• 대한토목학회논문집
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• 제26권5A호
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• pp.823-832
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• 2006

PSC 합성거더교의 사용성을 만족시키기 위해서는 사용하중 상태에서 구조물에 발생하는 응력과 변형을 정확히 예측하는 것이 필수적이다. 응력과 변형은 콘크리트의 건조수축과 크리프, 그리고 긴장재의 리락세이션에 의한 영향으로 시간에 따라 연속적으로 변화된다. 시간의존적인 영향의 중요성은 전체 구조가 일시에 제작되는 경우보다 단계별로 시공되는 프리캐스트 프리스트레스트 콘크리트 구조물에서 더욱 커진다. 본 연구에서는 기존 30 m PSC거더 표준단면을 이용한 PSC 합성거더교에 대해 긴장력 도입시기와 콘크리트바닥판 타설시기의 변동성을 고려한 장기거동해석을 수행하였다. 단순교와 연속교에 대해 시공단계별 장기거동 해석을 위한 PSC 합성거더교 전용해석프로그램을 개발하였으며 이를 이용하여 변수해석을 수행하였다. 시공단계별 변수해석결과를 토대로 PSC 합성거더교의 장기거동특성과 현행 프리스트레스 감소량과 관련된 현행규정의 적용한계성을 분석하였다.

• Geomechanics and Engineering
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• 제21권5호
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• pp.489-501
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• 2020

This paper conducts a complicated coupled effective stress analysis of X-section-in-place concrete (XCC) pile installation and consolidation processes using the dual-stage Eulerian-Lagrangian (DSEL) technique incorporating the modified Cam-clay model. The numerical model is verified by centrifuge data and field test results. The main objective of this study is to investigate the shape effect of XCC pile cross-section on radial total stress, excess pore pressure and time-dependent strength. The discrepancies of the penetration mechanism and set-up effects on pile shaft resistance between the XCC pile and circular pile are discussed. Particular attention is placed on the time-dependent strength around the XCC pile shaft. The results show that soil strength improved more significantly close to the flat side compared with the concave side. Additionally, the computed ultimate shaft resistance of XCC pile incorporating set-up effects is 1.45 times that of the circular pile. The present findings are likely helpful in facilitating the incorporation of set-up effects into XCC pile design practices.

• 가정과삶의질연구
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• 제32권1호
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• pp.1-12
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• 2014

The purpose of this study was to examine: (1) whether the level of parental monitoring changes during adolescence; (2) if it changes, what is the pattern of the change; and (3) whether the effects of adolescents' attachment to their parents on parental monitoring are dependent on time. Six waves of data from the Korea Youth Panel Study (KYPS) were used to address the research questions. The participants of the KYPS were 3,449 (1,725 boys and 1,724 girls) adolescents who participated in the study once a year for 6 years (from the 2nd grade in middle school until their high school graduation). Latent growth modeling (LGM) was used to analyze the data. The findings are as follows: the level of parental monitoring significantly increased over the six waves of the study, and the adolescents' attachment to their parents was a time-dependent predictor of parental monitoring. The results indicate that the quality of adolescents' attachment to their parents is an important factor that makes a difference in the level of parental monitoring by, possibly, affecting the level of adolescents' disclosure to their parents.

• Geomechanics and Engineering
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• 제18권3호
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• pp.299-313
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• 2019

This research investigated the nonlinear compressibility, permeability, the yielding due to structural degradation and their effects on consolidation behavior of structured soft soils. Based on oedometer and hydraulic conductivity test results of natural and reconstituted soft clays, linear log (1+e) ~ $log\;{\sigma}^{\prime}$ and log (1+e) ~ $log\;k_v$ relationships were developed to capture the variations in compressibility and permeability, and the yield stress ratio (YSR) was introduced to characterize the soil structure of natural soft clay. Semi-analytical solutions for one-dimensional consolidation of soft clay under time-dependent loading incorporating the effects of soil nonlinearity and soil structure were proposed. The semi-analytical solutions were verified against field measurements of a well-documented test embankment and they can give better accuracy in prediction of excess pore pressure compared to the predictions using the existing analytical solutions. Additionally, parametric studies were conducted to analyze the effects of YSR, compression index (${\lambda}_r$ and ${\lambda}_c$), and permeability index (${\eta}_k$) on the consolidation behavior of structured soft clays. The magnitude of the difference between degree of consolidation based on excess pore pressure ($U_p$) and that based on strain ($U_s$) depends on YSR. The parameter ${\lambda}_c/{\eta}_k$ plays a significant role in predicting consolidation behavior.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.214.1-214.1
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• 2003

Metabonomic analysis using Liquid Chromatography-Mass Spectrometry (LC-MS) was employed to test the feasibility to predict chemical-induced toxicity. Time-dependent metabolic variations were evaluated in rats treated with the model hepatotoxin, ${\alpha}$- naphthylisothiocyanate (ANIT). Urine samples of ANIT treated group and control group were collected up to 7 days postdose. Urine samples were analyzed by gradient HPLC combined with electrospray mass spectrometry. The chromatographic results were data-reduced and analyzed using principal component analysis to show the time dependent biochemical variations induced by ANIT toxicity. (omitted)

• 산업경영시스템학회지
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• 제36권4호
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• pp.130-137
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• 2013

In this paper, we consider a two-agent scheduling with sequence-dependent exponential learning effects consideration, where two agents A and B have to share a single machine for processing their jobs. The objective function for agent A is to minimize the total completion time of jobs for agent A subject to a given upper bound on the objective function of agent B, representing the makespan of jobs for agent B. By assuming that the learning ratios for all jobs are the same, we suggest an enumeration-based backward allocation scheduling for finding an optimal solution and exemplify it by using a small numerical example. This problem has various applications in production systems as well as in operations management.

