• The Journal of the Korea Contents Association
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• v.20 no.8
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• pp.418-428
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• 2020

This study aims to identify the impacts of parenting attitude, self-esteem and depression on school life adaptation in multicultural family adolescents focusing on the mediating effects of self-esteem and depression. To achieve this purpose, the seventh year of the 2016 Multicultural Youth Panel Survey(MAPS) data was used and among all respondents 1,236 multicultural adolescents under 16 years old whose mothers are foreign were collected. Our study findings are as follows: First, supervision and self-esteem had a positive effect, and neglect and depression had a negative effect on school life adaptation. Second, supervision and neglect had a partial influence on school life adaptation through the mediation of self-esteem and depression. Based on these findings, some practical implications was presented to enhance the adaptability of multicultural familiy adolescents to school life adaptation.

• The Journal of the Korea Contents Association
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• v.14 no.2
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• pp.131-145
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• 2014

This study is an empirical analysis on the relationship between social presence and online community users' continuance intention. Based on Bhattacherjee(2001)'s expectation-confirmation model (ECM) of IT continuance model, we test the influence of social presence on one's intention to continue using online communities. This study sampled 132 online community users. Research hypotheses are tested using the structural equation modelling(SEM) approach. The results of this study demonstrate that user satisfaction is influenced by perceived usefulness and perceived enjoyment. But, the confirmation of expectation did not affect user satisfaction. And, social presence has direct effects on perceived usefulness and perceived enjoyment. Further, social presence has a positive effect on users' continuance intention through mediating effect of perceived usefulness. This study suggests that perceived usefulness should be taken into account when carrying out the operating strategy of online communities.

• BMB Reports
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• v.45 no.4
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• pp.247-252
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• 2012

Although previous studies have demonstrated that BMP9 is highly capable of inducing osteogenic differentiation of mesenchymal stem cells, the molecular mechanism involved remains to be fully elucidated. In this study, we showed that BMP9 simultaneously promotes the activation of Smad1/5/8, p38 and ERK1/2 in C3H10T1/2 cells. Knockdown of Smad4 with RNA interference reduced nuclear translocation of Smad1/5/8, and disrupted BMP9-induced osteogenic differentiation. BMP9-induced osteogenic differentiation was blocked by p38 inhibitor SB203580, whereas enhanced by ERK1/2 inhibitor PD98059. SB203580 decreased BMP9-activated Smads singling, and yet PD98059 stimulated Smads singling in C3H10T1/2 cells. The effects of inhibitor were reproduced with adenovirus expressing siRNA targeted p38 and ERK1/2, respectively. Taken together, our findings revealed that Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation. Also, it is noteworthy that p38 and ERK1/2 may play opposing regulatory roles in mediating BMP9-induced osteogenic differentiation of C3H10T1/2 cells.

• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.275-281
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• 2014

Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome. Autophagy plays an important role of death-survival decisions in neuronal cells, which may influence to several neurodegenerative disorders including Parkinson's disease. Chebulagic acid, the major constituent of Terminalia chebula and Phyllanthus emblica, is a benzopyran tannin compound with various kinds of beneficial effects. This study was performed to investigate the autophagy enhancing effect of chebulagic acid on human neuroblastoma SH-SY5Y cell lines. We determined the effect of chebulagic acid on expression levels of autophagosome marker proteins such as, DOR/TP53INP2, Golgi-associated ATPase Enhancer of 16 kDa (GATE 16) and Light chain 3 II (LC3 II), as well as those of its upstream pathway proteins, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) and Beclin-1. All of those proteins were modulated by chebulagic acid treatment in a way of enhancing the autophagy. Additionally in our study, chebulagic acid also showed a protective effect against 1-methyl-4-phenylpyridinium ($MPP^+$) - induced cytotoxicity which mimics the pathological symptom of Parkinson's disease. This effect seems partially mediated by enhanced autophagy which increased the degradation of aggregated or misfolded proteins from cells. This study suggests that chebulagic acid is an attractive candidate as an autophagy-enhancing agent and therefore, it may provide a promising strategy to prevent or cure the diseases caused by accumulation of abnormal proteins including Parkinson's disease.

• Journal of Korea Port Economic Association
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• v.26 no.4
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• pp.40-62
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• 2010

Because of rapid changes in business environment and fierce competition, firms are facing a more competitive environment and a more serious global competition. Many of the previous literatures have indicated that a business which increases its market orientation will improve its market performance. Numerous authors have argued the interdepartmental dynamics as prior factor to market orientation, and relationship commitment are an essential part of successful long-term relationships. Based on previous literatures, this study proposes the structure about interdepartmental dynamics, market orientation, relationship commitment and performance. The purpose of this paper is to find the impact of market orientation and relationship commitment on customer performance. In addition, this suggests interdepartmental dynamics as prior factor to market orientation. Results indicate that interdepartmental connections can reduce interdepartmental conflict, and lower conflict is a key factor of market orientation. Furthermore, this paper finds evidences that support the mediating effects of the relationship commitment between market orientation and customer performance.

