• 방사선산업학회지
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• 제17권4호
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• pp.327-332
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• 2023

This study identified effects of Isoegomaketone for applicable patch on the arthritis in mice. Isoegomaketone (IK) was isolated from Perilla frutescens, which is annual herbal traditional medicinal, aromatic, functional food. IK has various physiological effects such as anti-inflammation, anti-oxidant, and anti-cancer. In the previous study, oral administration of IK to a mouse model of collagen antibody-induced arthritis(CAIA), which is similar to human rheumatoid arthritis(RA), alleviated symptoms. In this study, we attached a patch containing IK to mouse skin to demonstrate whether it had the same efficacy as oral administration in CAIA mouse. As a result of measuring the arthritis score, paw volume, and paw thickness, it was confirmed that arthritis symptoms were alleviated in the group to which the patch containing IK was attached. These results show that IK is effective in alleviating arthritis not only through oral administration but also through patches applied to skin, and that it has potential as a material for future patch development.

• 대한한의학원전학회지
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• 제27권4호
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• pp.15-20
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• 2014

Objectives : We search the contents about Bi disease in Huang Di Nei Jing(黃帝內經), to analyze the significance of Bi disease, etiopathogenisis and pathogenesis of Bi disease, treatment of Bi disease. Methods : We find that the key feature of Bi disease is joint pain induced by impatency of Qi and blood. Exterior and interior etiological factors are involved in, such as exogenous evil of cold and dampness, emotional disorders, intemperance of taking food, dysfunction of yingqi and weiqi, strong or weak constitution, etc. Results : The important pathogenesis are invaded by exogenous evil because of deficiency, disharmony of yingqi and weiqi and disharmony of five viscera. The key points of treatments are the individual concerned therapy and climate concerned therapy, selecting the acupoint according to the differentiation of symptoms and signs. Conclusions : The combined therapy should be used such as acupuncture and moxibustion, hot application of medicine, massage, Daoyin, outside apply, etc. These supply the theory foundation for etiological factor, pathogenesis, syndrome and treatment, and to direct the diagnosis and treatment of Bi disease later generations.

• 대한한의학원전학회지
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• 제28권2호
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• pp.61-66
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• 2015

Objectives : Through the analyze of formative factor of time sense and the vital movement temporal rhythm in Huang Di Nei Jing(黃帝內經). Methods : We find out the principle and methods of Chronomedicine and Health Preserving in Huang Di Nei Jing(黃帝內經), and this finding will direct the life nurturing for later generations. We find that time sense had been established in Huang Di Nei Jing(黃帝內經), which had yin-yang and five elements characteristic. Results : There have temporal rhythm of functions of zang-fu viscera, meridian and collateral, qi and blood. Based on the theory of correspondence between human body and natural environment, established principle of health maintenance about based on yin and yang, temporal rhythm of visceral qi. Conclusions : Established health maintenance methods based on time such as adjusting-spirit according to time, regular daily life, dietary regimen according to time, needling and moxibustion according to time. These methods will guide syndrome differentiation and therapeutic method and Medication which based on suitable time.

• Journal of Microbiology and Biotechnology
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• 제30권7호
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• pp.955-961
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• 2020

Lactic acid bacteria (LAB) have caused many microbiological incidents in the brewing industry, resulting in severe economic loss. Meanwhile, traditional culturing method for detecting LAB are time-consuming for brewers. The present review introduces LAB as spoilage microbes in daily life, with focus on LAB in the brewing industry, targeting at the spoilage mechanism of LAB in brewing industry including the special metabolisms, the exist of the viable but nonculturable (VBNC) state and the hop resistance. At the same time, this review compares the traditional and novel rapid detection methods for these microorganisms which may provide innovative control and detection strategies for preventing alcoholic beverage spoilage, such as improvement of microbiological quality control using advanced culture media or different isothermal amplification methods.

