• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 2부
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• pp.456-459
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• 2008

현재는 CE 와 PC 를 중심으로 한 디지털 컨버전스의 시대이지만, 그에 반대급부로 많은 제품군의 다양화가 동시에 이루어지고 있다. 각 제품들은 독립적으로 기능을 수행하고 있지만, 유비쿼터스, 홈 네트워크의 개념이 부각되며 모든 제품들은 추후 네트워크상에 연결되게 될 것이며, 기기와 기기간의 연결을 통한 사용에 대한 시장의 요구가 지배적으로 부각될 것이다. 이러한 추세로 볼 때, 제품의 다양화는 결국 수 많은 경우의 수를 가지는 연결형태를 낳을 수 밖에 없으며 제품의 다양화에 따른 수 많은 연결형태에 대한 정의와 제어구조가 필요하다. 이에 더불어 다양한 제품들을 네트워크 상에서 유기적으로 연결하여 사용할 수 있는 다양한 디자인 방법론이 제시되어 왔지만, 실제 사용자의 사용행태 및 각 기기가 가지고 있는 기능적인 특정을 반영하는 기준이 정립되어 있지 않은 경우가 많다. 본 논문에서는 이러한 많은 경우의 수의 연결형태를 구분하고, 제어구조를 확립하기 위한 기기간 연결성디자인방법론을 제시하고 있다. 연결성디자인 가이드라인은 폭 넓은 기기간 연결을 제공하여야 하며, 여러 기기간의 동시제어(3-box 모델)에 대한 고려도 있어야 한다. 연결성디자인의 가이드라인을 제시하기 위해 우리는 사용자의 제품경험단계를 연결, 설정, 사용, 해제의 4 단계로 나눔으로써 수 많은 경우의 수의 연결형태의 구분에 대한 초기적인 정의를 하였다. 이러한 초기적인 정의를 바탕으로, 세부적인 연결형태의 구분을 위해 본 논문에서는 각 사용자 경험단계별 연결형태의 기준을 제시한다.

• 대한의생명과학회지
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• 제15권4호
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• pp.309-317
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• 2009

Occupational exposure to inorganic dusts such as coal and silica has been identified as a chronic obstructive pulmonary disease (COPD) risk factor. This risk factor causes lung inflammation and protease-antiprotease imbalance. This abnormal inflammatory response of the lung induces parenchymal tissue destruction and leads to progressive airflow limitation that is characteristics of COPD. The aim of this study was to determine the relationship of proteases such as neutrophil elastase (NE) and matrix metalloproteinase (MMP)-9 and antiproteases such as alpha-1 antitrypsin (AAT) and tissue inhibitors of metalloproteinase (TIMP)-1 with lung function. The study population contained 223 retired workers exposed to inorganic dusts. We performed lung function test, including percent of forced expiratory volume in one second ($%FEV_1$) predicted and $%FEV_1$/forced vital capacity (FVC). We analyzed serum MMP-9, AAT, TIMP-1 and plasma NE concentrations by sandwich enzyme immunoassay. NE, AAT, and TIMP-1 concentrations in workers, who had $%FEV_1$<80% predicted, were higher than those of workers who had $%FEV_1{\geq}80%$ (P<0.05). Both AAT and TIMP-1 concentrations in workers with airflow limitation were higher than those of workers with normal airflow (P<0.05). $%FEV_1$ predicted showed significant negative correlation with AAT (r=-0.255, P<0.0l), TIMP-1 (r=-0.232, P<0.01), and NE (r=-0.196, P<0.01). $%FEV_1$/FVC predicted showed significant negative correlation with NE (r=-0.172, P<0.05). From the results of stepwise multiple regression analysis about $%FEV_1$ and $%FEV_1$/FVC, significant independents were NE (r=-0.135, P=0.001) and AAT (r=-0.100, P=0.013) in $%FEV_1$, and NE (r=-0.160, P=0.014) in $%FEV_1$/FVC. In the present study, there were significant correlations between airflow limitation and protease concentration and between airflow limitation and antiprotease concentration. Serum protease and antiprotease concentrations, however, may be affected by the biological and inflammatory responses. It is necessary to evaluate specimens more reflected the effects of proteases and antiproteases in the lung such as lung tissue, bronchoalveolar lavage fluid, and exhaled breath condensate (EBC).

