• IMMUNE NETWORK
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• 제3권3호
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• pp.235-241
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• 2003

Background: The protective immunity against tuberculosis (TB) involves both CD4+ T cells and CD8+ T cells. In our previous study, we defined four Mycobacterium tuberculosis derived peptide epitopes specific for HLA-$A^*0201$ restricted CD8+ T cells ($ThyA_{30-38}$, $RpoB_{127-135}$, $85B_{15-23}$, $PstA1_{75-83}$). In this study, we investigated the immune responses induced by these peptide specific CD8+ T cells in latently and chronically infected people with TB. Methods: We characterized these peptide specific CD8+ T cell population present in PBMC of both TB patients and PPD+healthy people using IFN-${\gamma}$elispot assay, intracellular staining and HLA-A2 dimer staining. Results: The frequency of peptide specific CD8+ T cell was in the range of 1 to 25 in $1.7{\times}10^5$ PBMC based on ex vivo IFN-${\gamma}$ elispot assay, demonstrating that these peptide specific CD8+ T cell responses are induced in both TB patients and PPD+ people. Short term cell lines (STCL) specific for these peptides proliferated in vitro and secreted IFN-${\gamma}$ upon antigenic stimulation in PPD+ donors. Lastly, HLA-$A^*0201$ dimer assays indicated that $PstA1_{75-83}$ specific CD8+ T cell population in PPD+ healthy donors is heterogeneous since approximately 25~33% of $PstA1_{75-83}$ specific CD8+ T cell population in PPD+ healthy donors produced IFN-${\gamma}$ upon peptide stimulation. Conclusion: Our results suggest that MHC class I restricted CD8+ T cell mediated immune responses to M. tuberculosis infection are induced in both TB patients and PPD + people; however, the CD8+ T cell population is functionally heterogeneous.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2001년도 학술발표회 발표논문집
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• pp.475-478
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• 2001

Runoff and nutrient concentrations were monitored to identify pollutant load characteristics of a subwatershed in the Jooam lake. Observed concentrations of T-N and T-P were $1.445{\sim}3.980mg/{\ell}\;and\;0{\sim}0.273mg/{\ell}$, respectively. Runoff load of T-N, T-P by single storm occurred June 24th 2001 contributed 55% of T-N and 41% T-P of total pollutant load during study period.

• 대한수학회보
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• 제43권3호
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• pp.645-652
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• 2006

The purpose of this paper is to describe some characterizations on rational and f-rational extensions of modules, to determine the forms of f-rational extensions of given f-torsion free module for a left exact radical t and investigate the maximal t-rational extensions of modules.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2003년도 학술발표논문집
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• pp.283-286
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• 2003

In order to examine effects of sampling frequency during rainfall-runoff process from paddy field on the estimation of pollution load, EMCs of several water sampling frequencies were examined. It was found that the difference of EMCs between one time sampling and two hours consecutive sampling during storm event showed $34.1{\sim}-19.1%$ for T-N, $55.4{\sim}-27.3%$ for T-P, $68.5{\sim}-41.0%$ for the SS, respectively. Five times sampling reduced difference of EMCs compared to those two hours interval sampling to $15.2{\sim}-15.2%$ for T-N, $20.0{\sim}-26.2%$ for T-P, $28.6{\sim}-35.7%$ for the SS, respectively.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2012년도 춘계학술대회 논문집
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• pp.481-482
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• 2012

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1998년도 The Third Asian Fuzzy Systems Symposium
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• pp.80-82
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• 1998

we introduce the concept of coverings, direct products, cascade products and wreath products of T-fuzzy finite state machines and investigate their algebraic structures.

• 한국수학교육학회지시리즈A:수학교육
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• 제18권1호
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• pp.21-23
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• 1980

In [3], an extension of B. Brosowski s T-invariant Point Theorem is given where the linearity of the function and the convexity of the set are relaxed. In this paper, our main purpose is to generalize S. P. Singh's T-invariant Point Theorem to Approximation Theory.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제4권1호
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• pp.39-48
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• 2000

In this paper we define T-fuzzy integrals of set-valued mappings, which are extensions of fuzzy integrals of the single-valued functions defined by Sugeno. And we discuss their properties.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1989년도 추계학술발표회 발표논문초록집; 이화여자대학교, 서울; 23 Sep. 1989
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• pp.126-132
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• 1989

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2007년도 춘계학술대회 논문집
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• pp.639-640
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• 2007