• IMMUNE NETWORK
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• v.24 no.1
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• pp.11.1-11.18
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• 2024

IL-15 belongs to the common gamma chain cytokine family and has pleiotropic immunological functions. IL-15 is a homeostatic cytokine essential for the development and maintenance of NK cells and memory CD8⁺ T cells. In addition, IL-15 plays a critical role in the activation, effector functions, tissue residency, and senescence of CD8⁺ T cells. IL-15 also activates virtual memory T cells, mucosal-associated invariant T cells and γδ T cells. Recently, IL-15 has been highlighted as a major trigger of TCR-independent activation of T cells. This mechanism is involved in T cell-mediated immunopathogenesis in diverse diseases, including viral infections and chronic inflammatory diseases. Deeper understanding of IL-15-mediated T-cell responses and their underlying mechanisms could optimize therapeutic strategies to ameliorate host injury by T cell-mediated immunopathogenesis. This review highlights recent advancements in comprehending the role of IL-15 in relation to T cell responses and immunopathogenesis under various host conditions.

• Journal of Korea Port Economic Association
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• v.24 no.4
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• pp.407-441
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• 2008

The interest of Cruise has been increased because of economic development and income growth in the world during last several decades. In Asian area the Cruise service also has been enlarged, especially in East Asia countries such as Korea, Japan, Singapore, Hongkong, Taiwan and China. This paper reviewed previous researches and clarify its concept and characteristics of Cruise Industry. And This paper aims to study the correct concepts and characteristics of Cruise marketing and investigate the current status and trend of Cruise Industry of the world and Korea. And it has groped and suggested various countermeasures, strategies and tactics in the 4Ps perspectives, considering the problems and conditions of Cruise service of Incheon Port.

• Culinary science and hospitality research
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• v.13 no.1 s.32
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• pp.1-10
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• 2007

Co-branding of food courts is turning into a trend with the activation of recent entrance of famous restaurants into shopping departments and other large-size buildings. This research analyzes the effects of co-brand food courts on the choices of dining enterprises by dealing with the customers of these newly activated food courts in shopping malls and large-size buildings. By analyzing the effects of the present status of customers' using food courts according to the characteristics of their choices of dining enterprises, food and brand elements were found to have an effect on the restaurant brand recognition of food courts, and price factor was found to have an effect on an visitors' recommendation intension. Therefore, customers who set importance on food and brand elements tend to take the brand of food courts into consideration as well; therefore, the maintenance of food quality and strengthening of brand image are mandatory in case of food court operation.

• The Journal of the Korea Contents Association
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• v.18 no.2
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• pp.73-80
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• 2018

The purpose of this study was to investigate the effect of rural cultural tourism factors on brand image of agricultural products. First, hardware component has a positive(+) effect on agricultural product brand image in part. Second, software component has a positive(+) effect on agricultural product brand image in part. Third, human resource factors have a positive (+) effect on agricultural product brand image in part The results showed that rural culture tourism constituent factor is an important factor affecting the image of agricultural products. This means that rural tourism can be an important factor in local income generation such as sales of agricultural products and regional development. It is necessary to develop strategies for rural development and income increase such as enhancement of attractiveness of rural cultural tourism elements and differentiation. In other words, the development of various strategies for rural cultural tourism elements can contribute to the image and activation of agricultural products.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.16
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• pp.117-154
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• 2001

The objective of the study is to propose to the strategy to make korean main ports to international logistics center in Northeast Asia. so this study's construction is constructed four steps. First, analysis the environment of economy, business and logistics industry in Northeast Asia. Second, analysis the constructions and characters of Free Zone Act. Third, analysis of Korean Government's policy about Free Zone. Forth, propose the growing strategy of Free Zone. In 1999 Northeast Asia was adopted in Korea, which will facilitate the process and strengthen the international logistics capability as a international logistics hub in Northeast Asia. But only adoption in the point of law is not enough to growing korean main seaport and airport to a international logistics hub. so various strategies are needed. In this study, we propose the growing strategies that are to establish and manage the free zone of ports and its hinterland are: the establishment of a long-term vision of international logistics complexes, the improvement of the proximity to markets/customers by way of linkage of global networks, the activation of the industrial complex in hinterland, the development of the skilled labor and the labor climate, the cooperation between governmental bodies and government/provincial bodies, continuous development of logistics infrastructure and so on.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.5
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• pp.349-353
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• 2012

Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the inhibitory function of CTLA-4 may be attractive in settings of undesirable T cell responses such as autoimmunity or transplant rejection. We have tested the hypothesis that transgenic constitutive expression of CTLA-4 can further attenuate immune responses when compared with normal inducible expression. Our results indicate that transgenic expression of CTLA-4 in mouse T cells (CTLA-4-Tg T cells) results in reduced cell cycle progression and increased apoptosis of TCR-stimulated T cells. CTLA-4-Tg T cells display reduced T cell proliferation in an in vivo model of graft versus host disease (GVHD). These results further our understanding of how CTLA-4 can be manipulated to inhibit immune responses and may help development of new therapeutic strategies for clinical settings of autoimmunity and transplantation.