• 콘크리트학회지
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• 제5권2호
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• pp.181-188
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• 1993

본 논문에서는 철근콘크리트 쉘 구조물의 크리프와 건조수축에 의한 시간의존성 효과를 포함하여 해석할 수 있는 기법을 개발하였다. Degenerate 쉘 요소를 해석에 사용하였으며 층 분할 기법을 이용하였다. 콘크리트의 압축 거동 모델은 탄-소성 모델 혹은 변형율 경화 모델을 사용할 수 있도록 하였고, 인장 영역에서는 균열 발생시 까지 선형 탄성으로 가정하였다. 철근은 등가의 두께를 가지는 철근 층으로 근사되었으며 각 철근 층은 철근의 배치 방향으로만 저항하는 일축거동을 하며 응력-변형율 곡선을 두 개의 직선으로 이상화 하였다. 비선형 해석을 위해 하중 증분 기법과 반복계산 기법을 사용하였으며 시간 의존성 효과를 고려하기 위해 시간영역을 같은 간격이 아닐 수도 있는 여러 개의 구간으로 나누어 해석하였다. 몇 개의 계산 예를 제시하고 다른 연구자들의 결과와 비교하여 본 연구의 타당성을 검토하였다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.319-322
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• 2005

When a concrete structure is subjected to load, its response is both immediate and time dependent. Under sustained load, the deformation of a structure gradually increases with time and eventually may be many time greater than its instantanneous value. The gradual development of strain with time is caused by creep and shrinkage. On this study, to estimate of stress variations on time effects in partially prestressed concrete composite girder bridges, computer program applied Age-adjusted Effective Modulus Method(AEMM) in used.

• 산업경영시스템학회지
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• 제38권3호
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• pp.169-180
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• 2015

Recently, scheduling problems with position-dependent processing times have received considerable attention in the literature, where the processing times of jobs are dependent on the processing sequences. However, they did not consider cases in which each processed job has different learning or aging ratios. This means that the actual processing time for a job can be determined not only by the processing sequence, but also by the learning/aging ratio, which can reflect the degree of processing difficulties in subsequent jobs. Motivated by these remarks, in this paper, we consider a two-agent single-machine scheduling problem with linear job-dependent position-based learning effects, where two agents compete to use a common single machine and each job has a different learning ratio. Specifically, we take into account two different objective functions for two agents: one agent minimizes the total weighted completion time, and the other restricts the makespan to less than an upper bound. After formally defining the problem by developing a mixed integer non-linear programming formulation, we devise a branch-and-bound (B&B) algorithm to give optimal solutions by developing four dominance properties based on a pairwise interchange comparison and four properties regarding the feasibility of a considered sequence. We suggest a lower bound to speed up the search procedure in the B&B algorithm by fathoming any non-prominent nodes. As this problem is at least NP-hard, we suggest efficient genetic algorithms using different methods to generate the initial population and two crossover operations. Computational results show that the proposed algorithms are efficient to obtain near-optimal solutions.

• 동의생리병리학회지
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• 제16권4호
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• pp.745-755
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• 2002

To examine the effects of Yunpyesan on the cell proliferation of A549 human lung carcinoma cell line, we performed various experiments such as dose-dependent effect of Yunpyesan on cell proliferation and viability, morphological changes, quantification of apoptotic cell death and alterations of apoptosis/cell cycle-regulatory gene products. Yunpyesan declined cell viability and proliferation in both a dose- and a time-dependent manner. The anti-proliferative effect by Yunpyesan treatment in A459 cells was associated with morphological changes such as membrane shrinking and cell rounding up. Yunpyesan Induced apoptotic cell death in a time-dependent manner, which was associated with degradation of poly-(ADP-ribose) polymerase (PARP), an apoptotic target protein, without alterations of the balance between Bcl-2 and Bax expressions. DNA flow cytometric histograms showed that population of G1 phase of the cell cycle was increased by Yunpyesan treatment in a dose-dependent manner. Western blot analysis revealed that cyclin D1 and A were reduced by Yunpyesan treatment, whereas cyclin dependent kinase (Cdk) inhibitor p27 was markedly increased in a time-dependent fashion. The level of tumor suppressor p53 proteins was also increased by Yunpyesan treatment and its increase might be linked to increase of Cdk inhibitor p27. In addition, Mdm2, negative regulator of p53, was down-regulated by Yunpyesan treatment. Since the expression of retinoblastome protein (pRB), a key regulator of G1/S progression, was reduced by Yunpyesan treatment, we supposed that phosphorylation of pRB might be also blocked. The present results indicated that Yunpyesan-induced inhibition of lung cancer cell proliferation is associated with the induction of apoptosis and the blockage of G1/S progression.