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1247-1251
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• 2012

Background: Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses to bacterial antigens. This study aimed to investigate the association between HLA-DQA1 and DQB1 genotypes and haplotypes vs H. pylori infection in an Indonesian population. Methods: We selected 294 healthy participants in Mataram, Lombok Island, Indonesia. H. pylori infection was determined by urea breath test (UBT). We analyzed HLA-DQA1 and DQB1 genotypes by PCR-RFLP and constructed haplotypes of HLA-DQA1 and DQB1 genes. Multiple comparisons were conducted according to the Bonferroni method. Results: The H. pylori infection rate was 11.2% in this Indonesian population. The DQB1*0401 genotype was noted to be associated with a high risk of H. pylori infection, compared with the DQB1*0301 genotype. None of the HLA-DQA1 or DQB1 haplotypes were related to the risk of H. pylori infection. Conclusions: The study suggests that HLADQB1 genes play important roles in H. pylori infection, but there was no statistically significant association between HLA-DQA1 or DQB1 haplotypes and H.pylori infection in our Lombok Indonesian population.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6089-6092
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• 2015

Background: The prevalence of metronidazole-resistant H. pylori is almost 50% in Thailand which severely limits the use of this drug for eradication therapy. The aims of this study were to evaluate the efficacy and safety profiles of 7-day bismuth-based quadruple therapy including metronidazole as an initial treatment for H. pylori infection in a high metronidazole resistance area. Materials and Methods: This study was performed at Thammasat University Hospital and King Chulalongkorn Memorial Hospital during January 2009 to October 2010. Patients with non-ulcer dyspepsia (NUD) with active H. pylori infection were assigned to receive seven days of quadruple therapy (pantoprazole 40 mg bid, bismuth subsalicylate 1,048 mg bid, amoxicillin 1 gm bid and metronidazole 400 mg tid). H. pylori infection was defined as positive H. pylori culture or two positive tests (rapid urease test and histology). Antibiotic susceptibility test for metronidazole by Epsilometer test (E-test) was performed in all positive cultures. At least four weeks after treatment, $^{13}C$ urea breath test ($^{13}C-UBT$) was performed to confirm H. pylori eradication. Results: A total of 114 patients were enrolled in this study, 50 males and 64 females with a mean age of 49.8 years. All 114 patients had a diagnosis of NUD. Overall eradication as confirmed by negative $^{13}C-UBT$ was achieved in 94 out of 114 patients (82.5%). 44 patients had positive cultures and success for E-test. In vitro metronidazole resistance was observed in 22/44 (50%) patients. Eradication rate in patients with metronidazole resistant strains was 16/22 (72.7%) and 20/22 (90.1%) with metronidazole sensitive strains (72.7% vs 90.1%, p-value=0.12; OR=3.75 [95%CI=0.6-31.5]). Minor adverse reactions included nausea, bitter taste, diarrhea and black stools but none of the patients dropped out from the study. Conclusions: Initial treatment with 7-day bismuth-based quadruple therapy including metronidazole, amoxycillin and pantoprazole is highly effective and well tolerated for metronidazole-sensitive H. pylori infections. However, the efficacy markedly decline with metronidazole resistance. Longer duration of this regimen might be required to improve the eradication rate and larger multi-center studies are needed to confirm this hypothesis.

