• Title/Summary/Keyword: Toxic model

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Development of a Lagrangian Stochastic Dispersion Model for Toxic Gas Release (독성 기체상 물질의 확산 및 대응 분석을 위한 라그랑지안 입자모델의 개발)

  • 이강웅;장유운;이미혜;조성억;조승현
    • Proceedings of the Korea Air Pollution Research Association Conference
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    • 1999.10a
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    • pp.149-151
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    • 1999
  • 우리 나라의 경우에 산업화가 가속화되면서 유해 독성 기체상 물질의 누출사고 위험성이 점점 높아져 가고 있는 실정이다. 우리 나라는 특히 산업인력의 조달과 지방경제 발달을 목적으로 중소도시 근방에 대규모 공단이 건설되어 있는 경우가 많다. 이러한 공단에는 위험물을 취급하는 공장과 위험물이 수송 및 이동되는 사례가 매우 많을 것으로 추정되며 이러한 경로를 통하여 유독가스 누출사고가 발생 할 경우 바로 인근 주민 및 작업 인원들의 생명을 위협할 수 있다.(중략)

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A MATHEMATICAL MODEL OF A PREY-PREDATOR TYPE FISHERY IN THE PRESENCE OF TOXICITY WITH FUZZY OPTIMAL HARVESTING

  • PAL, D.;MAHAPATRA, G.S.;MAHATO, S.K.;SAMANTA, G.P.
    • Journal of applied mathematics & informatics
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    • v.38 no.1_2
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    • pp.13-36
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    • 2020
  • In this paper, we have presented a multispecies prey-predator harvesting system based on Lotka-Voltera model with two competing species which are affected not only by harvesting but also by the presence of a predator, the third species. We also assume that the two competing fish species releases a toxic substance to each other. We derive the condition for global stability of the system using a suitable Lyapunov function. The possibility of existence of bionomic equilibrium is considered. The optimal harvest policy is studied and the solution is derived under imprecise inflation in fuzzy environment using Pontryagin's maximal principle. Finally some numerical examples are discussed to illustrate the model.

Toxicological and Pharmacological Studies of New Coumarin and Furocoumarin Derivatives in Albino rats

  • Shabrawy, Osama A. El;Batran, Seham Abd El Sattar El;Mahran, Mohamed Refat H.;Ibrahim, Nabila M.
    • Natural Product Sciences
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    • v.17 no.4
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    • pp.309-314
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    • 2011
  • Synthetic coumarin and furocoumarin derivatives were evaluated for anticoagulant activity and the effect on liver and kidney function. It was found that all of the compounds under investigation proved to be neither toxic nor lethal up to 500 mg/100 g body weight as a single dose for 24 hrs. All tested compounds showed a significant increase in prothrombin time (PT) in the acute model but failed to show a significant action in the chronic model. Furthermore, all tested compounds revealed a significant increase in activated partial thromboplastin time (APTT) as compared to control value in both acute and chronic model. Also, all tested compounds did not cause any significant changes on liver and kidney functions in rats.

HDTMA-Bentonite로부터 페놀류 화합물의 경쟁탈착

  • 신원식;김영규;송동익
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • 2001.04a
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    • pp.15-18
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    • 2001
  • Sorption/desorption studies were conducted to determine sorption/desorption characteristics of phenolic compounds (phenol and 4-chlorophenol) in organically modified natural bentonite. The cationic exchange capacity (CEC) of bentonite was exchanged with a cationic surfactant, hexadecyltrimethylammonium (HDTMA), to enhance the removal capacity of organic phenol contaminants dissolved in aqueous solution. This modification produces a change of the surface property of bentonite from hydrophilic to organophilic. The single-solute and bi-solute competitive adsorptions were performed In batch mode to investigate the removal of two toxic organic Phenols, chlorophenol and 4-chlorophenol on the HDTMA-bentonite. The adsorption affinity of the 4-chlorophenol was higher than phenol due to higher octanol:water partition coefficient (Kow). The single-solute and bi-solute competitive desorptions were also performed investigate the competitive desorption of the phenolic compounds from HDTMA-bentonite. Freundlich model was used to analyze the single-solute adsorption/desorption results, while the IAST model predicted the hi-solute adsorption/desorption equilibria. The IAST model well predicted hi-solute competitive adsorption/desorption behaviors.

