• BMB Reports
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• v.52 no.2
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• pp.119-126
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• 2019

The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) initiates the extrinsic apoptotic pathway through formation of the death-inducing signaling complex (DISC), followed by activation of effector caspases. TRAIL receptors are composed of death receptors (DR4 and DR5), decoy receptors (DcR1 and DcR2), and osteoprotegerin. Among them, only DRs activate apoptotic signaling by TRAIL. Since the levels of DR expressions are higher in cancer cells than in normal cells, TRAIL selectively activates apoptotic signaling pathway in cancer cells. However, multiple mechanisms, including down-regulation of DR expression and pro-apoptotic proteins, and up-regulation of anti-apoptotic proteins, make cancer cells TRAIL-resistant. Therefore, many researchers have investigated strategies to overcome TRAIL resistance. In this review, we focus on protein regulation in relation to extrinsic apoptotic signaling pathways via ubiquitination. The ubiquitin proteasome system (UPS) is an important process in control of protein degradation and stabilization, and regulates proliferation and apoptosis in cancer cells. The level of ubiquitination of proteins is determined by the balance of E3 ubiquitin ligases and deubiquitinases (DUBs), which determine protein stability. Regulation of the UPS may be an attractive target for enhancement of TRAIL-induced apoptosis. Our review provides insight to increasing sensitivity to TRAIL-mediated apoptosis through control of post-translational protein expression.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1671-1674
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• 2015

Cancer genomics and proteomics have undergone considerable broadening in the past decades and increasingly it is being realized that solid/liquid phase microarrays and high-throughput resequencing have provided platforms to improve our existing knowledge of determinants of cancer development, progression and survival. Loss of apoptosis is a widely and deeply studied process and different approaches are being used to restore apoptosis in resistant cancer phenotype. Modulating the balance between pro-apoptotic and anti-apoptotic proteins is essential to induce apoptosis. It is becoming more understood that pharmacological inhibition of the proteasome might prove to be an effective option in improving TRAIL induced apoptosis in cancer cells. Keeping in view rapidly accumulating evidence of carcinogenesis, metastasis, resistance against wide ranging therapeutics and loss of apoptosis, better knowledge regarding tumor suppressors, oncogenes, pro-apoptotic and anti-apotptic proteins will be helpful in translating the findings from benchtop to bedside.

• Journal of Korean Society for Geospatial Information Science
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• v.17 no.2
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• pp.81-90
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• 2009

Mountain trails play an important role in the daily life and health of the citizens, and also are major areas for recreation operators strive to balance the needs of pedestrian with the needs of wildlife and health improvement. In this view point, this research aims at analyzing the slope of mountain trails using mobile GPS and suggesting the suitable path to citizens for improving health. The result shows that the trail slope analysis by using mobile GPS could be effectively evaluated the degree of walk difficulty.

• The Journal of Natural Sciences
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• v.13 no.1
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• pp.97-111
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• 2003

This study aims at presenting the planning parameter of ski course by designing Gapyung ski course. This site is located at Hacheon-ri, Gapyung-gun, Kyunggi-do and has an area $1,594,001m^2$. Design objectives of Gapyung Ski Resort were to build the most suitable ski course on the site area and make a comparative ski resort. This design process covers the following : site inventory and analysis; integration of design program and terrain analysis; slope planning and trail balance; comparison with other ski resort. This ski resort was composed of 5 lifts and 10 ski trails which are divided into 2 intermediate course, 3 high intermediate course, 4 advanced course, and I expert course. Total length of slope distance is 8,738m. This ski resort will be developed for advanced skiers and snow boarders who enjoy a mogul and a half pipe course. Therefore, the strategy of this ski resort is marked for target market of high intermediate.

• Physical Therapy Rehabilitation Science
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• v.5 no.4
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• pp.193-197
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• 2016

Objective: In the present study, the effects of visual restriction and unstable base dual-task training (VUDT), stable base dual-task training (SDT), and on stroke patients' balance and concentration abilities were examined. Design: Two-group pretest-posttest design. Methods: Dual-task training was conducted for thirty persons with chronic stroke who were hospitalized or receiving physical therapy and were randomly assigned to either the VUDT group (n=15) or the SDT group (n=15). The subjects were divided into two groups of 15 participants each, the VUDT group and the SDT group. Dual-task training was administered for 30 minutes per session, three times a week for 8 weeks. The participants' balance was measured via the center of pressure migration distances, functional reach test (FRT), Berg Balance Scale (BBS), and attention was measured using the trail-making test and the Stroop test. Results: In comparisons within each group, the two groups showed significant differences before and after the training (p<0.05). In the comparisons between the groups, the VUDT group showed significant improvements in center of pressure (COP), FRT, and BBS, and TMT compared to the SDT group (p<0.05). Conclusions: It would be more effective to conduct dual-task training as a rehabilitation training program under vision restriction and unstable supporting surface conditions than to conduct the test under unstable supporting plane conditions to improve balance and attention in chronic stroke patients.

