• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 추계학술대회 논문집
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• pp.187-192
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• 2002

Research has shown that many smokers experience an increase in the desire to smoke when exposed to smoking-related cues. Cue exposure treatment (CET) refers to the manualized, repeated exposure to smoking-related cues, aimed at the reducing cue reactivity by extinction. In this study, we constructed a virtual reality system for evoking a desire of nicotine, which was based on the results of a Questionnaire of Nicotine-craving. And we investigated the effectiveness of the virtual reality system as compared to classical device (pictures). As a result, we reached the conclusion that virtual reality elicits more craving symptoms than the classical devices.

• 대한의용생체공학회:의공학회지
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• 제30권3호
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• pp.185-190
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• 2009

Biomedical mobile devices for ubiquitous healthcare consist of biomedical sensors and communication terminal. They have two types of configuration. One is the sensor-network type device using wired or wireless communication with intelligent sensors to acquire biomedical data. The other is the sensor embedded type device, where the data can be acquired directly by itself. There are many examples of sensor network type, such as, fall detection sensor, blood glucose sensor, and ECG sensors networked with commercial PDA phone and commercial phone terminal for ubiquitous healthcare. On the other hand, sensor embedded type mounts blood glucose sensor, accelerometer, and etc. on commercial phone. However, to enable true ubiquitous healthcare, motion sensing is essential, because users go around anywhere and their signals should be measured and monitored, when they are affected by the motion. Therefore, in this paper, two biomedical mobile devices with motion monitoring function were addressed. One is sensor-network type with motion monitoring function, which uses Zigbee communication to measure the ECG, PPG and acceleration. The other is sensor-embedded type with motion monitoring function, which also can measure the data and uses the built-in cellular phone network modem for remote connection. These devices are expected to be useful for ubiquitous healthcare in coming aged society in Korea.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.232-234
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• 1996

Cadiac output estimation scheme of LVAD using multi-dimensional interpolation technique was introduced in this paper. This paper also show appropriate input -output data for estimation. Experimental results show our approach is a good one for the estimation of nonlinear hemodynamics.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.263-267
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• 1996

An estimation algorithm based on training of fuzzy logic system using back-propagation is proposed, in this paper, for determining cardiac output in the TAH. The proposed estimation utilizes only a motor current waveform generated from the moving actuator of the electromechanical TAH without using any extra transducers as an information source for estimation. In in vitro tests, the resultant estimation performance was acceptable to alppy the proposed algorithm to animal experiments and further clinical applications.

• 대한의용생체공학회:의공학회지
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• 제29권3호
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• pp.173-178
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• 2008

Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and morphological features. A wide range of biopolymers can be electrospun into mats with a specific fiber arrangement and structural integrity. These features of nanofiber mats are morphologically similar to the extracellular matrix of natural tissues, which are characterized by a wide pore diameter distribution, a high porosity, effective mechanical properties, and specific biochemical properties. This has resulted in various kinds of applications for polymer nanofibers in the field of biomedicine and biotechnology. The current emphasis of research is on exploiting these properties and focusing on determining the appropriate conditions for electrospinning various biopolymers for biomedical applications, including scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, and vascular grafts, and for protective shields in specialty fabrics. This paper reviews the research on biomedical applications of electrospun nanofibers.

• 대한의생명과학회지
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• 제25권2호
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• pp.185-189
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• 2019

Breast cancer is the second most common cancer in women with approximately 522,000 deaths annually worldwide. microRNAs have recently been studied as potential biomarkers that regulate gene expression and are involved in tumorigenesis. Here we evaluated circulating miR-221 and miR-222 as potential biomarkers for breast cancer by quantitative reverse transcription PCR using blood plasma of 30 healthy controls and 30 breast cancer patients. The TNM stage on circulating miR-221 and miR-222 was also investigated. Circulating miR-221 and miR-222 were significantly up-regulated in breast cancer patients compared to those in healthy controls (P < 0.0022 and P = 0.0058, respectively). Furthermore, the relative expression level of circulating miR-221 in patients with stage III breast cancer was higher than in those with stage I and II. Taken together, we have shown circulating miR-221 and miR-222 could be useful biomarkers for the screening of breast cancer patients.

