• 한국산업보건학회지
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• 제23권3호
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• pp.243-249
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• 2013

Objectives: This study assessed the status of domestic industrial hygiene laboratories using data from on-site investigation for revision of quality control systems in 2012-2013. Methods: The target laboratories were 60 industrial hygiene laboratories chosen by random selection and nationwide distribution which had participated in on-site investigations for revision of quality control systems from March 2012 to August 2013. The investigation was performed on-site following standard quality control procedures. The score between each group was compared using Mann-Whitney and Kruskal-Wallis tests, and the correlation between analytical career, sex, academic major of analyst and score of analytical performance was expressed as Spearman's rank correlation coefficient. Results: The assessment revealed that the items to be improved, in sequence, were effort at staff training (score 65.5), ability to calculate data (score 73.4), establishment of internal quality control guidelines (score 75.7), laboratory facilities (score 77.1), degree of understanding and skill at gas chromatography (score 77.1). Analysis performance showed a positive correlation with career of analyst (r=0.56, p<0.01). Conclusions: The practice of on-site investigation for quality control systems showed the current status of industrial hygiene laboratories in the first trial. There were many laboratories which needed improvement and development of analytical systems. This assessment can provide information for the systematic operation and improvement of facilities at each laboratory. Further practice of this investigation will lead to a proficiency testing and accreditation system for autonomous quality control as is the practice in many countries, rather than mandatory practice by legal regulation.

• 농촌계획
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• 제13권2호
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• pp.133-142
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• 2007

Tourism and recreation spots in Korea have been developed metropolitan cities-oriented that facility construction has too much importance in local tourist site development more than satisfaction and experience. Tourism hardly seems to play its role as a motive power even in locals where tourism occupies much in their economic development. Therefore, the ministry of culture & tourism has introduced a plan to discover cultural and tourism resources as a development alternative which handles theme-ability and specialization. However, most projects of local tourism resources developed since 1999 have resulted similar features comparing to previous and existing tourist spots. And the main objectives of this paper have not been realized very well. This research hence forth suggests a program-based model development in tourism resources, with a case study of Gokun-gugok, one of the historical and cultural sites and is located in Hwachon-gun, Gangwon Province. Main points include: Since the Gokun-gugok landscape has been undermined and been loosed the traditional cultural value due to the road development, this study intends to plan to make the adventure of tourism destination including restoring the site as a cultural place. The Gokun-gugok site needs to develop combining various types of tours and adventures with instructive and educational programs to meet the visitors' needs. This research also intends to precede a development plan based on harmonizing natural, historical and cultural assets of the Gokun-gugok with facility maintains and tourism development. Meanwhile, the study stresses on realizing development of tourism resources categorizing programs by seasonality, visitor's economic class, and visit duration. Asa consequence, the research presents a "Culture & Tourism Academy" which deals with these types of adventure programs and informative educations. To assess feasibility of the development plan in terms of economy, environment and policy, the research conducted the site inspection and examined the site's surroundings, land properties and inundation. 145,000 square meters have been extracted as a feasible development area out of total 392,500 square meters. Finally, the study segmentizes target markets basedon the result of the survey on visitors and local residents. The more segmentized markets employ facilities according to their traditional characters.

• 한국수자원학회논문집
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• 제33권1호
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• pp.99-110
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• 2000