• 벤처창업연구
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• 제8권1호
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• pp.69-78
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• 2013

세계적인 월빙 및 웰니스 붐에 따른 건강 치유를 중시하는 라이프스타일의 정착과 21세기 최고의 유망 서비스산업으로 떠오르고 있는 의료관광 및 웰니스관광에 적극적으로 대응하기 위한 방안의 하나로 제주도의 향토자원을 활용한 스파산업 육성방향에 대하여 고찰하였다. 스파산업 육성에 활용할 수 있는 제주도의 향토자원은 자연환경, 광물자원, 수자원, 생물자원, 농산물, 민간요법의 6 종류의 자원인 것으로 파악되었다. 제주 향토자원을 활용 가능한 여러 가지 스파 트리트먼트 중에서도 제주를 상징할 수 있는 차별화된 스파 트리트먼트 즉, '제주 특화 스파 트리트먼트'로 개발이 가능한 것은 12가지로 판단되었다. 즉, 자연환경을 활용한 딸라소테라피, 광물자원을 활용한 스톤테라피 검은 모래찜질 화산회토를 이용한 온돌요법, 수자원을 활용한 탈라소테라피 음용요법 하이드로 테라피, 생물자원을 활용한 약초/한약재 찜질 삼림치유, 농산물을 활용한 스파퀴진, 민간요법을 활용한 얼굴미용 질병치유 및 건강증진 식이요법이다. 상기와 같은 12가지 스파 트리트먼트를 '제주 특화 스파 트리트먼트' 개발 활용하기 위해서는 향토자원의 물리화학적 특성에 관한 기초연구와 더불어 제품화 연구와 임상시험을 통화 효능연구가 선행되어야 한다. 또한, 개발된 스파 트리트먼트를 고객의 성향과 요구와 스파유형 등을 고려한 맞춤형 서비스 프로그램 개발과 표준화 및 매뉴얼화가 이루어져야 한다. 아울러, 제주 스파산업이 경쟁력 있는 산업으로 성장해 나가기 위해서는 제주특별자치도가 추진하고 있는 의료관광 및 웰니스관광과 연계와 더불어 창업 및 경영지원이 필요 할 것으로 판단된다.

• 패션비즈니스
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• 제22권2호
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• pp.1-13
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• 2018

3D printing technology, which is expected to play a leading role within the Fourth Industrial Revolution, is becoming distinguished not only in the space, automotive, medical and engineering industries, but also in the area of design. The fashion and textile structures created by 3D printing technology were classified into three types - basic structure, unified structure, and a new physical structure. When traditional weaving, knitting, and stitching was reinterpreted through 3D printing, there were apparent limitations in reproducing the characteristics of fabric structures due to differences in the materials and structures of traditional textiles. New physical structures are being developed to break away from merely reproducing traditional textile structures, and to bring out the characteristics of 3D printing technology. As examples of new physical structures, there are the kinematics structure which utilizes the hinge method, mesostructure cellular material, and the N12 disk structure. Such techniques potentially open a new paradigm of fashion and textile structures. Some innovative aspects of 3D printing technology may result in changes in the methods of collaboration, manufacturing, and distribution. Designers are receiving help from specialists of various backgrounds to merge 3D printing technology to create original works. Also, 3D printing not only makes personalized custom designs available, but shortens the distribution channels, foretelling a change within the fashion and textile industry.

• Advances in Traditional Medicine
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• 제7권5호
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• pp.549-555
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• 2008

Bupleuri radix (Umbelliferae), the dried root of Bupleurum Chinense DC, has been clinically used to mitigate pain sensation. The descending pain control system consists of three major components, and modulation of pain in the periaqueductal gray is the most extensively studied descending pain control system. However, the relation of Bupleuri radix on the descending pain control system has not been clarified. In the present study, modulation of the aqueous extract of Bupleuri radix on glycine-induced ion current in the acutely dissociated periaqueductal gray neurons was investigated by using nystatin-perforated patch-clamp technique under voltage-clamp condition. In the present results, the glycine-induced ion current was significantly suppressed by 0.1 mg/ml Bupleuri radix, while treatment with $10^{-5}\;M$ naltrexone, opioid receptor antagonist, alleviated Bupleuri radix-induced inhibition on glycine-induced ion current. The present study showed that the aqueous extract of Bupleuri radix may activate descending pain control system through inhibition on glycine-induced ion current in the periaqueductal gray neurons and this effect is mediated by opioid receptors.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권4호
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• pp.826-842
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• 2024

