• Journal of the Daesoon Academy of Sciences
• /
• v.37
• /
• pp.297-328
• /
• 2021

This paper aims to find out from what perspective Joseon Dynasty Confucian scholars evaluated and understood Yang Xiong's guiding principles and literature at the micro level and to reveal the academic trends of Joseon Dynasty Confucian scholars. This topic is approached as follows: first, an evaluation of Yang Xiong's way of living as a 'senior state official of Wang Mang (the controversial Emperor of the short-lived Xin Dynasty)'; second, Yang Xiong's literary character and his literary works; third, Yang Xiong's writing style; and fourth, Yang Xiong's view of good and evil. These can be summarized in three main ways: One is to agree with Zhu Xi's criticism of Yang Xiong as a 'senior state official of Wang Mang' and dismiss his guiding principles, academic achievements, literature, and other accomplishments. Most of these negatives have been found in Confucian scholars who are especially enthusiastic about theology. Examples include Hong Jikpil, Wi Baekgyu, Kim Wonhaeng, and Lee Sangjeong. In the case of kings such as King Yeong-Jo, the assessment of Yang Xiong is quite similar. The following assessments of Yang Xiong are positive though. Positive assessments are presented from two different views. One is a balanced approach that covers both the positive and negative aspects of Yang Xiong. For example, Heo-Kyun's understanding. Another positive view can be analyzed from three perspectives. The first case is when the scholars assessing Yang Xiong were not deeply influenced by Zhu Xi's criticism of him. Seo Geojeong and Seong-Hyeon are examples. The second case are those that broke away from theology or adhered to Silhak [Practical Studies]. Yi-Ik is an example. Third, assessments from scholars who posited that truth was of a pluralistic nature. Jang-Yu is an example of such scholars. Regarding theories of human nature; however, there was consensus among Confucian scholars that Mengzi held that human nature is good, and thereby it was common to criticize Yang Xiong's theory that human nature was a mixture of good and evil. From an ideal micro perspective, Joseon Dynasty Confucian scholars' different assessments of Yang Xiong show that their understanding and evaluation of Yang Xiong differed in accordance with their own differing worldviews and ideas.

• The Journal of Korean Philosophical History
• /
• no.38
• /
• pp.221-249
• /
• 2013

This paper aims to examine the meaning of 'Xuan(玄)' in the cosmogony, especially in the view of Yang-xiong(揚雄) and Ge-hong(葛洪). The concept 'Xuan' is thought to have originated in the XianQin text Laozi & Zhouyi. After the XianQin period, this concept has been defined as philosophical concept, and it has a variety of meanings. This paper discussed about the cause of creation, the differentiation process, and the existence principle, within the cosmogony of Yang-xiong & Ge-hong. First, the cause of creation in the Yang-xiong is efficient cause in the state of the elementary substance, but also is the principle that is applied to the phase of the creation. While the cause of creation in the Ge-hong is comprised of the cause of the creation and the existence principle. Thus, the meaning of the concept 'Xuan' in the both scholar is different from the matter monism. Second, the concept 'Xuan' in the both scholar contains the tendency of cosmogony and ontology. Yang-xiong maintains the cosmogony, but he also hold on the rudimentary view of ontology. While Ge-hong display a tendency of ontology. Third, Ge-hong accepted the view of Yang-xiong and he developed the meaning of the existence principle. And finally, the concept 'Xuan' in the both scholar forms a philosophical system. Yang-xiong insisted that the concept 'Xuan' is the basis of the universe, the human-being and the society. While through realizing the concept 'Xuan', Ge-hong tried to pursue the human-being's agelessness and the eternal life.

• The Journal of Korean Philosophical History
• /
• no.42
• /
• pp.165-195
• /
• 2014

This paper aims to examine the meaning of 'Xuan(玄)' in the cosmology and astronomy, especially in the view of Yang-xiong(揚雄) and Ge-hong(葛洪). The cosmology of the ancient China has opened a discussion about the Tian(天), through the discussion about the celestial structure, the structure and the location relation of the heaven & earth, in the Han-dynasty has been found a systematic theory. But in the ancient Chinese philosophy, the cosmology has been developed in the field of the astronomy & the Oriental calendar. In this context, Yang-xiong(揚雄) and Ge-hong(葛洪) have founded the system of the cosmology, it is as in the following. First, Yang-xiong criticized sharply the theory of Gaitian(蓋天說) and advanced the theory of Huntian(渾天說). And Ge-hong support the theory of Huntian(渾天說) and also accepted the theory of Xuanye(宣夜說). Second, Yang-xiong(揚雄) and Ge-hong(葛洪)'s cosmology is regarded as the theoretical premise of their cosmogony. As the discussion about the celestial structure, the structure and the location relation of the heaven & earth, both scholar discussed about the cause of creation, the differentiation process. And in the this context, they founded the cosmology as the concept 'Xuan'. Third, the concept 'Xuan' in the both scholar forms a philosophical system. Yang-xiong insisted that the concept 'Xuan' is the basis of the universe, the human-being and the society. While through realizing the concept 'Xuan', Ge-hong tried to pursue the human-being's agelessness and the eternal life. In this way, their view point of the cosmology is comprised of cosmogony & astronomy. With this perspective, they are going to found the system of their own philosophy.