• Culinary science and hospitality research
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• v.21 no.1
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• pp.116-128
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• 2015

This study examined customers from restaurants in hotels in the Busan and Gyeongnam region, South Korea, to confirm if dinging area decoration has any indirect effect on behavioral intention via customer emotional response and the mediating effects of customer emotional response in order to provide the basic materials of marketing strategies for continued customer visit to the hotel restaurants. The implications of the study are summarized as follows: First, if restaurant space is designed in consideration of gustatory, visual, auditory, tactile, and olfactory aspects, it becomes a reason for customers to re-purchase and spread good words of mouth. Second, restaurant food space should be designed to make customers pleasant and exciting. Third, the design of food restaurant design that induces customer emotional responses elevates customer re-purchase and intention to deliver words of mouth.

• Journal of Convergence for Information Technology
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• v.11 no.10
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• pp.230-238
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• 2021

This study sought to understand the mediating effect of job enthusiasm in relation to work-life balance and job performance of hospital workers. The data collected through a self-contained survey using structured questionnaires for employees of medical institutions in Busan and South Gyeongsang Province were analyzed using SPSS 26.0 and Process Macro programs. As a result of the analysis, job performance and non-role performance were the most influenced by passion (+), and work-life balance was evaluated as a factor that increased job enthusiasm. In addition, work-life balance directly influenced job performance, but indirectly influenced job performance as a medium. In particular, the work-life balance and the relationship between performance other than roles were fully mediated. In order to improve the job performance of hospital workers at the organizational level, it is necessary to increase job enthusiasm, which means that efforts are needed to establish an organizational culture that values work-life balance.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.543-551
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• 2019

The purpose of this study was to examine the fitness of a Path model to represent relations between stress, social support, depression, and suicidal ideation in middle-aged males. The participants were 236 middle-aged males, and data were collected from April 11 to June 1, 2018. The analysis was performed using descriptive statistics and Pearson's correlations in PASW Ver. 21.0, and AMOS Ver. 18.0 (a statistical structural equation modeling program), fitness characteristics of the final model were RMSEA 0.05, GFI 0.98, AGFI 0.95, and NFI 0.98. The major study results were as follows. First, stress had a direct effect on depression and drinking, and social support had a direct effect on depression. Second, stress and social support both directly affected suicidal ideation. Results also suggested depression had partial mediating effects on relations between stress, social support, and suicidal ideation. We suggest a program be devised to reduce suicidal ideation by middle-aged males. It is hoped our results will provide basic data for future studies.

• Food Science of Animal Resources
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• v.39 no.2
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• pp.179-196
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• 2019

We investigated the effect of high density lipoprotein from egg yolk (EYHDL) on serum, hepatic and fecal lipid and fatty acids (FAs) levels and on gene expression involved in FAs metabolism. Male KM mice were fed either normal diet (ND; n=20), high fat diet (HFD; n=20), or high fat diet containing EYHDL (EYHDL; 0.6 mg/g, every day by oral gavage, n=20) for 100 days. At the end of the experiment, the effects of treatments on biochemical parameters, FAs profiles and involved gene expression were analyzed. Our results revealed that EYHDL markedly suppressed the body weight gain, accumulation of abdominal fat tissues, serum concentrations of LDL-cholesterol (LDL-C) and triglycerides, hepatic triglycerides and cholesterol accumulation, while increased serum concentration of HDL-cholesterol (HDL-C). EYHDL intake also increased total cholesterol (TC) excretions compared with HFD group. Moreover, it alleviated the severity of fatty liver and improved glucose and insulin tolerance compared with HFD. More importantly, EYHDL partially normalized FAs profiles in serum, liver and fecaces and neutralized the HFD-induced upregulation of SREBP-1c, Acaca, Fasn, GPAT and Scd1. In conclusion, our findings indicate that EYHDL may have the potential to improve metabolic disturbances that occur in HFD mice and can be considered as an appropriate dietary recommendation for the treatment of metabolic syndrome (MetS).

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.233-247
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• 2021

To verify the mediating effects of parent attachment and self-resilience between childhood abuse trauma among Ex-offenders, prsent study collected data from 510 Ex- offenders who are given the housing support from Korea Rehabilitation Agency. SPSS 21.0, M-plus 7 programs were used to analysis the collecting data. As a result, there were positive correlation between childhood trauma and recidivism, and there were negative correlation among the recidivism, parent attachment, and self-resilience. Indirect affect of parnet attachment was found between childhood trauma and recidivism. Also, indirect affect of self-resilience was found between childhood trauma and recidivism among the Ex-offender. The implication, and limitation of this study are discussed.