• Molecules and Cells
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• v.38 no.4
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• pp.312-317
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• 2015

Depletion of intracellular zinc by N,N,N,N-tetrakis(2-pyridylmethyl) ethylenediamine (TPEN) induces p53-mediated protein synthesis-dependent apoptosis of mouse cortical neurons. Here, we examined the requirement for poly(ADP-ribose) polymerase (PARP)-1 as an upstream regulator of p53 in zinc depletion-induced neuronal apoptosis. First, we found that chemical inhibition or genetic deletion of PARP-1 markedly attenuated TPEN-induced apoptosis of cultured mouse cortical neurons. Poly(ADP-ribosyl)ation of p53 occurred starting 1 h after TPEN treatment. Suggesting the critical role of PARP-1, the TPEN-induced increase of stability and activity of p53 as well as poly(ADP-ribosyl)ation of p53 was almost completely blocked by PARP inhibition. Consistent with this, the induction of downstream pro-apoptotic proteins PUMA and NOXA was noticeably reduced by chemical inhibitors or genetic deletion of PARP-1. TPEN-induced cytochrome C release into the cytosol and caspase-3 activation were also blocked by inhibition of PARP-1. Taken together, these findings indicate that PARP-1 is essential for TPEN-induced neuronal apoptosis.

• Bulletin of the Korean Space Science Society
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• 2002.05b
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• pp.15.2-15
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• 2002

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.892-895
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• 2005

This study investigated changes of mechanical characteristics in the trabecular and cortical bone of the lumbar vertebrae of the ovariectomised(OVX) rat. In previous researches, there were many studies for morphology of osteoporotic bones based on Micro-CT (Micro - Computed Tomography). However, there were few studies for detecting and tracking changes of mechanical characteristics in the trabecular bone and cortical bone of the lumbar vertebrae for the OVX rat. For this study, one female Sprague-Dawley rat was used: an OVX rat. The 4th lumbar of the OVX rat was utilized as a specimen. Detecting and tracking changes of mechanical characteristics could be investigated in the trabecular and cortical bone of the lumbar vertebrae for an OVX rat using In-vivo Micro-CT. An OVX rat was scanned at week 0 (just before surgery), at week 4, and week 8 after surgery. Micro finite element(${\mu}\;FE$) analysis was used to investigate mechanical characteristics in the trabecular and cortical bone of the lumbar vertebrae for an OVX rat.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.07a
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• pp.624-627
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• 2001

Two kinds of Nd$_{1+x}$Ba$_{2-x}$Cu$_3$O$_{7-{\delta}}$, the sintering samples and zone melting samples, were heat treated under pure Ar at 95$0^{\circ}C$. The substitution of Nd ion for Ba ion in the Nd$_{1+x}$Ba$_{2-x}$Cu$_3$O$_{7-{\delta}}$ before and after the heat treatment were investigated by XRD. In order to know the effects of the heat treatment, the T$_{c}$ and J$_{c}$ of samples with the heat treatment and those without the heat treatment by Ar were comparatively studied. The results show that the substitution of Nd for Ba decreased, T$_{c}$, and J$_{c}$ increased after the treatment under Ar at 95$0^{\circ}C$. The Nd$_{1+x}$Ba$_{2-x}$Cu$_3$O$_{7-{\delta}}$ samples were oxygenated under pure oxygen at 30$0^{\circ}C$. From the XRD pattern it was found that the sample with x< 0.4 could transfer from tetragonal phase to orthorhombic phase after the oxygenation, but the sample with x>0.4 could not make the phase transition even after a long time oxygenation.ion even after a long time oxygenation.ation.n.ation.ation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.9A
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• pp.2153-2164
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• 1998

