• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.799-802
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• 2008

General behaviors based on hydraulic characteristics of natural streams and channels have been recently analyzed and developed via various numerical models. However in the states of natural hydraulics, an experimental research must be performed simultaneously with the mathematical analysis due to effects of hydraulic properties such as meander, sediment, and so on. In this study based on 2-D advection-dispersion equation, flow and tracer experiments were performed in the S-curved meandering laboratory channel with a rectangular cross-section. The channel was equipped with instrument carriages which was equipped with an auto-traversing system to be used with velocity measuring sensors throughout the depth and breadth of the flow field. To measure concentration distribution of the salt solution was adjusted to that of the flume water by adding methanol and a red dye (KMnO4) was added to aid the visualization of the tracer cloud, the tracer was instantaneously injected into the flow as a full-depth vertical line source by the instantaneous injector and the initial concentration of the tracer was 100,000 mg/l. The secondary current as well as the primary flow pattern was analyzed to investigate the flow distribution in the meandering channels. The velocity distribution of the primary flow for all cases skewed toward the inner bank at the first bend, and was almost symmetric at the crossovers, and then shifted toward the inner bank again at the next alternating bend. Thus, one can clearly notice that the maximum velocity occurs taking the shortest course along the channel, irrespective of the flow conditions. The result of the tracer tests shows that pollutant clouds are spreading following the maximum velocity lines in each cases with various mixing patterns like superposition, separation, and stagnation of pollutant clouds. Flow characteristics in each cases performed in this study can be compared with tracer dispersion characteristics with using evaluation of longitudinal and transverse dispersion coefficients(LDC, TDC). As expected, LDC and TDC in meandering parts have been evaluated with increasing distribution and straight parts have effected to evaluate minimum of LDC and TDC due to symmetric flow patterns and attenuations of secondary flow.

• Korean Journal of Remote Sensing
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• v.22 no.1
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• pp.49-61
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• 2006

The lifting scheme has been found to be a flexible method for constructing scalar wavelets with desirable properties. In this paper, it is extended to the UDAR data compression. A newly developed data compression approach to approximate the UDAR surface with a series of non-overlapping triangles has been presented. Generally a Triangulated Irregular Networks (TIN) are the most common form of digital surface model that consists of elevation values with x, y coordinates that make up triangles. But over the years the TIN data representation has become an important research topic for many researchers due its large data size. Compression of TIN is needed for efficient management of large data and good surface visualization. This approach covers following steps: First, by using a Delaunay triangulation, an efficient algorithm is developed to generate TIN, which forms the terrain from an arbitrary set of data. A new interpolation wavelet filter for TIN has been applied in two steps, namely splitting and elevation. In the splitting step, a triangle has been divided into several sub-triangles and the elevation step has been used to 'modify' the point values (point coordinates for geometry) after the splitting. Then, this data set is compressed at the desired locations by using second generation wavelets. The quality of geographical surface representation after using proposed technique is compared with the original UDAR data. The results show that this method can be used for significant reduction of data set.

• Toxicological Research
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• v.35 no.4
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• pp.295-301
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• 2019

In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 diverse chemicals estimated by modeling virtual oral administration in rats. To ensure that a broad range of chemical structures is present among the selected substances, the properties described by 196 chemical descriptors in a chemoinformatics tool were calculated for 50,000 randomly selected molecules in the original chemical space. To allow visualization, the resulting chemical space was projected onto a two-dimensional plane using generative topographic mapping. The calculated absorbance rates of the chemicals based on cell permeability studies were found to be inversely correlated to the no-observed-effect levels for hepatoxicity after oral administration, as obtained from the Hazard Evaluation Support System Integrated Platform in Japan (r = -0.88, p < 0.01, n = 27). The maximum plasma concentrations and the areas under the concentration-time curves (AUC) of a varied selection of chemicals were estimated using two different methods: simple one-compartment models (i.e., high-throughput toxicokinetic models) and simplified physiologically based pharmacokinetic (PBPK) modeling consisting of chemical receptor (gut), metabolizing (liver), and central (main) compartments. The results obtained from the two methods were consistent. Although the maximum concentrations and AUC values of the 53 chemicals roughly correlated in the liver and plasma, inconsistencies were apparent between empirically measured concentrations and the PBPK-modeled levels. The lowest-observed-effect levels and the virtual hepatic AUC values obtained using PBPK models were inversely correlated (r = -0.78, p < 0.05, n = 7). The present simplified PBPK models could estimate the relationships between hepatic/plasma concentrations and oral doses of general chemicals using both forward and reverse dosimetry. These methods are therefore valuable for estimating hepatotoxicity.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.318-318
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• 2016