• 한국수산과학회지
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• 제3권2호
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• pp.103-109
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• 1970

1969년 6월부터 1970넌 4월까지의 사이에 경남 거제군 둔덕면 법동리 앞바다에서 수하식으로 양식하고 있는 진주담치에 대해 조사한 결과는 다음과 같다. 1. 진주담치의 산란 성기는 $3\~4$월 사이라고 생각된다. 2. 진주담치의 성장식은 $$Y\;=\;1.508+0.659X-0.0559X^2+0.00367X^3$$으로 표시할 수 있고 특히 6월과 10월의 성장이 빠른 편이다. 3. 성장에 따라서 각군의 분산도 차차 커지는데 이 결과는 다음에서 보는 바와 같다. 4. 진주담치의 수명은 1년 6개월 내외로서 탈락 시기는 8월부터 10월 사이이다. 따라서 7월 이전에 수확해야 한다. 5. 진주담치의 최대 크기는 각고 9.48cm, 각장 4.49cm, 각폭 3.55cm, 각중량 22.05g 및 육중량 19.25g 내외이다. 6. 상대성장식은 각각 다음과 같다. 각고에 대한 각장은 Y=0.486X+0.334 각고에 대한 각폭은 Y=0.359X+0.107 육중에 대한 각중은 Y=0.882X+0.901 각고에 대한 육중은 $$Y\;=\;0.02828X^{2.90518}$$

• 한국치위생학회지
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• 제17권3호
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• pp.465-478
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• 2017

Objectives: The purpose of this study was to investigate the relationship between the level of subjective stress recognition and oral symptom experiences including toothache, gum diseases, and oral soft tissue diseases in the Korean adolescents. Methods: The subjects were 68,043 adolescents recruited using a web-based survey, National Korean Youth Risk Behavior in 2015 by the Korean Center for Disease Control. For statistical analysis, SPSS 21.0 for Windows was used. Descriptive analysis and a Chi-square test were conducted to determine the factors associated with general characteristics, health behaviors, oral health behaviors, and level of subjective stress recognition. Finally, to investigate the relationship between the level of subjective stress recognition and oral symptom experiences, logistic regression analysis was performed. Results: Toothache related subjective stress recognition level was significantly higher in the moderate group with the score of 1.59 (95% CI; 1.49-1.68), and was greater in the high group with 2.38 (95% CI; 2.24-2.53) compared to the low group. Gum disease related subjective stress recognition level was significantly higher in the moderate group with 1.41 (95% CI; 1.32-1.51), and was greater in the high group with 1.99 (95% CI; 1.86-2.13). Oral soft tissue disease related subjective stress recognition level was significantly higher in the moderate group with 1.59 (95% CI; 1.45-1.74), and was greater in the high group with 2.55 (95% CI; 2.33-2.79). Bad breath related subjective stress recognition level was significantly higher in the moderate group with 1.48 (95% CI; 1.39-1.57), and was greater in the high group with 2.10 (95% CI; 1.97-2.25). Conclusions: Higher subjective stress recognition level was found to affect the oral symptoms experienced. Therefore, the stress management plan should be prepared through the cause identification of the main stress in the adolescents. Practical and systematic education is needed for oral health management in the schools.

• 한국환경생태학회지
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• 제32권2호
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• pp.215-224
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• 2018

기후변화로 인한 곰솔림과 소나무림의 세력은 약해질 것으로 예상되고 있으나, 곰솔과 소나무에 대한 식재요구도는 여전히 높은 실정이다. 이에 본 연구는 한반도 난온대림지역에 속하는 부산일대, 남동부지역에 주요 조경수목인 소나무림과 곰솔림을 대상으로 자연림의 생육밀도를 파악한 후 난온대림에 적합한 생태적 식재밀도를 제시하고자 하였다. 연구는 한반도 남동부에 해당하는 부산광역시를 중심으로 소나무림 22개소, 곰솔림 60개소를 선정하여 $100m^2$ 방형구를 설치하여 조사구 내 출현하는 교목, 아교목층 수종의 흉고직경 및 개체수를 조사한 후, 회귀분석을 통해 평균흉고직경급별 적정 개체수 산정을 위한 회귀식을 도출하였다. 회귀분석 결과, 흉고직경의 생장에 따른 교목층 생육개체수 예측모형의 결정계수는 곰솔림 0.700, 소나무림 0.533으로 단일 요인에 의한 설명력으로는 매우 높은 것으로 분석되었다. 예측 회귀모형은 곰솔림의 경우 $Y=31.176e^{-0.055x}$, 소나무림의 경우 $Y=38.351e^{-0.059x}$(X=흉고직경, Y=개체수/$100m^2$)였다. 남동부지역의 곰솔림과 소나무림의 생육밀도는 중부지방보다 다소 높았다.

