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Effect of a Proton Pump Inhibitor on Tumor Bleeding Prevention in Unresectable Gastric Cancer Patients: a Double-Blind, Randomized, Placebo-Controlled Trial

  • Kim, Young-Il;Kim, Mi-Jung;Park, Sook Ryun;Kim, Hark Kyun;Cho, Soo-Jeong;Lee, Jong Yeul;Kim, Chan Gyoo;Kim, Gwang Ha;Park, Moo In;Nam, Byung-Ho;Park, Young Iee;Choi, Il Ju
    • Journal of Gastric Cancer
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    • v.17 no.2
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    • pp.120-131
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    • 2017
  • Purpose: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. Materials and Methods: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS). Results: This study initially planned to enroll 394 patients, but prematurely ended due to low recruitment rate. Overall, 127 patients were included in the analyses: 64 in the lansoprazole group and 63 in the placebo group. During the median follow-up of 6.4 months, tumor bleeding rates were 7.8% and 9.5%, in the lansoprazole and placebo groups, respectively, with the cumulative bleeding incidence not statistically different between the groups (P=0.515, Gray's test). However, during the initial 4 months, 4 placebo-treated patients developed tumor bleeding, whereas there were no bleeding events in the lansoprazole-treated patients (P=0.041, Gray's test). There was no difference in the proportion of patients who required transfusion between the groups. The OS between the lansoprazole (11.7 months) and the placebo (11.0 months) groups was not statistically different (P=0.610). Study drug-related serious adverse event or bleeding-related death did not occur. Conclusions: Treating patients with inoperable gastric cancer with lansoprazole did not significantly reduce the incidence of tumor bleeding. However, further studies are needed to evaluate whether lansoprazole can prevent tumor bleeding during earlier phases of chemotherapy (ClinicalTrial.gov, identifier No. NCT02150447).

The Review of KDAB Agriculture Project for the Rural Development in Bangladesh (방글라데쉬 농촌 개발을 위한 케이디에이비 농업 개발사업의 평가)

  • Kwon, Byung-Hee
    • Journal of Agricultural Extension & Community Development
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    • v.3 no.2
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    • pp.197-209
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    • 1996
  • Bangladesh that is known as the poorest country of the world has the large land of fertile soil and very good environment to live, even though we think she may be very bad to live. People being habituated to that good environment, the population explosion made the people to be starven, but the treatment has been simple support without deep analysis of the root of poverty. As the result it is general that the poverty is severer and severer in spite of continuous support. For the last century Korea changed from the country of poverty and despair to that of development and hope, to be model mid vision of under development countries including Bangladesh. At this point it is necessary to look back the way of development to help them to solve their poverty problem. That is the goal of this project, and this thesis is the result of it. It is evaluated for the 1st 5 years work of the project to apply the result to the next 5 years plan. This project had been proceeded from 1. Jul. 1990 to 30. Jun. 1995 at Chilmari area of Bangladesh, with teaching and training to wake up the mentality of the people, demonstration farming and cooperative association. It was proceeded as the Agriculture project of KDAB(Korean Development Association in Bangladesh, an NGO registered to Bangladesh) supported by Good Neighbors, KOICA and many churches and individuals. Especially the teaching and training work was proceeded as the branch of the Canaan Farmer`s School of Korea with instruction and support. After the basic survey for project, the confirmation of working place and the preparation of training facility, 10 times of long term training(3 months worse, boarding) was completed, with many times of short term training, informal training, demonstration farm, various demonstrating works. The results of the work are understanding of the not of problem by participatory observation, making plan to solve it, getting the trust from the people and beginning the practical work with the trainees for development of economy and living situation. The biggest problem of Bangladesh is being understood losing the desire to solve the poverty problem and the self-confidence to be able to do it. It is the conclusion that after solving the problem of thought and mentality, the education, technology and money can be effective for development. So the 1st 5 year project is evaluated as the basic work to analyse the root of problem, to chance mentality of people and to search income source. The next goal is to promote practical living level of people. For that it is necessary to develope die mentality of people including responsibility and self-confidence by teaching and training, to educate cooperative association and technology for economical development, to proceed integrated rural development work with economical development, educational improvement and reformation of environment. It is very important result that they decided to grow poultry for main economical source of Chilmari area, to do economical development work by joint operation of poultry through cooperative association.