위성은 준 실시간으로 국토 전체의 관측과 미계측/비접근 지역의 관측도 가능하여 가뭄, 홍수 등 수재해와 관련된 분석 자료로 활용되고 있으며, 위성 기반의 수재해 모니터링 적용성에 대한 연구 또한 수행되고 있다. 위성에서 관측된 자료는 NASA, JAXA 등의 위성 관리 센터에서 알고리즘을 적용하여 인터넷으로 제공하고, 최근 K-water에서는 수자원분야의 위성활용을 위해 위성 자료 수집 시스템을 갖추어 Aqua/Terra MODIS, GPM, GCOM-W1 등의 위성 자료를 수집하고 있다. 위성 자료는 5분~16일 등의 다양한 주기로 제공되고 있으며, 자료 타입, 측정 시간 등의 간단한 정보만 파일명으로 표시되어 위성의 위치(경위도) 및 해당 지점의 위성 자료를 얻기 위해서는 위성 자료를 확인해야만 하는 번거로움이 따른다. 본 연구에서는 순차적으로 관측된 위성 자료의 시 공간적 속성정보를 추출하고 해당 정보를 영상과 함께 맵핑하여, 시간의 흐름에 따른 위성 궤도의 시각화 방안을 제시하였다. 위성 궤도의 시각화 방안으로 사용된 위성 자료는 Terra MODIS의 'MOD02SSH', GPM GMI 센서의 'GPROF' 자료 타입을 사용하였다. 'MOD02SSH'는 5분 동안 5km의 공간해상도로 측정한 자료가 1개의 파일이며, 'GPROF'는 5분 동안 4km의 공간해상도로 측정한다. 공전 주기의 검증을 위해 케플러의 제3법칙을 적용한 Terra 위성의 공전주기는 98.75분으로 계산되며, 위성 자료의 공전주기는 98.87분으로 나타난다. 검증 결과 약 0.12초의 오차가 발생하며, 정확한 위성 고도와 높은 해상도의 위성 자료를 통해 오차의 감소가 가능하다. 이를 통해 시각화 된 동적 시계열 이미지는 시간에 따른 위성 궤도의 정보를 추출 할 수 있다. 이는 수재해 정보시스템의 모니터링을 위해 사용 가능하고, 시간에 따른 위성 궤도 정보를 통하여 필요한 시간대의 위성 위치 정보, 해당 지점의 관측 자료를 효율적으로 수집하여 자료 수집을 위한 시간 단축이 가능하며, 사용자 또는 관리자를 위한 모니터링 수행 또한 효율적인 운영이 가능할 것으로 사료된다.

• Molecules and Cells
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• v.44 no.9
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• pp.627-636
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• 2021

The three-dimensional organization of chromatin and its time-dependent changes greatly affect virtually every cellular function, especially DNA replication, genome maintenance, transcription regulation, and cell differentiation. Sequencing-based techniques such as ChIP-seq, ATAC-seq, and Hi-C provide abundant information on how genomic elements are coupled with regulatory proteins and functionally organized into hierarchical domains through their interactions. However, visualizing the time-dependent changes of such organization in individual cells remains challenging. Recent developments of CRISPR systems for site-specific fluorescent labeling of genomic loci have provided promising strategies for visualizing chromatin dynamics in live cells. However, there are several limiting factors, including background signals, off-target binding of CRISPR, and rapid photobleaching of the fluorophores, requiring a large number of target-bound CRISPR complexes to reliably distinguish the target-specific foci from the background. Various modifications have been engineered into the CRISPR system to enhance the signal-to-background ratio and signal longevity to detect target foci more reliably and efficiently, and to reduce the required target size. In this review, we comprehensively compare the performances of recently developed CRISPR designs for improved visualization of genomic loci in terms of the reliability of target detection, the ability to detect small repeat loci, and the allowed time of live tracking. Longer observation of genomic loci allows the detailed identification of the dynamic characteristics of chromatin. The diffusion properties of chromatin found in recent studies are reviewed, which provide suggestions for the underlying biological processes.

• Journal of the Korea Convergence Society
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• v.10 no.6
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• pp.1-6
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• 2019

This paper examines the complexity of recent SW development such as the 4th industry to apply the requirement engineering and redimimn application to the project to solve the difficulty of scope management during project management of medium and small businesses. These engineering techniques were applied to mid-sized and small-sized SW development projects. It was verified through supervision of 15 SW development projects. As a result, we observed about 30% reduction in related issues. In addition, Redmimn was introduced to SW development projects involving medium and small sized companies, and it proved that it has the effect of shortening delivery time through requirement management and tracking management. In order to secure the safety of the SW system development project, it is necessary to apply the required engineering techniques and tools, and it is necessary to continuously cultivate professional manpower to carry out this.