• Physical Therapy Rehabilitation Science
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• v.5 no.3
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• pp.138-142
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• 2016

Objective: The purpose of this study was to investigate how light touch with a finger affects balance ability when a posture is maintained in the condition of visual information blockage and to provide a fundamental material for developing balance ability in the process of rehabilitation treatment. Design: Cross-sectional study. Methods: The study subjects were 17 healthy men and women in their twenties and thirties who were studying at S University in Seoul. The system was comprised of an equilateral triangular force platform. Subjects were asked to step on the foot position of the force platform (Good Balance, Finland) barefooted for 30 seconds, with eyes closed, hands hanging down loosely, and feet comfortably apart. It was connected to a laptop by using Bluetooth technology. An experiment was conducted in the following three circumstances: 1) no-touch trial, 2) light touch to the back (T7 area), and 3) light touch to the middle finger of the left hand. Each subject was given a 10-minute break between consecutive measurements. The experimental circumstances were performed randomly. Anteroposterior sway (APSV), mediolateral sway velocity (MLSV), and velocity moment (VM) were measured. Results: The APSVs (mm/s) were $9.32{\pm}3.37$ and $5.45{\pm}2.98$; the MLSVs (mm/s), $6.39{\pm}3.35$ and $3.31{\pm}2.48$; and VM ($mm^2/s$), $17.13{\pm}11.75$ and $6.76{\pm}8.31$ in the first and second experimental circumstances, respectively. APSV, MLSV, and VM values were significantly improved with the 1) no-touch trial and 2) light touch to the back trail conditions compared with the 3) light touch to the middle finger of the left hand condition (p<0.05). Conclusions: This study revealed that the balance ability for maintaining a body posture was influenced more by light touch to the back (T7) than by light touch with the sensitive fingertip and body sway diminished after visual information was blocked.

• The Journal of Korean society of community based occupational therapy
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• v.10 no.2
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• pp.25-36
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• 2020

Objective : This study identified the effect of tailored occupational intervention applied to the elderly with mild dementia using the day care center. Methods : This study applied the single-group experimental design to 29 elderly with mild dementia who use the day care center in B area, and conducted a total of 10 sessions once a week, 60 minutes. Intervention consisted largely of group activities and individual activities, and individual activities were conducted one-on-one with various activities necessary to select occupational goals and achieve the goals through consultation between the elderly with mild dementia and the person in charge. The effects of tailored occupational intervention were confirmed through CERAD, BBS, and GDS. Results : Significant differences were shown in the total score of MMSE-KC, time orientation, attention, constructional praxis delayed recall, and trail making test B in the cognitive function changes, and standing to sitting, standing unsupported with eyes closed of BBS in the physical function changes, and in the GDS score in the depression changes (p<.05). Conclusion : Tailored occupational intervention has been shown to be effective in improving cognitive and physical functions of the elderly with mild dementia and reducing depression. This provided a basis for proposing a tailored occupational intervention as an intervention that can be applied to the elderly with mild dementia.

• Journal of the Korean Institute of Landscape Architecture
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• v.39 no.2
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• pp.1-9
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• 2011

This study concerns the Baekje Traditional Garden, one of the open spaces in the Lotte Resort in the Baekje Historical Reappearance Complex, which is part of the comprehensive plan for specific areas in the Baekje cultural area. The Baekje Traditional Garden has historic value, and its excellent garden style influenced the ancient Japanese gardens. This study dealt with three issues: (1) The context in which Lotte Buyeo Resort accepted the Baekje Traditional Garden, particularly the background and process of such; (2) The original form of the Baekje Traditional Garden; and (3) How the Baekje Traditional Garden should be represented in the open space of the resort. Representation is accomplished in two ways: using the structure of the original garden and in the borrowing of elements. For representation using the structure of the original garden, Imrugak was used as the main entrance space, and Wolsunjung was represented from the Ganbuklee remains. In the rear garden are wave watercourses and other garden facilities of the Wanggungri site in Iksan. Borrowing of elements, on the other hand, was accomplished in the plant plan and detailed development. In addition, mountaintops (three mountains and five mountain summits), a clean stream between mountains, and a pine forest are visualized in the garden. This is the representative landscape of the Taoist hermit world that appeared in the Baekje Gilt Bronze Incense Burner and Landscape pattern. The significance of this study is twofold. First, the Baekje Traditional Garden is a fresh trail because there has been no previous research concerning it. Second, while past research concerning traditional spaces focused on the results of representation, this study focused on the process of representation. This means that this research work tried to extend the study concerning the representation of traditional spaces from the conceptual to the practical approach. This study, however, also has its limitations. The authenticity of the representation suggested in this study may be questioned later because efforts have been made to preserve the original Baekje Traditional Garden. In addition, this study should seek a balance between authenticity on one hand and amusement and diversity of experience on the other, because the site is a resort.

• Korean Journal of Environment and Ecology
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• v.28 no.6
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• pp.779-788
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• 2014

This study, as a case where the environmental conflict and dispute arose between the use and the conservation as in the other protected areas in Korea, took the first step to build ecological citizenship to solve various and complicated issues in a fundamental level by providing a basic information on differentiated environmental perceptions of the locality and the visitors of Seoraksan National Park. The questionnaire survey was employed on September 6th and 7th with 150 residents of the park area and 200 visitors of Osaek-Daechungbong trail. Total number of 13 survey questions was introduced using Dunlap and Liere's NEP index. The result shows that the perception of 'balance of nature' was more dominant to the perception of 'humans over nature' and the perception to the 'limits to growth' was also somewhat positive in both groups. The differences in environmental perceptions between the groups exist; the visitor group tended to have more positive level of acceptance of NEP views. Such differences in perceptions suggest that a different normative approach should be taken to the residents of the national park with less pro-environment in their perceptions when policy making. It thus seemed possible that ecological citizenship could be realized since the younger and the higher education level are, the more pro-environment. The findings of the research may cause some concerns however, because the study has been confined as a case study with basic understanding of environmental perceptions and its differences between the interest groups. More extensive research is required to confirm if this is generalized.