This paper has presented the parameters for the coexistence between two systems in macro/microcell ovelaid W-CDMA WLL (wideband CDMA wireless local loop) and has calculated the capacity of forward/reverse link in microcell. To produce the capacity for analyzing system interference effects, we have shown tables and graphs with the parameters sucyh as RF channel bandwidth of WLL(W), the transmission rate of service message(R), the required signal power to noise power ratio( $E_{b/}$ $N_{0}$) for achieving accepatable error rate, te user number ( $N_{W1}$, $N_{W2}$) of the neighboring system, the signal power to interference power ratio(.GAMMA.$_{C1B}$, .GAMMA.$_{C2B}$) of the neighboring system, the normalized distance(d) between microcell and macrocell base-station, and microcell to macrocell radius ratio ( $R_{d}$). From the results, we have convinced that the capacity of microcell diminishes as increasing the user number ( $N_{W2}$) in macrocell, increasing the microcell radius, and decreasing the normalized distance(d) between microcell and macrocell base-station. Especially, we have known that when $R_{d}$=0.1, $N_{W2}$ must be below 24 at .GAMMA.$_{C2B}$ = 0 dB and below 8 at .GAMMA.$_{C2B}$ = 4 dB for the acceptable capacity raito to be over 80%. Therfore, this paper is usefult to design microcell W-CDMA WLL for accommodating more user number under the interference effects of macrocell W-CDMA WLL and is expected to be reference in power control if base-station.ation.ion.ation.ation.

• Journal of Ginseng Research
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• v.12 no.2
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• pp.158-163
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• 1988

P. ginseng seedlings treated with GA,2,4-D and B-9 (N,N-dimethylsuccinamic acid) were grown under dark. Growth efficiencies ($E_1$ = St/Ro, $E_2$ = St1(Ro-Rt), $E_3$ = (Ro- Rt)/ Ro where St. Ro and Rt are shoot weight, initial root weight and root weight at time 1. respectiv$E_1$y) and other r$E_1$ated factors and their interr$E_1$ationship were investigated. $E_1$ and $E_3$ showed quadratic r$E_1$ation with temperature change while $E_2$ showed negative linear r$E_1$ation. $E_1$ depended on more $E_3$ component than $E_2$ component. The values of $E_2$ and $E_3$ are almost same. $E_2$ was greater than that reported previously suggesting large variation between roots. GA greatly increased $E_2$ and $E_3$ in supraoptimum temperature range while B-9 greatly decreased $E_3$ in all temperature range and $E_2$ in suboptimum range. Shoot weight showed highly significant positive linear corr$E_1$ation with substrate amount in most cases of PGR and temperature and with respiration loss in some cases. Respiration loss showed significant linear corr$E_1$ation positiv$E_1$y with $E_1$ and $E_3$ and negativ$E_1$y with $E_2$ only in suboptimal temperature range.

• Molecules and Cells
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• v.21 no.2
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• pp.218-223
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• 2006

The effect of poly(ADP-ribosyl)ation on the stability of p53 in SK-HEP1 cells treated with UV light was examined. Intracellular levels of p53 increased in cells treated with a low dose of UV light ($20J/m^2$), whereas they increased but then declined after a higher dose of UV ($100J/m^2$). Intracellular levels of p53 in the UV treated SK-HEP1 cells were dependent on the UV dose. Use of proteasome inhibitors revealed that p53 is degraded by proteasomal proteolysis after high doses of UV light. We present evidence that, at low doses, poly(ADP-ribose)polymerase (PARP) poly(ADP-ribosyl) ates p53 and protects it from proteasomal degradation before caspase-3 is activated, whereas at high doses the cells undergo UV induced apoptosis and PARP is cleaved by caspase-3 before it can protect p53 from degradation. Destabilization of p53 by cleavage of PARP may be important in cell fate decision favoring apoptosis.

• Asian-Australasian Journal of Animal Sciences
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• v.11 no.2
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• pp.192-195
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• 1998

Biomass conversion efficiencies (B.C.E) of six fish species viz, Catla catla, Labeo, rohita, Cirrhina mrigala, Hypophthalmicthys molitrix, Ctenopharyngodon idella and Cyprinus carpio cultured under artificial feed (T1), broiler manure (T2), buffalo manure (T3), N:P:K (25:25:0) (T4) and control pond (T5) have been determined for the period of one year. The overall biomass conversion efficiencies under the influence of T2, T3, and T4 were statistically similar. However, the best (0.40) efficiency was determined under feed supplement-ation (T1).

• Journal of the Korean Institute of Telematics and Electronics
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• v.11 no.4
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• pp.1.2-4
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• 1974

Effects of nonreciprocal microwave propagation upon the width and height of a thin slab of transversely magnetized N-Si loaded in a rectangular waveguide are observed experimentally at the room temperature and the experimental results have been analysed qualitatively.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.1071-1072
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• 2011