• Journal of Genetic Medicine
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• v.13 no.2
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• pp.59-64
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• 2016

Gaucher disease type 1 (GD1) is an inherited lysosomal storage disorder caused by deficiency of acid ${\beta}$-glucosidase. The diminished enzyme activity leads to the accumulation of substrates and results in multi-systemic manifestations including hepatosplenomegaly, anemia, thrombocytopenia, and bone diseases. Enzyme replacement therapy (ERT) by infusion of recombinant protein has been the standard treatment for over 20 years. Despite the successful long-term treatment with ERT, several unmet needs remain in the treatment of GD1 such as severe pulmonary and skeletal manifestations. Substrate reduction therapy (SRT) reduces the accumulation of substrates by inhibiting their biosynthesis. Eliglustat, a new oral SRT, was approved in United States and Europe as a first-line therapy for treating adult patients with GD1 who have compatible CYP2D6 metabolism phenotypes. Although eliglustat is not yet available in Korea, introduction and summary of this new treatment modality are provided in this paper by review of literatures. Despite the fact that there are only limited studies to draw resolute conclusions, the current data demonstrated that eliglustat is not inferior to ERT in terms of its clinical efficacy. The approval of eligustat enables eligible adult GD1 patients to have the option of oral therapy although it still needs further studies on long-term outcomes. The individual patient should be assessed carefully for the choice of treatment modality when eliglustat becomes available in Korea. Furthermore, the clinical guidelines for Korean patients with GD1 regarding the use of eliglustat needs to be developed in near future.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.3
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• pp.95-105
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• 2022

Purpose : This study aims to systematically review the methods of occupational therapy intervention in children with autism spectrum disorders having sleep disorders and evaluate the improvements with intervention effects, based on experimental studies of children with sleep disorders. Methods : Studies published overseas from January 2011 to June 2021 were searched from a total of two databases. Science Direct and OTseeker. The five selected studies were analyzed by dividing them into age, number, intervention period, intervention type, intervention effect, evaluation tool, research design type, and evidence level. Results : The total number of subjects was 182, 95 subjects in ther experimental group, and 87 in the control group. The interventions included weighted blankets, swimming, and sleep education for parents. Ther interventions were found to increase total sleep time, improve mood when waking up, reduce sleep anxiety, reduce sleep time, reduce the number of waking up of during sleep, and reduce sleep resistance behavior. Conclusion : Many people have sleep disorders, with or without disabilities, and the number is gradually increasing. Consequently, research on occupational therapy intervention in children with autism spectrum disorder are actively conducted in foreign countries, and these interventions have a positive effect. Based on the results of this study, it can be concluded that such occupational therapy intervention studies are necessary for children with autism spectrum disorder with sleep disorders in Korea. In addition, further research on the quality of life of parents of children with autism spectrum disorders due to sleep disorders and their methods are required.

• Journal of Korean Physical Therapy Science
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• v.14 no.1_4
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• pp.37-54
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• 2007

We discuss why many current physical therapy entry-level programs are not designed to educate the type of physical therapy practitioners needed for the 21st century. We face a situation that we have to promote the profession's role in the prevention, diagnosis, and treatment of movement dysfunctions and the enhancement of the physical health and functional abilities of members of the public. The way how to train professional physical therapists became crucial. The purpose of study was to enhance the educational goals of physical therapy and the physical therapy curricula in Korea. In this study, we compared physical therapy training curricula recommended by WCPT with physical therapy training curricula in universities in other countries by dividing physical therapy curricula in universities and colleges into physical therapy students' electives, major required courses, labs and clinical practices, and counting the proportion of each category in the total credit hours. We discuss differences and similarities between curriculum in a university in Korea and curriculum in a university in the United States. We discussed possibly problematic portions of current physical therapy training curricula in korean universities. Finally, we statistically analyzed the regulations of WCPT and Health and Welfare Ministry in Japan, the Physical therapy curriculum of Creighton Entry-level DPT Program in the U.S. and the Inje University in Korea. The progressing direction of curricula in Korea had been researched. The future direction that korean physical therapy is to use an united curriculum that includes basic requirements of WCPT for all universities and colleges in Korea, rather than using each university's own modified version. The results of study can be helpful for developing a basic level of integrated curricula in universities and colleges in Korea.

• Journal of Korean Physical Therapy Science
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• v.5 no.2
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• pp.583-593
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• 1998

The purpose of this study was to analyze the effects of body shape variation of the clinical characteristics of patients who suffered from Adolescent idiopathic scoliosis. The data were collected from the spine clinics who were all thirty healthy make and female, from April, 1995 to May, 1998. The results of study were as follows ; 1. Total patients statistics mean age is 19years and 21 female, 9 male. 2. We divided 30 patients into four types(I, II, III, IV) by Evaluation form. As the result, Lots of patients included type IV. 3. Body type(IV) : Deformity style of Rt. shoulder & Lt. Pelvis forward style. 4. Body type IV showed a specific character in their life style. When the right shoulder forwarded and left pelvis is ant. tilting. The patients moved always their Lt. lower extremity first in Rt. lower extremity support the weight of body. And moved always their Rt. upper extremity in Lt. upper extremity support the weight of body.

