• Title/Summary/Keyword: Toxic information

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Identification of hazardous chemicalsin semiconductor manufacturing (반도체 제조업에서 유해화학물질의 확인)

  • Kim, Soo-Geun
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.22 no.1
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    • pp.20-25
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    • 2012
  • Objectives: Hazard identification is the most important step in occupational health monitoring at the workplace. This paper reviewed the several related stuffs to the hazard identification in the semiconductor industry. Methods: I checked the MSDS system, chemical toxic informations, trade secrets and by-products by experience and the literature used in semiconductor industry. Results: I found and experienced as follows; (1) There are a few inventory and history of chemicals used in workplace. Toxic information of chemicals to be available is very limited. (2) There are many trade secrets in MSDS for chemical mixtures. It is difficult to identify the accurate information from MSDS. (3) By-products is necessary to identify that they will produce in workplace. Conclusions: It is necessary to regulate the obligations of employers which check the inventory and history of chemicals used in workplace. It is necessary to amend the trade secrets in MSDS system.

Hazard Investigation of Cosmetic Ingredients in Korea (국내 화장품 원료성분에 대한 유해성 조사)

  • Choi, Hyeyoung;Choi, Sangjun;Park, Yunkyung;Choi, Inja
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.28 no.4
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    • pp.406-415
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    • 2018
  • Objective: The purpose of this study was to investigate the hazards of cosmetic ingredients in Korea. Methods: An Excel database of cosmetic ingredients was developed on a website(Korea Cosmetic Ingredient Dictionary) and used for a hazard assessment based on Tox-free, a database containing toxic information such as on carcinogens, mutagens or reproductive toxicants(CMRs) and endocrine disrupting chemicals(EDCs), as well as other regulated chemicals in Korea. Results: A total of 16,605 chemicals were registered with the cosmetic ingredient dictionary and 308 of them were identified as either CMRs or EDCs. CMRs included formaldehyde and nickel gluconate, and EDCs included parabens, benzophenon, styrene, and toluene. Reproductive toxicants such as xylene, zinc chloride, toluene, and formaldehyde were regulated by the Occupational Safety and Health Act and the Act on the Registration and Evaluation, etc. of Chemical Substances(the Chemical Control Act). Conclusions: Regulations on cosmetics components should be strengthened, and the right to know about cosmetics containing hazardous chemicals should be guaranteed.

An analysis of internet websites for searching domestic toxic information (국내 독성정보 검색을 위한 인터넷 웹사이트 분석)

  • Jung, Eun-Kyung;Kang, Ji-Hun
    • The Korean Journal of Emergency Medical Services
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    • v.24 no.3
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    • pp.117-128
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    • 2020
  • Purpose: This study analyzed the information and accessibility of toxic substances provided to Internet websites. Methods: From August 1, 2020, to August 31, 2020, we analyzed eight internet websites regarding toxic pharmaceuticals, pesticides, and chemicals. The website-evaluation criteria were divided into five categories for information and five categories for website convenience. Results: All eight websites about toxic substances were hosted by reliable institutions or organizations and provided accurate information in terms of informational relevance. The website run by the Safety and Health Corporation scored the highest with 100points. Analysis of the websites' accessibility to non-members' revealed that six (75.0%) were accessible, but two (12.5%) provided only limited information. Access to information through mobile apps was only available in three of the eight cases (37.5%). Conclusion: This study can be used as a reference for Internet websites about toxic substances. Toxicological information that can be viewed only with membership and manager approval requires membership in advance of viewing. In addition, emergency medical personnel working at a site or hospital should be familiar with the characteristics of toxicity information retrieval.

Application of Toxicogenomic Technology for the Improvement of Risk Assessment

  • Hwang, Myung-Sil;Yoon, Eun-Kyung;Kim, Ja-Young;Son, Bo-Kyung;Jang, Dong-Deuk;Yoo, Tae-Moo
    • Molecular & Cellular Toxicology
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    • v.4 no.3
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    • pp.260-266
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    • 2008
  • Recently, there has been scientific discussion on the utility of -omics techniques such as genomics, proteomics, and metabolomics within toxicological research and mechanism-based risk assessment. Toxicogenomics is a novel approach integrating the expression analysis of genes (genomic) or proteins (proteomic) with traditional toxicological methods. Since 1999, the toxicogenomic approach has been extensively applied for regulatory purposes in order to understand the potential toxic mechanisms that result from chemical compound exposures. Therefore, this article's purpose was to consider the utility of toxicogenomic profiles for improved risk assessment, explore the current limitations in applying toxicogenomics to regulation, and finally, to rationalize possible avenues to resolve some of the major challenges. Based on many recent works, the significant impact toxicogenomic techniques would have on human health risk assessment is better identification of toxicity pathways or mode-of-actions (MOAs). In addition, the application of toxicogenomics in risk assessment and regulation has proven to be cost effective in terms of screening unknown toxicants prior to more extensive and costly experimental evaluation. However, to maximize the utility of these techniques in regulation, researchers and regulators must resolve many parallel challenges with regard to data collection, integration, and interpretation. Furthermore, standard guidance has to be prepared for researchers and assessors on the scientifically appropriate use of toxicogenomic profiles in risk assessment. The National Institute of Toxicological Research (NITR) looks forward to an ongoing role as leader in addressing the challenges associated with the scientifically sound use of toxicogenomics data in risk assessment.