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Reducing Toxic Response Generation in Conversational Models using Plug and Play Language Model (Plug and Play Language Model을 활용한 대화 모델의 독성 응답 생성 감소)

  • Kim, Byeong-Joo;Lee, Geun-Bae
    • Annual Conference on Human and Language Technology
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    • 2021.10a
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    • pp.433-438
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    • 2021
  • 대화 시스템은 크게 사용자와 시스템이 특정 목적 혹은 자유 주제에 대해 대화를 진행하는 것으로 구분된다. 최근 자유주제 대화 시스템(Open-Domain Dialogue System)에 대한 연구가 활발히 진행됨에 따라 자유 주제를 기반으로 하는 상담 대화, 일상 대화 시스템의 독성 발화 제어 생성에 대한 연구의 중요성이 더욱 커지고 있다. 이에 본 논문에서는 대화 모델의 독성 응답 생성을 제어하기 위해 일상 대화 데이터셋으로 학습된 BART 모델에 Plug-and-Play Language Model 방법을 적용한다. 공개된 독성 대화 분류 데이터셋으로 학습된 독성 응답 분류기를 PPLM의 어트리뷰트(Attribute) 모델로 활용하여 대화 모델의 독성 응답 생성을 감소시키고 그 차이를 실험을 통해 정량적으로 비교한다. 실험 결과 어트리뷰트 모델을 활용한 모든 실험에서 독성 응답 생성이 감소함을 확인하였다.

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Development of Engineering Model for a Barge Moulted Seabed Sludge Treatment Plant (해저 오염 퇴적층 복원 처리를 위한 BMP 패키지 기술 개발)

  • 배준홍;하문근;어경해;김승혁;박찬후;김병우;구근회;윤철원
    • Journal of Ocean Engineering and Technology
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    • v.17 no.2
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    • pp.8-13
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    • 2003
  • Soil, ground water, and sea bed are exposed to a continuous accumulation of polluted materials, causing serious environmental damage. It has been reported that such pollution causes a massive mortality of fish stock in rivers due to the resuspension of toxic chemicals, occurring during strong wind conditions. Therefore, it becomes apparent that there is an immediate demand for the restoration treatment of polluted river bed (or sea bed) sediment layers. Pollution levels of major rivers and ports, such as Paldang, Kyungan rivers, and Masan port, are becoming of great public concern, and are posing a serious environmental threat. In particular, the pollution of the Shi-hwa river has become a nation wide issue for the last few years. In spite of such public concern, the pollution levels of such rivers or ports are worsening everyday. In this study, an environmentally sound engineering package is introduced that helps to restore the polluted river bed or sea bed sediments. This engineering package consists of a suction facility, followed by a series of mechanical, chemical, and biological treatment units. The suction facility is designed to minimize secondary pollution that occurs from the resuspension of toxic materials during suction. The sea bed cleaning engineering package is designed to be installed on the top of a floating barge. Such a combination of environmental plant and shipbuilding technology provides a cost-effective solution, minimizing the transportation between suction and treatment facilities.

A study on myo-inositol transport system in peripheral nerve isolated from lead-intoxicated rat. (납 중독 랫드의 말초신경내 myo-inositol 수송 체계에 관한 연구)

  • 정명규;조해용
    • Journal of environmental and Sanitary engineering
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    • v.11 no.2
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    • pp.21-26
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    • 1996
  • In our previous studies, we reported that lead intoxicated nerve cell by inhibition of the Na$^{+}$-K$^{+}$ ATPase activity and reduction of myo-inositol in nerve cell. As the second series of experiments, in order to understand toxic mechanism of lead for nerve cell, the characteristics of myo-inositol transport system and the effect of lead on its system have been studied in the sciatic nerves of control and lead-treated rats. A lead intoxicated animal model was induced by feeding diet containing lead to Sprague-Dawley rat for two weeks. Four weeks aged Sprague-Dawley rats were divided into three group : normal control group, 10ppm-lead treated group, 100ppm-lead treated group. All rats were sacrified at the end of two weeks. The rate o myo-inositol transport by sciatic nerve isolated from lead-treated rat was significantly decreased compared with that of control rat. This deficit results from that myo-inositol transport system which is carrier mediated and sodium-potassium dependent was inhibited by the lead treatment (both 10ppm and 100ppm) due to increase of the Km value without affecting Vmax value for myo-inositol carrier. These observations suggest that the toxic mechanism of lead on nerve myo-inositol transport system might be a change of affinity without change of maximum transport velocity for carrier.

