• 대한공업교육학회지
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• v.40 no.2
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• pp.44-71
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• 2015

This study is aimed to analyze the cognitive level of basic job skill for students, graduates, and teachers in a specialized high school, as well as for workers in a company, and to suggest an optimal educational curriculum by deciding the priority of the basic job skill in education in the field of mechanic, electric electronic semiconductor, and architecture civil engineering construction. This research was undertaken with the use of various statistic skills, the Borich method, and the locus for focus model. Also, this research shall be valued in synthetic understandings for curriculum revising. The educational priority which shall be applied to the mechanic, electric electronic semiconductor, and architecture civil engineering construction at specialized high school was analyzed, and according to this, a new curriculum was suggested. For mechanic, it put its educational priority on Expressing oneself, Problem solving, Self-development, Career development, Managing time, Negotiation, and Understanding technology. For electric electronic semiconductor, its focus was on Managing time, and for architecture civil engineering construction, they emphasized Problem solving, Self-development, Career development, Managing time, and Conflict management.

• Journal of the Korean Society of Safety
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• v.39 no.3
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• pp.60-67
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• 2024

This study aimed to identify challenges faced by occupational health and safety education institutions to derive and propose methods of improving occupational health and safety education. To achieve this, 13 personnel responsible for occupational health and safety education institutions were interviewed, resulting in the identification of 14 areas for improvement. Consequently, a survey was developed and conducted among 107 individuals from 195 occupational health and safety education institutions. The priorities of the 14 items were analyzed using methods such as the content validity ratio (CVR), paired t-test, locus for focus model, Borich's needs assessment, and effect size (Cohen's d). The research results highlighted significant challenges, including the importance of mitigating abnormal competition among occupational health and safety education institutions, improving awareness among employers and workers regarding the importance of occupational health and safety education, and developing programs that satisfy customer demands.

• Educational Technology International
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• v.24 no.2
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• pp.143-168
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• 2023

This study aims to analyze the perceptions and educational needs of pre-service teachers for the use of Artificial Intelligence (AI) in education. To this end, we collected survey data from 25 undergraduate students who were enrolled in a teacher education college in Seoul. The purpose of the survey was to measure the importance and current performance for instructional AI use based on the technological, pedagogical, and content knowledge (TPACK) framework, and to explore the priority of educational needs using Borich's needs analysis and the Locus for Focus model. The results of the study confirmed that Ethics and TPK competencies are prioritized. Additionally, the results indicated a high demand for practical knowledge that can be implemented in the practice of education. Based on the results, it is necessary to develop a teacher education program that focuses on ethical aspects and teaching strategy competencies in AI-based education.

• The Pure and Applied Mathematics
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• v.19 no.4
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• pp.315-325
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• 2012

Let A and B denote a point, a line or a circle, respectively. For a positive constant $a$, we examine the locus $C_{AB}$($a$) of points P whose distances from A and B are, respectively, in a constant ratio $a$. As a result, we establish some equivalent conditions for conic sections. As a byproduct, we give an easy way to plot points of conic sections exactly by a compass and a straightedge.

• Proceedings of the Safety Management and Science Conference
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• 2003.11a
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• pp.105-111
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• 2003

This paper examines to focus on General Strategy of e-logistics activity for SCM(Supply Chain Management) Build-up, especially the field service logistics Integration. And this research analyzes the case study (Business of Strategy Group Unit) Survey) involving effective logistics management that leads customer satisfaction, seeking to find out the key elements of competitive policy. Because problems arise from the differences between their goals and structures, which cause each sied to feel vulneralbe to opportunism or shirking of responsibilities by the other. The goal of a logistics system is to ensure that every family planning client always receives the contraceptives partner wants, and that they are in good condition and have not expired. In order to select, procure, and distribute the right Quantities of the right contraceptives, managers of the logistics system must keep informed of the rates of use of each contraceptive and of the Quantity of available supplies. As a result, We propose that a firm's e-logistics strategy is an important locus innovation and a crucial source of value creation for the firm its suppliers, partners, and customers.