• 대한약리학회:학술대회논문집
• /
• 2006.10a
• /
• pp.101.2-101.2
• /
• 2006

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.11
• /
• pp.4509-4513
• /
• 2015

Osteosarcoma is the most common primary bone tumor in humans, especially in childhood. However, the genetic etiology for its pathogenesis remains elusive. It is known that microRNAs (miRNAs) are involved in the development of tumor progression. Here we show that microRNA-9 (miR-9) is a potential oncogene upregulated in osteosarcoma cells. Knockdown of miR-9 in osteosarcoma resulted in suppressed colony formation and cell proliferation. Further study identified GCIP, a Grap2 and cyclin D interacting protein, as a direct target of miR-9. In addition, GCIP overexpression activated retinoblastoma 1 (Rb) and suppressed E2F transcriptional target expression in osteosarcoma cells. Moreover, GCIP depletion reversed miR-9 knockdown induced colony formation and cell proliferation suppression. In sum, these results highlight the importance of miR-9 as an oncogene in regulating the proliferation of osteosarcoma by directly targeting GCIP and may provide new insights into the pathogenesis of osteosarcoma.

• Journal of Korean Medical classics
• /
• v.18 no.3 s.30
• /
• pp.81-94
• /
• 2005

There appears 7 chapters about questioning and answering between Lei Gong - Huang Di in which includes many contents that do not appear in other chapters of Su Wen(${\ulcorner}$素問${\lrcorner}$) and Ling Shu(${\ulcorner}$靈樞${\lrcorner}$). Especially terms such as Kui Duo(揆度), Qi Heng(奇恒), Yin Yang(陰陽), Cong Rong(從容). Ci Xiong(雌雄), Wu Zhong(五中), Zhong Shi(終始), Bi Lei(比類), Ming Tang(明堂), Ren shi(人事) do not show what they implicate and are difficult to understand. However, from the context, we assume that they maybe terms related to diagnosis. Although the Yin Yang Mai Fa of Su Wen totally differs from Nan Jing, we will look for the orgin of it through Wu Zhong. Furthermore, we will look into the development of Ren Ying Cun Kou Mai(人迎寸口脈), which does not appear in the contents of questioning and answering between Lei Gong Huang Di. The term Bi Lei that only appears in questioning and answering between Lei Gong - Huang Di will be analyzed along with diagnostic skill and the co-explained term Ren Shi. A lot of Xe Zheng(虛證) provoked by a intrinsic factor, Ren Shi, and suitability of its development to Lei Gong - Huang Di 's Mai Fa will be more closely discussed.

• Journal of Microbiology and Biotechnology
• /
• v.24 no.4
• /
• pp.447-452
• /
• 2014

To isolate novel and useful microbial enzymes from uncultured gastrointestinal microorganisms, a fecal microbial metagenomic library of the pygmy loris was constructed. The library was screened for amylolytic activity, and 8 of 50,000 recombinant clones showed amylolytic activity. Subcloning and sequence analysis of a positive clone led to the identification a novel gene (amyPL) coding for ${\alpha}$-amylase. AmyPL was expressed in Escherichia coli BL21 (DE3) and the purified AmyPL was enzymatically characterized. This study is the first to report the molecular and biochemical characterization of a novel ${\alpha}$-amylase from a gastrointestinal metagenomic library.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.7
• /
• pp.3275-3279
• /
• 2012

Recently, population-based studies of type 2 diabetes patients have provided evidence that metformin treatment is associated with a reduced cancer incidence and mortality, but its mode of action remains unclear. Here we report effects of metformin on hepatocellular carcinoma (HCC) Hep-G2 cells and details of molecular mechanisms of metformin activity. Our research indicates that metformin displays anticancer activity against HCC through inhibition of the mTOR translational pathway in an AMPK-independent manner, leading to G1 arrest in the cell-cycle and subsequent cell apoptosis through the mitochondrion-dependent pathway. Furthermore, we showed that metformin strongly attenuated colony formation and dramatically inhibited Hep-G2 tumor growth in vivo. In conclusion, our studies suggested that metformin might have potential as a cytotoxic drug in the prevention and treatment of HCC.

• Journal of Microbiology
• /
• v.44 no.4
• /
• pp.457-460
• /
• 2006

A suspicious meningococcal meningitis death case was reported to the Beijing CDC. The blood specimen was analyzed via multi-PCR and MLST. 6 isolates from close contacts were analyzed via PFGE and MLST. According to the results of the above analyses, the cause of this case was identified as a serogroup A Neisseria meningitidis, which, in terms of sequence typing, belonged the ST7 group.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2005.07a
• /
• pp.243-246
• /
• 2005

The discharge characteristic of a novel AC PDP with Shadow mask (SM-PDP) has been studied with 2-D and 3-D simulations. Compared with the conventional coplanar PDP, the SM-PDP has lower ignition voltage, higher response frequency and higher brightness. It's easy to realize a high definition display while keeping a good performance with the SM-PDP. The discharge process as measured with a fast Intensified CCD (ICCD) compares favorably with the simulation results.