• Title/Summary/Keyword: and Zea mays

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Acetylcholinesterase Inhibitors from the Stem of Zea mays

  • Sim, Jae Young;Kim, Mi Ae;Kim, Myong Jo;Chun, Wanjoo;Kwon, Yongsoo
    • Natural Product Sciences
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    • v.20 no.1
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    • pp.13-16
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    • 2014
  • Five compounds were isolated from the stem of Zea mays. Based on spectral data, they were identified as 4-hydroxybenzaldehyde (1), N-trans-p-coumaryl tyramine (2), N-trans-ferulyl tryptamine (3), N-(p-coumaryl) serotonine (4), and N-(p-coumaryl)-tryptamine (5). All isolates were evaluated in vitro for their inhibitory activity on acetylcholinesterase. Among tested compounds, compounds 2 - 5 exhibited acetylcholinesterase inhibitory activity, with $IC_{50}$ values of 125, 60.4, 183.5 and 53.3 ${\mu}M$, respectively. Compound 1 did not show acetylcholinesterase inhibitory activity in the present study.

Volatile Components of Cornsilk(Zea mays L.) (옥수수 수염의 휘발성 성분)

  • 이재곤
    • The Korean Journal of Food And Nutrition
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    • v.12 no.4
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    • pp.375-379
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    • 1999
  • Volatile components of Cornsilk(Zea mays L.) were isolated by purge and trap headspace method and were analyzed by GC and GC/MSD. A total of 44 components were identified in the cornsilk volatile coponents including 9 alcohols 7 aldehydes and ketones 14 terpenes and terpene alcohols 3 pyrazines 5 hydrocarbons and 6 miscellaneous components. The major components were 2-propanol(8.08%) pen-tanol(1.82%) hexanol(2.86%) hexanal(3.68%) heptanal(7.40%) nonanal(7.93%) decanal (2.04%) $\alpha$-copaene(2.20%) limonene(1.68%) $\alpha$-selinene(1.03%) $\beta$-selinene(1.03%)

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Size-dependent Toxicity of Metal Oxide Particles on the Soil Microbial Community and Growth of Zea Mays (산화 금속 입자 크기가 옥수수의 성장과 토양 미생물 군집에 미치는 독성)

  • Kim, Sung-Hyun;Jung, Mi-Ae;Lee, In-Sook
    • Journal of Korean Society of Environmental Engineers
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    • v.31 no.12
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    • pp.1069-1074
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    • 2009
  • This study investigated soil microbial community and growth of Zea mays to compare the toxicity of nano and micro-sized Cu and Zn oxide particles in microcosm system. In the presence of nanoparticles, biomass of Zea mays reduced by 30% compared with micro-sized particles and inhibited growth. Dehydrogenase activity was inhibited by CuO nano although it was increased by ZnO nano particles. According to the Biolog test, the microbial diversity was decreased after exposed to CuO nanoparticles and ZnO microparticles. Therefore, though it is widely recognized that nanoparticles are more harmful than microparticles, we can conclude that the diversity of microbial community does not always influenced by the size of particles of nano and micro.

Formulation and Evaluation of Tablets Containing Unsaponifiable Fraction of Zea mays (Zea mays 불검화추출물을 함유하는 정제의 제제설계 및 평가)

  • Han, Yong-Hae;Chung, Youn-Bok;Han, Kun;Chung, Suk-Jae;Park, Man-Ki;Shim, Chang-Koo
    • YAKHAK HOEJI
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    • v.44 no.6
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    • pp.578-587
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    • 2000
  • The purpose of the present study was to design and prepare the optimum formulation for the oral administration of titrated extract of the unsaponifiable fraction of Zea mays L. (ETIZM). For this purpose, we simulated the blood concentration of ETIZM after its oral administration, changing the dissolution rate constants $(0.05{\sim}20\;hr^{-1})$. In vivo parameters, such as absorption rate constant $(k_a)$, elimination rate constant (k) and volume of distribution (Vd), were incorporated in the simulation on the basis of the experiments and literatures. When the dissolution rate constant $(k_r)$ is over $5\;hr^{-1}$, the absorption process appears to be the rate limiting step for the transport of ETIZM from the G.I. ract to the blood circulation. While less than $5\;hr^{-1}$, the dissolution rate considered to be the rate limiting step. Moreover, the optimum blood concentration was shown in the range from 1 to $5\;hr^{-1}$ of $k_r$ in the simulation. To design and prepare the tablets on the basis of the above results, 7 formula containing HPMC, PEG 4000 and PEG 6000 (1-5%, respectively) were prepared and evaluated. The tablets containing PEG 4000 (1%), PEG 6000 (1%) or PEG 4000 (5%) satisfy the optimum $k_r$ range ($1-5\;hr^{-1}$). These formulations, therefore, will be able to show the more effective blood concentration, compared with the commercial products after the oral administration.