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Interaction of Body Mass Index and Diabetes as Modifiers of Cardiovascular Mortality in a Cohort Study

  • Ma, Seung Hyun;Park, Bo-Young;Yang, Jae Jeong;Jung, En-Joo;Yeo, Yohwan;Whang, Yungi;Chang, Soung-Hoon;Shin, Hai-Rim;Kang, Daehee;Yoo, Keun-Young;Park, Sue Kyung
    • Journal of Preventive Medicine and Public Health
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    • v.45 no.6
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    • pp.394-401
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    • 2012
  • Objectives: Diabetes and obesity each increases mortality, but recent papers have shown that lean Asian persons were at greater risk for mortality than were obese persons. The objective of this study is to determine whether an interaction exists between body mass index (BMI) and diabetes, which can modify the risk of death by cardiovascular disease (CVD). Methods: Subjects who were over 20 years of age, and who had information regarding BMI, past history of diabetes, and fasting blood glucose levels (n=16 048), were selected from the Korea Multi-center Cancer Cohort study participants. By 2008, a total of 1290 participants had died; 251 and 155 had died of CVD and stroke, respectively. The hazard for deaths was calculated with hazard ratio (HR) and 95% confidence interval (95% CI) by Cox proportional hazard model. Results: Compared with the normal population, patients with diabetes were at higher risk for CVD and stroke deaths (HR, 1.84; 95% CI, 1.33 to 2.56; HR, 1.82; 95% CI, 1.20 to 2.76; respectively). Relative to subjects with no diabetes and normal BMI (21 to 22.9 $kg/m^2$), lean subjects with diabetes (BMI <21 $kg/m^2$) had a greater risk for CVD and stroke deaths (HR, 2.83; 95% CI, 1.57 to 5.09; HR, 3.27; 95% CI, 1.58 to 6.76; respectively), while obese subjects with diabetes (BMI ${\geq}25kg/m^2$) had no increased death risk (p-interaction <0.05). This pattern was consistent in sub-populations with no incidence of hypertension. Conclusions: This study suggests that diabetes in lean people is more critical to CVD deaths than it is in obese people.

Railway Governance and Power Structure in China

  • Lee, Jinjing
    • International Journal of Railway
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    • v.1 no.4
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    • pp.129-133
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    • 2008
  • Over the last $15{\sim}20$years, many countries have adopted policies of railway privatization to keep up with increasing competition from road and air transport. Although each country and case has its own history, market characteristics, political context as well as administrative process, railway privatizations (including railway restructure, concession etc.) in the west usually are accompanied with the establishment of new regulatory regimes. Therefore, railway governance has been innovating towards an interaction of government, regulator, industry bodies, user groups, trade unions and other interested groups within the regulatory framework. However, it is not the case in China. Although China had seen a partial privatization in some branch lines and is experiencing a much larger-scale privatization by establishing joint-ventures to build and operate high-speed passenger lines and implementing an asset-based securitization program, administrative control still occupies absolutely dominant position in the railway governance in China. Ministry of Railway (MOR) acts as the administrator, operator as well as regulator. There is no national policy that clearly positions railway in the transportation network and clarifies the role of government in railway development. There is also little participation from interested groups in the railway policy making, pricing, service standard or safety matter. Railway in China is solely governed by the mere executive agency. Efficiency-focused economic perspective explanation is far from satisfaction. A wider research perspective from political and social regime is of great potential to better explain and solve the problem. In the west, separation and constrains of power had long been established as a fundamental rule. In addition to internal separation of political power(legislation, execution and jurisdiction), rise of corporation in the 19th century and association revolution in the 20th century greatly fostered the growth of economic and social power. Therefore, political, social and economic organizations cooperate and compete with each other, which leads to a balanced and resonable power structure. While in China, political power, mainly party-controlled administrative power has been keeping a dominated position since the time of plan economy. Although the economic reform promoted the growth of economic power of enterprises, it is still not strong enough to compete with political power. Furthermore, under rigid political control, social organizations usually are affiliated to government, independent social power is still too weak to function. So, duo to the limited and slow reform in political and social regime in China, there is an unbalanced power structure within which political power is dominant, economic power expanding while social power still absent. Totally different power structure in China determines the fundamental institutional environment of her railway privatization and governance. It is expected that the exploration of who act behind railway governance and their acting strength (a power theory) will present us a better picture of railway governance as a relevant transportation mode. The paper first examines the railway governance in China and preliminarily establishes a linkage between railway governance and its fundamental institutional environment, i.e. power structure in a specific country. Secondly, the reason why there is no national policy in China is explored in the view of political power. In China, legislative power is more symbolic while party-controlled administrative power dominates political process and plays a fundamental role in Chinese railway governance. And then, in the part three railway finance reform is analyzed in the view of economic power, esp. the relationship of political power and economic power.