• 대한의생명과학회지
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• 제25권1호
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• pp.92-98
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• 2019

Metformin is a drug used for the treatment of diabetes and is associated with anti-inflammatory reaction, but the underlying mechanism is unclear. In this study, we investigated the effect of metformin on the inflammatory response in BV-2 microglial cells induced by lipopolysaccharide (LPS) and S100 calcium-binding protein A8 (S100A8). The results revealed that metformin significantly attenuated several inflammatory responses in BV-2 microglial cells, including the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-${\alpha}$ and interleukin (IL)-6, involved in the activation of Beclin-1, a crucial regulator of autophagy. In addition, metformin inhibited the LPS-induced phosphorylation of ERK. Metformin also suppressed the activation of NOD-like receptor pyrin domain containing 3 inflammasomes composed of NLRP3, caspase-1, and apoptosis-associated speck like protein containing a caspase recruitment domain, which are involved in the innate immune response. Notably, metformin decreased the secretion of S100A8-induced IL-6 production. These findings suggest that metformin alleviates the neuroinflammatory response via autophagy activation.

• 한국해양바이오학회지
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• 제13권1호
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• pp.28-47
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• 2021

Pectin is a natural polysaccharide and biopolymer that serves as a structural component of plant tissues' primary cell walls. Pectin is primarily composed of D-galacturonic acid linked by α-1, 4-glycosidic linkage and is further classified by the ratio of esterified galacturonic acid groups known as degree of esterification (DE). Pectin that contains more than half of its carboxylate units as methyl esters is known as a high methyl (HM) ester. Conversely, pectin that has less than half of its carboxylate units as methyl esters is known as a low methyl (LM) ester. Pectin has various bioactive properties, including anticancer, anti-inflammatory, antioxidant, antidiabetic, anticholesterol, antitumoral, and chemopreventive properties. Moreover, pectin is a useful biopolymer in biomedical applications. Biomedical engineering, which is founded on research aimed to improve the quality of life using new materials and technologies, is typically classified according to the use of hydrogels, nanofiber mats, and nanoparticles. This paper reviews the progress of recent research into pectin-based biomedical applications and the potential future biomedical applications of marine-derived pectin.

• 한국의학물리학회지:의학물리
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• 제21권1호
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• pp.29-34
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• 2010

본 연구에서는 치료용 양성자선 계측을 위한 광섬유 방사선량계 개발을 목적으로 최적화 과정의 기초연구를 통하여 광섬유 방사선량계를 제작하였다. 양성자선 계측의 최적화를 위해 유기섬광체의 종류에 따른 섬광량 및 브래그 피크의 피크/플래투를 측정하여 가장 효율이 뛰어난 섬광체를 선별하였고, 유기섬광체의 직경에 따라 물 팬텀의 각 깊이에서 손실되는 양성자선의 에너지에 대해 유기섬광체에서 발생되는 섬광량을 측정하여 유기섬광체의 직경에 따른 선형성을 도시하고 최적의 섬광체 직경을 선택하였다. 또한 양성자선의 조사각도에 대해 유기섬광체의 길이에 따른 섬광량 및 섬광량의 표준편차를 측정하여 입사각 의존도를 판별하고 최적의 섬광체 길이를 결정하였다. 최적화 과정을 통하여 제작된 센서 성능평가의 일환으로 양성자 가속기의 선량율 및 모니터 유닛에 따른 광섬유 방사선량계의 섬광량을 측정하였다.

• 대한의생명과학회지
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• 제10권1호
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• pp.23-29
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• 2004

Nebulin is a (Mr 600∼900 kDa) large actin-binding protein specific to skeletal muscle and thought to act as a molecular template that regulates the length of thin filaments. Cardiac muscles of higher vertebrates have been shown earlier to lack nebulin. Recently, full-length nebulin mRNA transcripts have been detected in heart muscle, but at lower levels than in skeletal muscle. Nebulin expression also was detected in the kidney, eye, and otic canal, suggesting that nebulin isoforms may also be expressed in these organs. We have searched for nebulin isoforms in brain of human using PCR and Northern blot. Here, we provide evidence that nebulin mRNA transcripts are expressed in brain. Seven nebulin isoforms (B, C, D, E, F, G and H form) are obtained in human skeletal muscle and four isoforms (B, C, G and H form) in human brain cDNA library. We cloned the 1.3 kb of nebulin fragment from human adult brain library by PCR. The identity of the PCR product was confirmed by sequence analysis. The partial brain nebulin sequence was 99% identical to the skeletal muscle cDNA as determined by Blast alignment. It contains two simple-repeats HR1, HR2 and linker-repeats exon l35∼143 except exon 140. It was different from skeletal muscle B form, which contain HR1 and HR8. These data suggest that nebulin isoform diversity occurs even more extensively than previously known, likely contributing to the distinct thin filament architecture of different striated muscles.