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Increase of Antioxidant Activities of Egg White Protein Hydrolysate by Fractionation without Using Toxic Chemicals

  • Park, Eun Young;Sato, Kenji
    • Culinary science and hospitality research
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    • v.24 no.2
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    • pp.103-111
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    • 2018
  • The objectives of the present study were to examine the antioxidant activity of autofocusing fractions from egg white protein hydrolysates and obtain higher antioxidant peptide fraction, which could be applied to the food model system. Alkaline protease hydrolysate of egg white protein exerted higher antioxidant activities than other protein hydrolysates and were fractionated on the basis of the amphoteric nature of sample peptides by preparative isoelectric focusing without toxic solvents and reagents, which is termed autofocusing. Neutral and basic fractions showed higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than the acidic fractions. The acidic and neutral fractions showed higher hydroxyl (OH) radical scavenging activity and oxygen radical absorbance capacity (ORAC) values than the basic fractions. The acidic fractions showed higher metal chelating activity than basic fractions. Antioxidant activities of some autofocusing fractions except for ORAC showed higher compared to the crude hydrolysate. These results suggest that peptides fractions from egg white protein are effective antioxidant, and that autofocusing could be useful to increase antioxidant activity for application to food system.

Removal of Toxic Pollutants from Aqueous Solutions by Adsorption onto Organo-kaolin

  • Sayed Ahmed, S.A.
    • Carbon letters
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    • v.10 no.4
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    • pp.305-313
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    • 2009
  • In this study, the adsorption of toxic pollutants onto cetyltrimethylammonium kaolin (CTAB-Kaolin) is investigated. The organo-kaolin is synthesized by exchanging cetyltrimethylammonium cations (CTAB) with inorganic ions on the surface of kaolin. The chemical analysis, the structural and textural properties of kaolin and CTAB-kaolin were investigated using elemental analysis, FTIR, SEM and adsorption of nitrogen at $-196^{\circ}C$. The kinetic adsorption and adsorption capacity of the organo-kaolin towards o-xylene, phenol and Cu(II) ion from aqueous solution was investigated. The kinetic adsorption data of o-xylene, phenol and Cu(II) are in agreement with a second order model. The equilibrium adsorption data were found to fit Langmuir equation. The uptake of o-xylene and phenol from their aqueous solution by kaolin, CTAB-kaolin and activated carbon proceed via physisorption. The removal of Cu(II) ion from water depends on the surface properties of the adsorbent. Onto kaolin, the Cu(II) ions are adsorbed through cation exchange with $Na^+$. For CTAB-kaolin, Cu(II) ions are mainly adsorbed via electrostatic attraction with the counter ions in the electric double layer ($Br^-$), via ion pairing, Cu(II) ions removal by the activated carbon is probably related to the carbon-oxygen groups particularly those of acid type. The adsorption capacities of CTAB-kaolin for the investigated adsorbates are considerably higher compared with those of unmodified kaolin. However, the adsorption capacities of the activated carbons are by far higher than those determined for CTAB-kaolin.

Protective Effects of YCY against Hepatotoxicity Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) in Rats

  • Woon Kwon;Chai, Hee-youl;Young min Cho;Park, Ehn-kyoung;Kim, Ik-soo;Ryu, Kang-sun;Hwang, Seock-Yeon;Yun, Chi-Young;Kang, Jong-Koo
    • Proceedings of the Korean Society of Veterinary Pathology Conference
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    • 2003.10a
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    • pp.46-46
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    • 2003
  • Polychlorinated dibenzo-p-dioxins (PCDDs) are widespread, persistant, and highly toxic environmental pollutants. TCDD is the most potent congener among PCDDs and the most thoroughly investigated model compound of this class of chemicals. These compounds elicit a variety of common biochemical and toxic response, including specific binding to the cytosolic AHR [1] and induces a variety of biological response ranging from induction of cytochrome P-450 1A (CYP1A) to liver damage and cancer [2]. This study was carried out to investigate the protective effects of YCY, extract of a cricket, Gryllus bimaculatus, on hepatotoxicity in 6-week-old SD rat exposured to TCDD (omitted)

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