A Comparative Study of the Hemodynamic Hypotheses for the Generation of Atherosclerosis

동맥경화증의 발생에 관한 혈류역학적 가설들에 대한 비교연구

  • 서상호 (숭실대학교 기계공학과) ;
  • 조민태 (숭실대학교 대학원 기계공학과) ;
  • 노형운 (숭실대학교 기계공학과) ;
  • 권혁문 (연세대학교 의과대학 심장내과)
  • Published : 2003.04.23

Abstract

Atherosclerosis, which is a degenerate disease, is believed to occur in the vascular system due to deposition of cholesterol and low density lipoprotein(LDL) or thrombosis on the blood vessel. Atherosclerosis narrows arterial lumen, which is known as stenosis phenomenon of blood vessel. Pathogenesis of atherosclerosis is thought to occur mainly by aging. Restenosis phenomenon is observed in the same site of insertion of a stent and balloon angioplasty after treatment of interventional theraphy. Several hypothetical theories related to the generation of atherosclerosis have been reported: high shear stress theory, low shear stress theory, high shear stress gradient theory, flow separation and turbulence theory and high pressure theory. However, no one theory clearly explains the causes of atherosclerosis. In the present study the generation of atherosclerosis in the left coronary artery is investigated. The hypotheses are verified by using the computer simulation.

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