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Promotion of Aldehyde Oxidase Activities by Ethanol in Maize (Zea mays) Roots (옥수수 (Zea mays) 뿌리에서 에탄올에 의한 알데히드 산화효소의 활성 증가)

  • Oh, Young-Joo;Park, Woong-June
    • Journal of Life Science
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    • v.17 no.8 s.88
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    • pp.1172-1175
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    • 2007
  • We observed that exogenously applied ethanol changed the activities of aldehyde oxidases (AO) in the primary roots of maize (Zea mays). The stimulatory effect of ethanol on the aldehyde oxidase activities was concentration dependent; the AO activities were slightly weaker with 0.2 - 0.4% ethanol and stronger with 0.8 - 1.0% ethanol than the level of control. The promotion of AO activities was not explained by the increased transcription of two AO genes in maize. In contrast, ethanol strongly increased the amount of AO proteins, indicating that ethanol enhanced AO activities by promoting the translation. Among three alcohols including ethanol, methanol and isopropanol, only ethanol promoted AO activities. These results suggested that enhancement of AO activities was specific to ethanol, whose level could be naturally increased when the plant roots drove fermentation to overcome low oxygen stresses.

Analysis of the statistical validity of clinical effectiveness data of a systemic titrated extract of Zea Mays L. unsaponifiable fraction chemotherapeutic agent (Insadol) (경구용 옥수수불검화정량추출물 치료제(인사돌)의 임상적 유효성 데이터의 통계적 타당성에 대한 연구)

  • Choi, Yong-Geun;Eckert, Steven E;Lee, Jeong-Yol;Shin, Sang-Wan
    • The Journal of the Korean dental association
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    • v.53 no.7
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    • pp.476-484
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    • 2015
  • Purpose: This study intended to analyze the validity of clinical effectiveness data of clinical trials testing systemic titrated extract of Zea Mays L. unsaponifiable fraction chemotherapeutic agent. Material and Methods: Among 5 clinical trials claimed as proof of clinical effectiveness on the Web site of the manufacturer of this chemotherapeutic agent, a review of 4 clinical trials, written in either Korean or English, was conducted. Data were extracted from studies for the following variables: year of publication, age, sample size, follow-up period, combination with contemporary periodontal treatments, randomization, randomization check, blinded measurement, and statistical test type. Results: The study subjects' age intervals were too diverse to decide a common target population to generalize the findings. No study stated clearly the rationale for the sample size determination. Follow-up period to observe the start of clinical effectiveness was inconsistent and decided without any rationale of pathophysiological latent period. Randomization to make the comparisons on the same start line was performed but failed in a study. Randomization effect was not checked in 4 studies. Performance of blinded measurement of clinical outcomes to prevent bias was unclear in 2 studies. Type of statistical test was inappropriate in 3 studies. Conclusions: Based on the analysis of the validity of data on clinical and demographic variables, the four available clinical trials have not demonstrated compelling evidence of therapeutic effectiveness of systemic titrated extract of Zea Mays L. unsaponifiable fraction chemotherapeutic agent to improve prognosis of periodontal disease either with the contemporary periodontal treatment or without it.

Effect of Thermal Pretreatment on the Functional Constituents of Waxy Corn (Zea mays L.)

  • Kim, Eun-Ok;Yu, Myong-Hwa;Lee, Ki-Teak;Yun, Kyoung-Seob;Choi, Sang-Won
    • Food Science and Biotechnology
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    • v.18 no.6
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    • pp.1336-1341
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    • 2009
  • Quantitative changes in functional constituents of waxy corn (Zea mays L.) by 5 different thermal pretreatments, including roasting, steaming, microwave, puffing, and extruding, were determined and compared with those of the raw waxy corn. There were no significant differences in fatty acid compositions among the corn treated with 5 thermal treatments. Levels of $\alpha$- and $\gamma$-tocopherols, soluble amino acids, and phytosterols decreased by thermal treatments, while those of p-coumaric and ferulic acids considerably increased by thermal treatments. In particular, the contents of tocopherols and phytosterols, and souble amino acid decreased significant in the steaming and puffing processes, respectively, whereas those of 2 free cinnamic acids increased significantly in the steaming and puffing processes. The extruding process showed smaller quantitative changes in tocopherols, phytosterols, and hydroxycinnamic acid derivatives compared to other heat pretreatments. These results suggest that the extruding process have a positive effect on valuable phytochemicals in waxy corn.