• 기본간호학회지
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• 제5권1호
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• pp.107-124
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• 1998

Based on King's goal attainment theory, this research deals with applying nursing intervention of mutual goal settings to gastrectomy patients. It tests the effects of nursing intervention, according to the patients' health locus of control, suggested as external boundary criteria for the theory by employing a quasi-experimental design which consists of a pretest-posttest non-equivalent control and experimental groups. The subjects of this research were 62 gastrectomy patients hospitalized at Y medical center and the experimental and control groups consisted of 31 subjects. The experimental group received nursing intervention at the mutual goal setting of 5 times from the day before the surgery to the 5th day after the surgery, while the control group received only routine nursing care. Recovery indicators of both groups were measured and compared. Measurement variables included patients' characteristics, health locus of control, forced vital capacity, forced expiratory volume in one second, peak expiratory flow, bowel movement recovery, mobility recovery, level of pain, patients' stress and patients' satisfaction. Data were analyzed using SPSS statistical package and the hypotheses were tested by ANOVA and ANCOVA. Results of the analyses are summarized as follows : 1) Internal health locus of control had higher effects of the nursing intervention of mutual goal setting than external health locus of control on pulmonary ventilatory functions of forced vital capacity, forced expiratory volume in one second, and peak expiratory flow. 2) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the bowel movement recovery between the internal and external health locus of control. 3) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the mobility recovery between the internal and external health locus of control. 4) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of pain between the internal and external health locus of control. 5) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of stress between the internal and external health locus of control. 6) There was a statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of satisfaction with provision of nursing information between the internal and external health locus of control, and there was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of satisfaction with outcome of nursing between the internal and external locus of control. On the basis of the research results, the following are recommended : 1) Repeated research on responses to health locus of control is necessary. 2) Not only the effectiveness of nursing intervention in acute recovery periods, but also the long term effects are to be investigated. 3) The development of instruments is needed to accurately measure mutual goal setting regarding postoperative deep breath, coughing, early ambulation, etc. so that the relationship among the postoperative recovery indicators may be explored. 4) It is required that an instrument be developed to measure perception which facilitates goal attainment in the interactive setting between patients and nurses.

• The Korean Journal of Physiology
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• 제11권2호
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• pp.45-50
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• 1977