As 5G and AI continue to develop, there has been a significant surge in the healthcare industry. The COVID-19 pandemic has posed immense challenges to the global health system. This study proposes an FL-supported edge computing model based on federated learning (FL) for predicting clinical outcomes of COVID-19 patients during hospitalization. The model aims to address the challenges posed by the pandemic, such as the need for sophisticated predictive models, privacy concerns, and the non-IID nature of COVID-19 data. The model utilizes the FATE framework, known for its privacy-preserving technologies, to enhance predictive precision while ensuring data privacy and effectively managing data heterogeneity. The model's ability to generalize across diverse datasets and its adaptability in real-world clinical settings are highlighted by the use of SHAP values, which streamline the training process by identifying influential features, thus reducing computational overhead without compromising predictive precision. The study demonstrates that the proposed model achieves comparable precision to specific machine learning models when dataset sizes are identical and surpasses traditional models when larger training data volumes are employed. The model's performance is further improved when trained on datasets from diverse nodes, leading to superior generalization and overall performance, especially in scenarios with insufficient node features. The integration of FL with edge computing contributes significantly to the reliable prediction of COVID-19 patient outcomes with greater privacy. The research contributes to healthcare technology by providing a practical solution for early intervention and personalized treatment plans, leading to improved patient outcomes and efficient resource allocation during public health crises.

• International Journal of Industrial Entomology and Biomaterials
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• 제4권2호
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• pp.93-100
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• 2002

Cocoon production, which is a representative of traditional sericulture shifted into silkworm powder production in the spring of 1995. This, infect, signifies the change from the dress-centered textile business to the bio-industry and the functional resource industry. One of the most outstanding shifting is utilization of silkworm larvae for anti-diabetic agent. In Asian countries including Korea, silkworm powder derived from the domestic silkworm (Bombyx mori L.) has long been favored for anti-diabetic agent, but its efficacy was not tested until last decade by modern scientific methods. In this article, we reviewed the major researches on the silkworm powder as a blood glucose-lowering substance. After the beginning test of the efficacy of silkworm powder by a cooperative research between Department of Sericulture and Entomlogy, NIAST, RDA and Kyung Hee University, substantial data have been accumulated so far, In a serial experiment to select best condition, the fifth instar larvae prepared by freeze dry method turned out to have the best blood glucose-lowering effect. In the pharmacological experiment to understand the mechanism of silkworm powder in small intestine, the silkworm powder turned out to inhibit the activity of ${\alpha}$-glucosidase, by competitively binding to $\alpha$-type disaccharides. The animal experiment showed that the extract of silkworm powder prevents a rapid increase of blood glucose level after meal and prevents hunger and law blood glucose level during empty stomach. In the experiment to isolate the major component of silkworm powder, which exerts blood glucose-lowering effect, 1-deoxynojirimy-cin (DNJ) was eventually mass-purified, and it turned out that DNJ isolated from silkworm powder was excellent in its blood glucose-lowering effect. In the experiment to understand the personal difference of the efficacy of the silkworm powder, clinical candidates were divided on the basis of the criterion of traditional Chinese medicine: Tae-Yang, Tae-Um, So-yang, and So-Um. The result showed that silkworm powder has a tendency to reduce blood glucose level at fasting and at 2 hours after meal, and this trend was somewhat obvious in the Tae-Um body type. In summary, we reviewed scientific papers on the efficacy of silkworm powder and its purified DNJ as a blood glucose-lowering agent. These suggest that silkworm powder truly possesses blood glucose-lowering effect as documented in the traditional Chinese medicine, although further researches will be required to develop them as "medical" resource instead of functional food.

• 문화기술의 융합
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• 제5권1호
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• pp.77-82
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• 2019

인공지능은 기술개발 속도가 가속화되어 생활, 의료, 금융 서비스 및 자율자동차 등 산업 전반에 적용되고 있다. 4차 산업혁명 시대의 핵심기술로 자리 잡고 있는 인공지능 경쟁력 확보를 위해 선진국들은 국가적 역량을 집중하고 있다. 반면 IT강국으로서의 인프라와 인적자원을 보유한 한국은 미국, 캐나다, 일본, 등 전통적인 인공지능 선진국뿐만 아니라 지능형 기술집약 산업 육성에 총력을 기울이는 후발주자 중국에도 뒤쳐져있는 상황이다. 지능정보 사회의 고도화에 따라 인공지능은 향후 국가의 산업경쟁력을 좌우할 기반기술인바, 국가적인 관심과 역량 결집이 필요하다. 또한 인공지능 기술의 종속을 막기 위하여 자체 기술개발 노력과 함께 선두업체와의 공동 개발이 중요하다. 이에 더하여 인공지능 시장 저변 확대를 위하여 제도 개선과 법률적 기반 마련이 시급하다.