• Toxicological Research
• /
• v.26 no.1
• /
• pp.53-59
• /
• 2010

This study was conducted to obtain acute information of the oral dose toxicity of DHU001, a polyherbal formula in male and female mice. In order to calculated 50% lethal dose ($LD_{50}$) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250 and 0 (vehicle control) ml/kg (body weight). The mortality and changes on body weight, clinical signs, gross observation, organ weight and histopathology of principle organs were monitored 14 days after treatment with DHU001. We could not find any mortalities, DHU001 treatment-related clinical signs, changes on the body and organ weights, gross and histopathological findings. The results obtained in this study suggest that $LD_{50}$ and approximate LD in mice after single oral dose of DHU001 were considered over 2000 mg/kg in both female and male mice.

• Toxicological Research
• /
• v.2 no.2
• /
• pp.79-87
• /
• 1986

Water extracts of 21 traditional Korean herbal drugs were prepared, and a dose range of 100 mg/kg to 400 mg/kg was administered orally into mice once a day for five days. Changes of serum enzyme activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), alkaline phosphatase, body weight changes and histo pathological examination of various organs were investigated. Water extract of Ephedra Herba caused severe body weight loss at a dose of 100 mg/kg and death from a dose level of 200 mg/kg by oral administration. Angelica koreanae Radix and Anthrisci Radix showed a slight body weight loss and damages to liver and kidney.

• Korean journal of health promotion
• /
• v.19 no.2
• /
• pp.91-95
• /
• 2019

Background: Obesity and deterioration of pulmonary function are known to increase all-cause mortality and morbidity associated with chronic diseases. Obesity is a known risk factor for decreasing pulmonary function; however, studies on the effect of changes in body weight or body mass index (BMI) on pulmonary function are rare. This study aimed to investigate the relationship between the change in body weight or BMI and the pulmonary function test (PFT) in Koreans who underwent consecutive screening at a health promotion center. Methods: We enrolled 5,032 patients who underwent consecutive screening health check-ups at a health promotion center in 2015 and 2017. The BMI was calculated as the body weight (kg) divided by the square of the height (m²) in 2015 and 2017. We analyzed the association between the change in body weight or BMI and PFT. Results: In males, PFT and changes in body weight were associated with forced expiratory volume in 1 second (FEV₁) but not with changes in BMI. In females, FEV₁/forced vital capacity and forced expiratory flow between 25-75% of vital capacity (FEF_25-75%) were significantly associated with the changes in body weight and BMI. A correlation analysis between body weight and BMI showed a negative correlation with FEF_25-75% in males. In females, FEV₁/FVC and FEF_25-75% were negatively correlated. Conclusions: We observed that the increase in body weight and BMI was significantly associated with pulmonary function. This finding suggests that careful monitoring of body weight and BMI may aid in maintaining proper pulmonary function, thereby, reducing mortality and morbidity.

• Journal of Nutrition and Health
• /
• v.37 no.6
• /
• pp.493-501
• /
• 2004

The purpose of this study was to evaluate weight control program provided by university health care center for female college students. The program was 8-week long and composed of diet, exercise, and behavioral modification. Evaluation was made on the completion of 8-week program and a follow-up survey was done at 3-24 months after the end of program by telephone or bye-mail. Total of 76 women completed the 8-week program and 51 for follow-up survey. On the completion of 8-week program, significant decreases in body weight, BMI, body fat (kg), ％ body fat, and WHR were resulted, however, no change in muscle mass was found. Even the subjects without weight change showed significant reduction in body fat (kg) and ％ body fat. Total food intake was decreased resulting in reduced intakes of most nutrients. Meal distribution of energy was changed; ％energy from snack decreased from 22％ to 14％, and proportion for breakfast increased. Blood values of hemoglobin, hematocrit, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride were within normal range, and no changes were observed by this program. The follow-up survey revealed that 88.3％ of the subjects continued to lose weight after completion of the program, while only 7.8％ gained weight. And 78.4％ of the subjects considered the program effective. In conclusion, the weight reducing regime with education is effective for long lasting weight control and health conscious behavior for female college student. Since the subjects reduced the size of meal, instead of cutting only calories down, food selection to meet all the nutrient requirements except energy should be emphasized.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.30 no.3
• /
• pp.521-527
• /
• 2001

