• 분석과학
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• 제30권6호
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• pp.338-347
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• 2017

본 연구의 목적은 돼지와 소를 대상으로 우리나라 대표 토양인 사양질, 식양질, 사질의 토양에 따른 실험실 규모 가축 매몰지를 설치하여 3년동안 분해특성을 살펴보는 것이다. 그 결과 가축 매몰지역 환경조사지침에 따른 가축 매몰지 발굴금지기간인 3년을 기준으로 대부분 분해되는 것을 확인하였으며, 사체분해를 위해 중요인자로 온도, 수분, pH, 토성, 영양소, 매몰지 깊이 등 다양한 외부환경 요인이 적절히 유지되어야 할것으로 판단되었다. 또한 소의 경우가 돼지보다 빠르게 분해되었는데, 토양에 따른 분해속도를 확인한 결과 사질 > 식양질 > 사양질 순으로 분해가 이루어지는 것으로 판단되었다.

• 대한한의학방제학회지
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• 제18권2호
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• pp.159-166
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• 2010

Objective : The objective of this study was to evaluate the single dose oral toxicity of Hwangryundaedok-tang extract in ICR mice. Methods : 0(control group), 1250, 2500 and 5000 mg/kg of Hwangryundaedok-tang extracts were orally administered to 20 male and 20 female ICR mice. After single oral administration of Hwangryundaedok-tang extract to ICR mice, we observed number of the death, clinical signs, changes of body weights for 14 days. After 14 day of Hwangryundaedok-tang extract administration, all mice were sacrificed and major organs were observed. Results : Compared with the control group, we could not find any toxic signs in the mortalities, clinical signs, body weight changes, necropsy findings and hematological values in all treated groups(1250, 2500 and 5000 mg/kg). Conclusions : $LD_{50}$ value of Hwangryundaedok-tang extracts may be over 5000 mg/kg and it may have no side toxic effect to ICR mice.

• Genomics & Informatics
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• 제10권3호
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• pp.167-174
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• 2012

AKT is a signal transduction protein that plays a central role in the tumorigenesis. There are 3 mammalian isoforms of this serine/threonine protein kinase-AKT1, AKT2, and AKT3-showing a broad tissue distribution. We first discovered 2 novel polymorphisms (AKT2 -9826 C/G and AKT3 -811 A/G), and we confirmed 6 known polymorphisms (AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, AKT3 -675 A/-, and AKT3 -244 C/T) of the AKT2 and AKT3 promoter region in 24 blood samples of Korean lung cancer patients using direct sequencing. To evaluate the role of AKT2 and AKT3 polymorphisms in the risk of Korean lung cancer, genotypes of the AKT2 and AKT3 polymorphisms (AKT2 -9826 C/G, AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, and AKT3 -675 A/-) were determined in 360 lung cancer patients and 360 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the AKT2 and AKT3 promoter regions were not significantly associated with the risk of lung cancer in the Korean population. These results suggest that polymorphisms of the AKT2 and AKT3 promoter regions do not contribute to the genetic susceptibility to lung cancer in the Korean population.

• 대한본초학회지
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• 제26권4호
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• pp.133-137
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• 2011

Objectives : Socheongryong-Tang (小靑龍湯, SCRT) has been widely used to treat respiratory disease. In this study, we investigated the protective effects of SCRT on hydrogen peroxide-induced hepatotoxicity. Methods : In the mouse primary liver cells, SCRT was pretreated for 1 h, and 1 mM $H_2O_2$ was treated to mouse primary liver cells. Cell viability was analyzed by using 3- 4,5-Dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay. Also, the activity of AST, ALT and LDH were measured for the evaluation the protective effect of SCRT on $H_2O_2$-induced hepatotoxicity. Intracellular ROS level was analyzed by FACS. Results : SCRT pretreatment decreased $H_2O_2$-induced hepatotoxicity and intracellular ROS production. Pretreatment of SCRT significantly reduced the cytotoxic effect induced by $H_2O_2$, associated with reducing DNA fragmentation and AST, ALT, LDH activities. Conclusions : These results suggest that SCRT has protective effect against $H_2O_2$-induced hepatotoxicity.

• 대한본초학회지
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• 제26권4호
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• pp.101-107
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• 2011

Objectives : Socheongryong-Tang (小靑龍湯, SCRT) has been widely used to treat respiratory disease. In this study, we investigate the acute toxicity and safety of fermented Socheongryong-Tang extract. Methods : To evaluate the acute toxicity and safety, 0 (control group), 1250, 2500 and 5000 mg/kg of Socheongryong-Tang and fermented Socheongryong-Tang extracts were orally administered to male and female ICR mice. After single administration, we observed survival rates, general toxicity, changes of body weight for the 14 days and autopsy. Results : Compared with the control group, we could not find any toxic alteration in all treated group (1250, 2500 and 5000 mg/kg). Conclusions : $LD_{50}$ of Socheongryong-Tang and fermented Socheongryong-Tang extracts might be over 5000 mg/kg and it is safe to ICR mice.

