Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Association Between HLA-DQ Genotypes and Haplotypes vs Helicobacter pylori Infection in an Indonesian Population

  • Zhao, Yang (Department of Public Health, Nagoya City University Graduate School of Medical Sciences) ;
  • Wang, Jingwen (Department of Public Health, Nagoya City University Graduate School of Medical Sciences) ;
  • Tanaka, Tsutomu (Department of Public Health, Nagoya City University Graduate School of Medical Sciences) ;
  • Hosono, Akihiro (Department of Neonatology and Pediatrics, Nagoya City University Graduate School of Medical Sciences) ;
  • Ando, Ryosuke (Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences) ;
  • Soeripto, Soeripto (Department of Anatomic Pathology, Gadjah Mada University Faculty of Medicine) ;
  • Triningsih, F.X. Ediati (Department of Anatomic Pathology, Gadjah Mada University Faculty of Medicine) ;
  • Triono, Tegu (Department of Anatomic Pathology, Gadjah Mada University Faculty of Medicine) ;
  • Sumoharjo, Suwignyo (Department of Anatomic Pathology, Gadjah Mada University Faculty of Medicine) ;
  • Astuti, E.Y. Wenny (Department of Anatomic Pathology, Gadjah Mada University Faculty of Medicine) ;
  • Gunawan, Stephanus (General Hospital of West Nusa Tenggara Province) ;
  • Tokudome, Shinkan (Department of Public Health, Nagoya City University Graduate School of Medical Sciences)
  • Published : 2012.04.30
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Abstract

Background: Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses to bacterial antigens. This study aimed to investigate the association between HLA-DQA1 and DQB1 genotypes and haplotypes vs H. pylori infection in an Indonesian population. Methods: We selected 294 healthy participants in Mataram, Lombok Island, Indonesia. H. pylori infection was determined by urea breath test (UBT). We analyzed HLA-DQA1 and DQB1 genotypes by PCR-RFLP and constructed haplotypes of HLA-DQA1 and DQB1 genes. Multiple comparisons were conducted according to the Bonferroni method. Results: The H. pylori infection rate was 11.2% in this Indonesian population. The DQB1*0401 genotype was noted to be associated with a high risk of H. pylori infection, compared with the DQB1*0301 genotype. None of the HLA-DQA1 or DQB1 haplotypes were related to the risk of H. pylori infection. Conclusions: The study suggests that HLADQB1 genes play important roles in H. pylori infection, but there was no statistically significant association between HLA-DQA1 or DQB1 haplotypes and H.pylori infection in our Lombok Indonesian population.

Keywords

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