Toxicological Research
- Volume 2 Issue 2
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- Pages.63-77
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- 1986
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
REPRODUCTION STUDIES WITH PRANOPROFEN: A NONSTEROIDAL ANTINFLAMMATORY AGENT IN RATS-PERINATAL AND POSTNATAL TEST.
- Moon, Hwa-Hwey (Department of safety Reseach National of Health Seoul) ;
- Kim, Pu-Young (Department of safety Reseach National of Health Seoul) ;
- Cho, Dae-Hyun (Department of safety Reseach National of Health Seoul) ;
- Heo, Ok-Soon (Department of safety Reseach National of Health Seoul) ;
- Park, Sook-Hee (Department of safety Reseach National of Health Seoul) ;
- Yoon, Tae-Bo (Department of safety Research National Institute of Health Seoul) ;
- Kim, Soon han (Department of safety Research National Institute of Health Seoul)
- Published : 1986.12.01
Abstract
prenatal and postanatal study on pranoprofen, as an antiinflammatory agent, was conducted by oral administration in Sprague-Dawley pregnancy rats from day 17 of gestation to day 21 of after delivery. Pranoprofen was intubated doses of 1.0, 2.5 and 5.0 mg/kg/day and dose of 5.0mg/kg/day of Indomethacin was used as positive control. After delivery, several study indexes such as length of gestation, No. of implantations, No. of live pups, No. of perinatal deaths, sex ratio and No. of malformation were checked and then all the newborns were feeded and investigated physical and behavioral changes.
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