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Weed Control Efficacy and Production of Fruit according to Several Weed Control Methods in an Apple Orchard (사과원에서 잡초방제 방법이 제초효과 및 과실생산에 미치는 영향)

  • jang, Il;Kang, Ji Eun;Kim, Hyang Mi;Park, Yong Seog;Lee, Jeong Deug;Suh, Sang Jae
    • Weed & Turfgrass Science
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    • v.4 no.2
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    • pp.104-110
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    • 2015
  • This study was conducted for 3 years in an apple orchard to investigate the efficacy of the glufosinate-ammonium (GFA) SL for weed control in comparison to non-woven fabric mulch, sod culture and machinery cutting treatments. Glufosinate-ammonium SL 18% was applied with 2 to 3 times, and the extents of injury caused by the different weed control methods were also investigated during the 3 years. The highest level of weed control was obtained by glufosinate-ammonium 3 times spray (98.7%), followed by machinery cutting (95.1%), glufosinate-ammonium 2 times spray (81.5%) and natural sod culture (5.8%). Amounts of fruit production in three times application of glufosinate-ammonium 540 g a.i. $ha^{-1}$, twice application of GFA, machinery cutting, non-woven fabric processing, sod culture and untreated control were 27.2, 26.2, 25.3, 24.1, 20.4 and 13.3 kg, respectively. There was no toxicity symptom of glufosinate-ammonium on the whole tree such as fruit, bud, trunk, branch and flower during the 3 years.

The Changes of Depositional Landforms in the Downstream Reach of Cha-Cheon (차천(車川) 하류 구간의 퇴적지형 변화)

  • Yu, Tai-Il
    • Journal of the Korean association of regional geographers
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    • v.12 no.3
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    • pp.352-363
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    • 2006
  • The purpose of this paper is to analyze changes in the depositional landform in the channel of Cha-cheon, a branch stream of Nakdong river(main stream) since the artificial straight channel has been constructed in 1973. The results of analyses are as follow. First, the Cha-cheon has flooded over one time in a year, and flowed backward over three times annually, according to analyze the data of the Hyeonpoong Gauging Station of rainfall and water level during a decade(1993$\sim$2002). Second, the flood plain within the artificial straightened channel has a nearly plain profile between the small dike and last riffle(point A). Deposits thickness of flood plain reduce gradually toward upstream. Third, grain size distribution of the flood plain deposits(0$\sim$20cm) within the artificial straightened channel has a coarsening trend in downstream reach of C point. It implies that the backward flow of Nakdong river(the main stream of Cha-cheon) make effect on the depositional mechanism of lowest reach in Cha-cheon. Finally, the result of analyzing grain size distribution of the flood plain deposits(0$\sim$20cm) within the artificial straightened channel implies that the c-point is the boundary between the vertical deposition of suspended load due to the backward flow of Nakdong river and the deposition of bed load supplied from hillslope of Cha-cheon basin.

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A Study on the Relations between Gi-gong and Taekwondo (태권도(跆拳道)에 대한 기공학적(氣功學的) 접근(接近))

  • Lee, Myeong-Chan;Sa, Hie-Su
    • Journal of the Korean Institute of Oriental Medical Informatics
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    • v.14 no.1
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    • pp.55-61
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    • 2008
  • The Taekwondo is the martial arts where possibility thousand Ul of history and the ancestor is put in with specific martial arts of our nation. Also it practiced with the self defense martial arts which rules over the body and a mind and it came, the country from crisis of imminent danger won a victory with the good state affair alcoholic beverage and it was come. The ancestors condition anger the Taekwondo where the soul is put in were born again with martial arts of the world and they became and the world-wide conference was adopted with the Olympic formal item which becomes the historian of of course sports and became the martial arts in the world-wide center. In like this features martial arts even from each country condition anger and the sports raises the phase of the country is racing with of course martial arts. Specially from China it makes the right shoe which is a Chinese martial arts with condition item and sports anger the features of the martial arts origination to do and there is a possibility of seeing the features which in the succession nose sleeping martial arts perforation defends it concentrates. The martial arts perforation character is letting in religion and philosophy thought of the Orient. Confucianism and Buddhism, it puts in the teaching of friendship thoughts and heaven and earth positive and negative principles, five lines and eight divination signs. Features of like this perforation our ancestors the positive and negative principles where the philosophy of the Orient is put in, there is a possibility of searching from life and the Taekwondo which it does with at five events together. With history of the ancestor it breathes together and all Taekwondo operation every one by one it puts in the thought of our ancestors as well. The some branch it tried to listen to the representative example which the feather holds hereupon in basic operation, the Taoist garment, the belt and width tax of Taekwondo. The flesh which is healthy in the spirit which is healthy holds the feather. Taekwondo Oh! as the true feelings one martial art which accomplishes the artificial flower of the dynamic thing and the static thing at end with the perforation essentially it is deep it will be able to confirm repeatedly fire tube characteristic.

