Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Asymmetric Synthesis of 12-epi-$PGF_{2α}$ by a Palladium-Mediated, Three-Component Coupling Reaction

  • Published : 1995.09.20
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Abstract

The prostaglandin analogue 12-epi-PGF2α (2) has been synthesized from optically active cis-4-t-butyldimethylsilyloxy-2-cyclopenten-1-ol (4b) in 4 steps in an overall yield of 21%. An extremely efficient Pd(Ⅱ)-mediated, three-component coupling reaction is employed to obtain the key intermediate 9.

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