• Journal of Korea Technology Innovation Society
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• v.16 no.4
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• pp.1163-1186
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• 2013

Big science such as nuclear fusion accelerators shares the characteristic of requiring long-term and massive budget input, human power, and related state-of-the-art technology. Because big science, by nature, thus requires large-scale budgets and facilities yet harbors the possibility of failure, most projects are led by the government. When the actual circumstances are examined, however, such projects are often implemented through the formation of cooperative relations with small and medium businesses (SMBs) possessing outstanding technological capacity. On the other hand, the reality is that the entry of corporations into the business ecosystem of big science is not easy and that even those that have once entered big science likewise fail to find sales outlets for technology that they have developed following the supply of single items, thus leading their technological capacity to lie idle. Consequently, based on an awareness of the problem, the present study seeks to propose strategies for activating the business ecosystem of nuclear fusion and accelerators and to present alternatives regarding which policy tasks must be pursued first by using the analytic hierarchy process (AHP) technique. The present study derived the four policy alternatives of approach, care, expansion, and infrastructures in accordance with the results of empirical analysis to activate the business ecosystem of nuclear fusion and accelerators and analyzed their priority in terms of urgency and effectiveness, the results of which were, in this order: care-approach-expansion-infrastructures. The significance of such research results lie in presenting the policy direction when the government determines which policy task must be pursued first and implements strategies for the activation of the business ecosystem of nuclear fusion and accelerators with limited financial resources in the future.

• Geophysics and Geophysical Exploration
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• v.26 no.3
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• pp.114-125
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• 2023

The physics-informed neural network (PINN) has been proposed to overcome the limitations of various numerical methods used to solve partial differential equations (PDEs) and the drawbacks of purely data-driven machine learning. The PINN directly applies PDEs to the construction of the loss function, introducing physical constraints to machine learning training. This technique can also be applied to wave equation modeling. However, to solve the wave equation using the PINN, second-order differentiations with respect to input data must be performed during neural network training, and the resulting wavefields contain complex dynamical phenomena, requiring careful strategies. This tutorial elucidates the fundamental concepts of the PINN and discusses considerations for wave equation modeling using the PINN approach. These considerations include spatial coordinate normalization, the selection of activation functions, and strategies for incorporating physics loss. Our experimental results demonstrated that normalizing the spatial coordinates of the training data leads to a more accurate reflection of initial conditions in neural network training for wave equation modeling. Furthermore, the characteristics of various functions were compared to select an appropriate activation function for wavefield prediction using neural networks. These comparisons focused on their differentiation with respect to input data and their convergence properties. Finally, the results of two scenarios for incorporating physics loss into the loss function during neural network training were compared. Through numerical experiments, a curriculum-based learning strategy, applying physics loss after the initial training steps, was more effective than utilizing physics loss from the early training steps. In addition, the effectiveness of the PINN technique was confirmed by comparing these results with those of training without any use of physics loss.

• The Journal of Society for e-Business Studies
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• v.8 no.2
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• pp.1-22
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• 2003

Web Services are rapidly gaining attention as the service oriented distributed computing paradigm over the Internet. Web services are currently highlighted not only due to its role as an enterprise application integrator, but also as the method of mediating inter-enterprise collaborative works. This research analyzes, categorizes, and provides current status and forecasting of core technology and standardization issues concerning web services. The results of this research could be used as the base information for understanding and establishing strategies concerning the fundamental technologies of web services. Also, the demand and status of domestic markets of web services are thoroughly analyzed. Based on this analysis, guidelines for the adaptation of web services by the government and domestic enterprises are presented. The results of this research provides appropriate alternatives to domestic enterprises by evaluating web service technology trends, and further on provides methods of web services market activation on a national scale

• Molecules and Cells
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• v.20 no.2
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• pp.263-270
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• 2005

Transactivation of EGF-receptor (EGFR) by G-protein coupled receptors (GPCRs) is emerging as an important pathway in cell proliferation, which plays a crucial role in the development of atherosclerotic lesion. Angiotensin II (Ang II) has been identified to have a major role in the formation of atherosclerotic lesions, although the underlying mechanisms remain largely unclear. We hypothesize that Ang II promotes the proliferation and migration of smooth muscle cells through the release of heparin-binding epidermal growth factor like growth factor (HB-EGF), transactivation of EGFR and activation of Akt and Erk 1/2, with matrix metalloproteases (MMPs) playing a dispensable role. Primary rat aortic smooth muscle cells were used in this study. Smooth muscle cells rendered quiescent by serum deprivation for 12 h were treated with Ang II (100 nM) in the presence of either GM6001 ($20{\mu}M$), a specific inhibitor of MMPs or AG1478 ($10{\mu}M$), an inhibitor of EGFR. The levels of phosphorylation of EGFR, Akt and Erk 1/2 were assessed in the cell lysates. Inhibition of MMPs by GM6001 significantly attenuated Ang II-stimulated phosphorylation of EGFR, suggesting that MMPs may be involved in the transactivation of EGFR by Ang II receptor. Furthermore Ang II-stimulated proliferation and migration of smooth muscle cells were significantly blunted by inhibiting MMPs and EGFR and applying HB-EGF neutralization antibody, indicating that MMPs, HB-EGF and EGFR activation is necessary for Ang-II stimulated migration and proliferation of smooth muscle cells. Our results suggest that inhibition of MMPs may represent one of the strategies to counter the mitogenic and motogenic effects of Ang II on smooth muscle cells and thereby prevent the formation and development of atherosclerotic lesions.