The effects of dietary restriction (DR) on antioxidant enzymes were studied in liver, lung and erythrocytes of diabetic rats. Experimental animals used Sprague-Dawley (SD; body weight 350$\pm$20g) male rats and Otsuka Long Evans Tokushima fatty (OLETE; body weight 5--$\pm$30g) male rats, as a model of type 2 diabetes mellitus. Type I diabetes was induced in SD rats by intramuscular injection of alloxan (80 mg/kg BW). Animals were randomly assigned either to continue the ad libitum diet or 40% DR (60% intake of ad libitum diet) groups. The body weight was measured at every 2 weeks to 4 months following DR. The activities of antioxidant enzymes (superoxide dismutase (SOD), catalase, glutathione peroxidase (GSHPx) were measured in liver, lung and erythrocytes and the concentration of TBARS as a marker of reactive oxygen species-induced tissue injry was also measured in rats after 4 months 40% DR. The body weight 4 months after 40% DR of control SD, alloxian-diabetid SD and OLETE rats were 80%, 98% and 75% of each control groups, respectively. The activities of SOD, catalase and GSHPx in lung and erythrocytes of rats were not change by 40% DR but in 4 month 40% DR rat liver, the activities of SOD and catalase were increased in control SD, alloxan-diabetic SD, and OLETF groups. The concentration of TBARS in lung and erythrocytes was also not changed by 40% DR, while liver TBARS concentration was decreased in OLETF and control SD rats compared to each non-DR control rats. These results suggested that the body weight changes in diabetic rats by DR was more prominent in type 2 diabetes and changes of antioxidant enzymes is most prominent in liver by DR either type 1 and 2 diabetic rats.

• The Journal of Korean Medicine
• /
• v.24 no.1
• /
• pp.9-28
• /
• 2003

Objects : The aim of this study was evaluate the effect of the Saengsig taken along with Behavior Modification Therapy, Methods : We examined the body compositions of 20 obese patients who were treated with Saengsig and Behavior Modification Therapy for 2 months by Inbody 2.0. Results : Changes of body composition due to Saengsig with Behavior Modification Therapy were reduction of body weight by $3.14{\pm}1.33{\;}kg$, lean body mass by $0.14{\pm}1.48{\;}kg$, fat mass by $3.00{\pm}1.53kg$ and BMI by $1.30{\pm}0.54$ Conclusion : Fat mass and body fat rate were significantly reduced after treatment with Saengsig with Behavior Modification Therapy.

• Safety and Health at Work
• /
• v.10 no.1
• /
• pp.95-102
• /
• 2019

Background: In a cluster-randomized trial, the Safety and Health Involvement For Truck drivers intervention produced statistically significant and medically meaningful weight loss at 6 months (-3.31 kg between-group difference). The current manuscript evaluates the relative impact of intervention components on study outcomes among participants in the intervention condition who reported for a post-intervention health assessment (n = 134) to encourage the adoption of effective tactics and inform future replications, tailoring, and enhancements. Methods: The Safety and Health Involvement For Truck drivers intervention was implemented in a Web-based computer and smartphone-accessible format and included a group weight loss competition and body weight and behavioral self-monitoring with feedback, computer-based training, and motivational interviewing. Indices were calculated to reflect engagement patterns for these components, and generalized linear models quantified predictive relationships between participation in intervention components and outcomes. Results: Participants who completed the full program-defined dose of the intervention had significantly greater weight loss than those who did not. Behavioral self-monitoring, computer-based training, and health coaching were significant predictors of dietary changes, whereas behavioral and body weight self-monitoring was the only significant predictor of changes in physical activity. Behavioral and body weight self-monitoring was the strongest predictor of weight loss. Conclusion: Web-based self-monitoring of body weight and health behaviors was a particularly impactful tactic in our mobile health intervention. Findings advance the science of behavior change in mobile health intervention delivery and inform the development of health programs for dispersed populations.