• Journal of Contemporary Eastern Asia
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• v.18 no.1
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• pp.7-29
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• 2019

This study describes an approach for comparative bibliometric analysis of scientific publications related to (i) individual or several departments comprising a university, and (ii) broader integrated subject areas using multiple disciplinary schemes. It uses a custom dataset of scientific publications (ca. 15,000 articles and reviews, published during 2009-2013, and recorded in the Web of Science Core Collections) with author affiliations to the research departments, dedicated to science, technology, engineering, mathematics, and medicine (STEMM), of a comprehensive university. The dataset was subjected, at first, to the department level and discipline level analyses using the newly available KAKEN-L3 classification (based on MEXT/JSPS Grants-in-Aid system), hierarchical clustering, correspondence analysis to decipher the major departmental and disciplinary clusters, and visualization of the department-discipline relationships using two-dimensional stacked bar diagrams. The next step involved the creation of subsets covering integrated subject areas and a comparative analysis of departmental contributions to a specific area (medical, health and life science) using several disciplinary schemes: Essential Science Indicators (ESI) 22 research fields, SCOPUS 27 subject areas, OECD Frascati 38 subordinate research fields, and KAKEN-L3 66 subject categories. To illustrate the effective use of the science mapping techniques, the same subset for medical, health and life science area was subjected to network analyses for co-occurrences of keywords, bibliographic coupling of the publication sources, and co-citation of sources in the reference lists. The science mapping approach demonstrates the ways to extract information on the prolific research themes, the most frequently used journals for publishing research findings, and the knowledge base underlying the research activities covered by the publications concerned.

• Animal Bioscience
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• v.34 no.1
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• pp.134-142
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• 2021

Objective: To understand the athletic characteristics of Thoroughbreds, high-throughput analysis has been conducted using horse muscle tissue. However, an in vitro system has been lacking for studying and validating genes from in silico data. The aim of this study is to validate genes from differentially expressed genes (DEGs) of our previous RNA-sequencing data in vitro. Also, we investigated the effects of exercise-induced stress including heat, oxidative, hypoxic and cortisol stress on horse skeletal muscle derived cells with the top six upregulated genes of DEGs. Methods: Enriched pathway analysis was conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) tool with upregulated genes in horse skeletal muscle tissue after exercise. Among the candidates, the top six genes were analysed through geneMANIA to investigate gene networks. Muscle cells derived from neonatal horse skeletal tissue were maintained and subjected to exercise-related stressors. Transcriptional changes in the top six genes followed by stressors were investigated using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Results: The inflammation response pathway was the most commonly upregulated pathway after horse exercise. Under non-cytotoxic conditions of exercise-related stressors, the transcriptional response of the top six genes was different among types of stress. Oxidative stress yielded the most similar expression pattern to DEGs. Conclusion: Our results indicate that transcriptional change after horse exercise in skeletal muscle tissue strongly relates to stress response. The qRT-PCR results showed that stressors contribute differently to the transcriptional regulation. These results would be valuable information to understand horse exercise in the stress aspect.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.6
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• pp.1-6
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• 2020

Road movement pollutant air environment big data is a link between real-time traffic data such as vehicle type, speed, and load using AVC, VDS, WIM, and DTG, which are always traffic volume survey equipment, and road shape (uphill, downhill, turning section) data using GIS. It consists of traffic flow data. Also, unlike general data, a lot of data per unit time is generated and has various formats. In particular, since about 7.4 million cases/hour or more of large-scale real-time data collected as detailed traffic flow information are collected, stored and processed, a system that can efficiently process data is required. Therefore, in this study, an open source-based data parallel processing performance optimization study is conducted for the visualization of big data in the air environment of road transport pollution.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.12
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• pp.13-20
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• 2018

This research is to analyze the public cases of information facilities in terms of central circulations in multi level volumes such as atrium or court which provide visual intervention between different spaces and physical connections such as bridges. Hunt Library design balances the understood pre-existing needs with the University's emerging needs to create a forward-thinking learning environment. While clearly a contemporary structure within a traditional context of the NCSU campus, the Hunt Library provides a positive platform for influencing its surroundings. Both technical and programmatic innovations are celebrated as part of the learning experience and provide a versatile and stimulating environment for students. Public library as open spaces connecting to an interactive social domain over communities can provide variety of learning environments, or technology based labs. There are many cases of the public information spaces with dynamic networks where participants can play their roles in physical space as well as in the intellectual stimulation. In the research, new public projects provide typologies of information spaces with user oriented media. The research is to address a creative transition between the reading space and the experimental links of the integration of state-of-the-art technology is highly visible in the building's design. The user-friendly browsing system that replaces the traditional browsing with the virtual shelves classified and archived by their form, is to reduce the storage space of the public library and it is to allow more space for collaborative learning. In addition to the intelligent robot of information storages, innovative features is the large-scale visualization space that supports team experiments to carry out collaborative online works and therefore the public library's various programs is to provide visitors with more efficient participatory environment.