본 연구에서는 마코프 연쇄에 근거하여 지점간 공간상관을 적절히 고려할 수 있는 일강우의 다지점 모의 발생 방법을 제안하였다. 유역 내 여러 지점 대표지점을 선정하여 강우의 발생의 간단한 1차 마코프 연쇄에 의해 모의되도록 하였고 강우강도는 과거자료에서 무작위하게 추출하는 방법을 적용하였다. 지점간 공간상관은 모든 지점에 대해 강우강도가 대표지점과 같은 시점의 것이 일관되게 선택되도록 함으로서 그대로 유지시킬수 있었다. 모의된 일강우자료는 평균, 분산이나 평균 무강우일수, 강우일수 등의 강우 특성은 잘 재현함을 알 수 있었으나, 원자료의 군집특성(시간축에서의)은 상대적으로 약화되어 1일 지체 상관계수가 원자료의 경우보다 작게 나타나고 있으며 아울러 평균 강우지속일수 및 무강우지속일수, 강우-강우 확률 및 무강우-무강우 확률이 원자료의 그것보다 약간 작게 나타남을 파악할 수 있었다. 그러나 이러한 단점은 유역을 대표할 수 있는 지점을 적절히 선택함으로서 또한 대표지점에 대한 강우발생의 상태를 무강우-강우에서 좀더 세분화함으로서 어느 정도 보완할 수 있을 것으로 판단된다.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2000년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2000
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• pp.91-97
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• 2000

Once a response spectrum is estimated for the site, if there is a need of generating realistic earthquakes time histories considering seismic sources and path effects, one alternative is to use statistical phase characteristics based on real earthquake records other than assuming arbitrary duration and envelope curves. In this study, statistics of group delay times derived from Japanese strong earthquake data were used for phase generation to fully capture the stochastic property of earthquakes. The result shows that simulated earthquake time histories can be generated according to earthquake magnitude and distances with target response spectrum.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 컴퓨터소사이어티 추계학술대회논문집
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• pp.19-22
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• 2003

Class area is a portion of memory where the constants, fields, and codes of the classes loaded into the Java virtual machine are kept. Knowing the site of the class area is very important especially for embedded Java system with limited memory resources. This paper induces a formula which makes it possible estimate the size of the area. The formula needs some constant values specific to target JVM implementation. We also show that these values can be found using some simple probe classes. An experimental result is included in this paper to confirm the correctness of our approach.

• BMB Reports
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• 제41권6호
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• pp.444-447
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• 2008

Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2002년도 제9회 학술 발표회 프로그램과 논문초록
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• pp.47-47
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• 2002

Nucleoredoxin (NRX) is a 435-amino-acid redox protein with similarity to TRX but with a -Trp-Cys-Pro-Pro-Cys- catalytic site (instead of - Trp-Cys-Gly-Pro-Cys-). It has been cloned from a mouse YAC library and localized to the nucleus In this study, amino acid sequences of rat and human NRX were determined by RT-PCR and genomic PCR. (omitted)

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2002년도 제9회 학술 발표회 프로그램과 논문초록
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• pp.30-30
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• 2002

The native forms of common globular proteins are in their most stable state but the native forms of plasma serpins (serine protease inhibitors) show high-energy state interactions. The high-energy state strain of a ${\alpha}$$_1$-antitrypsin, a prototype serpin, is distributed throughout the whole molecule, but the strain that regulates the function directly appears to be localized in the region where the reactive site loop is inserted during complex formation with a target protease.(omitted)

• 한국자기공명학회논문지
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• 제22권4호
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• pp.125-131
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• 2018

Chemical shift perturbation (CSP) is a simple NMR technique for studying binding of a protein to various ligands. CSP is the only technique that can directly provide both a value for the dissociation constant and a binding site from the same set of measurements. To accurately analyze the CSP data, the exact binding mode such as multiple binding, should be carefully considered. In this review, we analyzed systematically the CSP data with multiple modes. This analysis might provide insight into the mechanism on how proteins selectively recognize their target ligands to achieve the biological function.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제42권
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• pp.5.1-5.9
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• 2020

Immunomodulation is a technique for the modulation of immune responses against graft material to improve surgical success rates. The main target cell for the immunomodulation is a macrophage because it is the reaction site of the graft and controls the healing process. Macrophages can be classified into M1 and M2 types. Most immunomodulation techniques focus on the rapid differentiation of M2-type macrophage. An M2 inducer, 4-hexylresorcinol, has been recently identified and is used for bone grafts and dental implant coatings.