure to verify the applicability Finally the effect of viscous and viscoelastic dampers were compared by varying the loss factor of the viscoelastic material.

• Bulletin of the Korean Chemical Society
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• v.30 no.1
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• pp.153-156
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• 2009

Low temperature methane steam reforming to produce $H_2$ for fuel cells has been calculated thermodynamically considering both heat loss of the reformer and unreacted $H_2$ in fuel cell stack. According to the thermodynamic equilibrium analysis, it is possible to operate methane steam reforming at low temperatures. A scheme for the low temperature methane steam reforming to produce $H_2$ for fuel cells by burning both unconverted $CH_4$ and $H_2$ to supply the heat for steam methane reforming has been proposed. The calculated value of the heat balance temperature is strongly dependent upon the amount of unreacted $H_2$ and heat loss of the reformer. If unreacted $H_2$ increases, less methane is required because unreacted $H_2$ can be burned to supply the heat. As a consequence, it is suitable to increase the reaction temperature for getting higher $CH_4$ conversion and more $H_2$ for fuel cell stack. If heat loss increases from the reformer, it is necessary to supply more heat for the endothermic methane steam reforming reaction from burning unconverted $CH_4$, resulting in decreasing the reforming temperature. Experimentally, it has been confirmed that low temperature methane steam reforming is possible with stable activity.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.132.1-132.1
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• 2012

Radiation Belt Environment (RBE) model has developed to understand radiation belt dynamics as it considers whistler mode hiss and chorus waves which is responsible for relativistic electron acceleration and precipitation. Recently, many studies on electron loss by pitch-angle scattering have reported that elctromagnetic ion cyclotron (EMIC) wave is also responsible for main loss mechanism in dusk and equatorial regeion. Here, we attempt to incorporate EMIC into RBE model simulation code to understand more detailed physical dynamics in Radiation belt environemnt. We compare this developed model to data during storm events where both of electron loss and EMIC waves were detected.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.6 no.1
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• pp.28-36
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• 1995

In this paper, a design method of multiple n-way low loss power divider for x-band is propossed. To decrease loss, only two-stages of transmission lines are used with isolation resistors for match. Ex- perimental results for 3-way and 4-way power dividers have the divided power of 5.54~6.17dB and 6.76~7.37 dB, the return loss of more than 17dB and 12dB, and the isolation of more than 18dB and 10dB at center frequency, respectively, The measured results show good agreement with the theoretical analysis.

• Journal of Chest Surgery
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• v.3 no.2
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• pp.127-132
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• 1970

A patient was 29 year old house wife who was admitted to the Yonsei University Medical Center on 6 th of Nov., in 1970, with chief complaints of complete loss of bilateral visual acuity, generalized weakness, frequent palpitations, claudication of masseter muscles and intermittent fainting. These symptoms were developed 5 years prior to admission. Physical finding on admission revealed complete loss of bilateral visual acuity, absence of both radial and carotid pulse, but there was good femoral and popliteal pulse. She couldn't open her mouth as she desired and had weakness of mastication. Radiological findings of plane chest PA were not significant. Aortogram(Cineangiogram) showed non-visualization of both carotid and subclavian arteries. It showed only innominate and interal mammary artery preoperatively. The operative findings were as follows: There were complete obliterative changes in both common carotid and subclavian arteries, and periarteritis in the innominate artery. Tube Dacron Prosthesis Bypass with V-arm between innominate artery and both common carotid arteries was performed after thromboendarterectomy. Histopathological finding of the thromboend arterectomy specimen was compatible with pulseless disease, which showed marked fibrous thickening of intima and a diffuse inflammatory cell infiltration of the whole layers. Her postopererative course was uneventful. Follow up aortogram(Cineangiogram) was taken on 11th postoperative day, which revealed both common carotid arteries patent. Her preoperative Subjective symtoms disappeared remarkably, such as her visual acuity improved much, fainting and vertigo disappeared completely and she can go to bath room without difficulty and help. Another patient was 34 year old house wife who was admitted on August, 1964 with chief complaints of frequent fainting and progresive visual loss. She was operated only thromboendarterectomy of both common carotid arteries. Postoperative course was smooth and subjective symptoms were disappeared.