• Journal of the Korean Society of Physical Medicine
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• v.2 no.2
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• pp.161-171
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• 2007

Purpose : The purpose of this study was to evaluate the effect of footwear on gait in older adults. Methods : The footwear consists of loafer with fixation and mule and slipper without fixation. Twenty one female older adults voluntarily participated in this study. Each participant walked on the gait system GAITRite and measured temporal-spatial gait parameters. And the participants wore loafer, mule, slipper randomly. We measured stance time, swing time, heel-to-heel BOS, double support time, velocity, cadence, FAP as temporal-spatial gait parameters. Results : Three gait parameters showed significant difference statistically among 7 gait parameters. The stance time increased as loafer, mule, barefoot, slipper orderly. And there was a significant difference statistically (p<.05). The swing time increased as slipper, barefoot, mule, loafer orderly. And there was a significant difference statistically(p<.05). And the heel-to-heel BOS increased as barefoot, loafer, mule, slipper orderly. And there was a significant difference statistically(p<.05) according to footwear type. Conclusion : The footwear type with high stability like loafer is considered better than footwear type with low stability like mule and slipper for the elderly.

• Physical Therapy Korea
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• v.5 no.1
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• pp.63-78
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• 1998

The decrease of muscle power and muscle size between twenties and seventies was about 30% and 40% respectively. The loss of muscle mass by aging resulted in the decrease of muscle power. The loss of muscle mass was due to the decrease of number of Type I fiber and Type II fiber and size of each muscle fiber. The aging skeletal muscle didn't show the loss of glycolysis capacity but showed 20% decrease of the oxidative enzymes and muscle vascularization. The vigorous endurance exercise training with graded intensity played a role in the vascular proliferation, increase of activity of oxidative enzymes and improvement of $VO_2$ max. The graded resistance exercise also played a role in the muscle hypertrophy and increase of muscle power, if it performed with adequate intensity and period. The exercise adaptation of aging skeletal muscle prevented it from sarcopenia, provided the activity of daily living with great effect and provided the aging related disease, that is Type II diabetes mellitus, arteriosclerosis, hypertension, osteoporosis and obesity, with great effect.

• The Journal of Pediatrics of Korean Medicine
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• v.23 no.1
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• pp.115-126
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• 2009

Objectives The purpose of this study is to introduce oriental medicine music therapy related to the treatment of ADHD. Methods This study observed ADHD from the oriental medical point of view and tried to treat this disease with the oriental medicine music therapy. Results ADHD is caused by excess of Yang energy, flaming-up of fire, blood deficiency of the heart and the spleen, deficiency of the kidney essence, and instability of emotions. The ADHD patients with the case of excess of Yang energy and flaming-up of fire, patients were played Fire-Gi rhythm as a treatment, and they listened to Metal-Gi music. Whereas, the ADHD patient with blood deficiency of the heart and the spleen, invigoration of vital energy music therapy can be used. Another case of ADHD patients with deficiency of the kidney, Water-Gi rhythm and replenishing vital essence music therapy can be used. According to the patients' seven modes of emotions, the proper music should be chosen. Conclusions Oriental medicine music therapy can be a new type of treatment for ADHD patients.

• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.65-72
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• 2002

Recently, stem cell-mediated gene therapy is emerging as a novel therapeutic approach. For the successful gene modification of stem cells, the development of a suitable gene transfer technique needs to be preceded. This review focuses on the various gene transfer techniques based on nonviral and viral vectors, and physical methods. The advantages and disadvantages of each gene transfer method are compared, and the general properties of these vectors are discussed in relation to the gene transfer in stem cell research. This review also highlights the therapeutic application of stem cell-mediated gene therapy. The choice of gene transfer vectors may vary depending on the type of the stem cells and the target of stem cell therapy. Of various gene transfer methods, viral vector-based gene therapy has been emphasized due to the higher transfection efficiency. The current status and up-to-date findings of stem cell-mediated gene therapy are discussed in the viewpoint of the various targets of stem cell therapy such as the modification of stem cell potency, the acceleration of regeneration process and the formation of expressional organization.

• Korean Journal of Adult Nursing
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• v.16 no.1
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• pp.111-122
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• 2004

Purpose: The purpose of this study was to describe the using pattern of alternative therapies in the elderly. Method: 197 subjects, persons who were more than 60 years old, we interviewed. We modified and complemented Shin's(2000) instrument in accordance with purpose of this study. Data were analyzed statistically by using SAS program. Result: 1. It was shown that 66.84% of subjects have utilized one or more types of alternative therapy. 2. It was shown that the most frequently used types are acupuncture (48.83%), and ethmoid bone therapy (42.75%). 3. Acupuncture was shown to be the most satisfactory type of therapy (14.50%). 4. There was a significant difference in the use ratio by sex; female 73.47% and male 60.20%. 5. Among users of alternative therapies, the most frequent responses to each question were as follows; 1. Motive of Use - "for complete cure of symptoms" (32.31%). 2. Side effects - "no side effects" (95.97%). Conclusion: We found that elderly persons used alternative therapies more frequently than others perpulations. Diet therapy and Hand therapy were most commonly used in older people. Although the elderly use alternative therapy, they cannot place confidence in its scientific reliability. Therefore, we need to examine the effects of alternative therapy.

• Journal of People, Plants, and Environment
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• v.22 no.4
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• pp.395-410
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• 2019

The purpose of this study was to investigate 199 subfertile women's interest in and needs for forest therapy programs according to their demographic characteristics in a subfertile clinic in Seoul to provide basic data. The results of this study were summarized as follows. First, the perception and experience of subfertile women about forest therapy were all low, but their intention to participate was generally positive. Second, the type of forest therapy preferred by subfertile women was a half-day small group that they can participate with their spouse during weekends. Third, subfertile women expected phytoncide (35.8%) and a high level of oxygen (29.9%) from forest therapy programs. Fourth, subfertile women expected physical and mental health such as improved blood circulation and immunity, and meditation opportunity from forest therapy. Fifth, subfertile women expected from forest therapists understanding and sympathy (62.2%). This study conducted a survey on 199 subfertile women only. Through follow-up studies that involve more subfertile subjects and a broader region, it will be possible to develop more effective forest therapy programs for promoting the physical and mental health of subfertile subjects.