• Title/Summary/Keyword: Three-component reaction

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A Simple and Efficient One-Pot Three-Component Synthesis of Propargylamines Using Bismuth (III) Chloride

  • Teimouri, Abbas;Chermahini, Alireza Najafi;Narimani, M.
    • Bulletin of the Korean Chemical Society
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    • v.33 no.5
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    • pp.1556-1560
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    • 2012
  • A simple highly versatile and efficient method has been developed for the three-component coupling of aldehydes, amines and alkynes to prepare propargylamines, in the presence of a catalytic amount of $BiCl_3$. The advantages of methods are high yield, mild reaction conditions, no environmental pollution and easy work up procedure.

Magnesium Bistrifluoromethanesulfonimide Catalyzed Three-component Synthesis of Protected Homoallylic Amines

  • Wang, Hongshe;Zeng, June
    • Bulletin of the Korean Chemical Society
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    • v.32 no.7
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    • pp.2203-2206
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    • 2011
  • A mild and efficient procedure has been developed for the one-pot, three-component reaction of aldehydes, benzyl carbamate and allyltrimethylsilane in the presence of 3 mol % of magnesium bistrifluoromethanesulfonimide at room temperature to afford the corresponding protected homoallylic amines in high yields.

Asymmetric Synthesis of 12-epi-$PGF_{2α}$ by a Palladium-Mediated, Three-Component Coupling Reaction

  • 이남호;Richard C. Larock
    • Bulletin of the Korean Chemical Society
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    • v.16 no.9
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    • pp.859-863
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    • 1995
  • The prostaglandin analogue 12-epi-PGF2α (2) has been synthesized from optically active cis-4-t-butyldimethylsilyloxy-2-cyclopenten-1-ol (4b) in 4 steps in an overall yield of 21%. An extremely efficient Pd(Ⅱ)-mediated, three-component coupling reaction is employed to obtain the key intermediate 9.

Tin-Free Three-Component Coupling Reaction of Aryl Halides, Norbornadiene (or Norbornene), and Alkynols Using a Palladium Catalyst

  • Choi, Cheol-Kyu;Hong, Jin-Who;Tomita, Ikuyoshi;Endo, Takeshi
    • Bulletin of the Korean Chemical Society
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    • v.23 no.1
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    • pp.112-118
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    • 2002
  • Good-to-excellent yields of 2,3-Disubstituted norbornenes (or norbornanes) were obtained using a Pd/Cu catalyzed three-component ternary coupling reaction of aryl halides, norbornadiene (or norbornene), and alkynols in toluene at $100{\circ}C$ in the presence of 5.5 M NaOH as a base and benzyltriethylammonium chloride as a phase transfer catalyst. The results of experiments using various aromatic halides suggest that the ternary coupling reaction is promoted by bromide.

An Efficient Synthesis of α-Amino-δ-valerolactones by the Ugi Five-Center Three-Component Reaction

  • Kim, Young-Bae;Park, Soo-Jung;Geum, Gyo-Chang;Jang, Min-Seok;Kang, Soon-Bang;Lee, Duck-Hyung;Kim, You-Seung
    • Bulletin of the Korean Chemical Society
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    • v.23 no.9
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    • pp.1277-1320
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    • 2002
  • A novel approach to ${\alpha}-amino-{\delta}-valerolactone$ derivatives 8 by the intramolecular Ugi five-center three-component reaction (U-5C-3CR) using the multifunctional starting material, L-pentahomoserine 5 is described.

GLOBAL COUPLING EFFECTS ON A FREE BOUNDARY PROBLEM FOR THREE-COMPONENT REACTION-DIFFUSION SYSTEM

  • Ham, Yoon-Mee
    • Journal of the Korean Mathematical Society
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    • v.43 no.3
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    • pp.659-676
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    • 2006
  • In this paper, we consider three-component reaction-diffusion system. With an integral condition and a global coupling, this system gives us an interesting free boundary problem. We shall examine the occurrence of a Hopf bifurcation and the stability of solutions as the global coupling constant varies. The main result is that a Hopf bifurcation occurs for global coupling and this motion is transferred to the stable motion for strong global coupling.

Silica Gel-Supported Polyphosphoric Acid (PPA-SiO2) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction

  • Zeinali-Dastmalbaf, Mohsen;Davoodnia, Abolghasem;Heravi, Majid M.;Tavakoli-Hoseini, Niloofar;Khojastehnezhad, Amir;Zamani, Hassan Ali
    • Bulletin of the Korean Chemical Society
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    • v.32 no.2
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    • pp.656-658
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    • 2011
  • A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA-$SiO_2$) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.

Quantitative Analysis of Hydrate products of the Cement Paste Mixed with Admixtures (혼화재 혼입 시멘트 페이스트의 수화생성물 정량 분석)

  • Park, Dong-Cheon
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2021.11a
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    • pp.176-177
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    • 2021
  • In order to compensate for the defects of concrete made using only Portland cement, three-component powder mixed with blast slag and fly ash, and four-component powder concrete mixed with silica fume are being produced. When each of the admixtures is used alone, the above-described excellent performance is expressed and up to 70% of the powder is used. These technologies are also contributing to the reduction of greenhouse gases under Act on Low Carbon. Green Growth. However, calcium hydroxide is consumed as a stimulator or reaction in the case of silica fume, which causes latent hydroponicity of slag, pozzolane reaction, and silica mixtures represented by fly ash. It is known that the consumption of calcium hydroxide affects the alkalinity of concrete. As a result, the carbonation resistance is significantly lower among the durability of concrete. Research on quantification of such effects is insufficient. In this study, an experiment was conducted to quantify calcium hydroxide of the three-component and four-component powder paste using thermal analysis equipment (DTG), and the effect of the mixing amount was discussed.

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A Green One-Pot Protocol for Regioselective Synthesis of New Substituted 7,8-Dihydrocinnoline-5(6H)-ones

  • Khalafy, Jabbar;Rimaz, Mehdi;Ezzati, Mahnaz;Prager, Rolf H.
    • Bulletin of the Korean Chemical Society
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    • v.33 no.9
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    • pp.2890-2896
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    • 2012
  • A simple regioselective synthesis of cinnoline derivatives was achieved by a one-pot three component synthetic methodology. New substituted 7,8-dihydrocinnolin-5(6H)-ones are prepared via one-pot three component reaction of arylglyoxals with 1,3-cyclohexanedione and dimedone in the presence of hydrazine hydrate in moderate to good yields.