• Biomedical Science Letters
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• v.16 no.1
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• pp.25-32
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• 2010

Sprague-Dawley(SD) rats were orally administered with $N^G$-nitro-L-arginine methyl ester(L-NAME) which inhibits or blocks the production of nitric oxide from L-arginine in vascular endothelial cells and vessel tissue to statistically examine the effects of nitric oxide on some physiological changes such as blood pressure and heart rate, and to confirm the apoptosis induced by the suppressed nitric oxide activity in some related organs under light microscope. Systolic blood pressure significantly increased 28.5% by the chronic treatment of L-NAME for 8 weeks (P<0.001), no significant difference, however, was observed in heart rate between the control group and the L-NAME-treated group regardless of their age. Hematoxylin-eosin staining showed some histological alterations only in kidney among the examined organs; heart, liver, pancreas, and adrenal gland from the L-NAME-treated group. TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) test showed a strong positive reaction, representing that the chronic treatment of L-NAME facilitates apoptosis, in the cortex and medulla of kidney, but not any significance detectable in the other organs. These results conclude that chronic treatment of L-NAME significantly increases blood pressure, and that the followed inhibition of nitric oxide synthesis occurs a typical inducement of apoptosis in kidney.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.15 no.1
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• pp.55-66
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• 2011

Objectives: The purpose of this study is to review the simulator for cardiovascular system. Methods & Results: Simulators were classified according to the structure and function of cardiovascular system. Heart and blood vessel were selected as the represent of structure. Blood pressure and blood flow were chose as the functional index. With the view points of four keywords, four kinds of simulators were selected: artificial heart, pressure simulator, flow simulator, and pulse simulator. Conclusions: This paper discussed the state of the art of research and development of the selected four kinds of simulators.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.15 no.2
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• pp.159-168
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• 2011

Objectives: The purpose of this study is to develop the pulse wave analysis model with the palpation pressure and the skin effect. Methods: The position of pulse diagnosis was modeled with elastic string system. The skin was modeled with the elastic string, the palpation pressure with tension in the string, and the blood vessel pressure with external force on the string. Using the wave equation in the physics, the simplified pulse model was transformed to the mathematical model. Results: To the verification of the model, the effects of the palpation pressure and the skin effect were tested. Conclusions: There was optimal palpation pressure, describing the exact vessel pressure pattern and maximizing the amplitude of the skin displacement. For the optimal condition, the increased palpation pressure was needed with the increased skin thickness. Therefore, the developed pulse wave analysis model showed the good results.

• Korean Journal of Pharmacognosy
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• v.17 no.4
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• pp.263-271
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• 1986

In order to investigate experimentally the clinical effects of Taeksa-Tang that was prescribed to cure the severe dizziness, the water extract of Taeksa-Tang was experimented about the effects on the diuretic action, the serum lipid, the isolated ileum and heart, the blood vessel, the blood pressure and respiration. The results of this study were obtained as follows: The diuretic action was significantly shown in rabbits. The level of total cholesterol, triglyceride and phopholipid in serum of rabbits given high cholesterol diet were significantly decreased. The contraction of the isolated ileum of mice induced by acetylcholine chloride and barium chloride was remarkably inhibited. The vasodilating and hypotensive actions were noted in rabbits. Negative inotropic action on the isolated frog heart was recognized.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1915-1918
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• 2003

Atherosclerosis, which is a degenerate disease, is believed to occur in the vascular system due to deposition of cholesterol and low density lipoprotein(LDL) or thrombosis on the blood vessel. Atherosclerosis narrows arterial lumen, which is known as stenosis phenomenon of blood vessel. Pathogenesis of atherosclerosis is thought to occur mainly by aging. Restenosis phenomenon is observed in the same site of insertion of a stent and balloon angioplasty after treatment of interventional theraphy. Several hypothetical theories related to the generation of atherosclerosis have been reported: high shear stress theory, low shear stress theory, high shear stress gradient theory, flow separation and turbulence theory and high pressure theory. However, no one theory clearly explains the causes of atherosclerosis. In the present study the generation of atherosclerosis in the left coronary artery is investigated. The hypotheses are verified by using the computer simulation.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.741-746
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• 2003

The main objective of present study is to obtain information for flow characteristics, such as velocity and wall shear stress, of bifurcation in blood vessel. Branch flows for Newtonian fluids are simulated by using Fluent V.6.0. The numerical simulations are carried out for five cases divided by different values of bifurcation angle and area ratio. As a result of simulation, high wall shear stress is appeared at the bifurcated region. As increasing bifurcation angle, pressure drop is increasing. In addition, as the area is decreasing, pressure drop and wall shear stress is increasing.

