• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.35-40
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• 2005

Interaction of twelve erythromycin A analogues with 50S ribosomal subunit were studied employing AutoDock 3.0.5. Results showed that all active macrolides bound at the same binding site with erythromycin A in contrast to the inactive analogues which bound at location slightly different than erythromycin A. The binding site showed consistency with the X-ray data from the perspectives of hydrogen bonding and hydrophobic interactions formed by erythromycins, roxithromycin, azithromycin, cethromycin and telithromycin with the ribosome. The inactive derivatives of erythromycin A anhydride showed higher binding free energy, while 5-desosaminyl erythronolides A and B even though having quiet similar values of binding free energy with the active analogues, docked at binding sites which are quiet different than the active analogues. These results suggest the molecular docking technique can be used in predicting the binding of erythromycin A analogues to their ribosomal target.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 춘계학술대회 논문집
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• pp.307-310
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• 2008

Nonlinear Vortex Strength Correction Method is developed for improvement of vortex lattice method which can't calculate the separated flow conditions and the viscous effect. In this method, the vortex strength on the blade surface is determined by matching the lift force from vortex lattice method with the lift force from aerodynamic coefficients table as the same circulation is added to or subtracted from all chord wise vortices. For considering the nonlinearities due to the neighboring blade sections, sophisticated Newton-Rapson algorithm is applied. The validation of this method was done by comparing the simulations with the measurements on the NREL Phase-VI horizontal axis wind turbine(HAWT) in the NASA Ames wind tunnel under uniform conditions. This method gives good agreements with experiments in most cases.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1993년도 추계학술대회 논문집
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• pp.218-223
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• 1993

An UBET(Upper Bound Elemental Technique) program has been developed to analyze forging load, die-cavity filling and effective strain distribution for flashless forging. To analyze the process easily, it is suggested that the deformation is divided into two different parts. Those are axisymmetric part in corner and plane-strain part in lateral. The total power consumption is minimized through combination of two deformation parts by building block method, from which the upper-bound forging load, the flow pattern, the grid pattern, the veocity distribution and the effective strain are determined. To show the merit of flashless forging, the result of flashless and flash forging processes are compared through theory and experiment. Experiments have been carried out with plasticine billets at room temperature. The theoretical predictions of the forging load and the flow pattern are in good agreement with the experimental results.

• 한국정밀공학회지
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• 제12권9호
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• pp.126-136
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• 1995

Copper magnetron anode of a microsave-over consists of an cylindrical outer-tube and various inner-vanes. The magnetron anode is produced by the complex processes; vane blanking, pipe cutting and silver-alloy brazing of vanes. Recently, the backward extrusion process for forming vanes has been developed to avoid the complex procedures. The developed process is analyzed by using upper-bound elemental technique (UBET). In the UBET analysis, the upper-bound load, the configuration and the vane-height of final extruded product are determined by minimizing the roral power consumption with repect to chosen parameters. To verify theoretical analysis, experiments have been carried out with pure plasticine billets at room temperature, using different web-thickness and number of vanes. The theoretical predictions both for forming load and vane-height are in reasonable agreement with the experimental results.

• Communications for Statistical Applications and Methods
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• 제15권1호
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• pp.43-50
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• 2008

Multinomial logistic regression is a well known multiclass classification method in the field of statistical learning. More recently, the development of sparse multinomial logistic regression model has found application in microarray classification, where explicit identification of the most informative observations is of value. In this paper, we propose a sparse multinomial kernel logistic regression model, in which the sparsity arises from the use of a Laplacian prior and a fast exact algorithm is derived by employing a bound optimization approach. Experimental results are then presented to indicate the performance of the proposed procedure.

• 소성∙가공
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• 제7권2호
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• pp.177-185
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• 1998

The kinematically admissible veolcity field is developed for the shapes of dead metal zone and the curving velocity distribution in the eccentric plane dies extrusion. The shape of dead metal zone is defined as the boundary surface with the maximum friction constant between the deformable zone and the rigid zone. The curving phenomenon in the eccentric lane dies is caused by the eccentricity of plane dies. The axial velocity distribution in the plane dies is divided in to the uniform velocity and the deviated velocity. The deviated velocity is linearly changed with the distance from the center of cross-section of the workpiece. The results show that the curvature of products and the shapes of the dead metal one are determined by the minimization of the plastic work and that the curvature of the extruded products increase with the eccentricity.

• 상하수도학회지
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• 제22권1호
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• pp.169-174
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• 2008

In this study a trickling filter system was developed by using polypropylene media and polypropylene nylon media that has recently been developed. The experiment analyzed an ability of water purification of the two plastic media and the effects of biomass on the final effluent. As recycling ratio increases, polypropylene nylon suspender showed higher efficiency by 20%; and, when media height was lengthened twice, efficiency increased about 10%. EPS and biomass increased in proportion to the increase of recycling ratio, and bound-TOC showed a similar trend with bound-EPS (extra-cellular polymeric substances) concentration.

• Journal of Microbiology
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• 제42권3호
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• pp.248-252
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• 2004

In order to identify the protein(s) secreted into culture medium by the sool-l/retl-l mutation of Saccharomyces cerevisiae, proteins from the culture medium of cells grown at permissive (28$^{\circ}C$) and non-permissive temperatures (37$^{\circ}C$), were analyzed. Comparison of protein bands separated by SDS-PAGE identified a prominent band of 47-kDa band from a mutant grown at 37$^{\circ}C$. N-terminal amino acid sequencing of this 47-kDa protein showed high identity with enolases 1 and 2. Western blot analysis revealed that most of the cell wall-bound enolase was released into the culture medium of the mutant grown at 37$^{\circ}C$, some of which were separated as those with lower molecular weights. Our results, presented here, indicate the impairment of cell wall enolase biogenesis and assembly by the sool-l/retl-l mutation of S. cerevisiae.

• Macromolecular Research
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• 제9권1호
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• pp.37-44
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• 2001

A premixing effect for the properties of carbon black-filled rubber compounds was investigated using biblends of natural rubber (NR), styrene-butadiene rubber (SBR), and butadiene rubber (BR). Degree of mixing of the biblends was controlled by preblending time of 0.0, 2.5, and 5.0 min. Mooney viscosities of the compounds decreased by increasing the preblending time. Of three carbon black-filled compounds of NR/SBR, NR/BR, and SBR/BR compounds, only the SBR/BR blends showed a specific cure characteristics depending on the preblending time. For the bound rubber composition, the NR content was higher than SBR and BR. The difference in the rubber composition ratio of the bound rubber became smaller with increasing the preblending time. Physical properties of the vulcanizates such as hardness, modulus, tensile property, abrasion loss, and tans were also compared. Differences in properties of the compounds were discussed with miscibility of the dissimilar rubbers and degree of mixing.

• 한국경영과학회지
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• 제13권2호
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• pp.9-17
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• 1988

This vehicle scheduling problem with multiple depots and multiple vehicle types (VMM) is to determine the optimal vehicle routes to minimize the total travel costs. The object of this paper is to develope an exact algorithm for the VMM. In this paper the VMM is transformed into a mathematical model of the vehicle problem with multiple depots. Then an efficient branch and bound algorithm is developed to obtain an exact solution for this model. In order to enhance the efficiency, this algorithm emphasizes the follows; First, a heuristic algorithm is developed to get a good initial upper bound. Second, an primal-dual approach is used to solve subproblems which are called the quasi-assignment problem, formed by branching strategy is presented to reduce the number of the candidate subproblems.