• Korean Circulation Journal
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• v.53 no.4
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• pp.239-250
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• 2023

Background and Objectives: Brugada syndrome (BrS) is an inherited arrhythmia syndrome that presents as sudden cardiac death (SCD) without structural heart disease. One of the mechanisms of SCD has been suggested to be related to the uneven dispersion of transient outward potassium current (I_to) channels between the epicardium and endocardium, thus inducing ventricular tachyarrhythmia. Artemisinin is widely used as an antimalarial drug. Its antiarrhythmic effect, which includes suppression of I_to channels, has been previously reported. We investigated the effect of artemisinin on the suppression of electrocardiographic manifestations in a canine experimental model of BrS. Methods: Transmural pseudo-electrocardiograms and epicardial/endocardial transmembrane action potentials (APs) were recorded from coronary-perfused canine right ventricular wedge preparations (n=8). To mimic the BrS phenotypes, acetylcholine (3 μM), calcium channel blocker verapamil (1 μM), and I_to agonist NS5806 (6-10 μM) were used. Artemisinin (100-150 μM) was then perfused to ameliorate the ventricular tachyarrhythmia in the BrS models. Results: The provocation agents induced prominent J waves in all the models on the pseudo-electrocardiograms. The epicardial AP dome was attenuated. Ventricular tachyarrhythmia was induced in six out of 8 preparations. Artemisinin suppressed ventricular tachyarrhythmia in all 6 of these preparations and recovered the AP dome of the right ventricular epicardium in all preparations (n=8). J wave areas and epicardial notch indexes were also significantly decreased after artemisinin perfusion. Conclusions: Our findings suggest that artemisinin has an antiarrhythmic effect on wedge preparation models of BrS. It might work by inhibition of potassium channels including I_to channels, subsequently suppressing ventricular tachycardia/ventricular fibrillation.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.18 no.1
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• pp.1-12
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• 2013

Acoustic backscatter profiles were measured by Eco-sounder along an east-west section in the mid-eastern Yellow Sea and at an anchoring station in the low salinity region off the Keum River estuary in September 2012, with observing physical water property structure by CTD. Tidal front was established around the sand ridge developed in 50 m depth region. Internal waves measured by Eco-sounder during low tide period in the eastern side of the sand ridge were nonlinear depression waves with wave height of 15 m and mean wavelength of 500 m. These waves were interpreted into tidal internal waves that were produced by tidal current flowing over the sand ridge to the southeast. When weakly non-linear soliton model was applied, propagation speed and period of these internal depression wave were 50 m/s and 16~18 min. Red tides by Dinoflagelates Cochlodinium were observed in the sea surface where strong acoustic scattering layer was raised up to 7 m. Hourly CTD profiles taken at the anchoring station off the Keum River estuary showed the halocline depth change by tidal current and land-sea breeze. When tidal current flowed strongly to the northeast during flood period and land-breeze of 7 m/s blew to the west, the halocline was temporally raised up as much as 2 m and acoustic profile images showed a complex structure in the surface layer within 5-m depth: in tens of seconds the declined acoustic structure of strong and weak scattering signals alternatively appeared with entrainment and intrusion shape. These acoustic profile structures in the surface mixed layer were observed for the first time in the coastal sea of the mid-eastern Yellow Sea. The acoustic profile images and turbidity data suggest that relatively transparent low-layer water be intruded or entrained into the turbid upper-layer water by vertical shear between flood current and land breeze-induced surface current.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.3A
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• pp.321-327
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• 2006

In this paper, when a H-polarized plane wave is incident on the grating consisting of uniform resistive strips, electromagnetic scattering is analyzed using the moment of methods (MoM). The current density of each resistive strip on a grounded dielectric plane is fixed by zero at both edges. To satisfy the condition at both ends of each resistive strip, the induced surface current density is expanded in a series of cosine and sine functions. The scattered electromagnetic fields are expanded in a series of floquet mode functions. The boundary conditions are applied to obtain the unknown current coefficients. According to the variation of the involving parameters such as strip width and spacing and angle of the incident field, numerical simulations are performed by applying the Fourier-Galerkin moment method. The numerical results of the normalized reflected power for resistive strips case for zero and several resistivities are obtained.

• Journal of Ocean Engineering and Technology
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• v.30 no.2
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• pp.91-99
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• 2016

The global demand for oil and natural gas has increased, and resource development is moving to the deep sea. Floating and flexible offshore structures such as semi-submersible, spar, and FPSO structures have been widely used. The major equipment of floating structures is always exposed to waves, currents, and other marine environmental factors, which cause structural damage. Moreover, flexible risers are susceptible to an exciting force due to the motion of the floating body. The inline and transverse responses from the three-dimensional behavior of a floating structure occur because of various forces. Typical risers are made of steel pipe and applied in the oil and gas development field, but flexible materials such as polyethylene are suitable for OTEC risers. Consequently, the optimal design of a flexible offshore plant requires a dynamic behavior analysis of slender bodies made of the different materials commonly used for offshore flexible risers. In this study, a three-dimensional motion measurement device was used to analyze the displacements of riser models induced by external force factors, and forced oscillation of a riser was linked to forced oscillation under a steady flow and regular wave condition.