• Journal of Biomedical Engineering Research
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• v.18 no.2
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• pp.179-186
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• 1997

Steady and physiological flows of a Newtonian fluid and blood in the abdominal gorta/iliac artery bifurcation are numerically simulated to understand the etiology and pathogenesis of atherosclerosis. Distributions of velocity, pressure, and wall shear stress in the bifurcated arterial vessel model are calculated to investigate the differences of flow characteristics between steady and physiological flows and to compare flow characteristics of blood with that of a Newtonian fluid For the given Reynolds number the flow characteristics of physiological flows for a Newtonian fluid and blood in the bifurcated arterial vessel are quite different from thcse of steady flows. No flow separation or flow reversal in the bifurcated region appears downstream of a stenosis during the acceleration phase. However, during the deceleration phase the flow exhibits flow separation in the outer walls of daugtlter branches, which extends to the entire wall region.

• Proceedings of the KIEE Conference
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• 2002.07d
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• pp.2712-2714
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• 2002

Recently, the high blood pressure is appeared the most frequent disease of a man's the whole sickness. But, to treat this disease is uncertain and produces an adverse reaction of a medicine therapy. Also, a patients are burden high price for doctor's treatment. Therefore, we studied effectively and financially to execute the treatment of the high blood pressure using the Chinese Medicine Theorem that recently arousing a great interest of the people. The main theories of this paper are Blood Vessel Theory and Acupuncture. The composed circuits are low-frequency generating circuit, charging-discharging circuit. The former will substitute a needle that use in the acupuncture therapy method and the latter will charge and discharge the bioelectric action potential of a patient in Ear Acupuncture Point. Also, all circuits will be controlled a micro-computer circuit.

• The Journal of Internal Korean Medicine
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• v.16 no.1
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• pp.181-196
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• 1995

The present experiments were designed to investigate the effects of BangPoongSan on the cardiovascular system in the experimental Animals. And thus the change of blood pressure, auricular blood flow, artery contraction, death rate, platelet aggregation repression, plasma coagulation factor activity, plasma antithrombin activity, whole blood viscosity and plasma viscosity were studied. The result were summarized as the followings: 1. BangPoongSan dropped the blood pressure in the spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in white rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug presented the antithrombin activity in rat. 8. The drug reduced the whole blood viscosity and plasma viscosity in rat, but the latter was not valuable. According to the results, Bangpoongsan increased the blood flow and dropped the blood pressure by dilatation of blood vessel smooth muscle. And the drug presented the antithrombin acivity, inhibited the platelet aggregation and reduced blood viscosity. Therefore these effects are assumed to improve the cardiovascular circulation disorder and prevent thrombosis.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.8
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• pp.1606-1616
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• 2011

The blood pressure measuring equipment, which is being supplied and used most widely by being recognized convenience and accuracy now generally, is oscillometric blood pressure monitor. However, a change in blood pressure is basically influenced by diverse elements such as each individual's physiological status and physical condition. Thus, the measurement of blood pressure, which used single element called oscillation in blood pressure of being conveyed to cuff, is not considered on physiological elements such as cardiovascular system status and blood vessel stiffness index, and on external elements, thereby being quite in error. Accordingly, this study detected diverse bio-signals and body informations in each individual as the measurement subject such as ECG, PPG, and Korotkoff Sound in order to enhance convenience and accuracy of measuring blood pressure in the complex measurement equipment, thereby having extracted regression method for compensation in error of oscillometric blood pressure measurement on the wrist, and having improved accuracy of measuring blood pressure. To verify a method of improving accuracy, the blood pressure value in each of SBP, DBP, MAP was acquired through 4-stage experimental procedure targeting totally 51 subjects. Prior to experiment, the subjects were divided into two groups such as the experimental group for extracting regression method and the control group for verifying regression method. Its error was analyzed by comparing the reference blood pressure value, which was obtained through the auscultatory method, and the oscillometric blood pressure value on the wrist. To reduce the detected error, the blood pressure compensation regression method was calculated through multiple linear regression analysis on elements of blood pressure, individual body information, PTT, HR, K-Sound PSD change. Verification was carried out on improving significance and accuracy by applying the regression method to the data of control group. In the experimental results, as a result of confirming error on the reference blood pressure value in SBP, DBP, and MAP, which were acquired through applying regression method, the results of $-0.47{\pm}7.45$ mmHg, $-0.23{\pm}7.13$ mmHg, $0.06{\pm}6.39$ mmHg could be obtained. This is not only the numerical value of satisfying the sphygmomanometer reference of AAMI, but also shows the lower result than the numerical value in SBP : $-2.5{\pm}12.2$ mmHg, DBP : $-7.5{\pm}8.4$ mmHg, which is the mean error in the experimental results of Brram's research for verifying accuracy of Omron RX-M, which shows relatively high accuracy among wrist sphygmomanometers. Thus, the blood pressure compensation could be confirmed to be made within significant level.