• Journal of Nutrition and Health
• /
• v.31 no.4
• /
• pp.747-755
• /
• 1998

In order to study the relationship between body core temperature and adiposity , the core temperatures of normal weight female college students were measured during an instant-noodle lunch eaten in a laboratory at the ambient temperature of 22-24.8$^{\circ}C$. Ambient temperature was positively correlated with meal-start core temperature and meal duration. The difference between the peak postprandial and the meal-start core temperature was negatively correlated with body weight and BMI. This means that the thermogenic response induced by meal consumption was negatively associated with adiposity. Meal duration also showed a negative correlation with body weight, BMI, and hip girth. Thus, the obese eating style characterized by a rapid rate of food intake was also associated with adiposity in normal weight women. It was possibly a contributing factor in the development of obesity. In conclusion, adiposity is negatively associated with the difference between the peak postprandial and the meal-start core temperature and meal duration during a meal.

• Korean Journal of Biological Psychiatry
• /
• v.11 no.2
• /
• pp.127-135
• /
• 2004

Object:The goal of this study was to examine the changes in body weight and glucose levels of the patients treated with risperidone, clozapine or haloperidol in order to compare the effect of risperidone or clozapine with that of haloperidol. Methods:For nine months(January to September, 2003), a prospective study was performed in 60 patients with chronic schizophrenia who were in Seoul National Hospital. Two-week period was required for a drug wash-out. The patients were randomly assigned to risperidone, clozapine and haloperidol groups. They were given risperidone(n=20), clozapine(n=20) and haloperidol(n=20), respectively, everyday for 12 weeks. To examine the effects of these drugs on body weight and fasting glucose levels, we measured body weight and glucose levels of all the patients first without the drug treatment and at each end of 4, 8, and 12-week periods with the treatment. And we examined the differences among three groups in the changes of body weight and fasting glucose levels. Results:There were no significant differences in the changes of the body weight and fasting glucose levels between the atypical antipsychotics(risperidone or clozapine) and the typical antipsychotics(haloperidol). Conclusion:The study in the patients with chronic schizophrenia suggests that risperidone or clozapine do not cause any additional effects on body weight or glucose levels compared to haloperidol.

• Korean Journal of Health Education and Promotion
• /
• v.13 no.2
• /
• pp.130-166
• /
• 1996

As compared with body height and body weight by ages and sexes, by means of the data reported under other researchers from 1967 to 1994 for 33 years, this study obtained the estimate value of body height and body weight by ages and sexes for the same period, and figured out prediction value of body height and body weight in the ages of between 6 and 14 from 1995 to 2000. These surveys and measurements took for one year from October 1st 1994 to September 30th. As shown in the 〈Table 1〉, in order to calculate the establishment, estimate value and prediction value of the chronological regression model of body height and body weight, by well-grounded 17 representative research papers, this research statistically tested propriety of liner regression model by the residual analysis in advance of being reconciled to simple liner regression model by the autonomous variable-year and the subordinate variable-body weight and measured prediction value, theoretical value from 1962 to 1994 by means of 2nd or 3rd polynomial regression model, with this redult did prediction value from 1995 to 2000. 1. Chronological Change of Body Height and Body Weight The analysis result from regression model of the chronological body height and body weight for the aged 6 - 16 in both sexes ranging from 1962 to 1994, corned from the 〈Table 2-20〉. On the one hand, the measurement value of respective researchers had a bit changes by ages with age growing, but the other hand, theoretical value, prediction value showed the regular increase by the stages and all values indicated a straight line on growth and development with age growing. That is, in case of the aged 6, males had 109.93cm in 1962 and females 108.93cm, but we found the increase that males had 1I8.0cm, females 1I3.9cm. In theoretical value, prediction value, males showed the increase from 109.88cm to 1I7.89cm and females from 109.27cm to 1I5.64cm respectively. There was the same inclination toward all ages. 2. Comparision to Measurement Value and Prediction Value of Body Height and Body Weight in 1994 As shown in the 〈Table 21〉, in case of body height, measurement value and prediction value of body height and body weight by ages and sexes almost showed the similiar inclination and poor grade, in case of body weight, prediction value in males had a bit low value by all ages, and prediction value in females had a high value in adolescence, to the contrary, a low value in adult. 3. Prediction Value of Body Height and Body Weight from 1995 to 2000 This research showed that body height and body weight remarkably increased in adolescence but slowly in adult. This study represented that Korean physique was on the increase and must be measured continually hereafter.