Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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TOXICOLOGICAL STUDY ON TRADITIONAL KOREAN HERBAL DRUGS (V)

  • H.N. K. G (Department of Environmental Health, Gradute school of Public Health and Natural Products Reseach Institute, Seoul National University) ;
  • Moonshik Zong (Department of Environmental Health, Gradute school of Public Health and Natural Products Reseach Institute, Seoul National University) ;
  • Chang, Il-Moo (Department of Environmental Health, Gradute school of Public Health and Natural Products Reseach Institute, Seoul National University)
  • Published : 1986.12.01
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Abstract

Water extracts of 21 traditional Korean herbal drugs were prepared, and a dose range of 100 mg/kg to 400 mg/kg was administered orally into mice once a day for five days. Changes of serum enzyme activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), alkaline phosphatase, body weight changes and histo pathological examination of various organs were investigated. Water extract of Ephedra Herba caused severe body weight loss at a dose of 100 mg/kg and death from a dose level of 200 mg/kg by oral administration. Angelica koreanae Radix and Anthrisci Radix showed a slight body weight loss and damages to liver and kidney.

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