• 대한공간정보학회지
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• 제3권2호
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• pp.213-220
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• 1995

차량 항법 시스템에서 맵 매칭(map matching) 방법은 데드 레코닝(dead reckoning) 기법으로 구한 차량의 위치가 지도상의 도로위에 일치하지 않는 경우에 이를 도로위에 매칭(matching) 시키기 위한 방법이다. 본 논문에서는 교차로 부근에서 차량의 회전을 감지함으로서 센서 및 수치지도자료에 기인하는 위치오류를 보정할 수 있는 새로운 맵 매칭 알고리즘을 제안하였다. 제안된 알고리즘은 진행거리의 상대오차와 도로거리의 절대오차를 이용하여 교차로 지역의 범위를 설정하고, 설정된 지역에서 차량의 진행각을 감지하여 교차로에 연결된 각 도로에 대한 출발지점을 알아내고, 회전각과 진행각을 비교하여 새로운 위치를 알아내는 방법이다. 제안된 알고리즘의 효율성을 검증하기 위하여 거리센서로 속도센서를, 방향센서로서 광 자이로를 이용하여 휴대용 컴퓨터에 시스템을 구성하고, 대전지역을 시범지역으로 선정하여 알고리즘을 실험한 결과 그 유효성을 입증할 수 있었다.

• 대한골관절종양학회지
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• 제8권1호
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• pp.32-37
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• 2002

고등급 표면(high grade surface) 골육종은 골의 표면에서 발생하는 골육종의 희귀한 아형으로, 발생빈도는 전체 골육종의 1%에 못 미친다고 한다. 몇 편의 증례 보고와 연구 논문에서 이 고등급 표면 골육종을 소개하였는데, 국내의 경우 127예의 골육종 중 1예가 고등급 표면 골육종이었음을 기술한 논문이 있으나, 환자 및 진단과 치료에 대한 정보가 포함되어 있지 않았다. 저자들은 66세 여자 환자의 대퇴골 전자하부에서 발생한 고등급 표면 골육종 1예를 진단하고, 수술 전 항암 화학 요법, 광범위 절제술과 사지 구제술 및 수술 후 항암 화학 요법을 시행하였다. 이 종양은 위치만 골 표면에서 발생할 뿐 조직학적으로 전형적인 골수강내 골육종과 같으며, 다른 표면 골육종과는 달리 치료나 예후에 있어 전형적인 골수강 내 골육종과 같기 때문에, 진단과 치료에 있어 방골성 골육종이나 골막성 골육종 등의 표면 골육종과 구별하여야 할 것으로 생각한다.

• 한국해양공학회지
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• 제30권6호
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• pp.526-534
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• 2016

This study had the goal of designing onboard structures for a pre-pilot mining test (PPMT), which is required for the commercialization of the deep-sea mining industry. This PPMT is planned to validate the performance of a hydraulic lifting system and verify the concept of operating through a moon-pool in the east sea, Korea. All of the onboard equipment and facility were designed by KRISO. Because the test was performed at the first development, it is difficult to determine what risk will occur in the facility. Therefore, risk-based design is required in the facility for the PPMT, which includes the facility layout, failure mode and effect analysis (FMEA), and risk reduction plan. All of the expected performances of the lifting system itself and the onboard facilities were qualitatively validated using the risk-based design.

• Elastomers and Composites
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• 제50권3호
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• pp.223-230
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• 2015

Bacterial infection is one of the most common and universal cause of disease spreading associated with medical and surgical environment. Antimicrobial function of plasticized polyvinyl chloride (PVC) will be useful for making hygienic environments. Here, we synthesized the PVC composite by the addition of inorganic bacteriocide containing silver, zinc and zeolite. And we investigated the growth inhibition rate for Staphylococcus aureus and Klebsiella pneumoniae which were analyzed in the presence of PVC composite with different doses of inorganic bacteriocide (1~15 wt%). Bacterial proliferation was significantly inhibited by 3 wt% of inorganic bacteriocide containing PVC composite. And we found the inhibition of bacterial biofilm formation by 5 wt% of inorganic bacteriocide containing PVC composite by the observation of scanning electron microscopy (SEM). Our data suggested that the antimicrobial effect of inorganic bacteriocide was caused by disturbing the bacterial biofilm formation.

• 대한조선학회논문집
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• 제45권6호
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• pp.656-668
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• 2008

When it comes to design and acquire underwater vehicles such as a submarine and a torpedo according to the process of SBA(Simulation Based Acquisition)/SBD(Simulation Based Design), it is necessary to predict the performance of interest precisely and to perform the test over and over again using the M&S(Modeling and Simulation) of the engineering and the engagement level. In this paper, we research the DEVS(Discrete Event System Specification) and DTSS(Discrete Time System Specification) formalism based standard model architecture for the underwater vehicle which can support both the heterogeneous level of the M&S(Engineering/Engagement) and the different system of the M&S(Discrete Event System and Discrete Time System). To validate this standard modeling architecture, we apply it to the submarine normal diving simulation.