• Journal of Advanced Navigation Technology
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• v.15 no.3
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• pp.349-354
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• 2011

In this paper, H-polarized scattering problems by a resistive strip grating with zero resistivity at strip-edges over a grounded dielectric plane according to the strip width and grating period, the relative permittivity and thickness of a dielectric layer, and incident angles of a transverse electric (TE) plane wave are analyzed by applying the Fourier-Galerkin Moment Method (FGMM). The tapered resistivity of resistive strips has zero resistivity at strip edges, then the induced surface current density on the resistive strip is expanded in a series of Chebyshev polynomials of the second kind as a orthogonal ploynomials. The sharp variations of the reflected power are due to resonance effects were previously called wood's anomallies, the numerical results for the reflected power are compared with those of uniform resistivity in the existing papers.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.12
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• pp.954-963
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• 2017

In this paper, we analyzed the electric/magnetic field distribution and SAR distribution in a human body due to the resonant-type wireless power transfer(WPT) system with an operating frequency of 6.78 MHz. To analyze the field distribution under the unperturbed condition, a prototype system was fabricated and the measured results were compared with the simulation results. For safety during measurement, the available power to the transmitter coil is limited to 1 W. To analyze the induced current density and SAR distribution, a simple human model consisting of three layers, skin, fat, and muscle, was used for the simulation. The electromagnetic wave exposure levels obtained through measurement and simulation were compared with the recommended levels by the ICNIRP.

• Journal of Advanced Navigation Technology
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• v.15 no.4
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• pp.543-548
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• 2011

In this paper, H-polarized electromagnetic scattering problems by a resistive strip grating over a grounded dielectric plane according to the strip width and grating period, the relative permittivity and thickness of a dielectric layer, and incident angles of a TE (transverse electric) plane wave are analyzed by applying the FGMM (Fourier-Galerkin Moment Method). The tapered resistivity of resistive strips in this paper varies from finite resistivity at one edge to zero resistivity at the other edge, then the induced surface current density on the resistive strip is expanded in a series of Jacobi polynomials of the order ${\alpha}=1$, ${\beta}=0$ as a kind of orthogonal polynomials. The numerical results of the normalized reflected power show in good agreement with those of existing papers.

• Journal of the Korean Society for Marine Environment & Energy
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• v.19 no.3
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• pp.194-202
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• 2016

This study aims to review a topology optimization based on finite element analysis (FEA) for conceptual design of platform in the 10MW class floating type wave-wind hybrid power generation system (WHPGS). Two topology optimization theories, density method (DM) and homogenization design method (HDM) were used to check which one is more effective for a simplified structural design problem prior to the topology optimization of platform of WHPGS. From the results of the simplified design problem, the HDM was applied to the topology optimization of platform of WHPGS. For the conceptual platform design of WHPGS, FEA model was created and then the structural analysis was performed considering offshore environmental loads at installation site. Hydrodynamics analysis was carried out to calculate pressure on platform and tension forces in mooring lines induced from the offshore environmental loads such as design wave and current. Loading conditions for the structural analysis included the analysis results from the hydrodynamic analysis and the weights of WHPGS. Boundary condition was realized using inertia relief method. The topology optimization of WHPGS platform was performed using the HDM, and then the conceptual arrangement of main structural members was suggested. From the results, it was confirmed that the topology optimization might be a useful tool to design the conceptual arrangement of main structural members for a newly developed offshore structure such as the floating type WHPGS.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.2
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• pp.331-337
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• 1994

The scatting problem by E-polarized plane wave with obique incidence on a tapered resistive strip grating with zero resistivity(perfectly conducting) at strip-edges is analyzed by the method of moments in the spectral domain. Then the induced surface current density on the strip is expanded in a series of Chebyshev polynomials of the second kind. The expasion coefficients are calculated numerically in the spectral domain, the numerical results of the geometric-optical reflection coefficient for the tapered resistivity in this paper are compared with those for the existing uniform resistivity. And the position of sharp variation points in the magnitude of the geometric-optical reflection coefficient can be moved by varying the incident angle and the strip spacing, It is found out that these sparp variation points are due to the transition of higher mode between the propagation mode and the evanescent mode.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.52 no.9
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• pp.418-423
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• 2003

This paper describes an electronic compass using micromachined X- and Y-axis micro fluxgate sensors which were perpendicularly aligned each other to measure X- and Y-axis magnetic fields respectively. The fluxgate sensor was composed of rectangular-ring shaped magnetic core and solenoid excitation(49 turns) and pick-up(46 turns) coils. Excitation and pick-up coil patterns which were formed opposite to each other wound the magnetic core alternatively to improve the sensitivity and to excite the magnetic core in an optimal condition with reduced excitation current. The magnetic core has DC effective permeability of ~1000 and coercive field of ~0.1 Oe. The magnetic core is easily saturated due to the low coercive field and closed magnetic path for the excitation field. To decrease the difference of induced second harmonic voltages from X- and Y-axis, excitation condition of 2.8 $V_{P-P}$ and 1.2 MHz square wave was selected. Excellent linear response over the range of -100 $\mu$T to +100 $\mu$T was obtained with 210 V/T sensitivity. The size of each micro fluxgate sensor excluding pad region was about 2.6${\times}$1.7 $mm^2$ and the power consumption was estimated to be 14 mW.W.