The maximum voluntary ventilation (MVV) is one of the most widely used pulmonary function test, but its measuring method was very difficult and unreliable. However, it is need to get more easy and simple measuring method of MVV. Therefore, this study was attempted to get more easy and simple measuring method of MVV by means of the forced expiratory volume $(FEV_{T})$. The young and healthy 1,000 Korean students(592 male and 408 female) were cheesed for this purpose and whose ages were from 8 to 20 years. A spirometer (9L, Collins Co.) was used for the MVV and FEV, and they were measured 3 times at standing position, and the highest value was used. In the measurements, the subjects for MVV were asked for the breath as fast and deeply as possible for 12 seconds, and for FEV were asked for the rapid and forceful exhalation after a maximal inhalation (forced expiratory curve). In the FEV measurements toward the end of the expiration, the subjects were exhaused to continue the effort until no further gas was expired. During these measurements, the investigator stood by the subject to give a constant encouragement. FEV were calculated in the volume exhaled during the one-half $(FEV_{0{\cdot}5,}\;ml)$, the first second $(FEV_{1{\cdot}0,}\;ml)$ and the percentage of the total vital capacity exhaled during the one-half second $(FEV_{0{\cdot}5,}\;%)$. The results are summarized as follows: 1) The values of MVV were increased linearly with ages until 20 in both sexes. The values of male at the age of 20 was $168.2{\pm}2.5L/min$, and female at the age of 17 was $112.3{\pm}3.0L/min$, respectively. 2) The values of FEV (ml) were increased linearly with ages until 20 in both sexes. The values of $FEV_{0{\cdot}5}$ were $2,797{\pm}65.7ml$ in the male of 20 years and were $2,088{\pm}54.6ml$ in the female of 17 years, and of $FEV_{1{\cdot}0$ were $4,119{\pm}68.2ml$ in the male of 20 years and were $2,897{\pm}65.9ml$ in the female of 17 years, respectively. 3) The correlation coefficients between MVV and $FEV_{0{\cdot}5}\;or\;FEV_{1{\cdot}0$ (ml) were 0.82 or 0.85 in the male, and 0.77 or 0.79 in the female, respectively. 4) The prediction formulae for MVV to be derived from above results were: For male: MVV (L/min) =7.19+$0.05{\times}FEV_{0\cdot5}(ml)$, MVV (L/min)=11.25+$0.04{\times}FEV_{1\cdot0}(ml)$ For female: MVV (L/min)=16.03+$0.05{\times}FEV_{0\cdot5}(ml)$, MVV (L/min)=9.47+$0.03{\times}FEV_{1\cdot0}(ml)$.

• Environmental Analysis Health and Toxicology
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• 제17권3호
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• pp.197-205
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• 2002

Volatile organic compounds (VOCs) are an important public health problem throughout the world. Many important questions remain to be addressed in assessing exposure to these compounds. Because they are ubiquitous and highly volatile, special techniques must be applied in the analytical determination of VOCs. Personal exposure measurements are needed to evaluate the relationship between microenvironmental concentrations and actual exposures. It is also important to investigate exposure frequency, duration, and intensity, as well as personal exposure characteristics. In addition to air monitoring, biological monitoring may contribute significantly to risk assessment by allowing estimation of absorbed doses, rather than just the external exposure concentrations, which are evaluated by environmental and personal monitoring. This study was conducted to establish the analytic procedure of VOCs in air, blood, urine and exhaled breath and to evaluate the relationships among these environmental media. The subjects of this study were selected because they are occupationally exposed to high levels of VOCs. Environmental, personal, blood, urine and exhalation samples were collected. Purge ＆ trap, thermal desorber, gas chromatography and mass selective detector were used to analyze the collected samples. Analytical procedures were validated with the“break through test”, 'quot;recovery test for storage and transportation”,“method detection limit test”and“inter-laboratory QA/QC study”. Assessment of halogenated compounds indicted that they were significantly correlated to each other (p value < 0.01). In a similar manner, aromatic compounds were also correlated, except in urine sample. Linear regression was used to evaluate the relationships between personal exposures and environmental concentrations. These relationships for aromatic and halogenated are as follows: Halogen $s_{personal}$ = 3.875+0.068Halogen $s_{environmet}$, ($R^2$= .930) Aromatic $s_{personal}$ = 34217.757-31.266Aromatic $s_{environmet}$, ($R^2$= .821) Multiple regression was used to evaluate the relationship between exposures and various exposure deter-minants including, gender, duration of employment, and smoking history. The results of the regression model-ins for halogens in blood and aromatics in urine are as follows: Halogen $s_{blood}$ = 8.181+0.246Halogen $s_{personal}$+3.975Gender ($R^2$= .925), Aromatic $s_{urine}$ = 249.565+0.135Aromatic $s_{personal}$ -5.651 D.S ($R^2$ = .735), In conclusion, we have established analytic procedures for VOC measurement in biological and environmental samples and have presented data demonstrating relationships between VOCs levels in biological media and environmental samples. Abbreviation GC/MS, Gas Chromatography/Mass Spectrometer; VOCs, Volatile Organic Compounds; OVM, Organic Vapor Monitor; TO, Toxic Organicsapor Monitor; TO, Toxic Organics.