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The Change Analysis about Health Behavior and Examination Result of Periodical Medical Examiner (정기 검진자의 건강행태 및 검진결과 변화분석)

  • Lee, Tae-Yong;Yoon, Dal-Sik
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.2
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    • pp.923-933
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    • 2014
  • The subject of investigation was 13,828 people who took periodical medical examiner in some health examination centers two times in 2009 and 2011 so as to analyze changes of borderline group, disease group for 4 diseases(hypertension, diabetes, liver disease, hyperlipemia) and health behavior of some medical examiner. For the contents of investigation, drinking and smoking habit was investigated as a general characteristic of subjects. For the items of health examination, there were SBP, DBP, AST, ALT, GGT, Glucose, Total Cholesterol and Triglyceride. The main results are as follows. In comparison with the starting year of research, drinking and smoking rate of the final year was reduced respectively by 1.6% and 1.4%. And, borderline group by examination items, hypertension was reduced by 2.2% from 62.0% to 59.8% in the final year in comparison with the starting year of investigation, And, fasting blood glucose was 17.1%, hyperlipemia was 6.6%, LFT was 2.0% for the reduction. In disease group, hypertension was reduced by 0.6% from 6.7% to 6.1%. And, fast blood glucose was 1.9%, hyperlipemia was 4.2%, LFT was 1.3% for reduction. Borderline group showed more reduction in comparison with disease group in all of items. The above results showed borderline group showed more reduction of manifestation rate than disease group in all of 4 diseases. Therefore, it's expected that disease group will show reduction in the future. But, it's necessary to study on future's changes through the continuous management and tracing observation.

Physio-Ecological Characteristics of Purslane (Portulaca oleracea L.) (쇠비름(Portulaca oleracea L.)의 생리(生理) 생태적(生態的) 특성(特性))

  • Park, J.S.;Kim, K.U.;Lee, Y.D.
    • Korean Journal of Weed Science
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    • v.8 no.1
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    • pp.23-27
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    • 1988
  • This experiment was conducted to determine germination ability, life cycle, regrowth ability of Portulaca oleracea L. The newly harvested seeds from P. oleracea flowered before July 15 were able to germinate, but percent germination decreased markedly as the flowering time was later than July 15, showing no germination of seed collected at Sept. 12 which were flowered at August 30, 76.5% of seeds can be germinated in the light as seed stored in room condition for 90 days, but in dark condition, it needed 2 years of seed storage for germination. Low temperature treatment at $2^{\circ}C$ for 5 days enhanced seed germination of P. oleracea in both light and dark conditions. The maximum vagetative growth was observed at 30 to 75 days after seeding. The late seeding time such as July 1 shortened the period of vegetative growth. However, regardless of the seeding times, the first flowering was observed at about 40 days after seeding. Leaf numbers, shoot lengths, fresh and dry weights were greatly affected by the seeding dates, showing that the earlier seedings produced significantly higher shoot length, fresh and dry weight, leaf numbers and branch numbers than those of the late seedings. When all branches were removed on 68 days after seeding, their regrowth ability was 50.3% and cuttaged branches showed 78.1% regrowth as compared to intact plant.

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A Study on Gasan of the Cheonggyecheon in the Joseon Dynasty (조선시대 청계천 주변의 가산(假山)에 대한 연구)

  • Kim, Myo-jung;Jung, Ki-Ho;Kim, Du-Gyu
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.34 no.4
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    • pp.26-36
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    • 2016
  • This study aims to identify the place and location of Gasan around Cheonggyecheon in the Joseon Dynasty, and also to examine the current status of their changes or disappearance in the process of modernization. On top of literature research on old document and maps related to dredging of Cheonggyecheon, the field survey to understand the actual status and location of Gasan was conducted. The study contents are like below. First, through old document and maps related to Cheonggyecheon in the Joseon Dynasty, the contents and records related to Gasan around Cheonggyecheon were selected. Such Gasan were mainly built up by dredging work of branch/streamlet in the era of King Sejong, and also the large-scale dredging during the period of King Yeongjo. Second, the location of Gasan and forest around Cheonggyecheon shown in old maps was understood. With Ogansumun(Five-arched Floodgates) as the center, they were constructed on both hills of Cheonggyecheon inside/outside of the capital city, and its surrounding branches. Third, based on the measures to create a scale map based on Susunjeondo, the location of Gasan on old maps was found on the current map, and then the current status of places expressed as Gasan was surveyed. In the results of the study, even though most of the Gasan built up around Cheonggyecheon in the Joseon Dynasty have disappeared by the urban development performed since the end of 19th century, still, there are some remains left.