• Journal of the Korea Safety Management & Science
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• v.5 no.4
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• pp.117-130
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• 2003

This paper examines to focus on General Strategy of e-logistics activity for SCM(Supply Chain Management) Build-up, especially the field service logistics Integration. And this research analyzes the case study(Business of Strategy Group Unit) Survey) involving effective logistics management that leads customer satisfaction, seeking to find out the key elements of competitive policy. Because problems arise from the differences between their goals and structures, which cause each sied to feel vulneralbe to opportunism or shirking of responsibilities by the other. The goal of a logistics system is to ensure that every family planning client always receives the contraceptives partner wants, and that they are in good condition and have not expired. In order to select, procure, and distribute the right quantities of the right contraceptives, managers of the logistics system must keep informed of the rates of use of each contraceptive and of the quantity of available supplies. As a result, We propose that a firm's e-logistics strategy is an important locus innovation and a crucial source of value creation for the firm its suppliers, partners, and customers.

• The Microorganisms and Industry
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• v.16 no.1
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• pp.7-17
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• 1990

In summary, the nature of the amino acid changes that impart oncogenicity in either the focus formation or tumorigenicity assay can be inferred by analysis of PCR-amplified DNA from tumor-derived NIH3T3 transformants and confirmed by analysis of primary liver tumors. Putative activating mutations in the c-K-ras genetic locus have been shown to involve a single-base modification of either G-C base pair at codon 12 leading to aspartate or cystein substitutions for glycine. The oncogenicity of an N-ras oncogene containing the N-ras C gene region may be related to an amino acid substitution of valine for glycine at codon 13.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2031-2037
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• 2012

Background: Analysis of gene-gene and gene-environment interactions for complex multifactorial human disease faces challenges regarding statistical methodology. One major difficulty is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes or environmental exposures. Based on our previous case-control study in Chongqing of China, we have found increased risk of colorectal cancer exists in individuals carrying a novel homozygous TT at locus rs1329149 and known homozygous AA at locus rs671. Methods: In this study, we proposed statistical method-crossover analysis in combination with logistic regression model, to further analyze our data and focus on assessing gene-environmental interactions for colorectal cancer. Results: The results of the crossover analysis showed that there are possible multiplicative interactions between loci rs671 and rs1329149 with alcohol consumption. Multifactorial logistic regression analysis also validated that loci rs671 and rs1329149 both exhibited a multiplicative interaction with alcohol consumption. Moreover, we also found additive interactions between any pair of two factors (among the four risk factors: gene loci rs671, rs1329149, age and alcohol consumption) through the crossover analysis, which was not evident on logistic regression. Conclusions: In conclusion, the method based on crossover analysis-logistic regression is successful in assessing additive and multiplicative gene-environment interactions, and in revealing synergistic effects of gene loci rs671 and rs1329149 with alcohol consumption in the pathogenesis and development of colorectal cancer.

• Electronics and Telecommunications Trends
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• v.39 no.3
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• pp.13-24
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• 2024

The capabilities of the metaverse have been demonstrated by representative examples such as Roblox, Fortnite, and Zepeto, and it can enable gaming, social networking services, and other applications. Nevertheless, research on the metaverse has been fragmented owing to conflicting definitions, core values, and characteristics. This ambiguity in metaverse conventions has hindered related research, analysis, and policy establishment. As the confusion seems to aggravate, consistent concepts should be established. Although the coronavirus disease pandemic led to a collapse in metaverse usage, it is regaining public interest since 2022. To promote the metaverse development, we structure core values based on existing research and surveys of consumer expectations. We found that consumers perceive the metaverse as a realistic virtual space and a potential economic opportunity. Hence, it seems necessary to track the extent to which the metaverse core values satisfy consumer demands. Such core values should be consistently reflected in policies and technology development.

• BMB Reports
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• v.49 no.11
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• pp.598-606
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• 2016

ARF is an alternative reading frame product of the INK4a/ARF locus, inactivated in numerous human cancers. ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. It functions by sequestering MDM2 (a p53 E3 ligase) in the nucleolus, thus activating p53. Besides MDM2, ARF has numerous other interacting partners that induce either cellular senescence or apoptosis in a p53-independent manner. This further complicates the dynamics of the ARF network. Expression of ARF is frequently disrupted in human cancers, mainly due to epigenetic and transcriptional regulation. Vigorous studies on various transcription factors that either positively or negatively regulate ARF transcription have been carried out. However, recent focus on posttranslational modifications, particularly ubiquitination, indicates wider dynamic controls of ARF than previously known. In this review, we discuss the role and dynamic regulation of ARF in senescence and cancer.